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Empty sella syndrome

MedGen UID:
41766
Concept ID:
C0014008
Disease or Syndrome
Synonym: Empty sella turcica
SNOMED CT: Empty sella syndrome (237722004)
 
Monarch Initiative: MONDO:0006740

Definition

A syndrome characterized by flattening or regression of the pituitary gland within the sella turcica cavity, resulting in an MRI image of an empty sella turcica. Signs and symptoms are secondary to pituitary gland hypofunction. [from NCI]

Professional guidelines

PubMed

Kerns J, Itriyeva K, Fisher M
Curr Probl Pediatr Adolesc Health Care 2022 May;52(5):101184. Epub 2022 May 4 doi: 10.1016/j.cppeds.2022.101184. PMID: 35525789
Kalina MA, Kalina-Faska B, Gruszczyńska K, Baron J, Małecka-Tendera E
Childs Nerv Syst 2012 Jan;28(1):121-7. Epub 2011 Sep 21 doi: 10.1007/s00381-011-1594-7. PMID: 21935593Free PMC Article
Markou K, Goudakos J, Franco-Vidal V, Vergnolles V, Vignes JR, Darrouzet V
Am J Otolaryngol 2011 Mar-Apr;32(2):135-40. Epub 2010 Apr 13 doi: 10.1016/j.amjoto.2009.12.003. PMID: 20392531

Recent clinical studies

Etiology

Kerns J, Itriyeva K, Fisher M
Curr Probl Pediatr Adolesc Health Care 2022 May;52(5):101184. Epub 2022 May 4 doi: 10.1016/j.cppeds.2022.101184. PMID: 35525789
Prodam F, Caputo M, Mele C, Marzullo P, Aimaretti G
Nat Rev Endocrinol 2021 Feb;17(2):114-129. Epub 2020 Nov 27 doi: 10.1038/s41574-020-00437-2. PMID: 33247226
Graillon T, Passeri T, Boucekine M, Meyer M, Abritti R, Bernat AL, Labidi M, Dufour H, Froelich S
Pituitary 2021 Apr;24(2):292-301. Epub 2020 Nov 2 doi: 10.1007/s11102-020-01104-5. PMID: 33136230
Zetchi A, Labeyrie MA, Nicolini E, Fantoni M, Eliezer M, Houdart E
AJNR Am J Neuroradiol 2019 Oct;40(10):1695-1700. Epub 2019 Sep 19 doi: 10.3174/ajnr.A6210. PMID: 31537518Free PMC Article
De Marinis L, Bonadonna S, Bianchi A, Maira G, Giustina A
J Clin Endocrinol Metab 2005 Sep;90(9):5471-7. Epub 2005 Jun 21 doi: 10.1210/jc.2005-0288. PMID: 15972577

Diagnosis

Kerns J, Itriyeva K, Fisher M
Curr Probl Pediatr Adolesc Health Care 2022 May;52(5):101184. Epub 2022 May 4 doi: 10.1016/j.cppeds.2022.101184. PMID: 35525789
Chiloiro S, Giampietro A, Bianchi A, De Marinis L
Handb Clin Neurol 2021;181:29-40. doi: 10.1016/B978-0-12-820683-6.00003-8. PMID: 34238465
Graillon T, Passeri T, Boucekine M, Meyer M, Abritti R, Bernat AL, Labidi M, Dufour H, Froelich S
Pituitary 2021 Apr;24(2):292-301. Epub 2020 Nov 2 doi: 10.1007/s11102-020-01104-5. PMID: 33136230
Auer MK, Stieg MR, Crispin A, Sievers C, Stalla GK, Kopczak A
Dtsch Arztebl Int 2018 Feb 16;115(7):99-105. doi: 10.3238/arztebl.2018.0099. PMID: 29510819Free PMC Article
Chiloiro S, Giampietro A, Bianchi A, Tartaglione T, Capobianco A, Anile C, De Marinis L
Eur J Endocrinol 2017 Dec;177(6):R275-R285. Epub 2017 Aug 5 doi: 10.1530/EJE-17-0505. PMID: 28780516

Therapy

Prodam F, Caputo M, Mele C, Marzullo P, Aimaretti G
Nat Rev Endocrinol 2021 Feb;17(2):114-129. Epub 2020 Nov 27 doi: 10.1038/s41574-020-00437-2. PMID: 33247226
Taieb A, Maha KN, El Abed YH, Beizig AM, Chadli MC, Ach K
Pan Afr Med J 2017;27:278. Epub 2017 Aug 14 doi: 10.11604/pamj.2017.27.278.11361. PMID: 29187947Free PMC Article
Mehta GU, Bakhtian KD, Oldfield EH
J Neurosurg 2014 Sep;121(3):518-26. Epub 2014 May 23 doi: 10.3171/2014.3.JNS132012. PMID: 24857241
Wang EW, Vandergrift WA 3rd, Schlosser RJ
Otolaryngol Clin North Am 2011 Aug;44(4):845-56, vii. doi: 10.1016/j.otc.2011.06.018. PMID: 21819875
Brismar K
Acta Med Scand 1981;209(5):397-405. doi: 10.1111/j.0954-6820.1981.tb11615.x. PMID: 6787839

Prognosis

Besci Ö, Yaşar E, Erbaş İM, Acınıklı KY, Demir K, Böber E, Abacı A
Turk J Pediatr 2022;64(5):900-908. doi: 10.24953/turkjped.2021.4953. PMID: 36305440
Chen T, Li G, Wu D, Xie B, Feng Y, Xiao S, Li J, Liu Y, Yang J, Li X
Clin Neurol Neurosurg 2021 Apr;203:106586. Epub 2021 Mar 5 doi: 10.1016/j.clineuro.2021.106586. PMID: 33730618
Graillon T, Passeri T, Boucekine M, Meyer M, Abritti R, Bernat AL, Labidi M, Dufour H, Froelich S
Pituitary 2021 Apr;24(2):292-301. Epub 2020 Nov 2 doi: 10.1007/s11102-020-01104-5. PMID: 33136230
De Marinis L, Bonadonna S, Bianchi A, Maira G, Giustina A
J Clin Endocrinol Metab 2005 Sep;90(9):5471-7. Epub 2005 Jun 21 doi: 10.1210/jc.2005-0288. PMID: 15972577
Bjerre P
Acta Neurol Scand Suppl 1990;130:1-25. PMID: 2220326

Clinical prediction guides

Ji W, Chen X
Medicine (Baltimore) 2023 Mar 10;102(10):e33216. doi: 10.1097/MD.0000000000033216. PMID: 36897687Free PMC Article
Taieb A, Maha KN, El Abed YH, Beizig AM, Chadli MC, Ach K
Pan Afr Med J 2017;27:278. Epub 2017 Aug 14 doi: 10.11604/pamj.2017.27.278.11361. PMID: 29187947Free PMC Article
Poggi M, Monti S, Lauri C, Pascucci C, Bisogni V, Toscano V
Ann Ist Super Sanita 2012;48(1):91-6. doi: 10.4415/ANN_12_01_15. PMID: 22456022
De Marinis L, Bonadonna S, Bianchi A, Maira G, Giustina A
J Clin Endocrinol Metab 2005 Sep;90(9):5471-7. Epub 2005 Jun 21 doi: 10.1210/jc.2005-0288. PMID: 15972577
Mancini A, Calabrò F, Lagonigro G, Saporosi A, Colosimo C Jr, Anile C, Maira G, De Marinis L
J Nucl Med Allied Sci 1990 Apr-Jun;34(2):59-66. PMID: 2246674

Recent systematic reviews

Martínez JL, Domingo RA, Rowland NC, Vandergrift Iii WA
Neurol India 2022 May-Jun;70(3):857-863. doi: 10.4103/0028-3886.349629. PMID: 35864609
Riccio L, Donofrio CA, Tomacelli G, De Blasi R, Melatini A
Pituitary 2020 Aug;23(4):457-466. doi: 10.1007/s11102-020-01057-9. PMID: 32504302
Auer MK, Stieg MR, Crispin A, Sievers C, Stalla GK, Kopczak A
Dtsch Arztebl Int 2018 Feb 16;115(7):99-105. doi: 10.3238/arztebl.2018.0099. PMID: 29510819Free PMC Article
Barzaghi LR, Donofrio CA, Panni P, Losa M, Mortini P
Pituitary 2018 Feb;21(1):98-106. doi: 10.1007/s11102-017-0842-6. PMID: 29027644

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