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Hepatitis D virus infection

MedGen UID:
4182
Concept ID:
C0011226
Disease or Syndrome
Synonyms: Delta Hepatitis; Delta Infection; Hepatitides, Delta; Hepatitis D; Hepatitis, Delta; Infection, Delta; Infections, Delta
SNOMED CT: Viral hepatitis type D (707341005); Viral hepatitis D (707341005); Hepatitis D virus infection (707341005); Hepatitis D (707341005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005789
Orphanet: ORPHA402823

Definition

Hepatitis delta is a rare hepatic disease characterized by variable degrees of acute hepatitis resulting from infection with the hepatitis delta virus. Occasionally it may present a benign course, but most frequently it manifests with severe liver disease that may include fulminant liver failure, hepatic decompensation and rapid progression to cirrhosis. All patients present concomitant hepatitis B virus infection and an increased risk of developing hepatocellular carcinoma has been reported. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis D virus infection

Professional guidelines

PubMed

Abdrakhman A, Ashimkhanova A, Almawi WY
Antiviral Res 2021 Jan;185:104995. Epub 2020 Dec 13 doi: 10.1016/j.antiviral.2020.104995. PMID: 33321155
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688
Dalekos GN, Galanakis E, Zervou E, Tzoufi M, Lapatsanis PD, Tsianos EV
Hepatogastroenterology 2000 Jul-Aug;47(34):1072-6. PMID: 11020882

Recent clinical studies

Etiology

Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
Abdallah T, Ibrahim T, Hajmusa M, Abdulgayoom M, Elhassan A, Abusabeib A, Babikir M, Abdelrahim S, Daghfal J, Derbala M
East Mediterr Health J 2022 Nov 30;28(11):840-846. doi: 10.26719/emhj.22.081. PMID: 36515449
Jung S, Altstetter SM, Protzer U
World J Gastroenterol 2020 Jun 7;26(21):2781-2791. doi: 10.3748/wjg.v26.i21.2781. PMID: 32550754Free PMC Article
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

Diagnosis

Demirel A, Uraz S, Deniz Z, Daglilar E, Basar O, Tahan V, Ozaras R
J Viral Hepat 2024 Feb;31(2):120-128. Epub 2023 Nov 14 doi: 10.1111/jvh.13899. PMID: 37964693
Asselah T, Rizzetto M
N Engl J Med 2023 Jul 6;389(1):58-70. doi: 10.1056/NEJMra2212151. PMID: 37407002
Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Rizzetto M, Hamid S
Liver Int 2021 Jan;41(1):16-19. Epub 2020 Nov 23 doi: 10.1111/liv.14729. PMID: 33179354
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article

Therapy

Lange F, Garn J, Anagho HA, Vondran FWR, von Hahn T, Pietschmann T, Carpentier A
Liver Int 2023 Oct;43(10):2116-2129. Epub 2023 Jun 27 doi: 10.1111/liv.15655. PMID: 37366005
Sulkowski MS
J Viral Hepat 2023 Apr;30 Suppl 1:39-42. Epub 2023 Apr 7 doi: 10.1111/jvh.13825. PMID: 36856472
Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM
J Hepatol 2020 Sep;73(3):523-532. Epub 2020 Apr 23 doi: 10.1016/j.jhep.2020.04.008. PMID: 32335166Free PMC Article
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

Prognosis

Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Jang TY, Wei YJ, Liu TW, Yeh ML, Liu SF, Hsu CT, Hsu PY, Lin YH, Liang PC, Hsieh MH, Ko YM, Tsai YS, Chen KY, Lin CC, Tsai PC, Wang SC, Huang CI, Lin ZY, Chen SC, Chuang WL, Huang JF, Dai CY, Huang CF, Yu ML
Sci Rep 2021 Apr 14;11(1):8184. doi: 10.1038/s41598-021-87679-w. PMID: 33854160Free PMC Article
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688
Theamboonlers A, Hansurabhanon T, Verachai V, Chongsrisawat V, Poovorawan Y
Infection 2002 Jun;30(3):140-4. doi: 10.1007/s15010-002-2061-x. PMID: 12120938

Clinical prediction guides

Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Kefalakes H, Horgan XJ, Jung MK, Amanakis G, Kapuria D, Bolte FJ, Kleiner DE, Koh C, Heller T, Rehermann B
Gastroenterology 2021 Nov;161(5):1567-1583.e9. Epub 2021 Jul 21 doi: 10.1053/j.gastro.2021.07.027. PMID: 34302839Free PMC Article
Khodjaeva M, Ibadullaeva N, Khikmatullaeva A, Joldasova E, Ismoilov U, Colombo M, Caviglia GP, Rizzetto M, Musabaev E
Liver Int 2019 Nov;39(11):2077-2081. Epub 2019 Sep 20 doi: 10.1111/liv.14243. PMID: 31505080
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688

Recent systematic reviews

Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM
J Hepatol 2020 Sep;73(3):523-532. Epub 2020 Apr 23 doi: 10.1016/j.jhep.2020.04.008. PMID: 32335166Free PMC Article
Alfaiate D, Clément S, Gomes D, Goossens N, Negro F
J Hepatol 2020 Sep;73(3):533-539. Epub 2020 Mar 6 doi: 10.1016/j.jhep.2020.02.030. PMID: 32151618
Chen HY, Shen DT, Ji DZ, Han PC, Zhang WM, Ma JF, Chen WS, Goyal H, Pan S, Xu HG
Gut 2019 Mar;68(3):512-521. Epub 2018 Sep 18 doi: 10.1136/gutjnl-2018-316601. PMID: 30228220
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

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