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Loss of Chromosome 11p

MedGen UID:
419164
•Concept ID:
C2931795
•
Cell or Molecular Dysfunction
Synonyms: Chromosome 11, deletion 11p; Deletion 11p; Monosomy 11p

Definition

A cytogenetic abnormality that refers to the loss of all or part of the short arm of chromosome 11 (11p). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 11p

Professional guidelines

PubMed

The effects of 3-year growth hormone treatment and body composition in Polish patients with Silver-Russell syndrome.
Świąder-Leśniak A, Jurkiewicz D, Kołodziejczyk H, Kozłowska A, Korpysz A, Szalecki M, Chrzanowska K
Endokrynol Pol 2023;74(3):285-293. Epub 2023 Jun 19 doi: 10.5603/EP.a2023.0042. PMID: 37335065
Small cell lung cancer: etiology, biology, clinical features, staging, and treatment.
Cook RM, Miller YE, Bunn PA Jr
Curr Probl Cancer 1993 Mar-Apr;17(2):69-141. doi: 10.1016/0147-0272(93)90010-y. PMID: 8395998
Non-small cell lung cancer. Part II: Treatment.
Ihde DC, Minna JD
Curr Probl Cancer 1991 May-Jun;15(3):105-54. doi: 10.1016/0147-0272(91)90012-y. PMID: 1713139

Recent clinical studies

Etiology

The beta-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus.
Glaser T, Lewis WH, Bruns GA, Watkins PC, Rogler CE, Shows TB, Powers VE, Willard HF, Goguen JM, Simola KO
Nature 1986 Jun 26-Jul 2;321(6073):882-7. doi: 10.1038/321882a0. PMID: 3014343

Diagnosis

Pancreatoblastoma in Elderly Adults: Report of Two Patients.
Kulak O, Osipov A, Hendifar AE, Nissen NN, Cox BK, Hruban RH, Hutchings DA
Int J Surg Pathol 2023 Aug;31(5):772-777. Epub 2022 Oct 30 doi: 10.1177/10668969221133347. PMID: 36314453

Clinical prediction guides

Integrated genomic profiling identifies loss of chromosome 11p impacting transcriptomic activity in aggressive pituitary PRL tumors.
Wierinckx A, Roche M, Raverot G, Legras-Lachuer C, Croze S, Nazaret N, Rey C, Auger C, Jouanneau E, Chanson P, Trouillas J, Lachuer J
Brain Pathol 2011 Sep;21(5):533-43. Epub 2011 Feb 23 doi: 10.1111/j.1750-3639.2011.00476.x. PMID: 21251114Free PMC Article

Supplemental Content

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