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Necrotizing ulcerative gingivitis

MedGen UID:
42219
•Concept ID:
C0017575
•
Disease or Syndrome
Synonyms: Acute membranous gingivitis; Acute necrotizing ulcerative gingivitis; Fusospirillary gingivitis; Fusospirillosis; Phagedenic gingivitis; Vincent's gingivitis; Vincent's infection; Vincent's stomatitis
SNOMED CT: Acute necrotizing ulcerative gingivitis (399050001); Trench mouth (399050001); Vincent's gingivitis (399050001); Acute ulceromembranous gingivitis (399050001); Acute ulcerative gingivitis (172697005); AUG - Acute ulcerative gingivitis (172697005); Vincent's stomatitis (173599005); Acute necrotizing ulcerative gingivostomatitis (173599005); Necrotizing ulcerative gingivitis (707792000); Vincent disease (399050001); ANUG - acute necrotizing ulcerative gingivitis (399050001)
 
Monarch Initiative: MONDO:0006865

Definition

A bacterial infectious process affecting the gums. It is characterized by the development of necrotic, ulcerated, and painful lesions with creation of pseudomembranes extending along the gingival margins. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrotizing ulcerative gingivitis

Professional guidelines

PubMed

Necrotizing Periodontal Diseases in Children: A Literature Review and Adjustment of Treatment.
Marty M, Palmieri J, Noirrit-Esclassan E, Vaysse F, Bailleul-Forestier I
J Trop Pediatr 2016 Aug;62(4):331-7. Epub 2016 Mar 10 doi: 10.1093/tropej/fmw005. PMID: 26966241
Differential Diagnosis and Treatment Proposal for Acute Endodontic Infection.
Keine KC, Kuga MC, Pereira KF, Diniz AC, Tonetto MR, Galoza MO, Magro MG, de Barros YB, Bandéca MC, de Andrade MF
J Contemp Dent Pract 2015 Dec 1;16(12):977-83. doi: 10.5005/jp-journals-10024-1791. PMID: 27018033
The treatment of acute necrotizing ulcerative gingivitis.
Hartnett AC, Shiloah J
Quintessence Int 1991 Feb;22(2):95-100. PMID: 2068255

Recent clinical studies

Etiology

Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.
Siddiqui AZ, Vellappally S, Fouad H, Muckarrum SM
Photodiagnosis Photodyn Ther 2020 Mar;29:101668. Epub 2020 Jan 24 doi: 10.1016/j.pdpdt.2020.101668. PMID: 31988023
Necrotising Ulcerative Gingivitis: A Literature Review.
Dufty J, Gkranias N, Donos N
Oral Health Prev Dent 2017;15(4):321-327. doi: 10.3290/j.ohpd.a38766. PMID: 28761942
Periodontal disease in children and adolescents of Latin America.
Botero JE, Rösing CK, Duque A, Jaramillo A, Contreras A
Periodontol 2000 2015 Feb;67(1):34-57. doi: 10.1111/prd.12072. PMID: 25494597
Managing patients with necrotizing ulcerative periodontitis.
Todescan S, Nizar R
J Can Dent Assoc 2013;79:d44. PMID: 23763731
Tobacco smoking and periodontal diseases.
Qandil R, Sandhu HS, Matthews DC
J Can Dent Assoc 1997 Mar;63(3):187-92, 194-5. PMID: 9086680

Diagnosis

Pemphigus Vulgaris.
Silva SC, Nasser R, Payne AS, Stoopler ET
J Emerg Med 2019 Jan;56(1):102-104. Epub 2018 Nov 30 doi: 10.1016/j.jemermed.2018.10.028. PMID: 30503724
Necrotising Ulcerative Gingivitis: A Literature Review.
Dufty J, Gkranias N, Donos N
Oral Health Prev Dent 2017;15(4):321-327. doi: 10.3290/j.ohpd.a38766. PMID: 28761942
Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
Necrotizing ulcerative gingivitis.
Rowland RW
Ann Periodontol 1999 Dec;4(1):65-73; discussion 78. doi: 10.1902/annals.1999.4.1.65. PMID: 10863376
Necrotizing ulcerative gingivitis.
Ahl DR
US Navy Med 1983 Jan-Feb;74(1):30-2. PMID: 6587667

Therapy

Pemphigus Vulgaris.
Silva SC, Nasser R, Payne AS, Stoopler ET
J Emerg Med 2019 Jan;56(1):102-104. Epub 2018 Nov 30 doi: 10.1016/j.jemermed.2018.10.028. PMID: 30503724
Trench Mouth.
Chaubal T, Bapat R
Am J Med 2017 Nov;130(11):e493-e494. Epub 2017 Jun 8 doi: 10.1016/j.amjmed.2017.05.020. PMID: 28602875
Oral Ulcerations.
Fetterolf B, Zaballa A, Strote J
West J Emerg Med 2015 Dec;16(7):1196-7. Epub 2015 Dec 8 doi: 10.5811/westjem.2015.8.28358. PMID: 26759682Free PMC Article
Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
Necrotizing ulcerative gingivitis.
Rowland RW
Ann Periodontol 1999 Dec;4(1):65-73; discussion 78. doi: 10.1902/annals.1999.4.1.65. PMID: 10863376

Prognosis

Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
Aggressive and acute periodontal diseases.
Albandar JM
Periodontol 2000 2014 Jun;65(1):7-12. doi: 10.1111/prd.12013. PMID: 24738583
Necrotizing ulcerative gingivitis.
Rowland RW
Ann Periodontol 1999 Dec;4(1):65-73; discussion 78. doi: 10.1902/annals.1999.4.1.65. PMID: 10863376
Noma (cancrum oris): questions and answers.
Enwonwu CO, Falkler WA Jr, Idigbe EO, Savage KO
Oral Dis 1999 Apr;5(2):144-9. doi: 10.1111/j.1601-0825.1999.tb00080.x. PMID: 10522212
Periodontal complications of HIV infection.
Greenspan JS
Compend Suppl 1994;(18):S694-8; quiz S714-7. PMID: 8039207

Clinical prediction guides

Effectiveness of photodynamic therapy adjunct to oral debridement in improving clinical, microbiological, and pain in necrotizing ulcerative gingivitis.
Al-Kheraif AA, Javed R, Al-Momani MM, Wasi A, Khan AA
J Biophotonics 2023 Oct;16(10):e202300197. Epub 2023 Jul 11 doi: 10.1002/jbio.202300197. PMID: 37369626
Chronic Ulcerative Stomatitis (CUS) as an Interdisciplinary Diagnostic Challenge: A Literature Review.
Cichońska D, Komandera D, Mazuś M, Kusiak A
Int J Mol Sci 2022 Nov 9;23(22) doi: 10.3390/ijms232213772. PMID: 36430253Free PMC Article
Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.
Siddiqui AZ, Vellappally S, Fouad H, Muckarrum SM
Photodiagnosis Photodyn Ther 2020 Mar;29:101668. Epub 2020 Jan 24 doi: 10.1016/j.pdpdt.2020.101668. PMID: 31988023
Prevalence and treatment of necrotizing ulcerative gingivitis (NUG) in the British Armed Forces: a case-control study.
Dufty J, Gkranias N, Petrie A, McCormick R, Elmer T, Donos N
Clin Oral Investig 2017 Jul;21(6):1935-1944. Epub 2016 Nov 9 doi: 10.1007/s00784-016-1979-9. PMID: 27830369
Microbiological understandings and mysteries of noma (cancrum oris).
Falkler WA Jr, Enwonwu CO, Idigbe EO
Oral Dis 1999 Apr;5(2):150-5. doi: 10.1111/j.1601-0825.1999.tb00081.x. PMID: 10522213

Recent systematic reviews

Evaluation of metronidazole oral monotherapy in anaerobic oral infections.
Dar-Odeh N, Atef A, Flaifl Y, Bobamuratova D, Akily B, Meer R, Abu-Hammad O
Int J Clin Pharmacol Ther 2024 Nov;62(11):517-524. doi: 10.5414/CP204565. PMID: 39120079
Microbiological Study of Periodontal Disease in Populations with HIV: a Systematic Review and Meta-Analysis.
Valian NK, Houshmand B, Ardakani MT, Mahmoudi S
Clin Lab 2023 May 1;69(5) doi: 10.7754/Clin.Lab.2022.220738. PMID: 37145081
Chronic ulcerative stomatitis: A systematic review of the clinical and microscopic features.
Ferrisse TM, Travassos DC, Rocha AF, Massucato EM, Bufalino A
Med Oral Patol Oral Cir Bucal 2019 Nov 1;24(6):e698-e703. doi: 10.4317/medoral.22213. PMID: 31655827Free PMC Article
Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria.
Azzi L, Cerati M, Lombardo M, Pellilli M, Croveri F, Maurino V, Tagliabue A, Tettamanti L, Olszewska M
Oral Dis 2019 Sep;25(6):1465-1491. Epub 2019 Jan 6 doi: 10.1111/odi.13001. PMID: 30457193
Necrotizing Periodontal Diseases in Children: A Literature Review and Adjustment of Treatment.
Marty M, Palmieri J, Noirrit-Esclassan E, Vaysse F, Bailleul-Forestier I
J Trop Pediatr 2016 Aug;62(4):331-7. Epub 2016 Mar 10 doi: 10.1093/tropej/fmw005. PMID: 26966241

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