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Necrotizing ulcerative gingivitis

MedGen UID:
42219
•Concept ID:
C0017575
•
Disease or Syndrome
Synonyms: Acute membranous gingivitis; Acute necrotizing ulcerative gingivitis; Fusospirillary gingivitis; Fusospirillosis; Phagedenic gingivitis; Vincent's gingivitis; Vincent's infection; Vincent's stomatitis
SNOMED CT: Acute necrotizing ulcerative gingivitis (399050001); Trench mouth (399050001); Vincent's gingivitis (399050001); Acute ulceromembranous gingivitis (399050001); Acute ulcerative gingivitis (172697005); AUG - Acute ulcerative gingivitis (172697005); Vincent's stomatitis (173599005); Acute necrotizing ulcerative gingivostomatitis (173599005); Necrotizing ulcerative gingivitis (707792000); Vincent disease (399050001); ANUG - acute necrotizing ulcerative gingivitis (399050001)
 
Monarch Initiative: MONDO:0006865

Definition

A bacterial infectious process affecting the gums. It is characterized by the development of necrotic, ulcerated, and painful lesions with creation of pseudomembranes extending along the gingival margins. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrotizing ulcerative gingivitis

Professional guidelines

PubMed

Necrotizing Periodontal Diseases in Children: A Literature Review and Adjustment of Treatment.
Marty M, Palmieri J, Noirrit-Esclassan E, Vaysse F, Bailleul-Forestier I
J Trop Pediatr 2016 Aug;62(4):331-7. Epub 2016 Mar 10 doi: 10.1093/tropej/fmw005. PMID: 26966241
The treatment of acute necrotizing ulcerative gingivitis.
Hartnett AC, Shiloah J
Quintessence Int 1991 Feb;22(2):95-100. PMID: 2068255
Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment.
Johnson BD, Engel D
J Periodontol 1986 Mar;57(3):141-50. doi: 10.1902/jop.1986.57.3.141. PMID: 3514841

Recent clinical studies

Etiology

Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.
Siddiqui AZ, Vellappally S, Fouad H, Muckarrum SM
Photodiagnosis Photodyn Ther 2020 Mar;29:101668. Epub 2020 Jan 24 doi: 10.1016/j.pdpdt.2020.101668. PMID: 31988023
Necrotising Ulcerative Gingivitis: A Literature Review.
Dufty J, Gkranias N, Donos N
Oral Health Prev Dent 2017;15(4):321-327. doi: 10.3290/j.ohpd.a38766. PMID: 28761942
Periodontal disease in children and adolescents of Latin America.
Botero JE, Rösing CK, Duque A, Jaramillo A, Contreras A
Periodontol 2000 2015 Feb;67(1):34-57. doi: 10.1111/prd.12072. PMID: 25494597
Epidemiology of acute necrotizing ulcerative gingivitis.
Melnick SL, Roseman JM, Engel D, Cogen RB
Epidemiol Rev 1988;10:191-211. doi: 10.1093/oxfordjournals.epirev.a036022. PMID: 3066627
Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment.
Johnson BD, Engel D
J Periodontol 1986 Mar;57(3):141-50. doi: 10.1902/jop.1986.57.3.141. PMID: 3514841

Diagnosis

Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.
Siddiqui AZ, Vellappally S, Fouad H, Muckarrum SM
Photodiagnosis Photodyn Ther 2020 Mar;29:101668. Epub 2020 Jan 24 doi: 10.1016/j.pdpdt.2020.101668. PMID: 31988023
Necrotising Ulcerative Gingivitis: A Literature Review.
Dufty J, Gkranias N, Donos N
Oral Health Prev Dent 2017;15(4):321-327. doi: 10.3290/j.ohpd.a38766. PMID: 28761942
Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
Necrotizing ulcerative gingivitis.
Rowland RW
Ann Periodontol 1999 Dec;4(1):65-73; discussion 78. doi: 10.1902/annals.1999.4.1.65. PMID: 10863376
Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment.
Johnson BD, Engel D
J Periodontol 1986 Mar;57(3):141-50. doi: 10.1902/jop.1986.57.3.141. PMID: 3514841

Therapy

Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.
Siddiqui AZ, Vellappally S, Fouad H, Muckarrum SM
Photodiagnosis Photodyn Ther 2020 Mar;29:101668. Epub 2020 Jan 24 doi: 10.1016/j.pdpdt.2020.101668. PMID: 31988023
Pemphigus Vulgaris.
Silva SC, Nasser R, Payne AS, Stoopler ET
J Emerg Med 2019 Jan;56(1):102-104. Epub 2018 Nov 30 doi: 10.1016/j.jemermed.2018.10.028. PMID: 30503724
Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
Necrotizing ulcerative gingivitis.
Rowland RW
Ann Periodontol 1999 Dec;4(1):65-73; discussion 78. doi: 10.1902/annals.1999.4.1.65. PMID: 10863376
The treatment of acute necrotizing ulcerative gingivitis.
Hartnett AC, Shiloah J
Quintessence Int 1991 Feb;22(2):95-100. PMID: 2068255

Prognosis

Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
HIV infection and periodontal diseases: an overview of the post-HAART era.
Mataftsi M, Skoura L, Sakellari D
Oral Dis 2011 Jan;17(1):13-25. Epub 2010 Oct 28 doi: 10.1111/j.1601-0825.2010.01727.x. PMID: 21029260
Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms.
Feller L, Lemmer J
J Int Acad Periodontol 2008 Jan;10(1):10-5. PMID: 18333595
Necrotizing ulcerative gingivitis.
Rowland RW
Ann Periodontol 1999 Dec;4(1):65-73; discussion 78. doi: 10.1902/annals.1999.4.1.65. PMID: 10863376
Cases of HIV-associated characteristic periodontal diseases.
Pistorius A, Willershausen B
Eur J Med Res 1999 Mar 26;4(3):121-5. PMID: 10085280

Clinical prediction guides

Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.
Siddiqui AZ, Vellappally S, Fouad H, Muckarrum SM
Photodiagnosis Photodyn Ther 2020 Mar;29:101668. Epub 2020 Jan 24 doi: 10.1016/j.pdpdt.2020.101668. PMID: 31988023
Prevalence and treatment of necrotizing ulcerative gingivitis (NUG) in the British Armed Forces: a case-control study.
Dufty J, Gkranias N, Petrie A, McCormick R, Elmer T, Donos N
Clin Oral Investig 2017 Jul;21(6):1935-1944. Epub 2016 Nov 9 doi: 10.1007/s00784-016-1979-9. PMID: 27830369
Tp63 in oral development, neoplasia, and autoimmunity.
Romano RA, Solomon LW, Sinha S
J Dent Res 2012 Feb;91(2):125-32. Epub 2011 Jun 6 doi: 10.1177/0022034511411302. PMID: 21646640
Oral infections and other manifestations of HIV disease.
Patton LL, van der Horst C
Infect Dis Clin North Am 1999 Dec;13(4):879-900. doi: 10.1016/s0891-5520(05)70114-8. PMID: 10579114
Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: clinical staging and predisposing factors.
Horning GM, Cohen ME
J Periodontol 1995 Nov;66(11):990-8. doi: 10.1902/jop.1995.66.11.990. PMID: 8558402

Recent systematic reviews

Microbiological Study of Periodontal Disease in Populations with HIV: a Systematic Review and Meta-Analysis.
Valian NK, Houshmand B, Ardakani MT, Mahmoudi S
Clin Lab 2023 May 1;69(5) doi: 10.7754/Clin.Lab.2022.220738. PMID: 37145081
Chronic ulcerative stomatitis: A systematic review of the clinical and microscopic features.
Ferrisse TM, Travassos DC, Rocha AF, Massucato EM, Bufalino A
Med Oral Patol Oral Cir Bucal 2019 Nov 1;24(6):e698-e703. doi: 10.4317/medoral.22213. PMID: 31655827Free PMC Article
Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria.
Azzi L, Cerati M, Lombardo M, Pellilli M, Croveri F, Maurino V, Tagliabue A, Tettamanti L, Olszewska M
Oral Dis 2019 Sep;25(6):1465-1491. Epub 2019 Jan 6 doi: 10.1111/odi.13001. PMID: 30457193
Necrotizing Periodontal Diseases in Children: A Literature Review and Adjustment of Treatment.
Marty M, Palmieri J, Noirrit-Esclassan E, Vaysse F, Bailleul-Forestier I
J Trop Pediatr 2016 Aug;62(4):331-7. Epub 2016 Mar 10 doi: 10.1093/tropej/fmw005. PMID: 26966241

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