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Necrotizing ulcerative gingivitis

MedGen UID:
42219
•Concept ID:
C0017575
•
Disease or Syndrome
Synonyms: Acute membranous gingivitis; Acute necrotizing ulcerative gingivitis; Fusospirillary gingivitis; Fusospirillosis; Phagedenic gingivitis; Vincent's gingivitis; Vincent's infection; Vincent's stomatitis
SNOMED CT: Acute necrotizing ulcerative gingivitis (399050001); Trench mouth (399050001); Vincent's gingivitis (399050001); Acute ulceromembranous gingivitis (399050001); Acute ulcerative gingivitis (172697005); AUG - Acute ulcerative gingivitis (172697005); Vincent's stomatitis (173599005); Acute necrotizing ulcerative gingivostomatitis (173599005); Necrotizing ulcerative gingivitis (707792000); Vincent disease (399050001); ANUG - acute necrotizing ulcerative gingivitis (399050001)
 
Monarch Initiative: MONDO:0006865

Definition

A bacterial infectious process affecting the gums. It is characterized by the development of necrotic, ulcerated, and painful lesions with creation of pseudomembranes extending along the gingival margins. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrotizing ulcerative gingivitis

Professional guidelines

PubMed

A single dose oral tinidazole for the treatment of acute necrotizing ulcerative gingivitis.
Sadek SI, El-Ashiry G
Egypt Dent J 1979 Jul;25(3):231-9. PMID: 299154
Treatment of acute necrotizing ulcerative gingivitis by chlorhexidine and cetrimide a clinical report--I.
Moustafa MH, Sadek SI, Salam NA
Egypt Dent J 1975 Apr;21(2):19-24. PMID: 1073673
Topical antibiotic treatment of acute necrotizing ulcerative gingivitis.
Collins JF, Hood HM
J Oral Med 1967 Apr;22(2):59-64. PMID: 5264868

Recent clinical studies

Etiology

Necrotising Ulcerative Gingivitis: A Literature Review.
Dufty J, Gkranias N, Donos N
Oral Health Prev Dent 2017;15(4):321-327. doi: 10.3290/j.ohpd.a38766. PMID: 28761942
Managing patients with necrotizing ulcerative periodontitis.
Todescan S, Nizar R
J Can Dent Assoc 2013;79:d44. PMID: 23763731
Periodontal diseases in Africa.
Baelum V, Scheutz F
Periodontol 2000 2002;29:79-103. doi: 10.1034/j.1600-0757.2002.290105.x. PMID: 12102704
Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms.
Murayama Y, Kurihara H, Nagai A, Dompkowski D, Van Dyke TE
Periodontol 2000 1994 Oct;6:116-24. doi: 10.1111/j.1600-0757.1994.tb00031.x. PMID: 9673175
Periodontal diseases in young individuals.
Dougherty MA, Slots J
J Calif Dent Assoc 1993 Jan;21(1):55-69. PMID: 7682608

Diagnosis

Pemphigus Vulgaris.
Silva SC, Nasser R, Payne AS, Stoopler ET
J Emerg Med 2019 Jan;56(1):102-104. Epub 2018 Nov 30 doi: 10.1016/j.jemermed.2018.10.028. PMID: 30503724
Necrotising Ulcerative Gingivitis: A Literature Review.
Dufty J, Gkranias N, Donos N
Oral Health Prev Dent 2017;15(4):321-327. doi: 10.3290/j.ohpd.a38766. PMID: 28761942
Trench Mouth.
Chaubal T, Bapat R
Am J Med 2017 Nov;130(11):e493-e494. Epub 2017 Jun 8 doi: 10.1016/j.amjmed.2017.05.020. PMID: 28602875
Oral Ulcerations.
Fetterolf B, Zaballa A, Strote J
West J Emerg Med 2015 Dec;16(7):1196-7. Epub 2015 Dec 8 doi: 10.5811/westjem.2015.8.28358. PMID: 26759682Free PMC Article
Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591

Therapy

Pemphigus Vulgaris.
Silva SC, Nasser R, Payne AS, Stoopler ET
J Emerg Med 2019 Jan;56(1):102-104. Epub 2018 Nov 30 doi: 10.1016/j.jemermed.2018.10.028. PMID: 30503724
Trench Mouth.
Chaubal T, Bapat R
Am J Med 2017 Nov;130(11):e493-e494. Epub 2017 Jun 8 doi: 10.1016/j.amjmed.2017.05.020. PMID: 28602875
Oral Ulcerations.
Fetterolf B, Zaballa A, Strote J
West J Emerg Med 2015 Dec;16(7):1196-7. Epub 2015 Dec 8 doi: 10.5811/westjem.2015.8.28358. PMID: 26759682Free PMC Article
Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
Oral lesions.
Hinds EC, Kent JN
Am J Gastroenterol 1971 Mar;55(3):225-36. PMID: 4931041

Prognosis

Acute periodontal lesions.
Herrera D, Alonso B, de Arriba L, Santa Cruz I, Serrano C, Sanz M
Periodontol 2000 2014 Jun;65(1):149-77. doi: 10.1111/prd.12022. PMID: 24738591
Decision making for the patient who presents with acute dental pain.
Rodriguez DS, Sarlani E
AACN Clin Issues 2005 Jul-Sep;16(3):359-72. doi: 10.1097/00044067-200507000-00009. PMID: 16082238
Periodontal diseases in Africa.
Baelum V, Scheutz F
Periodontol 2000 2002;29:79-103. doi: 10.1034/j.1600-0757.2002.290105.x. PMID: 12102704
Necrotizing ulcerative gingivitis.
Rowland RW
Ann Periodontol 1999 Dec;4(1):65-73; discussion 78. doi: 10.1902/annals.1999.4.1.65. PMID: 10863376
Periodontal health and HIV infection.
Robinson PG, Sheiham A, Challacombe SJ, Zakrzewska JM
Oral Dis 1997 May;3 Suppl 1:S149-52. doi: 10.1111/j.1601-0825.1997.tb00349.x. PMID: 9456679

Clinical prediction guides

Periodontal diseases in Africa.
Baelum V, Scheutz F
Periodontol 2000 2002;29:79-103. doi: 10.1034/j.1600-0757.2002.290105.x. PMID: 12102704
Periodontal health in 200 HIV-positive patients.
Riley C, London JP, Burmeister JA
J Oral Pathol Med 1992 Mar;21(3):124-7. doi: 10.1111/j.1600-0714.1992.tb00995.x. PMID: 1583595
Acute necrotizing ulcerative gingivitis is associated with attachment loss.
MacCarthy D, Claffey N
J Clin Periodontol 1991 Nov;18(10):776-9. doi: 10.1111/j.1600-051x.1991.tb00071.x. PMID: 1753002
Periodontal disease in Down's syndrome: a review.
Reuland-Bosma W, van Dijk J
J Clin Periodontol 1986 Jan;13(1):64-73. doi: 10.1111/j.1600-051x.1986.tb01416.x. PMID: 2935562
Stress, adaptation, and immunity: studies in humans.
Locke SE
Gen Hosp Psychiatry 1982 Apr;4(1):49-58. doi: 10.1016/0163-8343(82)90027-5. PMID: 7042458

Recent systematic reviews

Evaluation of metronidazole oral monotherapy in anaerobic oral infections.
Dar-Odeh N, Atef A, Flaifl Y, Bobamuratova D, Akily B, Meer R, Abu-Hammad O
Int J Clin Pharmacol Ther 2024 Nov;62(11):517-524. doi: 10.5414/CP204565. PMID: 39120079
Microbiological Study of Periodontal Disease in Populations with HIV: a Systematic Review and Meta-Analysis.
Valian NK, Houshmand B, Ardakani MT, Mahmoudi S
Clin Lab 2023 May 1;69(5) doi: 10.7754/Clin.Lab.2022.220738. PMID: 37145081
Chronic ulcerative stomatitis: A systematic review of the clinical and microscopic features.
Ferrisse TM, Travassos DC, Rocha AF, Massucato EM, Bufalino A
Med Oral Patol Oral Cir Bucal 2019 Nov 1;24(6):e698-e703. doi: 10.4317/medoral.22213. PMID: 31655827Free PMC Article
Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria.
Azzi L, Cerati M, Lombardo M, Pellilli M, Croveri F, Maurino V, Tagliabue A, Tettamanti L, Olszewska M
Oral Dis 2019 Sep;25(6):1465-1491. Epub 2019 Jan 6 doi: 10.1111/odi.13001. PMID: 30457193
Necrotizing Periodontal Diseases in Children: A Literature Review and Adjustment of Treatment.
Marty M, Palmieri J, Noirrit-Esclassan E, Vaysse F, Bailleul-Forestier I
J Trop Pediatr 2016 Aug;62(4):331-7. Epub 2016 Mar 10 doi: 10.1093/tropej/fmw005. PMID: 26966241

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