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HTLV-2 infection

MedGen UID:
42515
•Concept ID:
C0020102
•
Disease or Syndrome
Synonyms: Human T lymphotropic virus type 2 infection; Human T-cell leukemia virus type 2 infection
SNOMED CT: Human T-lymphotropic virus 2 infection (425740005); HTLV-II infection (425740005); HTLV-2 infection (425740005)
 
Monarch Initiative: MONDO:0021183

Definition

Diseases caused by HUMAN T-LYMPHOTROPIC VIRUS 2. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHTLV-2 infection

Professional guidelines

PubMed

Transient increment of HTLV-2 proviral load in HIV-1-co-infected patients during treatment intensification with raltegravir.
Abad-Fernández M, Cabrera C, García E, Vallejo A
J Clin Virol 2014 Mar;59(3):204-7. Epub 2014 Jan 7 doi: 10.1016/j.jcv.2013.12.010. PMID: 24457115
Geographic distribution of human T-lymphotropic virus types 1 and 2 among mothers of newborns tested during neonatal screening, Minas Gerais, Brazil.
Ribeiro MA, Proietti FA, Martins ML, Januário JN, Ladeira RV, Oliveira Mde F, Carneiro-Proietti AB
Rev Panam Salud Publica 2010 May;27(5):330-7. doi: 10.1590/s1020-49892010000500002. PMID: 20602066

Recent clinical studies

Etiology

Human T-lymphotropic virus 2 (HTLV-2) prevalence of blood donors in the state of Pará, Brazil.
Correa LP, da Costa Farias F, Dos Santos Barile KA, Palmeira MK, de Melo Amaral CE
Braz J Microbiol 2023 Sep;54(3):1745-1750. Epub 2023 Jul 16 doi: 10.1007/s42770-023-01067-2. PMID: 37454039Free PMC Article
Prevalence and Risk Factors for HTLV-1/2 Infection inRiverside and Rural Populations of the State of Pará.
de Lima ACR, Lopes FT, de Oliveira Freitas V, Assad MN, de Sousa RS, Gonçalves JSS, Gomes JLC, Dos Santos BC, Lima CNC, Abreu IN, Dos Santos Brito WR, Pereira KAS, da Silva Torres MK, Lima SS, Aben-Athar CYU, Guerreiro JF, Cayres Vallinoto IMV, Vallinoto ACR, Feitosa RNM
Viruses 2022 Oct 15;14(10) doi: 10.3390/v14102262. PMID: 36298817Free PMC Article
HTLV infection in Brazil's second-largest indigenous reserve.
Amianti C, Bandeira LM, Cesar GA, Weis-Torres S, Tanaka TSO, Machado IR, Gonçalves CCM, Simionatto S, Schnaufer ECDS, Freitas FB, Vallinoto ACR, Croda J, Motta-Castro ARC
Sci Rep 2022 Oct 6;12(1):16701. doi: 10.1038/s41598-022-21086-7. PMID: 36202887Free PMC Article
Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon.
Brito WRDS, Cardoso-Costa GL, Roland Junior LM, Pereira KAS, Lopes FT, Dos Santos BC, de Lima ACR, Abreu IN, Lima CNC, Lima SS, Cayres Vallinoto IMV, Dos Santos EJM, Guerreiro JF, Vallinoto ACR
Front Public Health 2022;10:871865. Epub 2022 Mar 30 doi: 10.3389/fpubh.2022.871865. PMID: 35433598Free PMC Article
HIV-2 and HTLV-1 infections in Spain, a non-endemic region.
de Mendoza C, Caballero E, Aguilera A, Pirón M, Ortiz de Lejarazu R, Rodríguez C, Cabezas T, González R, Treviño A, Soriano V; Spanish HIV-2/HTLV Group
AIDS Rev 2014 Jul-Sep;16(3):152-9. PMID: 25180694

Diagnosis

Human T-lymphotropic virus 2 (HTLV-2) prevalence of blood donors in the state of Pará, Brazil.
Correa LP, da Costa Farias F, Dos Santos Barile KA, Palmeira MK, de Melo Amaral CE
Braz J Microbiol 2023 Sep;54(3):1745-1750. Epub 2023 Jul 16 doi: 10.1007/s42770-023-01067-2. PMID: 37454039Free PMC Article
Development and validation of a duplex real-time PCR for the rapid detection and quantitation of HTLV-1.
Ji H, Chang L, Yan Y, Wang L
Virol J 2023 Jan 17;20(1):9. doi: 10.1186/s12985-023-01970-y. PMID: 36650537Free PMC Article
Prevalence and Risk Factors for HTLV-1/2 Infection inRiverside and Rural Populations of the State of Pará.
de Lima ACR, Lopes FT, de Oliveira Freitas V, Assad MN, de Sousa RS, Gonçalves JSS, Gomes JLC, Dos Santos BC, Lima CNC, Abreu IN, Dos Santos Brito WR, Pereira KAS, da Silva Torres MK, Lima SS, Aben-Athar CYU, Guerreiro JF, Cayres Vallinoto IMV, Vallinoto ACR, Feitosa RNM
Viruses 2022 Oct 15;14(10) doi: 10.3390/v14102262. PMID: 36298817Free PMC Article
Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon.
Brito WRDS, Cardoso-Costa GL, Roland Junior LM, Pereira KAS, Lopes FT, Dos Santos BC, de Lima ACR, Abreu IN, Lima CNC, Lima SS, Cayres Vallinoto IMV, Dos Santos EJM, Guerreiro JF, Vallinoto ACR
Front Public Health 2022;10:871865. Epub 2022 Mar 30 doi: 10.3389/fpubh.2022.871865. PMID: 35433598Free PMC Article
HIV-2 and HTLV-1 infections in Spain, a non-endemic region.
de Mendoza C, Caballero E, Aguilera A, Pirón M, Ortiz de Lejarazu R, Rodríguez C, Cabezas T, González R, Treviño A, Soriano V; Spanish HIV-2/HTLV Group
AIDS Rev 2014 Jul-Sep;16(3):152-9. PMID: 25180694

Therapy

Clinical Outcome in Human T-Lymphotropic Virus Type 2 Carriers Following Organ Transplantation.
Benito R, Gil J, Sahagún J, Soriano V
Transplant Proc 2021 Mar;53(2):743-745. Epub 2020 Sep 10 doi: 10.1016/j.transproceed.2020.08.029. PMID: 32921433
Transient increment of HTLV-2 proviral load in HIV-1-co-infected patients during treatment intensification with raltegravir.
Abad-Fernández M, Cabrera C, García E, Vallejo A
J Clin Virol 2014 Mar;59(3):204-7. Epub 2014 Jan 7 doi: 10.1016/j.jcv.2013.12.010. PMID: 24457115

Prognosis

Human T Lymphotropic Virus 1-Associated Myelopathy: Overview of Human T Cell Lymphotropic Virus-1/2 Tests and Potential Biomarkers.
Puccioni-Sohler M, Poton AR, Cabral-Castro MJ, Yamano Y, Taylor G, Casseb J
AIDS Res Hum Retroviruses 2022 Dec;38(12):924-932. Epub 2022 Aug 18 doi: 10.1089/AID.2022.0028. PMID: 35819286
ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity.
Cachat A, Alais S, Chevalier SA, Journo C, Fusil F, Dutartre H, Boniface A, Ko NL, Gessain A, Cosset FL, Suspène R, Vartanian JP, Mahieux R
Retrovirology 2014 Nov 12;11:93. doi: 10.1186/s12977-014-0093-9. PMID: 25389016Free PMC Article
HTLV-2 infection in injection drug users in King County, Washington.
Zunt JR, Tapia K, Thiede H, Lee R, Hagan H
Scand J Infect Dis 2006;38(8):654-63. doi: 10.1080/00365540600617009. PMID: 16857611Free PMC Article
Can the level of immunosuppression in human immunodeficiency virus-infected patients affect the reliability of human T-cell lymphotropic virus type 2 serological diagnosis?
Bassani S, Toro C, Jiménez V, Rodés B, Soriano V
Clin Vaccine Immunol 2006 Jan;13(1):160-1. doi: 10.1128/CVI.13.1.160-161.2006. PMID: 16426016Free PMC Article
Presence of a functional but dispensable nuclear export signal in the HTLV-2 Tax protein.
Chevalier SA, Meertens L, Calattini S, Gessain A, Kiemer L, Mahieux R
Retrovirology 2005 Nov 14;2:70. doi: 10.1186/1742-4690-2-70. PMID: 16285885Free PMC Article

Clinical prediction guides

Prevalence and Risk Factors for HTLV-1/2 Infection inRiverside and Rural Populations of the State of Pará.
de Lima ACR, Lopes FT, de Oliveira Freitas V, Assad MN, de Sousa RS, Gonçalves JSS, Gomes JLC, Dos Santos BC, Lima CNC, Abreu IN, Dos Santos Brito WR, Pereira KAS, da Silva Torres MK, Lima SS, Aben-Athar CYU, Guerreiro JF, Cayres Vallinoto IMV, Vallinoto ACR, Feitosa RNM
Viruses 2022 Oct 15;14(10) doi: 10.3390/v14102262. PMID: 36298817Free PMC Article
HTLV infection in Brazil's second-largest indigenous reserve.
Amianti C, Bandeira LM, Cesar GA, Weis-Torres S, Tanaka TSO, Machado IR, Gonçalves CCM, Simionatto S, Schnaufer ECDS, Freitas FB, Vallinoto ACR, Croda J, Motta-Castro ARC
Sci Rep 2022 Oct 6;12(1):16701. doi: 10.1038/s41598-022-21086-7. PMID: 36202887Free PMC Article
Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon.
Brito WRDS, Cardoso-Costa GL, Roland Junior LM, Pereira KAS, Lopes FT, Dos Santos BC, de Lima ACR, Abreu IN, Lima CNC, Lima SS, Cayres Vallinoto IMV, Dos Santos EJM, Guerreiro JF, Vallinoto ACR
Front Public Health 2022;10:871865. Epub 2022 Mar 30 doi: 10.3389/fpubh.2022.871865. PMID: 35433598Free PMC Article
The Relevance of a Diagnostic and Counseling Service for People Living With HTLV-1/2 in a Metropolis of the Brazilian Amazon.
Lopes FT, de Sousa RS, Carvalho Gomes JL, Vallinoto MC, de Lima ACR, Lima SS, Freitas FB, Feitosa RNM, Rangel da Silva ANM, Machado LFA, Aben-Athar CYP, Maia da Silva EL, Cayres Vallinoto IMV, Vallinoto ACR
Front Public Health 2022;10:864861. Epub 2022 Mar 28 doi: 10.3389/fpubh.2022.864861. PMID: 35419336Free PMC Article
Molecular and cellular interactions of HIV-1/HTLV coinfection and impact on AIDS progression.
Casoli C, Pilotti E, Bertazzoni U
AIDS Rev 2007 Jul-Sep;9(3):140-9. PMID: 17982939

Recent systematic reviews

Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis.
Vieira BA, Bidinotto AB, Dartora WJ, Pedrotti LG, de Oliveira VM, Wendland EM
Sci Rep 2021 Jul 28;11(1):15367. doi: 10.1038/s41598-021-94934-7. PMID: 34321555Free PMC Article

Supplemental Content

Table of contents

    Genetic Testing Registry

    Clinical resources

    Practice guidelines

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    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
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