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Chills

MedGen UID:
43211
Concept ID:
C0085593
Sign or Symptom
Synonym: Chill
SNOMED CT: Chill (43724002)
 
HPO: HP:0025143

Definition

A sudden sensation of feeling cold. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChills

Conditions with this feature

Hyperimmunoglobulin D with periodic fever
MedGen UID:
140768
Concept ID:
C0398691
Disease or Syndrome
Mevalonate kinase deficiency is a condition characterized by recurrent episodes of fever, which typically begin during infancy. Each episode of fever lasts about 3 to 6 days, and the frequency of the episodes varies among affected individuals. In childhood the fevers seem to be more frequent, occurring as often as 25 times a year, but as the individual gets older the episodes occur less often.\n\nMevalonate kinase deficiency has additional signs and symptoms, and the severity depends on the type of the condition. There are two types of mevalonate kinase deficiency: a less severe type called hyperimmunoglobulinemia D syndrome (HIDS) and a more severe type called mevalonic aciduria (MVA).\n\nPeople with MVA have signs and symptoms of the condition at all times, not just during episodes of fever. Affected children have developmental delay, problems with movement and balance (ataxia), recurrent seizures (epilepsy), progressive problems with vision, and failure to gain weight and grow at the expected rate (failure to thrive). Individuals with MVA typically have an unusually small, elongated head. In childhood or adolescence, affected individuals may develop eye problems such as inflammation of the eye (uveitis), a blue tint in the white part of the eye (blue sclera), an eye disorder called retinitis pigmentosa that causes vision loss, or clouding of the lens of the eye (cataracts). Affected adults may have short stature and may develop muscle weakness (myopathy) later in life. During fever episodes, people with MVA may have an enlarged liver and spleen (hepatosplenomegaly), lymphadenopathy, abdominal pain, diarrhea, and skin rashes. Children with MVA who are severely affected with multiple problems may live only into early childhood; mildly affected individuals may have a normal life expectancy.\n\nDuring episodes of fever, people with HIDS typically have enlargement of the lymph nodes (lymphadenopathy), abdominal pain, joint pain, diarrhea, skin rashes, and headache. Occasionally they will have painful sores called aphthous ulcers around their mouth. In females, these may also occur around the vagina. Rarely, people with HIDS develop a buildup of protein deposits (amyloidosis) in the kidneys that can lead to kidney failure. Fever episodes in individuals with HIDS can be triggered by vaccinations, surgery, injury, or stress. Most people with HIDS have abnormally high levels of immune system proteins called immunoglobulin D (IgD) and immunoglobulin A (IgA) in the blood. It is unclear why some people with HIDS have high levels of IgD and IgA and some do not. Elevated levels of these immunoglobulins do not appear to cause any signs or symptoms. Individuals with HIDS do not have any signs and symptoms of the condition between fever episodes and typically have a normal life expectancy.
Anti-glomerular basement membrane disease
MedGen UID:
140788
Concept ID:
C0403529
Disease or Syndrome
A rare, fulminant small vessel vasculitis that affects the capillary beds of the kidneys and lungs and characterized by the presence of anti-glomerular basement membrane (GBM) and, in its full-blown form, anti-alveolar basement membrane (ABM) antibodies. Consequently, it may manifest as a rapidly progressive, isolated glomerulonephritis (anti-GBM nephritis) or as a pulmonary-renal syndrome with severe lung hemorrhage.
Familial cold autoinflammatory syndrome 1
MedGen UID:
1647324
Concept ID:
C4551895
Disease or Syndrome
Cryopyrin-associated periodic syndromes (CAPS) are a group of conditions that have overlapping signs and symptoms and the same genetic cause. The group includes three conditions known as familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID). These conditions were once thought to be distinct disorders but are now considered to be part of the same condition spectrum. FCAS1 is the least severe form of CAPS, MWS is intermediate in severity, and NOMID is the most severe form.\n\nThe signs and symptoms of CAPS affect multiple body systems. Generally, CAPS are characterized by periodic episodes of skin rash, fever, and joint pain. These episodes can be triggered by exposure to cold temperatures, fatigue, other stressors, or they may arise spontaneously. Episodes can last from a few hours to several days. These episodes typically begin in infancy or early childhood and persist throughout life.\n\nWhile the CAPS spectrum shares similar signs and symptoms, the individual conditions tend to have distinct patterns of features. People with FCAS1 are particularly sensitive to the cold, and exposure to cold temperatures can trigger a painful or burning rash. The rash usually affects the torso and limbs but may spread to the rest of the body. In addition to fever and joint pain, other possible symptoms include muscle aches, chills, drowsiness, eye redness, headache, and nausea.\n\nIndividuals with MWS develop the typical periodic episodes of skin rash, fever, and joint pain after cold exposure, although episodes may occur spontaneously or all the time. Additionally, they can develop progressive hearing loss in their teenage years. Other features of MWS include skin lesions or kidney damage from abnormal deposits of a protein called amyloid (amyloidosis).\n\nIn people with NOMID, the signs and symptoms of the condition are usually present from birth and persists throughout life. In addition to skin rash and fever, affected individuals may have joint inflammation, swelling, and joint deformities called contractures that may restrict movement. People with NOMID typically have headaches, seizures, and cognitive impairment resulting from chronic meningitis, which is inflammation of the tissue that covers and protects the brain and spinal cord (meninges). Other features of NOMID include eye problems, short stature, distinctive facial features, and kidney damage caused by amyloidosis.

Professional guidelines

PubMed

Gaitonde DY, Moore FC, Morgan MK
Am Fam Physician 2019 Dec 15;100(12):751-758. PMID: 31845781
Feuerstein JD, Cheifetz AS
Mayo Clin Proc 2017 Jul;92(7):1088-1103. Epub 2017 Jun 7 doi: 10.1016/j.mayocp.2017.04.010. PMID: 28601423
Coker TJ, Dierfeldt DM
Am Fam Physician 2016 Jan 15;93(2):114-20. PMID: 26926407

Recent clinical studies

Etiology

Gaitonde DY, Moore FC, Morgan MK
Am Fam Physician 2019 Dec 15;100(12):751-758. PMID: 31845781
Feuerstein JD, Cheifetz AS
Mayo Clin Proc 2017 Jul;92(7):1088-1103. Epub 2017 Jun 7 doi: 10.1016/j.mayocp.2017.04.010. PMID: 28601423
Kumar V
Indian J Pediatr 2017 Feb;84(2):139-143. Epub 2016 Sep 19 doi: 10.1007/s12098-016-2232-x. PMID: 27641976
Coker TJ, Dierfeldt DM
Am Fam Physician 2016 Jan 15;93(2):114-20. PMID: 26926407
Orbach H, Katz U, Sherer Y, Shoenfeld Y
Clin Rev Allergy Immunol 2005 Dec;29(3):173-84. doi: 10.1385/CRIAI:29:3:173. PMID: 16391392

Diagnosis

Watts MM, Grammer LC
Allergy Asthma Proc 2019 Nov 1;40(6):425-428. doi: 10.2500/aap.2019.40.4263. PMID: 31690386
Laffer M, Ackerman L
Skinmed 2018;16(1):51-53. Epub 2018 Feb 1 PMID: 29551116
Kolman KB, Losey KR
J Fam Pract 2018 Jan;67(1):39-42. PMID: 29309474
Coburn B, Morris AM, Tomlinson G, Detsky AS
JAMA 2012 Aug 1;308(5):502-11. doi: 10.1001/jama.2012.8262. PMID: 22851117
Eccles R
Lancet Infect Dis 2005 Nov;5(11):718-25. doi: 10.1016/S1473-3099(05)70270-X. PMID: 16253889Free PMC Article

Therapy

Zheng JP, Ling Y, Jiang LS, Mootsikapun P, Lu HZ, Chayakulkeeree M, Zhang LX, Arttawejkul P, Hu FY, Truong TNL, Perez RA, Gu X, Sun HM, Jiang JJ, Liu RJ, Ding Z, Zhan YQ, Yang ZF, Guan WJ, Zhong NS
Virol J 2023 Nov 28;20(1):277. doi: 10.1186/s12985-023-02144-6. PMID: 38017515Free PMC Article
Berger M, Li E, Rice S, Davey CG, Ratheesh A, Adams S, Jackson H, Hetrick S, Parker A, Spelman T, Kevin R, McGregor IS, McGorry P, Amminger GP
J Clin Psychiatry 2022 Aug 3;83(5) doi: 10.4088/JCP.21m14130. PMID: 35921510
Ribas A, Dummer R, Puzanov I, VanderWalde A, Andtbacka RHI, Michielin O, Olszanski AJ, Malvehy J, Cebon J, Fernandez E, Kirkwood JM, Gajewski TF, Chen L, Gorski KS, Anderson AA, Diede SJ, Lassman ME, Gansert J, Hodi FS, Long GV
Cell 2017 Sep 7;170(6):1109-1119.e10. doi: 10.1016/j.cell.2017.08.027. PMID: 28886381Free PMC Article
Madrid E, Urrútia G, Roqué i Figuls M, Pardo-Hernandez H, Campos JM, Paniagua P, Maestre L, Alonso-Coello P
Cochrane Database Syst Rev 2016 Apr 21;4(4):CD009016. doi: 10.1002/14651858.CD009016.pub2. PMID: 27098439Free PMC Article
Klotz L, Boccon-Gibod L, Shore ND, Andreou C, Persson BE, Cantor P, Jensen JK, Olesen TK, Schröder FH
BJU Int 2008 Dec;102(11):1531-8. doi: 10.1111/j.1464-410X.2008.08183.x. PMID: 19035858

Prognosis

Hughes BL, Clifton RG, Rouse DJ, Saade GR, Dinsmoor MJ, Reddy UM, Pass R, Allard D, Mallett G, Fette LM, Gyamfi-Bannerman C, Varner MW, Goodnight WH, Tita ATN, Costantine MM, Swamy GK, Gibbs RS, Chien EK, Chauhan SP, El-Sayed YY, Casey BM, Parry S, Simhan HN, Napolitano PG, Macones GA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network
N Engl J Med 2021 Jul 29;385(5):436-444. doi: 10.1056/NEJMoa1913569. PMID: 34320288Free PMC Article
Watts MM, Grammer LC
Allergy Asthma Proc 2019 Nov 1;40(6):425-428. doi: 10.2500/aap.2019.40.4263. PMID: 31690386
Guo Y, Tian X, Wang X, Xiao Z
Front Immunol 2018;9:1299. Epub 2018 Jun 8 doi: 10.3389/fimmu.2018.01299. PMID: 29951056Free PMC Article
Curtis BR
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):187-193. doi: 10.1182/asheducation-2017.1.187. PMID: 29222255Free PMC Article
Coburn B, Morris AM, Tomlinson G, Detsky AS
JAMA 2012 Aug 1;308(5):502-11. doi: 10.1001/jama.2012.8262. PMID: 22851117

Clinical prediction guides

Guttman-Yassky E, Simpson EL, Reich K, Kabashima K, Igawa K, Suzuki T, Mano H, Matsui T, Esfandiari E, Furue M
Lancet 2023 Jan 21;401(10372):204-214. Epub 2022 Dec 9 doi: 10.1016/S0140-6736(22)02037-2. PMID: 36509097
Guide SV, Gonzalez ME, Bağcı IS, Agostini B, Chen H, Feeney G, Steimer M, Kapadia B, Sridhar K, Quesada Sanchez L, Gonzalez F, Van Ligten M, Parry TJ, Chitra S, Kammerman LA, Krishnan S, Marinkovich MP
N Engl J Med 2022 Dec 15;387(24):2211-2219. doi: 10.1056/NEJMoa2206663. PMID: 36516090
Berger M, Li E, Rice S, Davey CG, Ratheesh A, Adams S, Jackson H, Hetrick S, Parker A, Spelman T, Kevin R, McGregor IS, McGorry P, Amminger GP
J Clin Psychiatry 2022 Aug 3;83(5) doi: 10.4088/JCP.21m14130. PMID: 35921510
Watts MM, Grammer LC
Allergy Asthma Proc 2019 Nov 1;40(6):425-428. doi: 10.2500/aap.2019.40.4263. PMID: 31690386
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278

Recent systematic reviews

Yon H, Shin H, Shin JI, Shin JU, Shin YH, Lee J, Rhee SY, Koyanagi A, Jacob L, Smith L, Lee SW, Rahmati M, Ahmad S, Cho W, Yon DK
Rev Med Virol 2023 Jul;33(4):e2446. Epub 2023 Apr 13 doi: 10.1002/rmv.2446. PMID: 37056203
Allahyari F, Molaee H, Hosseini Nejad J
Z Naturforsch C J Biosci 2023 Jan 27;78(1-2):1-8. Epub 2022 Sep 12 doi: 10.1515/znc-2022-0092. PMID: 36087300
Sales GMPG, Barbosa ICP, Canejo Neta LMS, Melo PL, Leitão RA, Melo HMA
Rev Assoc Med Bras (1992) 2018 Jan;64(1):63-70. doi: 10.1590/1806-9282.64.01.63. PMID: 29561944
Tsioutis C, Zafeiri M, Avramopoulos A, Prousali E, Miligkos M, Karageorgos SA
Acta Trop 2017 Feb;166:16-24. Epub 2016 Oct 29 doi: 10.1016/j.actatropica.2016.10.018. PMID: 27983969
Madrid E, Urrútia G, Roqué i Figuls M, Pardo-Hernandez H, Campos JM, Paniagua P, Maestre L, Alonso-Coello P
Cochrane Database Syst Rev 2016 Apr 21;4(4):CD009016. doi: 10.1002/14651858.CD009016.pub2. PMID: 27098439Free PMC Article

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