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Hypoactive sexual desire disorder

MedGen UID:
43792
•Concept ID:
C0020594
•
Mental or Behavioral Dysfunction
Synonym: Hypoactive Sexual Desire Disorder
SNOMED CT: Lack or loss of sexual desire (270903007); Hypoactive sexual desire disorder (270903007)
 
Monarch Initiative: MONDO:0001821

Definition

A disorder characterized by a recurrent or persistent lack of desire for sexual activity. The lack of sexual desire is not attributable to another psychiatric disorder or to the physiological effects of substance use or a general medical condition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypoactive sexual desire disorder

Professional guidelines

PubMed

Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment.
Pettigrew JA, Novick AM
J Midwifery Womens Health 2021 Nov;66(6):740-748. Epub 2021 Sep 12 doi: 10.1111/jmwh.13283. PMID: 34510696Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355

Recent clinical studies

Etiology

Testosterone use for hypoactive sexual desire disorder in postmenopausal women.
Parish SJ, Kling JM
Menopause 2023 Jul 1;30(7):781-783. Epub 2023 Jun 13 doi: 10.1097/GME.0000000000002190. PMID: 37314872
The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Evaluation of safety for flibanserin.
Clayton AH, Brown L, Kim NN
Expert Opin Drug Saf 2020 Jan;19(1):1-8. Epub 2019 Dec 23 doi: 10.1080/14740338.2020.1707804. PMID: 31855607
Androgen Therapy in Women.
Vegunta S, Kling JM, Kapoor E
J Womens Health (Larchmt) 2020 Jan;29(1):57-64. Epub 2019 Nov 5 doi: 10.1089/jwh.2018.7494. PMID: 31687883

Diagnosis

Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment.
Pettigrew JA, Novick AM
J Midwifery Womens Health 2021 Nov;66(6):740-748. Epub 2021 Sep 12 doi: 10.1111/jmwh.13283. PMID: 34510696Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Female Sexual Dysfunction.
Clayton AH, Valladares Juarez EM
Med Clin North Am 2019 Jul;103(4):681-698. doi: 10.1016/j.mcna.2019.02.008. PMID: 31078200
Female Sexual Dysfunction.
Clayton AH, Valladares Juarez EM
Psychiatr Clin North Am 2017 Jun;40(2):267-284. Epub 2017 Mar 25 doi: 10.1016/j.psc.2017.01.004. PMID: 28477652

Therapy

Testosterone use for hypoactive sexual desire disorder in postmenopausal women.
Parish SJ, Kling JM
Menopause 2023 Jul 1;30(7):781-783. Epub 2023 Jun 13 doi: 10.1097/GME.0000000000002190. PMID: 37314872
The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Androgen Therapy in Women.
Vegunta S, Kling JM, Kapoor E
J Womens Health (Larchmt) 2020 Jan;29(1):57-64. Epub 2019 Nov 5 doi: 10.1089/jwh.2018.7494. PMID: 31687883
Sexual Health in Menopause.
Scavello I, Maseroli E, Di Stasi V, Vignozzi L
Medicina (Kaunas) 2019 Sep 2;55(9) doi: 10.3390/medicina55090559. PMID: 31480774Free PMC Article

Prognosis

Low Sexual Desire in Breast Cancer Survivors and Patients: A Review.
Luo F, Link M, Grabenhorst C, Lynn B
Sex Med Rev 2022 Jul;10(3):367-375. Epub 2022 Apr 8 doi: 10.1016/j.sxmr.2022.02.001. PMID: 35410784
Hypoactive sexual desire disorder: inventing a disease to sell low libido.
Meixel A, Yanchar E, Fugh-Berman A
J Med Ethics 2015 Oct;41(10):859-62. Epub 2015 Jun 29 doi: 10.1136/medethics-2014-102596. PMID: 26124287
Introduction: Sexual health matters!
Buster JE
Fertil Steril 2013 Oct;100(4):897. Epub 2013 Aug 29 doi: 10.1016/j.fertnstert.2013.08.019. PMID: 23993893
Hypoactive sexual desire disorder.
Davison SL
Curr Opin Obstet Gynecol 2012 Aug;24(4):215-20. doi: 10.1097/GCO.0b013e328355847e. PMID: 22729093
Role of testosterone in the treatment of hypoactive sexual desire disorder.
Schwenkhagen A, Studd J
Maturitas 2009 Jun 20;63(2):152-9. Epub 2009 Apr 8 doi: 10.1016/j.maturitas.2009.02.011. PMID: 19359109

Clinical prediction guides

Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial.
Kamenov Z, Fileva S, Kalinov K, Jannini EA
Maturitas 2017 May;99:20-26. Epub 2017 Feb 12 doi: 10.1016/j.maturitas.2017.01.011. PMID: 28364864
Flibanserin.
Vallejos X, Wu C
J Pharm Pract 2017 Apr;30(2):256-260. Epub 2016 Jul 9 doi: 10.1177/0897190016630409. PMID: 26873507
Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-analysis.
Jaspers L, Feys F, Bramer WM, Franco OH, Leusink P, Laan ET
JAMA Intern Med 2016 Apr;176(4):453-62. doi: 10.1001/jamainternmed.2015.8565. PMID: 26927498
Efficacy and Safety of Flibanserin in Women with Hypoactive Sexual Desire Disorder: A Systematic Review and Meta-Analysis.
Gao Z, Yang D, Yu L, Cui Y
J Sex Med 2015 Nov;12(11):2095-104. doi: 10.1111/jsm.13037. PMID: 26745616
Role of testosterone in the treatment of hypoactive sexual desire disorder.
Schwenkhagen A, Studd J
Maturitas 2009 Jun 20;63(2):152-9. Epub 2009 Apr 8 doi: 10.1016/j.maturitas.2009.02.011. PMID: 19359109

Recent systematic reviews

A Systematic Literature Review of Health-related Quality of Life Measures for Women with Hypoactive Sexual Desire Disorder and Female Sexual Interest/Arousal Disorder.
Lim-Watson MZ, Hays RD, Kingsberg S, Kallich JD, Murimi-Worstell IB
Sex Med Rev 2022 Jan;10(1):23-41. Epub 2021 Sep 1 doi: 10.1016/j.sxmr.2021.07.003. PMID: 34481749
Neuroimaging of Female Sexual Desire and Hypoactive Sexual Desire Disorder.
Cacioppo S
Sex Med Rev 2017 Oct;5(4):434-444. Epub 2017 Aug 31 doi: 10.1016/j.sxmr.2017.07.006. PMID: 28865901
Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-analysis.
Jaspers L, Feys F, Bramer WM, Franco OH, Leusink P, Laan ET
JAMA Intern Med 2016 Apr;176(4):453-62. doi: 10.1001/jamainternmed.2015.8565. PMID: 26927498
Efficacy and Safety of Flibanserin in Women with Hypoactive Sexual Desire Disorder: A Systematic Review and Meta-Analysis.
Gao Z, Yang D, Yu L, Cui Y
J Sex Med 2015 Nov;12(11):2095-104. doi: 10.1111/jsm.13037. PMID: 26745616
Efficacy of psychological interventions for sexual dysfunction: a systematic review and meta-analysis.
Frühauf S, Gerger H, Schmidt HM, Munder T, Barth J
Arch Sex Behav 2013 Aug;42(6):915-33. Epub 2013 Apr 5 doi: 10.1007/s10508-012-0062-0. PMID: 23559141

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