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Hypoactive sexual desire disorder

MedGen UID:
43792
•Concept ID:
C0020594
•
Mental or Behavioral Dysfunction
Synonym: Hypoactive Sexual Desire Disorder
SNOMED CT: Lack or loss of sexual desire (270903007); Hypoactive sexual desire disorder (270903007)
 
Monarch Initiative: MONDO:0001821

Definition

A disorder characterized by a recurrent or persistent lack of desire for sexual activity. The lack of sexual desire is not attributable to another psychiatric disorder or to the physiological effects of substance use or a general medical condition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypoactive sexual desire disorder

Professional guidelines

PubMed

Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment.
Pettigrew JA, Novick AM
J Midwifery Womens Health 2021 Nov;66(6):740-748. Epub 2021 Sep 12 doi: 10.1111/jmwh.13283. PMID: 34510696Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355

Recent clinical studies

Etiology

Testosterone use for hypoactive sexual desire disorder in postmenopausal women.
Parish SJ, Kling JM
Menopause 2023 Jul 1;30(7):781-783. Epub 2023 Jun 13 doi: 10.1097/GME.0000000000002190. PMID: 37314872
The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Evaluation of safety for flibanserin.
Clayton AH, Brown L, Kim NN
Expert Opin Drug Saf 2020 Jan;19(1):1-8. Epub 2019 Dec 23 doi: 10.1080/14740338.2020.1707804. PMID: 31855607
Androgen Therapy in Women.
Vegunta S, Kling JM, Kapoor E
J Womens Health (Larchmt) 2020 Jan;29(1):57-64. Epub 2019 Nov 5 doi: 10.1089/jwh.2018.7494. PMID: 31687883

Diagnosis

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment.
Pettigrew JA, Novick AM
J Midwifery Womens Health 2021 Nov;66(6):740-748. Epub 2021 Sep 12 doi: 10.1111/jmwh.13283. PMID: 34510696Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Female Sexual Dysfunction.
Clayton AH, Valladares Juarez EM
Med Clin North Am 2019 Jul;103(4):681-698. doi: 10.1016/j.mcna.2019.02.008. PMID: 31078200

Therapy

Testosterone use for hypoactive sexual desire disorder in postmenopausal women.
Parish SJ, Kling JM
Menopause 2023 Jul 1;30(7):781-783. Epub 2023 Jun 13 doi: 10.1097/GME.0000000000002190. PMID: 37314872
The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Androgen Therapy in Women.
Vegunta S, Kling JM, Kapoor E
J Womens Health (Larchmt) 2020 Jan;29(1):57-64. Epub 2019 Nov 5 doi: 10.1089/jwh.2018.7494. PMID: 31687883
Sexual Health in Menopause.
Scavello I, Maseroli E, Di Stasi V, Vignozzi L
Medicina (Kaunas) 2019 Sep 2;55(9) doi: 10.3390/medicina55090559. PMID: 31480774Free PMC Article

Prognosis

Quantifying the variability in the assessment of reproductive hormone levels.
Abbara A, Adams S, Phylactou M, Izzi-Engbeaya C, Mills EG, Thurston L, Koysombat K, Hanassab S, Heinis T, Tan TM, Tsaneva-Atanasova K, Comninos AN, Voliotis M, Dhillo WS
Fertil Steril 2024 Feb;121(2):334-345. Epub 2023 Nov 15 doi: 10.1016/j.fertnstert.2023.11.010. PMID: 37977226
Sexual dysfunction and disorders as a consequence of infertility: a systematic review and meta-analysis.
Leeners B, Tschudin S, Wischmann T, Kalaitzopoulos DR
Hum Reprod Update 2023 Jan 5;29(1):95-125. doi: 10.1093/humupd/dmac030. PMID: 35900268
Low Sexual Desire in Breast Cancer Survivors and Patients: A Review.
Luo F, Link M, Grabenhorst C, Lynn B
Sex Med Rev 2022 Jul;10(3):367-375. Epub 2022 Apr 8 doi: 10.1016/j.sxmr.2022.02.001. PMID: 35410784
Hypoactive sexual desire disorder.
Davison SL
Curr Opin Obstet Gynecol 2012 Aug;24(4):215-20. doi: 10.1097/GCO.0b013e328355847e. PMID: 22729093
Low sexual desire--is it all in her head? Pathophysiology, diagnosis, and treatment of hypoactive sexual desire disorder.
Simon JA
Postgrad Med 2010 Nov;122(6):128-36. doi: 10.3810/pgm.2010.11.2230. PMID: 21084789

Clinical prediction guides

Low Sexual Desire in Breast Cancer Survivors and Patients: A Review.
Luo F, Link M, Grabenhorst C, Lynn B
Sex Med Rev 2022 Jul;10(3):367-375. Epub 2022 Apr 8 doi: 10.1016/j.sxmr.2022.02.001. PMID: 35410784
Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial.
Kamenov Z, Fileva S, Kalinov K, Jannini EA
Maturitas 2017 May;99:20-26. Epub 2017 Feb 12 doi: 10.1016/j.maturitas.2017.01.011. PMID: 28364864
Efficacy and safety of transdermal testosterone in postmenopausal women with hypoactive sexual desire disorder: a systematic review and meta-analysis.
Achilli C, Pundir J, Ramanathan P, Sabatini L, Hamoda H, Panay N
Fertil Steril 2017 Feb;107(2):475-482.e15. Epub 2016 Dec 1 doi: 10.1016/j.fertnstert.2016.10.028. PMID: 27916205
Flibanserin.
Vallejos X, Wu C
J Pharm Pract 2017 Apr;30(2):256-260. Epub 2016 Jul 9 doi: 10.1177/0897190016630409. PMID: 26873507
Flibanserin for the treatment of hypoactive sexual desire disorder in premenopausal women.
Dhanuka I, Simon JA
Expert Opin Pharmacother 2015;16(16):2523-9. Epub 2015 Sep 22 doi: 10.1517/14656566.2015.1090426. PMID: 26395164

Recent systematic reviews

Sexual dysfunction and disorders as a consequence of infertility: a systematic review and meta-analysis.
Leeners B, Tschudin S, Wischmann T, Kalaitzopoulos DR
Hum Reprod Update 2023 Jan 5;29(1):95-125. doi: 10.1093/humupd/dmac030. PMID: 35900268
A Systematic Literature Review of Health-related Quality of Life Measures for Women with Hypoactive Sexual Desire Disorder and Female Sexual Interest/Arousal Disorder.
Lim-Watson MZ, Hays RD, Kingsberg S, Kallich JD, Murimi-Worstell IB
Sex Med Rev 2022 Jan;10(1):23-41. Epub 2021 Sep 1 doi: 10.1016/j.sxmr.2021.07.003. PMID: 34481749
Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire Disorder.
Mayer D, Lynch SE
Ann Pharmacother 2020 Jul;54(7):684-690. Epub 2020 Jan 1 doi: 10.1177/1060028019899152. PMID: 31893927
Neuroimaging of Female Sexual Desire and Hypoactive Sexual Desire Disorder.
Cacioppo S
Sex Med Rev 2017 Oct;5(4):434-444. Epub 2017 Aug 31 doi: 10.1016/j.sxmr.2017.07.006. PMID: 28865901
Efficacy and safety of transdermal testosterone in postmenopausal women with hypoactive sexual desire disorder: a systematic review and meta-analysis.
Achilli C, Pundir J, Ramanathan P, Sabatini L, Hamoda H, Panay N
Fertil Steril 2017 Feb;107(2):475-482.e15. Epub 2016 Dec 1 doi: 10.1016/j.fertnstert.2016.10.028. PMID: 27916205

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