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Iridocyclitis

MedGen UID:
43961
Concept ID:
C0022073
Disease or Syndrome
Synonyms: Cyclitides, Heterochromic; Cyclitis, Heterochromic; Heterochromic Cyclitides; Heterochromic Cyclitis; Iridocyclitides
SNOMED CT: Iridocyclitis (77971008)
 
HPO: HP:0001094
Monarch Initiative: MONDO:0004773

Definition

A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body. [from HPO]

Term Hierarchy

Conditions with this feature

Behcet disease
MedGen UID:
2568
Concept ID:
C0004943
Disease or Syndrome
Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects small blood vessels in the mouth, genitals, skin, and eyes.\n\nPainful mouth sores called aphthous ulcers are usually the first sign of Behçet disease. These sores can occur on the lips, tongue, inside the cheeks, the roof of the mouth, the throat, and the tonsils. The ulcers look like common canker sores, and they typically heal within one to two weeks. About 75 percent of all people with Behçet disease develop similar ulcers on the genitals. These ulcers occur most frequently on the scrotum in men and on the labia in women.\n\nBehçet disease can also cause painful bumps and sores on the skin. Most affected individuals develop pus-filled bumps that resemble acne. These bumps can occur anywhere on the body. Some affected people also have red, tender nodules called erythema nodosum. These nodules usually develop on the legs but can also occur on the arms, face, and neck.\n\nAn inflammation of the eye called uveitis is found in more than half of people with Behçet disease. Eye problems are more common in younger people with the disease and affect men more often than women. Uveitis can result in blurry vision and an extreme sensitivity to light (photophobia). Rarely, inflammation can also cause eye pain and redness. If untreated, the eye problems associated with Behçet disease can lead to blindness.\n\nJoint involvement is also common in Behçet disease. Often this affects one joint at a time, with each affected joint becoming swollen and painful and then getting better.\n\nLess commonly, Behçet disease can affect the brain and spinal cord (central nervous system), gastrointestinal tract, large blood vessels, heart, lungs, and kidneys. Central nervous system abnormalities can lead to headaches, confusion, personality changes, memory loss, impaired speech, and problems with balance and movement. Involvement of the gastrointestinal tract can lead to a hole in the wall of the intestine (intestinal perforation), which can cause serious infection and may be life-threatening.\n\nThe signs and symptoms of Behçet disease usually begin in a person's twenties or thirties, although they can appear at any age. Some affected people have relatively mild symptoms that are limited to sores in the mouth and on the genitals. Others have more severe symptoms affecting various parts of the body, including the eyes and the vital organs. The features of Behçet disease typically come and go over a period of months or years. In most affected individuals, the health problems associated with this disorder improve with age.
Polyglandular autoimmune syndrome, type 1
MedGen UID:
39125
Concept ID:
C0085859
Disease or Syndrome
Autoimmune polyglandular syndrome type I (APS1) is characterized by the presence of 2 of 3 major clinical symptoms: Addison disease, and/or hypoparathyroidism, and/or chronic mucocutaneous candidiasis (Neufeld et al., 1981). However, variable APS1 phenotypes have been observed, even among sibs. In addition, some patients may exhibit apparent isolated hypoparathyroidism, an early manifestation of APS1 with peak incidence at around age 5 years; over long-term follow-up, the development of additional features of APS1 may be observed (Cranston et al., 2022).
Sarcoidosis, susceptibility to, 1
MedGen UID:
394568
Concept ID:
C2697310
Finding
Any sarcoidosis in which the cause of the disease is a mutation in the HLA-DRB1 gene.

Professional guidelines

PubMed

Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989
Yoo JH, Chodosh J, Dana R
Semin Ophthalmol 2011 Jul-Sep;26(4-5):261-9. doi: 10.3109/08820538.2011.588653. PMID: 21958172
Kähler KC, Hauschild A
J Dtsch Dermatol Ges 2011 Apr;9(4):277-86. Epub 2010 Nov 17 doi: 10.1111/j.1610-0387.2010.07568.x. PMID: 21083648

Recent clinical studies

Etiology

Agrawal R, Oo HH, Balne PK, Ng L, Tong L, Leo YS
Ocul Immunol Inflamm 2018;26(5):654-659. Epub 2017 Mar 20 doi: 10.1080/09273948.2017.1294184. PMID: 28318359
de Paula Freitas B, Ventura CV, Maia M, Belfort R Jr
Curr Opin Ophthalmol 2017 Nov;28(6):595-599. doi: 10.1097/ICU.0000000000000420. PMID: 28795959
Martínez-Pulgarín DF, Chowdhury FR, Villamil-Gomez WE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE
Travel Med Infect Dis 2016 Sep-Oct;14(5):451-457. Epub 2016 May 26 doi: 10.1016/j.tmaid.2016.05.008. PMID: 27238905
Grzybowski A, Nita M, Virmond M
Clin Dermatol 2015 Jan-Feb;33(1):79-89. doi: 10.1016/j.clindermatol.2014.07.003. PMID: 25432813
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Diagnosis

Gueudry J, Muraine M
J Fr Ophtalmol 2018 Jan;41(1):e11-e21. Epub 2017 Dec 29 doi: 10.1016/j.jfo.2017.11.003. PMID: 29290458
Agrawal R, Oo HH, Balne PK, Ng L, Tong L, Leo YS
Ocul Immunol Inflamm 2018;26(5):654-659. Epub 2017 Mar 20 doi: 10.1080/09273948.2017.1294184. PMID: 28318359
Megaw R, Agarwal PK
Surv Ophthalmol 2017 May-Jun;62(3):277-285. Epub 2016 Dec 22 doi: 10.1016/j.survophthal.2016.12.005. PMID: 28012873
Grzybowski A, Nita M, Virmond M
Clin Dermatol 2015 Jan-Feb;33(1):79-89. doi: 10.1016/j.clindermatol.2014.07.003. PMID: 25432813
Terelak-Borys B, Skonieczna K, Grabska-Liberek I
Med Sci Monit 2012 Aug;18(8):RA138-144. doi: 10.12659/msm.883260. PMID: 22847215Free PMC Article

Therapy

Murdaca G, Tonacci A, Negrini S, Greco M, Borro M, Puppo F, Gangemi S
Autoimmun Rev 2019 Sep;18(9):102350. Epub 2019 Jul 16 doi: 10.1016/j.autrev.2019.102350. PMID: 31323357
Martínez-Pulgarín DF, Chowdhury FR, Villamil-Gomez WE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE
Travel Med Infect Dis 2016 Sep-Oct;14(5):451-457. Epub 2016 May 26 doi: 10.1016/j.tmaid.2016.05.008. PMID: 27238905
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989
Citirik M, Batman C, Aslan O, Adabag A, Ozalp S, Zilelioglu O
Ocul Immunol Inflamm 2005 Feb;13(1):95-9. doi: 10.1080/09273940490912380. PMID: 15804778
Moorthy RS, Rao NA, Sidikaro Y, Foos RY
Ophthalmology 1994 Dec;101(12):1923-8. doi: 10.1016/s0161-6420(94)31082-7. PMID: 7997329

Prognosis

Suresh S, Tsui E
Curr Opin Ophthalmol 2020 Nov;31(6):532-537. doi: 10.1097/ICU.0000000000000705. PMID: 33009086
Martínez-Pulgarín DF, Chowdhury FR, Villamil-Gomez WE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE
Travel Med Infect Dis 2016 Sep-Oct;14(5):451-457. Epub 2016 May 26 doi: 10.1016/j.tmaid.2016.05.008. PMID: 27238905
Grzybowski A, Nita M, Virmond M
Clin Dermatol 2015 Jan-Feb;33(1):79-89. doi: 10.1016/j.clindermatol.2014.07.003. PMID: 25432813
Bonfioli AA, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):199-206. doi: 10.1080/08820530500231953. PMID: 16282155
Panicker JN, Mammachan R, Jayakumar RV
Postgrad Med J 2001 Sep;77(911):589-90. doi: 10.1136/pmj.77.911.589. PMID: 11524519Free PMC Article

Clinical prediction guides

Katircioglu YA, Celik T, Acar DD, Burcu A
Int Ophthalmol 2023 Sep;43(9):3199-3206. Epub 2023 May 15 doi: 10.1007/s10792-023-02720-3. PMID: 37184806
de Paula Freitas B, Ventura CV, Maia M, Belfort R Jr
Curr Opin Ophthalmol 2017 Nov;28(6):595-599. doi: 10.1097/ICU.0000000000000420. PMID: 28795959
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989
Jadaon J, Shushan A, Ezra Y, Sela HY, Ozcan C, Rojansky N
Acta Obstet Gynecol Scand 2005 Oct;84(10):939-44. doi: 10.1111/j.0001-6349.2005.00761.x. PMID: 16167908
O'Connor GR
Trans Ophthalmol Soc U K (1962) 1985;104 ( Pt 3):219-31. PMID: 3895609

Recent systematic reviews

O'Rourke J, Townsend CL, Milanzi E, Collins IJ, Castro H, Judd A, Vicari M, Jesson J, Leroy V, Penazzato M, Renaud F
J Int AIDS Soc 2023 Feb;26(2):e26037. doi: 10.1002/jia2.26037. PMID: 36823283Free PMC Article
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Ejere HO, Schwartz E, Wormald R, Evans JR
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD002219. doi: 10.1002/14651858.CD002219.pub2. PMID: 22895928Free PMC Article
Terelak-Borys B, Skonieczna K, Grabska-Liberek I
Med Sci Monit 2012 Aug;18(8):RA138-144. doi: 10.12659/msm.883260. PMID: 22847215Free PMC Article
Cantini F, Niccoli L, Nannini C, Kaloudi O, Bertoni M, Cassarà E
Int J Rheum Dis 2010 Oct;13(4):300-17. doi: 10.1111/j.1756-185X.2010.01540.x. PMID: 21199465

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