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Pre-B Acute Lymphoblastic Leukemia

MedGen UID:
44126
Concept ID:
C0023485
Neoplastic Process
Synonyms: Leukemia, Pre B Cell; Leukemia, Pre-B-Cell; Leukemias, Pre-B-Cell; Pre B ALL; Pre B Cell Leukemia; Pre B-ALL; Pre-B ALL; Pre-B-Cell Leukemia; Pre-B-Cell Leukemias; Precursor B Cell Lymphoblastic Leukemia; Precursor B Cell Lymphoblastic Leukemia Lymphoma; Precursor B Cell Lymphoblastic Lymphoma; Precursor B-Cell Lymphoblastic Leukemia; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor B-Cell Lymphoblastic Lymphoma

Definition

An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The pre-B lymphoblasts contain cytoplasmic immunoglobulin. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

McElroy S, Myers GD, Flatt T
J Pediatr Hematol Oncol 2023 May 1;45(4):e518-e521. Epub 2023 Jan 10 doi: 10.1097/MPH.0000000000002613. PMID: 36706304
Blaeschke F, Stenger D, Kaeuferle T, Willier S, Lotfi R, Kaiser AD, Assenmacher M, Döring M, Feucht J, Feuchtinger T
Cancer Immunol Immunother 2018 Jul;67(7):1053-1066. Epub 2018 Mar 31 doi: 10.1007/s00262-018-2155-7. PMID: 29605883Free PMC Article
Fei F, Lim M, Schmidhuber S, Moll J, Groffen J, Heisterkamp N
Mol Cancer 2012 Jun 21;11:42. doi: 10.1186/1476-4598-11-42. PMID: 22721004Free PMC Article

Recent clinical studies

Etiology

McElroy S, Myers GD, Flatt T
J Pediatr Hematol Oncol 2023 May 1;45(4):e518-e521. Epub 2023 Jan 10 doi: 10.1097/MPH.0000000000002613. PMID: 36706304
Hosein Pour Feizi A, Zeinali S, Toporski J, Sheervalilou R, Mehranfar S
Asian Pac J Cancer Prev 2020 Dec 1;21(12):3493-3500. doi: 10.31557/APJCP.2020.21.12.3493. PMID: 33369444Free PMC Article
Rezazadeh D, Moradi MT, Kazemi A, Mansouri K
Int J Lab Hematol 2015 Aug;37(4):530-5. Epub 2015 Feb 27 doi: 10.1111/ijlh.12332. PMID: 25726706
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article
Williams MT, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman KE, McAndrew R, Thomas A, Spence A, Gibson B, Graham GJ, Halsey C
Blood 2014 May 15;123(20):3116-27. Epub 2014 Apr 3 doi: 10.1182/blood-2013-05-499970. PMID: 24700781

Diagnosis

Diwan A, Barsode S
J Assoc Physicians India 2024 Mar;72(3):97-99. doi: 10.59556/japi.72.0446. PMID: 38736127
Zhu H, Ma H, Dong N, Wu M, Li D, Liu L, Shi Q, Ju X
BMC Cancer 2023 Feb 6;23(1):122. doi: 10.1186/s12885-023-10589-9. PMID: 36747147Free PMC Article
Martínez-Anaya D, Moreno-Lorenzana D, Reyes-León A, Juárez-Figueroa U, Dean M, Aguilar-Hernández MM, Rivera-Sánchez N, García-Islas J, Vieyra-Fuentes V, Zapata-Tarrés M, Juárez-Villegas L, Paredes-Aguilera R, Vega-Vega L, Rivera-Luna R, Juárez-Velázquez MDR, Pérez-Vera P
Int J Mol Sci 2022 Aug 24;23(17) doi: 10.3390/ijms23179587. PMID: 36076986Free PMC Article
Georgakopoulos N, Diamantopoulos P, Micci F, Giannakopoulou N, Zervakis K, Dimitrakopoulou A, Viniou NA
In Vivo 2018 Sep-Oct;32(5):1241-1245. doi: 10.21873/invivo.11371. PMID: 30150451Free PMC Article
Rezazadeh D, Moradi MT, Kazemi A, Mansouri K
Int J Lab Hematol 2015 Aug;37(4):530-5. Epub 2015 Feb 27 doi: 10.1111/ijlh.12332. PMID: 25726706

Therapy

Kantarjian H, Haddad FG, Jain N, Sasaki K, Short NJ, Loghavi S, Kanagal-Shamanna R, Jorgensen J, Khouri I, Kebriaei P, Alvarado Y, Kadia T, Paul S, Garcia-Manero G, Dabaja B, Yilmaz M, Jacob J, Garris R, O'Brien S, Ravandi F, Jabbour E
J Hematol Oncol 2023 May 2;16(1):44. doi: 10.1186/s13045-023-01444-2. PMID: 37131217Free PMC Article
Charmsaz S, Al-Ejeh F, Yeadon TM, Miller KJ, Smith FM, Stringer BW, Moore AS, Lee FT, Cooper LT, Stylianou C, Yarranton GT, Woronicz J, Scott AM, Lackmann M, Boyd AW
Leukemia 2017 Aug;31(8):1779-1787. Epub 2016 Dec 6 doi: 10.1038/leu.2016.371. PMID: 27922598
Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S
Dtsch Arztebl Int 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. PMID: 26667979Free PMC Article
Advani A
Best Pract Res Clin Haematol 2015 Jun-Sep;28(2-3):116-23. Epub 2015 Oct 22 doi: 10.1016/j.beha.2015.10.008. PMID: 26590768
Fei F, Lim M, Schmidhuber S, Moll J, Groffen J, Heisterkamp N
Mol Cancer 2012 Jun 21;11:42. doi: 10.1186/1476-4598-11-42. PMID: 22721004Free PMC Article

Prognosis

Kantarjian H, Haddad FG, Jain N, Sasaki K, Short NJ, Loghavi S, Kanagal-Shamanna R, Jorgensen J, Khouri I, Kebriaei P, Alvarado Y, Kadia T, Paul S, Garcia-Manero G, Dabaja B, Yilmaz M, Jacob J, Garris R, O'Brien S, Ravandi F, Jabbour E
J Hematol Oncol 2023 May 2;16(1):44. doi: 10.1186/s13045-023-01444-2. PMID: 37131217Free PMC Article
Hosein Pour Feizi A, Zeinali S, Toporski J, Sheervalilou R, Mehranfar S
Asian Pac J Cancer Prev 2020 Dec 1;21(12):3493-3500. doi: 10.31557/APJCP.2020.21.12.3493. PMID: 33369444Free PMC Article
Georgakopoulos N, Diamantopoulos P, Micci F, Giannakopoulou N, Zervakis K, Dimitrakopoulou A, Viniou NA
In Vivo 2018 Sep-Oct;32(5):1241-1245. doi: 10.21873/invivo.11371. PMID: 30150451Free PMC Article
Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S
Dtsch Arztebl Int 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. PMID: 26667979Free PMC Article
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article

Clinical prediction guides

Kurata M, Onishi I, Takahara T, Yamazaki Y, Ishibashi S, Goitsuka R, Kitamura D, Takita J, Hayashi Y, Largaesapda DA, Kitagawa M, Nakamura T
Cancer Sci 2021 Dec;112(12):4920-4930. Epub 2021 Oct 23 doi: 10.1111/cas.15164. PMID: 34653294Free PMC Article
Mishra D, Singh S, Narayan G
Asian Pac J Cancer Prev 2016;17(8):3865-9. PMID: 27644631
Yamamoto K, Kawamoto S, Mizutani Y, Yakushijin K, Yamashita T, Nakamachi Y, Kawano S, Hayashi Y, Matsuoka H, Minami H
Cytogenet Genome Res 2016;149(3):165-170. Epub 2016 Sep 9 doi: 10.1159/000448447. PMID: 27607436
Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S
Dtsch Arztebl Int 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. PMID: 26667979Free PMC Article
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article

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