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Lyme disease

MedGen UID:
44213
•Concept ID:
C0024198
•
Disease or Syndrome
Synonyms: B. burgdorferi Infection; B. burgdorferi Infections; Borrelia burgdorferi Infection; Borrelia burgdorferi Infections; Borreliosis, Lyme; Disease, Lyme; Lyme Borreliosis; Lyme Disease
SNOMED CT: Infection due to Borrelia burgdorferi sensu lato (23502006); Lyme disease (23502006); Steere's disease (23502006); Lyme borreliosis (23502006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019632
Orphanet: ORPHA91546

Definition

Lyme disease (named after the towns in the USA where the disease was first identified) is a bacterial infection caused by <i>Borrelia burgdorferi</i>. [from ORDO]

Professional guidelines

PubMed

Lyme borreliosis: diagnosis and management.
Kullberg BJ, Vrijmoeth HD, van de Schoor F, Hovius JW
BMJ 2020 May 26;369:m1041. doi: 10.1136/bmj.m1041. PMID: 32457042
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Lyme disease: diagnosis and management.
Ross Russell AL, Dryden MS, Pinto AA, Lovett JK
Pract Neurol 2018 Dec;18(6):455-464. Epub 2018 Oct 3 doi: 10.1136/practneurol-2018-001998. PMID: 30282764

Recent clinical studies

Etiology

Lyme Disease in Children.
McCarthy CA, Helis JA, Daikh BE
Infect Dis Clin North Am 2022 Sep;36(3):593-603. doi: 10.1016/j.idc.2022.03.002. PMID: 36116837
Epidemiology of Lyme Disease.
Mead P
Infect Dis Clin North Am 2022 Sep;36(3):495-521. doi: 10.1016/j.idc.2022.03.004. PMID: 36116831
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article
Epidemiology of Lyme disease.
Mead PS
Infect Dis Clin North Am 2015 Jun;29(2):187-210. doi: 10.1016/j.idc.2015.02.010. PMID: 25999219

Diagnosis

Epidemiology of Lyme Disease.
Mead P
Infect Dis Clin North Am 2022 Sep;36(3):495-521. doi: 10.1016/j.idc.2022.03.004. PMID: 36116831
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Lyme Disease.
Carriveau A, Poole H, Thomas A
Nurs Clin North Am 2019 Jun;54(2):261-275. Epub 2019 Mar 26 doi: 10.1016/j.cnur.2019.02.003. PMID: 31027665
Lyme disease: diagnosis and management.
Ross Russell AL, Dryden MS, Pinto AA, Lovett JK
Pract Neurol 2018 Dec;18(6):455-464. Epub 2018 Oct 3 doi: 10.1136/practneurol-2018-001998. PMID: 30282764
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article

Therapy

Lyme borreliosis: diagnosis and management.
Kullberg BJ, Vrijmoeth HD, van de Schoor F, Hovius JW
BMJ 2020 May 26;369:m1041. doi: 10.1136/bmj.m1041. PMID: 32457042
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Lyme Disease.
Carriveau A, Poole H, Thomas A
Nurs Clin North Am 2019 Jun;54(2):261-275. Epub 2019 Mar 26 doi: 10.1016/j.cnur.2019.02.003. PMID: 31027665
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article

Prognosis

Lyme Disease in Children.
McCarthy CA, Helis JA, Daikh BE
Infect Dis Clin North Am 2022 Sep;36(3):593-603. doi: 10.1016/j.idc.2022.03.002. PMID: 36116837
Lyme Disease.
Carriveau A, Poole H, Thomas A
Nurs Clin North Am 2019 Jun;54(2):261-275. Epub 2019 Mar 26 doi: 10.1016/j.cnur.2019.02.003. PMID: 31027665
Lyme neuroborreliosis.
Koedel U, Pfister HW
Curr Opin Infect Dis 2017 Feb;30(1):101-107. doi: 10.1097/QCO.0000000000000332. PMID: 27820708
Lyme disease.
Wright D
J Am Acad Nurse Pract 2001 May;13(5):223-6; quiz 227-8. doi: 10.1111/j.1745-7599.2001.tb00024.x. PMID: 11930473
Lyme disease.
Evans J
Curr Opin Rheumatol 1995 Jul;7(4):322-8. doi: 10.1097/00002281-199507000-00010. PMID: 7547110

Clinical prediction guides

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease.
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ Jr, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Cody Meissner H, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS
Arthritis Care Res (Hoboken) 2021 Jan;73(1):1-9. Epub 2020 Nov 29 doi: 10.1002/acr.24495. PMID: 33251700
Clinical and economic outcomes evaluated in Lyme disease: a systematic review.
Mattingly TJ 2nd, Shere-Wolfe K
Parasit Vectors 2020 Jul 9;13(1):341. doi: 10.1186/s13071-020-04214-y. PMID: 32646476Free PMC Article
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642
Lyme borreliosis.
Stanek G, Strle F
Lancet 2003 Nov 15;362(9396):1639-47. doi: 10.1016/S0140-6736(03)14798-8. PMID: 14630446
Lyme neuroborreliosis.
Haass A
Curr Opin Neurol 1998 Jun;11(3):253-8. doi: 10.1097/00019052-199806000-00011. PMID: 9642545

Recent systematic reviews

Diagnosis and treatment of "chronic Lyme": primum non nocere.
Sébastien P, Jacques D, Catherine P, Xavier G
BMC Infect Dis 2023 Oct 2;23(1):642. doi: 10.1186/s12879-023-08618-w. PMID: 37784031Free PMC Article
Disseminated Lyme disease and dilated cardiomyopathy: A systematic review.
Motamed M, Liblik K, Miranda-Arboleda AF, Wamboldt R, Wang CN, Cingolani O, Rebman AW, Novak CB, Aucott JN, Farina JM, Baranchuk A
Trends Cardiovasc Med 2023 Nov;33(8):531-536. Epub 2022 Jun 3 doi: 10.1016/j.tcm.2022.05.010. PMID: 35667636
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease.
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ Jr, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Cody Meissner H, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS
Arthritis Care Res (Hoboken) 2021 Jan;73(1):1-9. Epub 2020 Nov 29 doi: 10.1002/acr.24495. PMID: 33251700
Clinical and economic outcomes evaluated in Lyme disease: a systematic review.
Mattingly TJ 2nd, Shere-Wolfe K
Parasit Vectors 2020 Jul 9;13(1):341. doi: 10.1186/s13071-020-04214-y. PMID: 32646476Free PMC Article
Lyme Neuroborreliosis.
Rauer S, Kastenbauer S, Fingerle V, Hunfeld KP, Huppertz HI, Dersch R
Dtsch Arztebl Int 2018 Nov 9;115(45):751-756. doi: 10.3238/arztebl.2018.0751. PMID: 30573008Free PMC Article

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