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Lyme disease

MedGen UID:
44213
•Concept ID:
C0024198
•
Disease or Syndrome
Synonyms: B. burgdorferi Infection; B. burgdorferi Infections; Borrelia burgdorferi Infection; Borrelia burgdorferi Infections; Borreliosis, Lyme; Disease, Lyme; Lyme Borreliosis; Lyme Disease
SNOMED CT: Infection due to Borrelia burgdorferi sensu lato (23502006); Lyme disease (23502006); Steere's disease (23502006); Lyme borreliosis (23502006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019632
Orphanet: ORPHA91546

Definition

Lyme disease (named after the towns in the USA where the disease was first identified) is a bacterial infection caused by <i>Borrelia burgdorferi</i>. [from ORDO]

Professional guidelines

PubMed

Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Lyme disease: diagnosis and management.
Ross Russell AL, Dryden MS, Pinto AA, Lovett JK
Pract Neurol 2018 Dec;18(6):455-464. Epub 2018 Oct 3 doi: 10.1136/practneurol-2018-001998. PMID: 30282764
Diagnosis and treatment of Lyme arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2015 Jun;29(2):269-80. doi: 10.1016/j.idc.2015.02.004. PMID: 25999223Free PMC Article

Recent clinical studies

Etiology

Lyme Disease in Children.
McCarthy CA, Helis JA, Daikh BE
Infect Dis Clin North Am 2022 Sep;36(3):593-603. doi: 10.1016/j.idc.2022.03.002. PMID: 36116837
Epidemiology of Lyme Disease.
Mead P
Infect Dis Clin North Am 2022 Sep;36(3):495-521. doi: 10.1016/j.idc.2022.03.004. PMID: 36116831
Comparison of Lyme Disease in the United States and Europe.
Marques AR, Strle F, Wormser GP
Emerg Infect Dis 2021 Aug;27(8):2017-2024. doi: 10.3201/eid2708.204763. PMID: 34286689Free PMC Article
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article

Diagnosis

Epidemiology of Lyme Disease.
Mead P
Infect Dis Clin North Am 2022 Sep;36(3):495-521. doi: 10.1016/j.idc.2022.03.004. PMID: 36116831
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Lyme Disease.
Carriveau A, Poole H, Thomas A
Nurs Clin North Am 2019 Jun;54(2):261-275. Epub 2019 Mar 26 doi: 10.1016/j.cnur.2019.02.003. PMID: 31027665
Lyme disease: diagnosis and management.
Ross Russell AL, Dryden MS, Pinto AA, Lovett JK
Pract Neurol 2018 Dec;18(6):455-464. Epub 2018 Oct 3 doi: 10.1136/practneurol-2018-001998. PMID: 30282764

Therapy

Lyme borreliosis: diagnosis and management.
Kullberg BJ, Vrijmoeth HD, van de Schoor F, Hovius JW
BMJ 2020 May 26;369:m1041. doi: 10.1136/bmj.m1041. PMID: 32457042
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Lyme Disease.
Carriveau A, Poole H, Thomas A
Nurs Clin North Am 2019 Jun;54(2):261-275. Epub 2019 Mar 26 doi: 10.1016/j.cnur.2019.02.003. PMID: 31027665
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article

Prognosis

Lyme Disease in Children.
McCarthy CA, Helis JA, Daikh BE
Infect Dis Clin North Am 2022 Sep;36(3):593-603. doi: 10.1016/j.idc.2022.03.002. PMID: 36116837
Scleritis in Lyme Disease.
Berkenstock MK, Long K, Miller JB, Burkholder BB, Aucott JN, Jabs DA
Am J Ophthalmol 2022 Sep;241:139-144. Epub 2022 May 2 doi: 10.1016/j.ajo.2022.04.017. PMID: 35513033
Lyme Disease.
Carriveau A, Poole H, Thomas A
Nurs Clin North Am 2019 Jun;54(2):261-275. Epub 2019 Mar 26 doi: 10.1016/j.cnur.2019.02.003. PMID: 31027665
Lyme neuroborreliosis.
Koedel U, Pfister HW
Curr Opin Infect Dis 2017 Feb;30(1):101-107. doi: 10.1097/QCO.0000000000000332. PMID: 27820708
Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center.
Hohman MH, Hadlock TA
Laryngoscope 2014 Jul;124(7):E283-93. Epub 2014 Jan 15 doi: 10.1002/lary.24542. PMID: 24431233

Clinical prediction guides

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease.
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ Jr, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Cody Meissner H, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS
Arthritis Care Res (Hoboken) 2021 Jan;73(1):1-9. Epub 2020 Nov 29 doi: 10.1002/acr.24495. PMID: 33251700
Clinical and economic outcomes evaluated in Lyme disease: a systematic review.
Mattingly TJ 2nd, Shere-Wolfe K
Parasit Vectors 2020 Jul 9;13(1):341. doi: 10.1186/s13071-020-04214-y. PMID: 32646476Free PMC Article
Lyme borreliosis.
Stanek G, Strle F
Lancet 2003 Nov 15;362(9396):1639-47. doi: 10.1016/S0140-6736(03)14798-8. PMID: 14630446
Lyme borreliosis.
Nadelman RB, Wormser GP
Lancet 1998 Aug 15;352(9127):557-65. doi: 10.1016/S0140-6736(98)01146-5. PMID: 9716075
Lyme neuroborreliosis.
Haass A
Curr Opin Neurol 1998 Jun;11(3):253-8. doi: 10.1097/00019052-199806000-00011. PMID: 9642545

Recent systematic reviews

Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis.
Zhou G, Xu X, Zhang Y, Yue P, Luo S, Fan Y, Chen J, Liu M, Dong Y, Li B, Kong J, Wen S, Liu A, Bao F
BMC Infect Dis 2021 Nov 8;21(1):1141. doi: 10.1186/s12879-021-06837-7. PMID: 34749665Free PMC Article
Neurosyphilis and Lyme neuroborreliosis.
Dersch R, Singh AE
Curr Opin Neurol 2021 Jun 1;34(3):403-409. doi: 10.1097/WCO.0000000000000923. PMID: 33709978
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease.
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ Jr, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Cody Meissner H, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS
Arthritis Care Res (Hoboken) 2021 Jan;73(1):1-9. Epub 2020 Nov 29 doi: 10.1002/acr.24495. PMID: 33251700
Clinical and economic outcomes evaluated in Lyme disease: a systematic review.
Mattingly TJ 2nd, Shere-Wolfe K
Parasit Vectors 2020 Jul 9;13(1):341. doi: 10.1186/s13071-020-04214-y. PMID: 32646476Free PMC Article
Lyme Neuroborreliosis.
Rauer S, Kastenbauer S, Fingerle V, Hunfeld KP, Huppertz HI, Dersch R
Dtsch Arztebl Int 2018 Nov 9;115(45):751-756. doi: 10.3238/arztebl.2018.0751. PMID: 30573008Free PMC Article

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