U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Follicular lymphoma, susceptibility to, 1(FL1)

MedGen UID:
442784
Concept ID:
C2751665
Finding
Synonyms: FL1; Follicular lymphoma 1
 
Monarch Initiative: MONDO:0013088
OMIM®: 613024

Definition

Follicular non-Hodgkin lymphoma is an indolent B-cell malignancy with an annual incidence exceeding 10,000 cases in the United States (Bohen et al., 2003). One form of susceptibility to follicular lymphoma (FL1) is associated with a region on chromosome 6p21.33. [from OMIM]

Clinical features

From HPO
Follicular lymphoma
MedGen UID:
7417
Concept ID:
C0024301
Neoplastic Process
An indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement.

Professional guidelines

PubMed

Cerhan JR, Fredericksen ZS, Novak AJ, Ansell SM, Kay NE, Liebow M, Dogan A, Cunningham JM, Wang AH, Witzig TE, Habermann TM, Asmann YW, Slager SL
Cancer Epidemiol Biomarkers Prev 2012 Oct;21(10):1799-806. Epub 2012 Aug 21 doi: 10.1158/1055-9965.EPI-12-0696. PMID: 22911334Free PMC Article
Ismail SI, Ababneh NA, Khader Y, Abu-Khader AA, Awidi A
Cancer Genet Cytogenet 2009 Dec;195(2):120-4. doi: 10.1016/j.cancergencyto.2009.06.026. PMID: 19963111

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

Recent clinical studies

Etiology

Hernández-Verdin I, Labreche K, Benazra M, Mokhtari K, Hoang-Xuan K, Alentorn A
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010122. PMID: 33374413Free PMC Article
Purdue MP, Lan Q, Langseth H, Grimsrud TK, Hildesheim A, Rothman N
Int J Cancer 2020 Jun 15;146(12):3312-3319. Epub 2019 Oct 11 doi: 10.1002/ijc.32684. PMID: 31523805Free PMC Article
Din L, Sheikh M, Kosaraju N, Smedby KE, Bernatsky S, Berndt SI, Skibola CF, Nieters A, Wang S, McKay JD, Cocco P, Maynadié M, Foretová L, Staines A, Mack TM, de Sanjosé S, Vyse TJ, Padyukov L, Monnereau A, Arslan AA, Moore A, Brooks-Wilson AR, Novak AJ, Glimelius B, Birmann BM, Link BK, Stewart C, Vajdic CM, Haioun C, Magnani C, Conti DV, Cox DG, Casabonne D, Albanes D, Kane E, Roman E, Muzi G, Salles G, Giles GG, Adami HO, Ghesquières H, De Vivo I, Clavel J, Cerhan JR, Spinelli JJ, Hofmann J, Vijai J, Curtin K, Costenbader KH, Onel K, Offit K, Teras LR, Morton L, Conde L, Miligi L, Melbye M, Ennas MG, Liebow M, Purdue MP, Glenn M, Southey MC, Din M, Rothman N, Camp NJ, Wong Doo N, Becker N, Pradhan N, Bracci PM, Boffetta P, Vineis P, Brennan P, Kraft P, Lan Q, Severson RK, Vermeulen RCH, Milne RL, Kaaks R, Travis RC, Weinstein SJ, Chanock SJ, Ansell SM, Slager SL, Zheng T, Zhang Y, Benavente Y, Taub Z, Madireddy L, Gourraud PA, Oksenberg JR, Cozen W, Hjalgrim H, Khankhanian P
Genet Epidemiol 2019 Oct;43(7):844-863. Epub 2019 Aug 13 doi: 10.1002/gepi.22242. PMID: 31407831Free PMC Article
Lin HY, Shi H, Li CY, Chen QC, Huang TB, Liu PC, Lou LM
J BUON 2015 Jan-Feb;20(1):261-8. PMID: 25778326
Hess G, Smith SM, Berkenblit A, Coiffier B
Semin Oncol 2009 Dec;36 Suppl 3:S37-45. doi: 10.1053/j.seminoncol.2009.10.012. PMID: 19963099

Diagnosis

Jønsson V, Awan H, Jones ND, Johannesen TB, Thøgersen K, Steig BÁ, Andorsdottir G, Tjønnfjord GE
Sci Rep 2022 Apr 12;12(1):6138. doi: 10.1038/s41598-022-09602-1. PMID: 35413962Free PMC Article
Xue T, Yu BH, Yan WH, Jiang XN, Tian T, Zhou XY, Li XQ
Hematol Oncol 2020 Dec;38(5):665-672. Epub 2020 Sep 10 doi: 10.1002/hon.2778. PMID: 32627854
Mintz MA, Cyster JG
Immunol Rev 2020 Jul;296(1):48-61. Epub 2020 May 15 doi: 10.1111/imr.12860. PMID: 32412663Free PMC Article
Purdue MP, Lan Q, Langseth H, Grimsrud TK, Hildesheim A, Rothman N
Int J Cancer 2020 Jun 15;146(12):3312-3319. Epub 2019 Oct 11 doi: 10.1002/ijc.32684. PMID: 31523805Free PMC Article
Lin HY, Shi H, Li CY, Chen QC, Huang TB, Liu PC, Lou LM
J BUON 2015 Jan-Feb;20(1):261-8. PMID: 25778326

Therapy

Baecklund F, Foo JN, Askling J, Eloranta S, Glimelius I, Liu J, Hjalgrim H, Rosenquist R, Padyukov L, Smedby KE
Am J Epidemiol 2017 Apr 15;185(8):681-687. doi: 10.1093/aje/kww118. PMID: 28369180
Miao Y, Hu S, Lu X, Li S, Wang W, Medeiros LJ, Lin P
Hum Pathol 2016 Dec;58:72-77. Epub 2016 Aug 18 doi: 10.1016/j.humpath.2016.07.025. PMID: 27544800
Lin HY, Shi H, Li CY, Chen QC, Huang TB, Liu PC, Lou LM
J BUON 2015 Jan-Feb;20(1):261-8. PMID: 25778326
Heredia-Galvez B, Ruiz-Cosano J, Torres-Moreno D, Español I, Morales-Lara MJ, Pérez-Ceballos E, González-Conejero R, Gutiérrez-Cívicos R, Vicente V, Pérez-Guillermo M, Conesa-Zamora P
Ann Hematol 2014 Feb;93(2):243-7. doi: 10.1007/s00277-013-1864-4. PMID: 23959437
Hess G, Smith SM, Berkenblit A, Coiffier B
Semin Oncol 2009 Dec;36 Suppl 3:S37-45. doi: 10.1053/j.seminoncol.2009.10.012. PMID: 19963099

Prognosis

Bhavsar S, Liu YC, Gibson SE, Moore EM, Swerdlow SH
Am J Surg Pathol 2022 Jan 1;46(1):71-82. doi: 10.1097/PAS.0000000000001750. PMID: 34392269
Nozaki Y, Yamamoto H, Iwasaki T, Sato M, Jiromaru R, Hongo T, Yasumatsu R, Oda Y
Hum Pathol 2020 Dec;106:82-92. Epub 2020 Sep 25 doi: 10.1016/j.humpath.2020.09.004. PMID: 32980422
Xue T, Yu BH, Yan WH, Jiang XN, Tian T, Zhou XY, Li XQ
Hematol Oncol 2020 Dec;38(5):665-672. Epub 2020 Sep 10 doi: 10.1002/hon.2778. PMID: 32627854
Kleinstern G, Camp NJ, Berndt SI, Birmann BM, Nieters A, Bracci PM, McKay JD, Ghesquières H, Lan Q, Hjalgrim H, Benavente Y, Monnereau A, Wang SS, Zhang Y, Purdue MP, Zeleniuch-Jacquotte A, Giles GG, Vermeulen R, Cocco P, Albanes D, Teras LR, Brooks-Wilson AR, Vajdic CM, Kane E, Caporaso NE, Smedby KE, Salles G, Vijai J, Chanock SJ, Skibola CF, Rothman N, Slager SL, Cerhan JR
Cancer Epidemiol Biomarkers Prev 2020 May;29(5):1074-1078. Epub 2020 Feb 27 doi: 10.1158/1055-9965.EPI-19-0803. PMID: 32108027Free PMC Article
Miao Y, Hu S, Lu X, Li S, Wang W, Medeiros LJ, Lin P
Hum Pathol 2016 Dec;58:72-77. Epub 2016 Aug 18 doi: 10.1016/j.humpath.2016.07.025. PMID: 27544800

Clinical prediction guides

Özkaya E, Tosun İ, Tüfekçİ EF, Buruk CK, Kaklıkkaya N, Aydın F
Acta Microbiol Immunol Hung 2020 Nov 30;67(4):252-257. doi: 10.1556/030.2020.01301. PMID: 33258797
Xue T, Yu BH, Yan WH, Jiang XN, Tian T, Zhou XY, Li XQ
Hematol Oncol 2020 Dec;38(5):665-672. Epub 2020 Sep 10 doi: 10.1002/hon.2778. PMID: 32627854
Din L, Sheikh M, Kosaraju N, Smedby KE, Bernatsky S, Berndt SI, Skibola CF, Nieters A, Wang S, McKay JD, Cocco P, Maynadié M, Foretová L, Staines A, Mack TM, de Sanjosé S, Vyse TJ, Padyukov L, Monnereau A, Arslan AA, Moore A, Brooks-Wilson AR, Novak AJ, Glimelius B, Birmann BM, Link BK, Stewart C, Vajdic CM, Haioun C, Magnani C, Conti DV, Cox DG, Casabonne D, Albanes D, Kane E, Roman E, Muzi G, Salles G, Giles GG, Adami HO, Ghesquières H, De Vivo I, Clavel J, Cerhan JR, Spinelli JJ, Hofmann J, Vijai J, Curtin K, Costenbader KH, Onel K, Offit K, Teras LR, Morton L, Conde L, Miligi L, Melbye M, Ennas MG, Liebow M, Purdue MP, Glenn M, Southey MC, Din M, Rothman N, Camp NJ, Wong Doo N, Becker N, Pradhan N, Bracci PM, Boffetta P, Vineis P, Brennan P, Kraft P, Lan Q, Severson RK, Vermeulen RCH, Milne RL, Kaaks R, Travis RC, Weinstein SJ, Chanock SJ, Ansell SM, Slager SL, Zheng T, Zhang Y, Benavente Y, Taub Z, Madireddy L, Gourraud PA, Oksenberg JR, Cozen W, Hjalgrim H, Khankhanian P
Genet Epidemiol 2019 Oct;43(7):844-863. Epub 2019 Aug 13 doi: 10.1002/gepi.22242. PMID: 31407831Free PMC Article
Miao Y, Hu S, Lu X, Li S, Wang W, Medeiros LJ, Lin P
Hum Pathol 2016 Dec;58:72-77. Epub 2016 Aug 18 doi: 10.1016/j.humpath.2016.07.025. PMID: 27544800
Lin HY, Shi H, Li CY, Chen QC, Huang TB, Liu PC, Lou LM
J BUON 2015 Jan-Feb;20(1):261-8. PMID: 25778326

Recent systematic reviews

Lin HY, Shi H, Li CY, Chen QC, Huang TB, Liu PC, Lou LM
J BUON 2015 Jan-Feb;20(1):261-8. PMID: 25778326

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...