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Loss of Chromosome 13q

MedGen UID:
443930
•Concept ID:
C2930913
•
Cell or Molecular Dysfunction
Synonyms: Chromosome 13q deletion; Chromosome 13q monosomy; Deletion 13q; Monosomy 13q

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 13 (13q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 13q
Follow this link to review classifications for Loss of Chromosome 13q in Orphanet.

Professional guidelines

PubMed

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Assessing genome-wide copy number aberrations and copy-neutral loss-of-heterozygosity as best practice: An evidence-based review from the Cancer Genomics Consortium working group for plasma cell disorders.
Pugh TJ, Fink JM, Lu X, Mathew S, Murata-Collins J, Willem P, Fang M; Cancer Genomics Consortium Plasma Cell Disorders Working Group
Cancer Genet 2018 Dec;228-229:184-196. Epub 2018 Oct 5 doi: 10.1016/j.cancergen.2018.07.002. PMID: 30393007
BCL2 and miR-15/16: from gene discovery to treatment.
Pekarsky Y, Balatti V, Croce CM
Cell Death Differ 2018 Jan;25(1):21-26. Epub 2017 Oct 6 doi: 10.1038/cdd.2017.159. PMID: 28984869Free PMC Article

Recent clinical studies

Etiology

Loss of chromosome 13q is a frequently acquired event in genetic progression of soft tissue sarcomas in the abdominal cavity.
Weng WH, Lerner M, Grandér D, Ahlén J, Villablanca A, Pang ST, Wejde J, Lui WO, Larsson C
Int J Oncol 2005 Jan;26(1):5-16. PMID: 15586219
Genetic aberrations in prostate carcinoma detected by comparative genomic hybridization and microsatellite analysis: association with progression and angiogenesis.
Strohmeyer DM, Berger AP, Moore DH 2nd, Bartsch G, Klocker H, Carroll PR, Loening SA, Jensen RH
Prostate 2004 Apr 1;59(1):43-58. doi: 10.1002/pros.20028. PMID: 14991865

Diagnosis

Spindle Cell/Pleomorphic Lipoma With Trichodiscoma-like Epithelial Hyperplasia Mimicking Atypical Fibroxanthoma/Pleomorphic Dermal Sarcoma.
Aghighi M, Andea AA, Patel RM, Fullen DR, Bresler SC
Am J Dermatopathol 2022 Oct 1;44(10):764-767. Epub 2022 Apr 27 doi: 10.1097/DAD.0000000000002206. PMID: 35503875
Genetic aberrations in prostate carcinoma detected by comparative genomic hybridization and microsatellite analysis: association with progression and angiogenesis.
Strohmeyer DM, Berger AP, Moore DH 2nd, Bartsch G, Klocker H, Carroll PR, Loening SA, Jensen RH
Prostate 2004 Apr 1;59(1):43-58. doi: 10.1002/pros.20028. PMID: 14991865

Prognosis

Genetic aberrations in prostate carcinoma detected by comparative genomic hybridization and microsatellite analysis: association with progression and angiogenesis.
Strohmeyer DM, Berger AP, Moore DH 2nd, Bartsch G, Klocker H, Carroll PR, Loening SA, Jensen RH
Prostate 2004 Apr 1;59(1):43-58. doi: 10.1002/pros.20028. PMID: 14991865

Clinical prediction guides

Comprehensive genetic characterization of rosette-forming glioneuronal tumors: independent component analysis by tissue microdissection.
Kitamura Y, Komori T, Shibuya M, Ohara K, Saito Y, Hayashi S, Sasaki A, Nakagawa E, Tomio R, Kakita A, Nakatsukasa M, Yoshida K, Sasaki H
Brain Pathol 2018 Jan;28(1):87-93. Epub 2017 Feb 9 doi: 10.1111/bpa.12468. PMID: 27893178Free PMC Article
Loss of chromosome 13q is a frequently acquired event in genetic progression of soft tissue sarcomas in the abdominal cavity.
Weng WH, Lerner M, Grandér D, Ahlén J, Villablanca A, Pang ST, Wejde J, Lui WO, Larsson C
Int J Oncol 2005 Jan;26(1):5-16. PMID: 15586219

Supplemental Content

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