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Epidural spinal canal neoplasm

MedGen UID:
4504
•Concept ID:
C0014536
•
Neoplastic Process
Synonyms: Epidural Neoplasm; Epidural Neoplasms; Epidural Tumor; Epidural Tumors; Neoplasms, Epidural
SNOMED CT: Extradural neoplasm (1153337000); Neoplasm of extradural space (1153337000); Neoplasm of epidural space (1153337000)
 
Monarch Initiative: MONDO:0002713

Definition

A primary or metastatic neoplasm that involves the space between the vertebral periosteum and dura mater that surrounds the spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpidural spinal canal neoplasm

Professional guidelines

PubMed

Oncologic Emergencies: Recognition and Initial Management.
Higdon ML, Atkinson CJ, Lawrence KV
Am Fam Physician 2018 Jun 1;97(11):741-748. PMID: 30215936
The NOMS framework: approach to the treatment of spinal metastatic tumors.
Laufer I, Rubin DG, Lis E, Cox BW, Stubblefield MD, Yamada Y, Bilsky MH
Oncologist 2013 Jun;18(6):744-51. Epub 2013 May 24 doi: 10.1634/theoncologist.2012-0293. PMID: 23709750Free PMC Article
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Evaluation and Management of Cauda Equina Syndrome.
Kuris EO, McDonald CL, Palumbo MA, Daniels AH
Am J Med 2021 Dec;134(12):1483-1489. Epub 2021 Aug 30 doi: 10.1016/j.amjmed.2021.07.021. PMID: 34473966
Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.
Kurucu N, Akyüz C, Varan A, Akçören Z, Aydin B, Yalçin B, Kutluk T
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e395-e400. doi: 10.1097/MPH.0000000000001858. PMID: 32520843
Microsurgical treatment for spinal epidural angiolipomas.
Yang T, Niu C
Acta Neurol Belg 2021 Apr;121(2):421-427. Epub 2019 Jul 15 doi: 10.1007/s13760-019-01192-6. PMID: 31309454
Stereotactic radiosurgery for metastatic spine tumors.
Chan NK, Abdullah KG, Lubelski D, Steinmetz MP, Benzel EC, Shin JH, Mroz TE
J Neurosurg Sci 2014 Mar;58(1):37-44. PMID: 24614791
Back pain emergencies.
Winters ME, Kluetz P, Zilberstein J
Med Clin North Am 2006 May;90(3):505-23. doi: 10.1016/j.mcna.2005.11.002. PMID: 16473102

Diagnosis

Pure epidural extraosseous cavernous hemangioma with thoracic myelopathy: case report and review of literature.
Guntin J, Ricciardelli A, Flores A, Chen J, Treiber J, Fuentes A
Spinal Cord Ser Cases 2024 Jul 15;10(1):48. doi: 10.1038/s41394-024-00655-0. PMID: 39009566Free PMC Article
Microsurgical treatment for spinal epidural angiolipomas.
Yang T, Niu C
Acta Neurol Belg 2021 Apr;121(2):421-427. Epub 2019 Jul 15 doi: 10.1007/s13760-019-01192-6. PMID: 31309454
Acute Spinal Cord Compression.
Ropper AE, Ropper AH
N Engl J Med 2017 Apr 6;376(14):1358-1369. doi: 10.1056/NEJMra1516539. PMID: 28379788
Diagnosis and treatment of epidural metastases.
Yáñez ML, Miller JJ, Batchelor TT
Cancer 2017 Apr 1;123(7):1106-1114. Epub 2016 Dec 27 doi: 10.1002/cncr.30521. PMID: 28026861
Epidural lipomatosis.
Quint DJ, Boulos RS, Sanders WP, Mehta BA, Patel SC, Tiel RL
Radiology 1988 Nov;169(2):485-90. doi: 10.1148/radiology.169.2.3174998. PMID: 3174998

Therapy

Efficacy and Safety of Ketamine to Treat Cancer Pain in Adult Patients: A Systematic Review.
Jiao J, Fan J, Zhang Y, Chen L
J Pain Symptom Manage 2024 Mar;67(3):e185-e210. Epub 2023 Nov 14 doi: 10.1016/j.jpainsymman.2023.11.004. PMID: 37972720
Comparation Among Opioid-Based, Low Opioid and Opioid Free Anesthesia in Colorectal Oncologic Surgery.
Toleska M, Dimitrovski A, Dimitrovska NT
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Mar 1;44(1):117-126. Epub 2023 Mar 29 doi: 10.2478/prilozi-2023-0013. PMID: 36987755
Pain control in thoracic oncology.
Peeters-Asdourian C, Massard G, Rana PH, Van Houtte P, White AP, Grigoriu B, Lossignol D, Almalki M, Alexiou J, Engelholm JL, Sculier JP
Eur Respir J 2017 Sep;50(3) Epub 2017 Sep 10 doi: 10.1183/13993003.00611-2017. PMID: 28890435
Diagnostic and Therapeutic Strategies for Patients with Malignant Epidural Spinal Cord Compression.
Patel DA, Campian JL
Curr Treat Options Oncol 2017 Aug 10;18(9):53. doi: 10.1007/s11864-017-0497-6. PMID: 28795286
Myelopathies in patients with cancer.
Graber JJ, Nolan CP
Arch Neurol 2010 Mar;67(3):298-304. doi: 10.1001/archneurol.2010.20. PMID: 20212227

Prognosis

Neoplastic Myelopathies.
Pruitt AA
Continuum (Minneap Minn) 2021 Feb 1;27(1):121-142. doi: 10.1212/CON.0000000000000964. PMID: 33522739
Microsurgical treatment for spinal epidural angiolipomas.
Yang T, Niu C
Acta Neurol Belg 2021 Apr;121(2):421-427. Epub 2019 Jul 15 doi: 10.1007/s13760-019-01192-6. PMID: 31309454
Diagnosis and treatment of epidural metastases.
Yáñez ML, Miller JJ, Batchelor TT
Cancer 2017 Apr 1;123(7):1106-1114. Epub 2016 Dec 27 doi: 10.1002/cncr.30521. PMID: 28026861
Paragangliomas of the Spine.
Lv G, Lu L, Dai Z
Turk Neurosurg 2017;27(3):401-407. doi: 10.5137/1019-5149.JTN.16276-15.1. PMID: 27593782
Myelomatous meningitis.
Chamberlain MC, Glantz M
Cancer 2008 Apr 1;112(7):1562-7. doi: 10.1002/cncr.23330. PMID: 18260094

Clinical prediction guides

Efficacy and Safety of Ketamine to Treat Cancer Pain in Adult Patients: A Systematic Review.
Jiao J, Fan J, Zhang Y, Chen L
J Pain Symptom Manage 2024 Mar;67(3):e185-e210. Epub 2023 Nov 14 doi: 10.1016/j.jpainsymman.2023.11.004. PMID: 37972720
Comparation Among Opioid-Based, Low Opioid and Opioid Free Anesthesia in Colorectal Oncologic Surgery.
Toleska M, Dimitrovski A, Dimitrovska NT
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Mar 1;44(1):117-126. Epub 2023 Mar 29 doi: 10.2478/prilozi-2023-0013. PMID: 36987755
Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.
Kurucu N, Akyüz C, Varan A, Akçören Z, Aydin B, Yalçin B, Kutluk T
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e395-e400. doi: 10.1097/MPH.0000000000001858. PMID: 32520843
Spine Oncology: Imaging and Intervention.
Gibbs WN, Nael K, Doshi AH, Tanenbaum LN
Radiol Clin North Am 2019 Mar;57(2):377-395. Epub 2018 Dec 10 doi: 10.1016/j.rcl.2018.10.002. PMID: 30709476
Management - spinal metastases.
Nater A, Sahgal A, Fehlings M
Handb Clin Neurol 2018;149:239-255. doi: 10.1016/B978-0-12-811161-1.00016-5. PMID: 29307356

Recent systematic reviews

Efficacy and Safety of Ketamine to Treat Cancer Pain in Adult Patients: A Systematic Review.
Jiao J, Fan J, Zhang Y, Chen L
J Pain Symptom Manage 2024 Mar;67(3):e185-e210. Epub 2023 Nov 14 doi: 10.1016/j.jpainsymman.2023.11.004. PMID: 37972720
Intraoperative Neurophysiological Monitoring During Spinal Cord Stimulation Surgery: A Systematic Review.
Schlaeppi JA, Schreen R, Seidel K, Pollo C
Neuromodulation 2023 Oct;26(7):1319-1327. doi: 10.1016/j.neurom.2023.06.010. PMID: 37802585
Awake Breast Surgery: A Systematic Review.
Vanni G, Costanzo G, Pellicciaro M, Materazzo M, Buonomo C, Federico T, Giacobbi E, Servadei F, Anemona L, Noce A, Dauri M, Buonomo OC
In Vivo 2023 Jul-Aug;37(4):1412-1422. doi: 10.21873/invivo.13225. PMID: 37369489Free PMC Article
Low Back Pain in the Emergency Department: Prevalence of Serious Spinal Pathologies and Diagnostic Accuracy of Red Flags.
Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933
Systematic Review and Meta-Analysis of Epidural Analgesia Versus Different Analgesic Regimes Following Oesophagogastric Resection.
Hughes M, Yim I, Deans DAC, Couper GW, Lamb PJ, Skipworth RJE
World J Surg 2018 Jan;42(1):204-210. doi: 10.1007/s00268-017-4141-1. PMID: 28741191

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