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Epidural spinal canal neoplasm

MedGen UID:
4504
•Concept ID:
C0014536
•
Neoplastic Process
Synonyms: Epidural Neoplasm; Epidural Neoplasms; Epidural Tumor; Epidural Tumors; Neoplasms, Epidural
SNOMED CT: Extradural neoplasm (1153337000); Neoplasm of extradural space (1153337000); Neoplasm of epidural space (1153337000)
 
Monarch Initiative: MONDO:0002713

Definition

A primary or metastatic neoplasm that involves the space between the vertebral periosteum and dura mater that surrounds the spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpidural spinal canal neoplasm

Professional guidelines

PubMed

Oncologic Emergencies: Recognition and Initial Management.
Higdon ML, Atkinson CJ, Lawrence KV
Am Fam Physician 2018 Jun 1;97(11):741-748. PMID: 30215936
The NOMS framework: approach to the treatment of spinal metastatic tumors.
Laufer I, Rubin DG, Lis E, Cox BW, Stubblefield MD, Yamada Y, Bilsky MH
Oncologist 2013 Jun;18(6):744-51. Epub 2013 May 24 doi: 10.1634/theoncologist.2012-0293. PMID: 23709750Free PMC Article
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Evaluation and Management of Cauda Equina Syndrome.
Kuris EO, McDonald CL, Palumbo MA, Daniels AH
Am J Med 2021 Dec;134(12):1483-1489. Epub 2021 Aug 30 doi: 10.1016/j.amjmed.2021.07.021. PMID: 34473966
Epidural Steroid Injections for the Management of Spinal Malignancy-Related Pain: A Pragmatic Review and Retrospective Study.
Oh DC, Rispoli L, Ghosh P, Gulati A
Pain Pract 2021 Mar;21(3):285-298. Epub 2020 Nov 1 doi: 10.1111/papr.12957. PMID: 33025670
Low Back Pain in the Emergency Department: Prevalence of Serious Spinal Pathologies and Diagnostic Accuracy of Red Flags.
Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933
Stereotactic Body Radiotherapy for Spinal Metastases: What are the Risks and How Do We Minimize Them?
Chang JH, Shin JH, Yamada YJ, Mesfin A, Fehlings MG, Rhines LD, Sahgal A
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S238-S245. doi: 10.1097/BRS.0000000000001823. PMID: 27488294Free PMC Article
Back pain emergencies.
Winters ME, Kluetz P, Zilberstein J
Med Clin North Am 2006 May;90(3):505-23. doi: 10.1016/j.mcna.2005.11.002. PMID: 16473102

Diagnosis

Microsurgical treatment for spinal epidural angiolipomas.
Yang T, Niu C
Acta Neurol Belg 2021 Apr;121(2):421-427. Epub 2019 Jul 15 doi: 10.1007/s13760-019-01192-6. PMID: 31309454
Acute Spinal Cord Compression.
Ropper AE, Ropper AH
N Engl J Med 2017 Apr 6;376(14):1358-1369. doi: 10.1056/NEJMra1516539. PMID: 28379788
Diagnosis and treatment of epidural metastases.
Yáñez ML, Miller JJ, Batchelor TT
Cancer 2017 Apr 1;123(7):1106-1114. Epub 2016 Dec 27 doi: 10.1002/cncr.30521. PMID: 28026861
Pediatric spinal neoplasms.
Blaser S, Harwood-Nash D
Top Magn Reson Imaging 1993 Summer;5(3):190-202. PMID: 8347341
Epidural lipomatosis.
Quint DJ, Boulos RS, Sanders WP, Mehta BA, Patel SC, Tiel RL
Radiology 1988 Nov;169(2):485-90. doi: 10.1148/radiology.169.2.3174998. PMID: 3174998

Therapy

Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.
Kurucu N, Akyüz C, Varan A, Akçören Z, Aydin B, Yalçin B, Kutluk T
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e395-e400. doi: 10.1097/MPH.0000000000001858. PMID: 32520843
Pain control in thoracic oncology.
Peeters-Asdourian C, Massard G, Rana PH, Van Houtte P, White AP, Grigoriu B, Lossignol D, Almalki M, Alexiou J, Engelholm JL, Sculier JP
Eur Respir J 2017 Sep;50(3) Epub 2017 Sep 10 doi: 10.1183/13993003.00611-2017. PMID: 28890435
Diagnostic and Therapeutic Strategies for Patients with Malignant Epidural Spinal Cord Compression.
Patel DA, Campian JL
Curr Treat Options Oncol 2017 Aug 10;18(9):53. doi: 10.1007/s11864-017-0497-6. PMID: 28795286
Myelopathies in patients with cancer.
Graber JJ, Nolan CP
Arch Neurol 2010 Mar;67(3):298-304. doi: 10.1001/archneurol.2010.20. PMID: 20212227
Epidural spinal cord compression.
Spinazzé S, Caraceni A, Schrijvers D
Crit Rev Oncol Hematol 2005 Dec;56(3):397-406. doi: 10.1016/j.critrevonc.2005.04.005. PMID: 16310372

Prognosis

Neoplastic Myelopathies.
Pruitt AA
Continuum (Minneap Minn) 2021 Feb 1;27(1):121-142. doi: 10.1212/CON.0000000000000964. PMID: 33522739
Surgical management of spinal metastases.
Galgano M, Fridley J, Oyelese A, Telfian A, Kosztowski T, Choi D, Gokaslan ZL
Expert Rev Anticancer Ther 2018 May;18(5):463-472. Epub 2018 Apr 2 doi: 10.1080/14737140.2018.1453359. PMID: 29560739
Diagnosis and treatment of epidural metastases.
Yáñez ML, Miller JJ, Batchelor TT
Cancer 2017 Apr 1;123(7):1106-1114. Epub 2016 Dec 27 doi: 10.1002/cncr.30521. PMID: 28026861
Paragangliomas of the Spine.
Lv G, Lu L, Dai Z
Turk Neurosurg 2017;27(3):401-407. doi: 10.5137/1019-5149.JTN.16276-15.1. PMID: 27593782
Myelomatous meningitis.
Chamberlain MC, Glantz M
Cancer 2008 Apr 1;112(7):1562-7. doi: 10.1002/cncr.23330. PMID: 18260094

Clinical prediction guides

Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.
Kurucu N, Akyüz C, Varan A, Akçören Z, Aydin B, Yalçin B, Kutluk T
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e395-e400. doi: 10.1097/MPH.0000000000001858. PMID: 32520843
Conventional Radiotherapy and Stereotactic Radiosurgery in the Management of Metastatic Spine Disease.
Zhang HR, Li JK, Yang XG, Qiao RQ, Hu YC
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820945798. doi: 10.1177/1533033820945798. PMID: 32757820Free PMC Article
Neurologic, Oncologic, Mechanical, and Systemic and Other Decision Frameworks for Spinal Disease.
Newman WC, Laufer I, Bilsky MH
Neurosurg Clin N Am 2020 Apr;31(2):151-166. Epub 2020 Feb 6 doi: 10.1016/j.nec.2019.11.005. PMID: 32147008
Spine Oncology: Imaging and Intervention.
Gibbs WN, Nael K, Doshi AH, Tanenbaum LN
Radiol Clin North Am 2019 Mar;57(2):377-395. Epub 2018 Dec 10 doi: 10.1016/j.rcl.2018.10.002. PMID: 30709476
Management - spinal metastases.
Nater A, Sahgal A, Fehlings M
Handb Clin Neurol 2018;149:239-255. doi: 10.1016/B978-0-12-811161-1.00016-5. PMID: 29307356

Recent systematic reviews

Radiofrequency ablation for spinal osteoid osteoma: A systematic review of safety and treatment outcomes.
Sagoo NS, Haider AS, Chen AL, Vannabouathong C, Larsen K, Sharma R, Palmisciano P, Alamer OB, Igbinigie M, Wells DB, Aoun SG, Passias PG, Vira S
Surg Oncol 2022 May;41:101747. Epub 2022 Mar 25 doi: 10.1016/j.suronc.2022.101747. PMID: 35358911
Low Back Pain in the Emergency Department: Prevalence of Serious Spinal Pathologies and Diagnostic Accuracy of Red Flags.
Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933
Systematic Review and Meta-Analysis of Epidural Analgesia Versus Different Analgesic Regimes Following Oesophagogastric Resection.
Hughes M, Yim I, Deans DAC, Couper GW, Lamb PJ, Skipworth RJE
World J Surg 2018 Jan;42(1):204-210. doi: 10.1007/s00268-017-4141-1. PMID: 28741191
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
Stereotactic Body Radiotherapy for Spinal Metastases: What are the Risks and How Do We Minimize Them?
Chang JH, Shin JH, Yamada YJ, Mesfin A, Fehlings MG, Rhines LD, Sahgal A
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S238-S245. doi: 10.1097/BRS.0000000000001823. PMID: 27488294Free PMC Article

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