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Fluoxetine response

MedGen UID:
450456
Concept ID:
CN077984
Sign or Symptom
Synonym: Prozac response
Drug:
Fluoxetine
MedGen UID:
42053
Concept ID:
C0016365
Pharmacologic Substance
A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Muratore AF, Attia E
Curr Psychiatry Rep 2022 Jul;24(7):345-351. Epub 2022 May 16 doi: 10.1007/s11920-022-01340-5. PMID: 35576089Free PMC Article
Nuñez NA, Joseph B, Pahwa M, Kumar R, Resendez MG, Prokop LJ, Veldic M, Seshadri A, Biernacka JM, Frye MA, Wang Z, Singh B
J Affect Disord 2022 Apr 1;302:385-400. Epub 2022 Jan 2 doi: 10.1016/j.jad.2021.12.134. PMID: 34986373Free PMC Article
Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors
Ann Rheum Dis 2017 Aug;76(8):1327-1339. Epub 2016 Nov 9 doi: 10.1136/annrheumdis-2016-209909. PMID: 27941129

Curated

DailyMed Drug Label, FLUOXETINE capsule HUMAN PRESCRIPTION DRUG LABEL, 2019

DailyMed Drug Label, fluoxetine, 2018

Recent clinical studies

Etiology

Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449
DeLong GR, Ritch CR, Burch S
Dev Med Child Neurol 2002 Oct;44(10):652-9. doi: 10.1017/s0012162201002717. PMID: 12418789
Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, Jerabek PA
Am J Psychiatry 2002 May;159(5):728-37. doi: 10.1176/appi.ajp.159.5.728. PMID: 11986125
Schneider LS, Small GW, Hamilton SH, Bystritsky A, Nemeroff CB, Meyers BS
Am J Geriatr Psychiatry 1997 Spring;5(2):97-106. PMID: 9106373
Dalack GW, Glassman AH, Rivelli S, Covey L, Stetner F
Am J Psychiatry 1995 Mar;152(3):398-403. doi: 10.1176/ajp.152.3.398. PMID: 7864266

Diagnosis

Lin CH, Lane HY, Chen CC, Juo SH, Yen CF
J Clin Psychopharmacol 2011 Apr;31(2):187-93. doi: 10.1097/JCP.0b013e318210856f. PMID: 21346612
Gudayol-Ferré E, Herrera-Guzmán I, Camarena B, Cortés-Penagos C, Herrera-Abarca JE, Martínez-Medina P, Cruz D, Hernández S, Genis A, Carrillo-Guerrero MY, Avilés Reyes R, Guàrdia-Olmos J
J Affect Disord 2010 Dec;127(1-3):343-51. Epub 2010 Jul 2 doi: 10.1016/j.jad.2010.06.002. PMID: 20584552
DeLong GR, Ritch CR, Burch S
Dev Med Child Neurol 2002 Oct;44(10):652-9. doi: 10.1017/s0012162201002717. PMID: 12418789
Ackerman DL, Greenland S, Bystritsky A
J Clin Psychopharmacol 1999 Oct;19(5):459-65. doi: 10.1097/00004714-199910000-00010. PMID: 10505588
Dalack GW, Glassman AH, Rivelli S, Covey L, Stetner F
Am J Psychiatry 1995 Mar;152(3):398-403. doi: 10.1176/ajp.152.3.398. PMID: 7864266

Therapy

Camarena B, Álvarez-Icaza D, Hernández S, Aguilar A, Münch L, Martínez C, Becerra-Palars C
Clin Neuropharmacol 2019 Jan/Feb;42(1):9-13. doi: 10.1097/WNF.0000000000000315. PMID: 30520759
Manoharan A, Rajkumar RP, Shewade DG, Sundaram R, Muthuramalingam A, Paul A
Hum Psychopharmacol 2016 May;31(3):178-84. Epub 2016 Mar 27 doi: 10.1002/hup.2525. PMID: 27018372
Blazquez A, Mas S, Plana MT, Lafuente A, Lázaro L
Eur Child Adolesc Psychiatry 2012 Nov;21(11):599-610. Epub 2012 Jul 12 doi: 10.1007/s00787-012-0305-6. PMID: 22791347
Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449
Schneider LS, Small GW, Hamilton SH, Bystritsky A, Nemeroff CB, Meyers BS
Am J Geriatr Psychiatry 1997 Spring;5(2):97-106. PMID: 9106373

Prognosis

Manoharan A, Rajkumar RP, Shewade DG, Sundaram R, Muthuramalingam A, Paul A
Hum Psychopharmacol 2016 May;31(3):178-84. Epub 2016 Mar 27 doi: 10.1002/hup.2525. PMID: 27018372
Lin CH, Lane HY, Chen CC, Juo SH, Yen CF
J Clin Psychopharmacol 2011 Apr;31(2):187-93. doi: 10.1097/JCP.0b013e318210856f. PMID: 21346612
Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449
DeLong GR, Ritch CR, Burch S
Dev Med Child Neurol 2002 Oct;44(10):652-9. doi: 10.1017/s0012162201002717. PMID: 12418789
Ackerman DL, Greenland S, Bystritsky A, Small GW
J Clin Psychopharmacol 2000 Dec;20(6):658-65. doi: 10.1097/00004714-200012000-00012. PMID: 11106138

Clinical prediction guides

Camarena B, Álvarez-Icaza D, Hernández S, Aguilar A, Münch L, Martínez C, Becerra-Palars C
Clin Neuropharmacol 2019 Jan/Feb;42(1):9-13. doi: 10.1097/WNF.0000000000000315. PMID: 30520759
Manoharan A, Rajkumar RP, Shewade DG, Sundaram R, Muthuramalingam A, Paul A
Hum Psychopharmacol 2016 May;31(3):178-84. Epub 2016 Mar 27 doi: 10.1002/hup.2525. PMID: 27018372
Blázquez A, Mas S, Plana MT, Gassó P, Méndez I, Torra M, Arnaiz JA, Lafuente A, Lázaro L
J Clin Psychopharmacol 2014 Jun;34(3):318-26. doi: 10.1097/JCP.0000000000000121. PMID: 24743718
Lin CH, Lane HY, Chen CC, Juo SH, Yen CF
J Clin Psychopharmacol 2011 Apr;31(2):187-93. doi: 10.1097/JCP.0b013e318210856f. PMID: 21346612
Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449

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