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Citalopram response

MedGen UID:
808076
Concept ID:
CN221263
Sign or Symptom
Synonym: Celexa response
Drug:
Citalopram
MedGen UID:
979
Concept ID:
C0008845
Pharmacologic Substance
A bicyclic phthalene derivative and selective serotonin reuptake inhibitor (SSRI), with antidepressant and anxiolytic activities. Citalopram selectively inhibits the neuronal reuptake of the neurotransmitter serotonin (5-HT) in presynaptic cells in the central nervous system, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on its receptors. Increased serotonergic neurotransmission results in antidepressive and anxiolytic effects. [from NCI]
 
Gene (location): CYP2C19 (10q23.33)

Definition

Serotonin reuptake inhibitor antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and serotonin modulators with SSRI-like properties are pharmacotherapy options for major depressive and anxiety disorders. Inadequate response and treatment-related adverse events are known challenges in antidepressant therapy. Genetic variations in genes encoding the drug metabolizing enzymes, CYP2D6, CYP2C19 and CYP2B6, have been shown to alter antidepressant biotransformation, which may potentially affect dosing, efficacy, and tolerability. [from PharmGKB]

Term Hierarchy

Professional guidelines

PubMed

Crandall CJ, Mehta JM, Manson JE
JAMA 2023 Feb 7;329(5):405-420. doi: 10.1001/jama.2022.24140. PMID: 36749328
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR
Lancet 2018 Apr 7;391(10128):1357-1366. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(17)32802-7. PMID: 29477251Free PMC Article
Davies SJ, Burhan AM, Kim D, Gerretsen P, Graff-Guerrero A, Woo VL, Kumar S, Colman S, Pollock BG, Mulsant BH, Rajji TK
J Psychopharmacol 2018 May;32(5):509-523. Epub 2018 Jan 17 doi: 10.1177/0269881117744996. PMID: 29338602Free PMC Article

Curated

CPIC® Guideline for Serotonin Reuptake Inhibitor Antidepressants and CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A, 2023

Recent clinical studies

Etiology

Shinozaki G, Romanowicz M, Mrazek DA, Kung S
J Affect Disord 2013 Sep 25;150(3):1200-3. Epub 2013 Jun 4 doi: 10.1016/j.jad.2013.05.028. PMID: 23759279
Lee SH, Lee MS, Lee JH, Kim SW, Kang RH, Choi MJ, Park SJ, Kim SJ, Lee JM, Cole SP, Lee MG
J Clin Psychopharmacol 2010 Apr;30(2):116-25. doi: 10.1097/JCP.0b013e3181d2ef42. PMID: 20520284
Garriock HA, Kraft JB, Shyn SI, Peters EJ, Yokoyama JS, Jenkins GD, Reinalda MS, Slager SL, McGrath PJ, Hamilton SP
Biol Psychiatry 2010 Jan 15;67(2):133-8. doi: 10.1016/j.biopsych.2009.08.029. PMID: 19846067Free PMC Article

Diagnosis

Jakubovski E, Bloch MH
J Clin Psychiatry 2014 Jul;75(7):738-47. doi: 10.4088/JCP.13m08727. PMID: 24912106Free PMC Article
Arias B, Fabbri C, Gressier F, Serretti A, Mitjans M, Gastó C, Catalán R, De Ronchi D, Fañanás L
Neuropsychobiology 2013;67(1):41-7. Epub 2012 Dec 4 doi: 10.1159/000343388. PMID: 23221997
Mrazek DA, Biernacka JM, O'Kane DJ, Black JL, Cunningham JM, Drews MS, Snyder KA, Stevens SR, Rush AJ, Weinshilboum RM
Pharmacogenet Genomics 2011 Jan;21(1):1-9. doi: 10.1097/fpc.0b013e328340bc5a. PMID: 21192344Free PMC Article

Therapy

Shumake J, Mallard TT, McGeary JE, Beevers CG
Sci Rep 2021 Feb 12;11(1):3780. doi: 10.1038/s41598-021-83338-2. PMID: 33580158Free PMC Article
Arias B, Fabbri C, Serretti A, Drago A, Mitjans M, Gastó C, Catalán R, Fañanás L
J Affect Disord 2014 Oct;168:91-7. Epub 2014 Jul 5 doi: 10.1016/j.jad.2014.06.048. PMID: 25043320
Jakubovski E, Bloch MH
J Clin Psychiatry 2014 Jul;75(7):738-47. doi: 10.4088/JCP.13m08727. PMID: 24912106Free PMC Article
Mrazek DA, Biernacka JM, O'Kane DJ, Black JL, Cunningham JM, Drews MS, Snyder KA, Stevens SR, Rush AJ, Weinshilboum RM
Pharmacogenet Genomics 2011 Jan;21(1):1-9. doi: 10.1097/fpc.0b013e328340bc5a. PMID: 21192344Free PMC Article
Mrazek DA, Rush AJ, Biernacka JM, O'Kane DJ, Cunningham JM, Wieben ED, Schaid DJ, Drews MS, Courson VL, Snyder KA, Black JL 3rd, Weinshilboum RM
Am J Med Genet B Neuropsychiatr Genet 2009 Apr 5;150B(3):341-51. doi: 10.1002/ajmg.b.30816. PMID: 18618621Free PMC Article

Prognosis

Shumake J, Mallard TT, McGeary JE, Beevers CG
Sci Rep 2021 Feb 12;11(1):3780. doi: 10.1038/s41598-021-83338-2. PMID: 33580158Free PMC Article
Jakubovski E, Bloch MH
J Clin Psychiatry 2014 Jul;75(7):738-47. doi: 10.4088/JCP.13m08727. PMID: 24912106Free PMC Article
Murphy E, Hou L, Maher BS, Woldehawariat G, Kassem L, Akula N, Laje G, McMahon FJ
Neuropsychopharmacology 2013 Dec;38(13):2598-606. Epub 2013 Jul 5 doi: 10.1038/npp.2013.166. PMID: 23827886Free PMC Article
Arias B, Fabbri C, Gressier F, Serretti A, Mitjans M, Gastó C, Catalán R, De Ronchi D, Fañanás L
Neuropsychobiology 2013;67(1):41-7. Epub 2012 Dec 4 doi: 10.1159/000343388. PMID: 23221997
Lee SH, Lee MS, Lee JH, Kim SW, Kang RH, Choi MJ, Park SJ, Kim SJ, Lee JM, Cole SP, Lee MG
J Clin Psychopharmacol 2010 Apr;30(2):116-25. doi: 10.1097/JCP.0b013e3181d2ef42. PMID: 20520284

Clinical prediction guides

Shumake J, Mallard TT, McGeary JE, Beevers CG
Sci Rep 2021 Feb 12;11(1):3780. doi: 10.1038/s41598-021-83338-2. PMID: 33580158Free PMC Article
Jakubovski E, Bloch MH
J Clin Psychiatry 2014 Jul;75(7):738-47. doi: 10.4088/JCP.13m08727. PMID: 24912106Free PMC Article
Murphy E, Hou L, Maher BS, Woldehawariat G, Kassem L, Akula N, Laje G, McMahon FJ
Neuropsychopharmacology 2013 Dec;38(13):2598-606. Epub 2013 Jul 5 doi: 10.1038/npp.2013.166. PMID: 23827886Free PMC Article
Garriock HA, Tanowitz M, Kraft JB, Dang VC, Peters EJ, Jenkins GD, Reinalda MS, McGrath PJ, von Zastrow M, Slager SL, Hamilton SP
Am J Psychiatry 2010 May;167(5):565-73. Epub 2010 Mar 1 doi: 10.1176/appi.ajp.2009.08081167. PMID: 20194481Free PMC Article
Peters EJ, Slager SL, Jenkins GD, Reinalda MS, Garriock HA, Shyn SI, Kraft JB, McGrath PJ, Hamilton SP
Pharmacogenet Genomics 2009 Jan;19(1):1-10. doi: 10.1097/FPC.0b013e3283163ecd. PMID: 19077664Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • CPIC, 2023
      CPIC® Guideline for Serotonin Reuptake Inhibitor Antidepressants and CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A, 2023

    Consumer resources

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