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Thalassemia minor

MedGen UID:
450549
•Concept ID:
C0869532
•
Disease or Syndrome
Synonym: Beta thalassemia minor
 
Monarch Initiative: MONDO:0044210

Definition

The inheritance of only one mutated beta-globin allele (beta+ or beta0). [from MONDO]

Professional guidelines

PubMed

An Expert Overview on Therapies in Non-Transfusion-Dependent Thalassemia: Classical to Cutting Edge in Treatment.
Saeidnia M, Fazeli P, Farzi A, Atefy Nezhad M, Shabani-Borujeni M, Erfani M, Tamaddon G, Karimi M
Hemoglobin 2023 Nov;47(2):56-70. Epub 2023 Jun 16 doi: 10.1080/03630269.2022.2158099. PMID: 37325871
Thalassemia Minor and Major: Current Management.
Choudhry VP
Indian J Pediatr 2017 Aug;84(8):607-611. Epub 2017 Apr 24 doi: 10.1007/s12098-017-2325-1. PMID: 28435994
Guidelines for diagnosis and management of Beta-thalassemia intermedia.
Karimi M, Cohan N, De Sanctis V, Mallat NS, Taher A
Pediatr Hematol Oncol 2014 Oct;31(7):583-96. doi: 10.3109/08880018.2014.937884. PMID: 25247665

Recent clinical studies

Etiology

Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious.
Eren R, Karışmaz A, Aslan C, Doğu MH, Altındal Ş, Yokuş O, Suyanı E
Med Princ Pract 2021;30(1):69-72. Epub 2020 May 27 doi: 10.1159/000508981. PMID: 32460294Free PMC Article
β-Thalassemia heterozygote state detrimentally affects health expectation.
Graffeo L, Vitrano A, Scondotto S, Dardanoni G, Pollina Addario WS, Giambona A, Sacco M, Di Maggio R, Renda D, Taormina F, Triveri A, Attanasio M, Gluud C, Maggio A
Eur J Intern Med 2018 Aug;54:76-80. Epub 2018 Jun 19 doi: 10.1016/j.ejim.2018.06.009. PMID: 29934240
Thalassemia Minor and Major: Current Management.
Choudhry VP
Indian J Pediatr 2017 Aug;84(8):607-611. Epub 2017 Apr 24 doi: 10.1007/s12098-017-2325-1. PMID: 28435994
Raph blood group system.
Hayes M
Immunohematology 2014;30(1):6-10. PMID: 25238243
Beta-thalassemia.
Galanello R, Origa R
Orphanet J Rare Dis 2010 May 21;5:11. doi: 10.1186/1750-1172-5-11. PMID: 20492708Free PMC Article

Diagnosis

A stepwise diagnostic approach for undiagnosed Anemia in children: A model for low-middle income country.
Aly NH, Elalfy MS, Elhabashy SA, Mowafy NM, Russo R, Andolfo I, Iolascon A, Ragab IA
Blood Cells Mol Dis 2023 Nov;103:102779. Epub 2023 Jul 16 doi: 10.1016/j.bcmd.2023.102779. PMID: 37558589
β-Thalassemia intermedia: a comprehensive overview and novel approaches.
Asadov C, Alimirzoeva Z, Mammadova T, Aliyeva G, Gafarova S, Mammadov J
Int J Hematol 2018 Jul;108(1):5-21. Epub 2018 Jan 29 doi: 10.1007/s12185-018-2411-9. PMID: 29380178
Thalassemia Minor and Major: Current Management.
Choudhry VP
Indian J Pediatr 2017 Aug;84(8):607-611. Epub 2017 Apr 24 doi: 10.1007/s12098-017-2325-1. PMID: 28435994
Guidelines for diagnosis and management of Beta-thalassemia intermedia.
Karimi M, Cohan N, De Sanctis V, Mallat NS, Taher A
Pediatr Hematol Oncol 2014 Oct;31(7):583-96. doi: 10.3109/08880018.2014.937884. PMID: 25247665
Beta-thalassemia.
Galanello R, Origa R
Orphanet J Rare Dis 2010 May 21;5:11. doi: 10.1186/1750-1172-5-11. PMID: 20492708Free PMC Article

Therapy

An Expert Overview on Therapies in Non-Transfusion-Dependent Thalassemia: Classical to Cutting Edge in Treatment.
Saeidnia M, Fazeli P, Farzi A, Atefy Nezhad M, Shabani-Borujeni M, Erfani M, Tamaddon G, Karimi M
Hemoglobin 2023 Nov;47(2):56-70. Epub 2023 Jun 16 doi: 10.1080/03630269.2022.2158099. PMID: 37325871
Role of red blood cells "annexin V" and platelets "P-selectin" in patients with thalassemia.
Mahdi ZN, Al-Mudallal SS, Hameed BM
Hematol Oncol Stem Cell Ther 2019 Mar;12(1):15-18. Epub 2018 Jul 17 doi: 10.1016/j.hemonc.2018.07.001. PMID: 30028953
Revisiting beta thalassemia intermedia: past, present, and future prospects.
Ben Salah N, Bou-Fakhredin R, Mellouli F, Taher AT
Hematology 2017 Dec;22(10):607-616. Epub 2017 Jun 7 doi: 10.1080/10245332.2017.1333246. PMID: 28589785
Guidelines for diagnosis and management of Beta-thalassemia intermedia.
Karimi M, Cohan N, De Sanctis V, Mallat NS, Taher A
Pediatr Hematol Oncol 2014 Oct;31(7):583-96. doi: 10.3109/08880018.2014.937884. PMID: 25247665
Prevalence of beta-thalassemia trait and glucose-6-phosphate dehydrogenase deficiency in Iranian Jews.
Karimi M, Yavarian M, Afrasiabi A, Dehbozorgian J, Rachmilewitz E
Arch Med Res 2008 Feb;39(2):212-4. Epub 2007 Oct 31 doi: 10.1016/j.arcmed.2007.09.001. PMID: 18164966

Prognosis

COVID-19 AND CHILDREN: COMPLICATIONS AND LATE OUTCOMES.
Zhvania M, Kvezereli-Kopadze M, Kutubidze T, Kapanadze N, Gordeladze M, Iakobashvili A, Nakhutsrishvili E
Georgian Med News 2021 Apr;(313):124-127. PMID: 34103443
β-Thalassemia heterozygote state detrimentally affects health expectation.
Graffeo L, Vitrano A, Scondotto S, Dardanoni G, Pollina Addario WS, Giambona A, Sacco M, Di Maggio R, Renda D, Taormina F, Triveri A, Attanasio M, Gluud C, Maggio A
Eur J Intern Med 2018 Aug;54:76-80. Epub 2018 Jun 19 doi: 10.1016/j.ejim.2018.06.009. PMID: 29934240
Comparison between β-thalassemia minor and normal individuals using the Wechsler Adult Intelligence Scale.
Zangiabadi N, Yarahmadi F, Darekordi A, Shabani M, Dadgar MM
Hemoglobin 2013;37(5):467-76. Epub 2013 Jun 28 doi: 10.3109/03630269.2013.806330. PMID: 23806085
Beta-thalassemia.
Galanello R, Origa R
Orphanet J Rare Dis 2010 May 21;5:11. doi: 10.1186/1750-1172-5-11. PMID: 20492708Free PMC Article
Beta-thalassemia minor during pregnancy.
Sheiner E, Levy A, Yerushalmi R, Katz M
Obstet Gynecol 2004 Jun;103(6):1273-7. doi: 10.1097/01.AOG.0000126575.34482.fb. PMID: 15172864

Clinical prediction guides

Beta thalassemia minor is a beneficial determinant of red blood cell storage lesion.
Tzounakas VL, Anastasiadi AT, Stefanoni D, Cendali F, Bertolone L, Gamboni F, Dzieciatkowska M, Rousakis P, Vergaki A, Soulakis V, Tsitsilonis OE, Stamoulis K, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH
Haematologica 2022 Jan 1;107(1):112-125. doi: 10.3324/haematol.2020.273946. PMID: 33730845Free PMC Article
COVID-19 AND CHILDREN: COMPLICATIONS AND LATE OUTCOMES.
Zhvania M, Kvezereli-Kopadze M, Kutubidze T, Kapanadze N, Gordeladze M, Iakobashvili A, Nakhutsrishvili E
Georgian Med News 2021 Apr;(313):124-127. PMID: 34103443
Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious.
Eren R, Karışmaz A, Aslan C, Doğu MH, Altındal Ş, Yokuş O, Suyanı E
Med Princ Pract 2021;30(1):69-72. Epub 2020 May 27 doi: 10.1159/000508981. PMID: 32460294Free PMC Article
Comparison between β-thalassemia minor and normal individuals using the Wechsler Adult Intelligence Scale.
Zangiabadi N, Yarahmadi F, Darekordi A, Shabani M, Dadgar MM
Hemoglobin 2013;37(5):467-76. Epub 2013 Jun 28 doi: 10.3109/03630269.2013.806330. PMID: 23806085
Beta-thalassemia minor during pregnancy.
Sheiner E, Levy A, Yerushalmi R, Katz M
Obstet Gynecol 2004 Jun;103(6):1273-7. doi: 10.1097/01.AOG.0000126575.34482.fb. PMID: 15172864

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