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Hypoperistalsis

MedGen UID:
451002
Concept ID:
C0232475
Finding
Synonyms: Decreased peristalsis; Intestinal hypoperistalsis
SNOMED CT: Decreased peristalsis (77853002); Hypoperistalsis (77853002)
 
HPO: HP:0100771

Definition

Reduced or inadequate peristalsis, with resultant slow passage of contents through the digestive tract. [from HPO]

Conditions with this feature

Mungan syndrome
MedGen UID:
369554
Concept ID:
C1969653
Disease or Syndrome
Mungan syndrome (MGS) is characterized by chronic intestinal pseudoobstruction (CIPO), megaduodenum, long-segment Barrett esophagus, and cardiac abnormalities of variable severity (summary by Bonora et al., 2015).
Multisystemic smooth muscle dysfunction syndrome
MedGen UID:
462551
Concept ID:
C3151201
Disease or Syndrome
Smooth muscle dysfunction syndrome (SMDYS) presents with a recognizable pattern of complications, including congenital mydriasis, patent ductus arteriosus (PDA), pulmonary artery hypertension, aortic and other arterial aneurysms, moyamoya-like cerebrovascular disease, intestinal hypoperistalsis and malrotation, and hypotonic bladder. It is caused by heterozygous mutations of the ACTA2 gene altering the arginine-179 codon (summary by Regalado et al., 2018).
Megacystis-microcolon-intestinal hypoperistalsis syndrome 4
MedGen UID:
1783600
Concept ID:
C5543519
Disease or Syndrome
Megacystis-microcolon-intestinal hypoperistalsis syndrome-4 (MMIHS4) is a severe early-onset disorder characterized by impaired smooth muscle contractility in the bladder and intestines (Kandler et al., 2020). For a discussion of genetic heterogeneity of MMIHS, see 249210.

Professional guidelines

PubMed

Kaw A, Kaw K, Hostetler EM, Beleza-Meireles A, Smith-Collins A, Armstrong C, Scurr I, Cotts T, Aatre R, Bamshad MJ, Earl D, Groner A, Agre K, Raveh Y, Kwartler CS, Milewicz DM
Am J Med Genet A 2022 Aug;188(8):2389-2396. Epub 2022 May 14 doi: 10.1002/ajmg.a.62775. PMID: 35567597Free PMC Article
Friedmacher F, Puri P
Pediatr Surg Int 2013 Sep;29(9):855-72. doi: 10.1007/s00383-013-3351-3. PMID: 23943250
Osborne NG, Bonilla-Musoles F, Machado LE, Raga F, Bonilla F Jr, Ruiz F, Pérez Guardia CM, Ahluwalia B
J Ultrasound Med 2011 Jun;30(6):833-41. doi: 10.7863/jum.2011.30.6.833. PMID: 21632999

Recent clinical studies

Etiology

Alcalá-González LG, Accarino A, Martí R, Sánchez-Tejerina D, Llauradó A, Azpiroz F, Malagelada C
Neurogastroenterol Motil 2023 Oct;35(10):e14643. Epub 2023 Jul 13 doi: 10.1111/nmo.14643. PMID: 37448106
Gamboa HE, Sood M
Curr Gastroenterol Rep 2019 Dec 17;21(12):70. doi: 10.1007/s11894-019-0737-y. PMID: 31848803
Fontanella F, Maggio L, Verheij JBGM, Duin LK, Adama Van Scheltema PN, Cohen-Overbeek TE, Pajkrt E, Bekker M, Willekes C, Bax CJ, Gracchi V, Oepkes D, Bilardo CM
Ultrasound Obstet Gynecol 2019 Jun;53(6):779-787. doi: 10.1002/uog.19182. PMID: 30043466Free PMC Article
Taghavi K, Sharpe C, Stringer MD
J Pediatr Urol 2017 Feb;13(1):7-15. Epub 2016 Oct 8 doi: 10.1016/j.jpurol.2016.09.003. PMID: 27889224
Friedmacher F, Puri P
Pediatr Surg Int 2013 Sep;29(9):855-72. doi: 10.1007/s00383-013-3351-3. PMID: 23943250

Diagnosis

Chen CP
Taiwan J Obstet Gynecol 2024 Jan;63(1):17-18. doi: 10.1016/j.tjog.2023.11.006. PMID: 38216262
Hashmi SK, Ceron RH, Heuckeroth RO
Am J Physiol Gastrointest Liver Physiol 2021 Jun 1;320(6):G919-G935. Epub 2021 Mar 17 doi: 10.1152/ajpgi.00066.2021. PMID: 33729000Free PMC Article
Taghavi K, Sharpe C, Stringer MD
J Pediatr Urol 2017 Feb;13(1):7-15. Epub 2016 Oct 8 doi: 10.1016/j.jpurol.2016.09.003. PMID: 27889224
Ballisty MM, Braithwaite KA, Shehata BM, Dickson PN
Pediatr Radiol 2013 Apr;43(4):454-9. Epub 2012 Aug 29 doi: 10.1007/s00247-012-2479-y. PMID: 22926452
Puri P, Gosemann JH
Semin Pediatr Surg 2012 Nov;21(4):310-8. doi: 10.1053/j.sempedsurg.2012.07.005. PMID: 22985836

Therapy

Goldberg MB, Abbas AE, Smith MS, Parkman HP, Schey R, Dempsey DT
Innovations (Phila) 2016 Nov/Dec;11(6):396-399. doi: 10.1097/IMI.0000000000000318. PMID: 27922988
Okada M, Sato M, Ogura M, Kamei K, Matsuoka K, Ito S
BMC Res Notes 2016 Mar 31;9:196. doi: 10.1186/s13104-016-1997-3. PMID: 27036403Free PMC Article
Kiyokawa T, Hiki N, Nunobe S, Honda M, Ohashi M, Sano T, Yamaguchi T
Ann Surg Oncol 2015 Nov;22(12):3962-9. Epub 2015 Mar 25 doi: 10.1245/s10434-015-4489-0. PMID: 25805234
Kubota A, Shiraishi J, Kawahara H, Okuyama H, Yoneda A, Nakai H, Nara K, Kitajima H, Fujimura M, Kuwae Y, Nakayama M
Pediatr Int 2011 Dec;53(6):887-91. doi: 10.1111/j.1442-200X.2011.03381.x. PMID: 21486380
Annerén G, Meurling S, Olsen L
Am J Med Genet 1991 Nov 1;41(2):251-4. doi: 10.1002/ajmg.1320410224. PMID: 1785644

Prognosis

Alcalá-González LG, Accarino A, Martí R, Sánchez-Tejerina D, Llauradó A, Azpiroz F, Malagelada C
Neurogastroenterol Motil 2023 Oct;35(10):e14643. Epub 2023 Jul 13 doi: 10.1111/nmo.14643. PMID: 37448106
Sandy NS, Huysentruyt K, Mulder DJ, Warner N, Chong K, Morel C, AlQahtani S, Wales PW, Martin MG, Muise AM, Avitzur Y
J Pediatr Gastroenterol Nutr 2022 May 1;74(5):575-581. doi: 10.1097/MPG.0000000000003400. PMID: 35149643Free PMC Article
Taghavi K, Sharpe C, Stringer MD
J Pediatr Urol 2017 Feb;13(1):7-15. Epub 2016 Oct 8 doi: 10.1016/j.jpurol.2016.09.003. PMID: 27889224
Gosemann JH, Puri P
Pediatr Surg Int 2011 Oct;27(10):1041-6. doi: 10.1007/s00383-011-2954-9. PMID: 21792650
Kupferman JC, Stewart CL, Schapfel DM, Kaskel FJ, Fine RN
Pediatr Nephrol 1995 Oct;9(5):626-7. doi: 10.1007/BF00860960. PMID: 8580028

Clinical prediction guides

Alcalá-González LG, Accarino A, Martí R, Sánchez-Tejerina D, Llauradó A, Azpiroz F, Malagelada C
Neurogastroenterol Motil 2023 Oct;35(10):e14643. Epub 2023 Jul 13 doi: 10.1111/nmo.14643. PMID: 37448106
Kapur RP, Goldstein AM, Loeff DS, Myers CT, Paschal CR
Pediatr Dev Pathol 2022 Nov-Dec;25(6):581-597. Epub 2022 Jun 12 doi: 10.1177/10935266221107449. PMID: 35695198
Sandy NS, Huysentruyt K, Mulder DJ, Warner N, Chong K, Morel C, AlQahtani S, Wales PW, Martin MG, Muise AM, Avitzur Y
J Pediatr Gastroenterol Nutr 2022 May 1;74(5):575-581. doi: 10.1097/MPG.0000000000003400. PMID: 35149643Free PMC Article
Hashmi SK, Ceron RH, Heuckeroth RO
Am J Physiol Gastrointest Liver Physiol 2021 Jun 1;320(6):G919-G935. Epub 2021 Mar 17 doi: 10.1152/ajpgi.00066.2021. PMID: 33729000Free PMC Article
Moreno CA, Metze K, Lomazi EA, Bertola DR, Barbosa RH, Cosentino V, Sobreira N, Cavalcanti DP
Am J Med Genet A 2016 Nov;170(11):2965-2974. Epub 2016 Aug 2 doi: 10.1002/ajmg.a.37857. PMID: 27481187Free PMC Article

Recent systematic reviews

Sandy NS, Huysentruyt K, Mulder DJ, Warner N, Chong K, Morel C, AlQahtani S, Wales PW, Martin MG, Muise AM, Avitzur Y
J Pediatr Gastroenterol Nutr 2022 May 1;74(5):575-581. doi: 10.1097/MPG.0000000000003400. PMID: 35149643Free PMC Article
Nakamura H, O'Donnell AM, Puri P
Pediatr Surg Int 2019 Feb;35(2):175-180. Epub 2018 Nov 1 doi: 10.1007/s00383-018-4390-6. PMID: 30386895
Taghavi K, Sharpe C, Stringer MD
J Pediatr Urol 2017 Feb;13(1):7-15. Epub 2016 Oct 8 doi: 10.1016/j.jpurol.2016.09.003. PMID: 27889224
Mc Laughlin D, Puri P
Pediatr Surg Int 2013 Sep;29(9):947-51. doi: 10.1007/s00383-013-3357-x. PMID: 23955298
Gosemann JH, Puri P
Pediatr Surg Int 2011 Oct;27(10):1041-6. doi: 10.1007/s00383-011-2954-9. PMID: 21792650

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