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Female sexual arousal disorder

MedGen UID:
452103
•Concept ID:
C0015786
•
Mental or Behavioral Dysfunction
Synonym: Female Sexual Arousal Disorder
SNOMED CT: Female sexual arousal disorder (46372006)

Definition

A disorder characterized by a recurrent or persistent inability to attain or maintain until completion of sexual activity an adequate physical response of sexual excitement, consisting of vasocongestion in the pelvis, vaginal lubrication and expansion, and swelling of the external genitalia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale sexual arousal disorder

Professional guidelines

PubMed

Drugs in early clinical development for the treatment of female sexual dysfunction.
Belkin ZR, Krapf JM, Goldstein AT
Expert Opin Investig Drugs 2015 Feb;24(2):159-67. Epub 2014 Nov 6 doi: 10.1517/13543784.2015.978283. PMID: 25376023
Evaluation and treatment of female sexual disorders.
Kingsberg S, Althof SE
Int Urogynecol J Pelvic Floor Dysfunct 2009 May;20 Suppl 1:S33-43. doi: 10.1007/s00192-009-0833-x. PMID: 19440781
Topical alprostadil treatment of female sexual arousal disorder.
Kielbasa LA, Daniel KL
Ann Pharmacother 2006 Jul-Aug;40(7-8):1369-76. Epub 2006 Jun 6 doi: 10.1345/aph.1G472. PMID: 16757679

Recent clinical studies

Etiology

Pharmacotherapy for Sexual Dysfunction in Women.
Lee JH, Lee JE, Harsh V, Clayton AH
Curr Psychiatry Rep 2022 Feb;24(2):99-109. Epub 2022 Feb 1 doi: 10.1007/s11920-022-01322-7. PMID: 35102537
The Evolution of the Female Sexual Disorder/Dysfunction Definitions, Nomenclature, and Classifications: A Review of DSM, ICSM, ISSWSH, and ICD.
Parish SJ, Cottler-Casanova S, Clayton AH, McCabe MP, Coleman E, Reed GM
Sex Med Rev 2021 Jan;9(1):36-56. Epub 2020 Aug 13 doi: 10.1016/j.sxmr.2020.05.001. PMID: 32800563
Female sexual arousal disorders.
Giraldi A, Rellini AH, Pfaus J, Laan E
J Sex Med 2013 Jan;10(1):58-73. Epub 2012 Sep 13 doi: 10.1111/j.1743-6109.2012.02820.x. PMID: 22974112
PDE-5 inhibition and sexual response: pharmacological mechanisms and clinical outcomes.
Rosen RC, McKenna KE
Annu Rev Sex Res 2002;13:36-88. PMID: 12836729
The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function.
Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'Agostino R Jr
J Sex Marital Ther 2000 Apr-Jun;26(2):191-208. doi: 10.1080/009262300278597. PMID: 10782451

Diagnosis

Pharmacotherapy for Sexual Dysfunction in Women.
Lee JH, Lee JE, Harsh V, Clayton AH
Curr Psychiatry Rep 2022 Feb;24(2):99-109. Epub 2022 Feb 1 doi: 10.1007/s11920-022-01322-7. PMID: 35102537
The Evolution of the Female Sexual Disorder/Dysfunction Definitions, Nomenclature, and Classifications: A Review of DSM, ICSM, ISSWSH, and ICD.
Parish SJ, Cottler-Casanova S, Clayton AH, McCabe MP, Coleman E, Reed GM
Sex Med Rev 2021 Jan;9(1):36-56. Epub 2020 Aug 13 doi: 10.1016/j.sxmr.2020.05.001. PMID: 32800563
Female sexual arousal disorders.
Giraldi A, Rellini AH, Pfaus J, Laan E
J Sex Med 2013 Jan;10(1):58-73. Epub 2012 Sep 13 doi: 10.1111/j.1743-6109.2012.02820.x. PMID: 22974112
Women's sexual desire and arousal disorders.
Brotto LA, Bitzer J, Laan E, Leiblum S, Luria M
J Sex Med 2010 Jan;7(1 Pt 2):586-614. doi: 10.1111/j.1743-6109.2009.01630.x. PMID: 20092454
The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function.
Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'Agostino R Jr
J Sex Marital Ther 2000 Apr-Jun;26(2):191-208. doi: 10.1080/009262300278597. PMID: 10782451

Therapy

Pharmacotherapy for Sexual Dysfunction in Women.
Lee JH, Lee JE, Harsh V, Clayton AH
Curr Psychiatry Rep 2022 Feb;24(2):99-109. Epub 2022 Feb 1 doi: 10.1007/s11920-022-01322-7. PMID: 35102537
Hypoactive sexual desire in women.
Kingsberg SA, Rezaee RL
Menopause 2013 Dec;20(12):1284-300. doi: 10.1097/GME.0000000000000131. PMID: 24219879
Sildenafil citrate for female sexual arousal disorder: a future possibility?
Schoen C, Bachmann G
Nat Rev Urol 2009 Apr;6(4):216-22. doi: 10.1038/nrurol.2009.25. PMID: 19352396
Topical alprostadil treatment of female sexual arousal disorder.
Kielbasa LA, Daniel KL
Ann Pharmacother 2006 Jul-Aug;40(7-8):1369-76. Epub 2006 Jun 6 doi: 10.1345/aph.1G472. PMID: 16757679
PDE-5 inhibition and sexual response: pharmacological mechanisms and clinical outcomes.
Rosen RC, McKenna KE
Annu Rev Sex Res 2002;13:36-88. PMID: 12836729

Prognosis

Predictors of Sex-Induced Crisis, Sexual Function and Marital Satisfaction in Women With Sickle Cell Disease.
Adesoye OB, Akhigbe RE
J Sex Med 2022 Nov;19(11):1625-1633. Epub 2022 Sep 7 doi: 10.1016/j.jsxm.2022.07.013. PMID: 36088276
Randomized crossover study investigating daily versus on-demand vulvar Visnadine spray in women affected by female sexual arousal disorder.
Caruso S, Mauro D, Cariola M, Fava V, Rapisarda AMC, Cianci A
Gynecol Endocrinol 2018 Feb;34(2):110-114. Epub 2017 Jul 27 doi: 10.1080/09513590.2017.1354366. PMID: 28749253
Sildenafil in women with sexual arousal disorder following spinal cord injury.
Alexander MS, Rosen RC, Steinberg S, Symonds T, Haughie S, Hultling C
Spinal Cord 2011 Feb;49(2):273-9. Epub 2010 Aug 24 doi: 10.1038/sc.2010.107. PMID: 20733587
Diabetes and female sexual dysfunction: moving beyond "benign neglect".
Muniyappa R, Norton M, Dunn ME, Banerji MA
Curr Diab Rep 2005 Jun;5(3):230-6. doi: 10.1007/s11892-005-0014-3. PMID: 15929871
Tactile sensitivity in women with sexual arousal disorder.
Frohlich PF, Meston CM
Arch Sex Behav 2005 Apr;34(2):207-17. doi: 10.1007/s10508-005-1798-6. PMID: 15803254

Clinical prediction guides

Sleep Disorders Are Associated with Female Sexual Desire and Genital Response - A U.S. Claims Database Analysis.
Agrawal P, Singh SM, Kohn J, Kohn TP, Clifton M
Urology 2023 Feb;172:79-83. Epub 2022 Nov 28 doi: 10.1016/j.urology.2022.11.017. PMID: 36455681
The co-effect of sensate focus technique and sexual position changing on sexual function of women who use medical treatment for endometriosis.
Tajik M, Shahali S, Shadjoo K
J Obstet Gynaecol 2022 Nov;42(8):3706-3711. Epub 2022 Dec 21 doi: 10.1080/01443615.2022.2158316. PMID: 36541405
Prevalence of Female Sexual Dysfunction Among Premenopausal Women: A Systematic Review and Meta-Analysis of Observational Studies.
McCool ME, Zuelke A, Theurich MA, Knuettel H, Ricci C, Apfelbacher C
Sex Med Rev 2016 Jul;4(3):197-212. Epub 2016 Apr 19 doi: 10.1016/j.sxmr.2016.03.002. PMID: 27871953
Diabetes and female sexual dysfunction: moving beyond "benign neglect".
Muniyappa R, Norton M, Dunn ME, Banerji MA
Curr Diab Rep 2005 Jun;5(3):230-6. doi: 10.1007/s11892-005-0014-3. PMID: 15929871
The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function.
Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'Agostino R Jr
J Sex Marital Ther 2000 Apr-Jun;26(2):191-208. doi: 10.1080/009262300278597. PMID: 10782451

Recent systematic reviews

Prevalence of Female Sexual Dysfunction Among Premenopausal Women: A Systematic Review and Meta-Analysis of Observational Studies.
McCool ME, Zuelke A, Theurich MA, Knuettel H, Ricci C, Apfelbacher C
Sex Med Rev 2016 Jul;4(3):197-212. Epub 2016 Apr 19 doi: 10.1016/j.sxmr.2016.03.002. PMID: 27871953

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