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Palmoplantar pustulosis

MedGen UID:
45290
Concept ID:
C0030246
Disease or Syndrome
Synonym: Pustulosis palmaris et plantaris
SNOMED CT: Acropustulosis (83839005); Pustulosis palmaris et plantaris (27520001); Recalcitrant pustular eruption of palms and soles (27520001); PPP - Palmoplantar pustulosis (27520001); Palmoplantar pustular psoriasis (27520001); Pustular acrodermatitis (27520001); Pustular psoriasis of palms and soles (27520001); Palmoplantar pustulosis (27520001)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
 
HPO: HP:0100847
Monarch Initiative: MONDO:0015597
Orphanet: ORPHA163927

Definition

A chronic, relapsing, pustular eruption that is localized to the palms and soles. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPalmoplantar pustulosis
Follow this link to review classifications for Palmoplantar pustulosis in Orphanet.

Conditions with this feature

Chronic multifocal osteomyelitis
MedGen UID:
140822
Concept ID:
C0410422
Disease or Syndrome
Chronic recurrent multifocal osteomyelitis-3 (CRMO3) is an autosomal dominant autoinflammatory bone disease characterized by early childhood onset of bone pain and arthritis caused by sterile osteomyelitis. The disorder results from constitutive activation of the IL1-mediated inflammatory pathway due to loss of IL1 receptor sensitivity to its antagonist IL1RN (147679). et al. (2023) suggested the term 'Loss of IL1R1 Sensitivity to IL1RA (IL1RN)' or 'LIRSA' as a designation for this disorder. For a discussion of genetic heterogeneity of CRMO, see 609628.

Professional guidelines

PubMed

Murakami M
Expert Opin Biol Ther 2020 Aug;20(8):841-852. Epub 2020 May 12 doi: 10.1080/14712598.2020.1760244. PMID: 32321322
Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Köks S, Kingo K, Smith C, Barker JN; ERASPEN Network
J Eur Acad Dermatol Venereol 2017 Nov;31(11):1792-1799. Epub 2017 Aug 29 doi: 10.1111/jdv.14386. PMID: 28585342
Raposo I, Torres T
Am J Clin Dermatol 2016 Aug;17(4):349-58. doi: 10.1007/s40257-016-0191-7. PMID: 27113059

Recent clinical studies

Etiology

Chen W, Ito T, Lin SH, Song Z, Al-Khuzaei S, Jurik AG, Plewig G
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1501-1506. Epub 2022 May 12 doi: 10.1111/jdv.18172. PMID: 35462435
Kishimoto M, Taniguchi Y, Tsuji S, Ishihara Y, Deshpande GA, Maeda K, Okada M, Komagata Y, Kobayashi S, Okubo Y, Tomita T, Kaname S
Mod Rheumatol 2022 Jul 1;32(4):665-674. doi: 10.1093/mr/roab103. PMID: 34967407
Misiak-Galazka M, Zozula J, Rudnicka L
Am J Clin Dermatol 2020 Jun;21(3):355-370. doi: 10.1007/s40257-020-00503-5. PMID: 32008176Free PMC Article
Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, Cooper HL, Irvine AD, Oon HH, Kingo K, Köks S, Mrowietz U, Puig L, Reynolds N, Tan ES, Tanew A, Torz K, Trattner H, Valentine M, Wahie S, Warren RB, Wright A, Bata-Csörgő Z, Szell M, Griffiths CEM, Burden AD, Choon SE, Smith CH, Barker JN, Navarini AA, Capon F
J Allergy Clin Immunol 2019 Mar;143(3):1021-1026. Epub 2018 Jul 21 doi: 10.1016/j.jaci.2018.06.038. PMID: 30036598Free PMC Article
Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Köks S, Kingo K, Smith C, Barker JN; ERASPEN Network
J Eur Acad Dermatol Venereol 2017 Nov;31(11):1792-1799. Epub 2017 Aug 29 doi: 10.1111/jdv.14386. PMID: 28585342

Diagnosis

Kishimoto M, Taniguchi Y, Tsuji S, Ishihara Y, Deshpande GA, Maeda K, Okada M, Komagata Y, Kobayashi S, Okubo Y, Tomita T, Kaname S
Mod Rheumatol 2022 Jul 1;32(4):665-674. doi: 10.1093/mr/roab103. PMID: 34967407
Bachelez H
Acta Derm Venereol 2020 Jan 30;100(3):adv00034. doi: 10.2340/00015555-3388. PMID: 31971600Free PMC Article
Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, Cooper HL, Irvine AD, Oon HH, Kingo K, Köks S, Mrowietz U, Puig L, Reynolds N, Tan ES, Tanew A, Torz K, Trattner H, Valentine M, Wahie S, Warren RB, Wright A, Bata-Csörgő Z, Szell M, Griffiths CEM, Burden AD, Choon SE, Smith CH, Barker JN, Navarini AA, Capon F
J Allergy Clin Immunol 2019 Mar;143(3):1021-1026. Epub 2018 Jul 21 doi: 10.1016/j.jaci.2018.06.038. PMID: 30036598Free PMC Article
Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Köks S, Kingo K, Smith C, Barker JN; ERASPEN Network
J Eur Acad Dermatol Venereol 2017 Nov;31(11):1792-1799. Epub 2017 Aug 29 doi: 10.1111/jdv.14386. PMID: 28585342
Oji V, Luger TA
Clin Exp Rheumatol 2015 Sep-Oct;33(5 Suppl 93):S14-9. Epub 2015 Oct 15 PMID: 26472560

Therapy

Spencer RK, Jin JQ, Elhage KG, Davis MS, Hakimi M, Bhutani T, Liao W
J Am Acad Dermatol 2023 Aug;89(2):423-425. Epub 2023 Apr 29 doi: 10.1016/j.jaad.2023.04.043. PMID: 37121476
Baum P, Visvanathan S, Garcet S, Roy J, Schmid R, Bossert S, Lang B, Bachelez H, Bissonnette R, Thoma C, Krueger JG
J Allergy Clin Immunol 2022 Apr;149(4):1402-1412. Epub 2021 Oct 20 doi: 10.1016/j.jaci.2021.09.035. PMID: 34678325
Bell KA, Pourang A, Mesinkovska NA, Cardis MA
Dermatol Online J 2021 Apr 15;27(4) PMID: 33999573
Misiak-Galazka M, Zozula J, Rudnicka L
Am J Clin Dermatol 2020 Jun;21(3):355-370. doi: 10.1007/s40257-020-00503-5. PMID: 32008176Free PMC Article
Ortiz NE, Nijhawan RI, Weinberg JM
Dermatol Ther 2013 Sep-Oct;26(5):390-9. doi: 10.1111/dth.12086. PMID: 24099069

Prognosis

Putra-Szczepaniak M, Maj J, Jankowska-Konsur A, Czarnecka A, Hryncewicz-Gwóźdź A
Adv Clin Exp Med 2020 Jan;29(1):157-163. doi: 10.17219/acem/112613. PMID: 31990461
Andersen YMF, Augustin M, Petersen J, Hagenström K, Mallbris L, Burge R, Egeberg A
Br J Dermatol 2019 Nov;181(5):976-982. Epub 2019 Jun 2 doi: 10.1111/bjd.17832. PMID: 30815849
Oji V, Luger TA
Clin Exp Rheumatol 2015 Sep-Oct;33(5 Suppl 93):S14-9. Epub 2015 Oct 15 PMID: 26472560
Wetter DA
CMAJ 2013 Aug 6;185(11):982. Epub 2012 Dec 3 doi: 10.1503/cmaj.121143. PMID: 23209116Free PMC Article
Cotten A, Flipo RM, Mentre A, Delaporte E, Duquesnoy B, Chastanet P
Radiographics 1995 Sep;15(5):1147-54. doi: 10.1148/radiographics.15.5.7501856. PMID: 7501856

Clinical prediction guides

Chen W, Ito T, Lin SH, Song Z, Al-Khuzaei S, Jurik AG, Plewig G
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1501-1506. Epub 2022 May 12 doi: 10.1111/jdv.18172. PMID: 35462435
Murakami M
Expert Opin Biol Ther 2020 Aug;20(8):841-852. Epub 2020 May 12 doi: 10.1080/14712598.2020.1760244. PMID: 32321322
Putra-Szczepaniak M, Maj J, Jankowska-Konsur A, Czarnecka A, Hryncewicz-Gwóźdź A
Adv Clin Exp Med 2020 Jan;29(1):157-163. doi: 10.17219/acem/112613. PMID: 31990461
Yamamoto T
Clin Drug Investig 2019 Mar;39(3):241-252. doi: 10.1007/s40261-018-00745-6. PMID: 30632109
Oji V, Luger TA
Clin Exp Rheumatol 2015 Sep-Oct;33(5 Suppl 93):S14-9. Epub 2015 Oct 15 PMID: 26472560

Recent systematic reviews

Spencer RK, Jin JQ, Elhage KG, Davis MS, Hakimi M, Bhutani T, Liao W
J Am Acad Dermatol 2023 Aug;89(2):423-425. Epub 2023 Apr 29 doi: 10.1016/j.jaad.2023.04.043. PMID: 37121476
Lu JD, Lytvyn Y, Mufti A, Zaaroura H, Sachdeva M, Kwan S, Abduelmula A, Kim P, Yeung J
Int J Dermatol 2023 Jan;62(1):12-21. Epub 2022 Feb 6 doi: 10.1111/ijd.16064. PMID: 35128653
Bell KA, Pourang A, Mesinkovska NA, Cardis MA
Dermatol Online J 2021 Apr 15;27(4) PMID: 33999573
Obeid G, Do G, Kirby L, Hughes C, Sbidian E, Le Cleach L
Br J Dermatol 2021 Jun;184(6):1023-1032. Epub 2020 Nov 19 doi: 10.1111/bjd.19560. PMID: 32961599
Marsland AM, Chalmers RJ, Hollis S, Leonardi-Bee J, Griffiths CE
Cochrane Database Syst Rev 2006 Jan 25;2006(1):CD001433. doi: 10.1002/14651858.CD001433.pub2. PMID: 16437433Free PMC Article

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