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Cardio-renal syndrome

MedGen UID:
453248
•Concept ID:
C2242703
•
Disease or Syndrome
Synonyms: Cardio Renal Syndrome; Cardio-Renal Syndrome; Cardio-Renal Syndromes; Cardiorenal Syndrome; Cardiorenal Syndromes; Reno Cardiac Syndrome; Reno-Cardiac Syndrome; Reno-Cardiac Syndromes; Renocardiac Syndrome; Renocardiac Syndromes; Syndrome, Cardio-Renal; Syndrome, Cardiorenal; Syndrome, Reno-Cardiac; Syndrome, Renocardiac; Syndromes, Cardio-Renal; Syndromes, Cardiorenal; Syndromes, Reno-Cardiac; Syndromes, Renocardiac
SNOMED CT: Cardiorenal syndrome (445236007)
 
Monarch Initiative: MONDO:0044079

Definition

A disorder of the heart and kidneys in which dysfunction of one of the organs induces dysfunction of the other organ. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardio-renal syndrome

Professional guidelines

PubMed

Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association.
Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, Lerma EV, Mezue K, Molitch M, Mullens W, Ronco C, Tang WHW, McCullough PA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Circulation 2019 Apr 16;139(16):e840-e878. doi: 10.1161/CIR.0000000000000664. PMID: 30852913
Role of biomarkers in the diagnosis and management of cardio-renal syndromes.
Cruz DN, Fard A, Clementi A, Ronco C, Maisel A
Semin Nephrol 2012 Jan;32(1):79-92. doi: 10.1016/j.semnephrol.2011.11.011. PMID: 22365166
Cardio-renal syndrome type 5: epidemiology, pathophysiology, and treatment.
Soni SS, Ronco C, Pophale R, Bhansali AS, Nagarik AP, Barnela SR, Saboo SS, Raman A
Semin Nephrol 2012 Jan;32(1):49-56. doi: 10.1016/j.semnephrol.2011.11.007. PMID: 22365162

Recent clinical studies

Etiology

Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.
Njoroge JN, Teerlink JR
Circ Res 2021 May 14;128(10):1468-1486. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318186. PMID: 33983837Free PMC Article
Cardiorenal Syndrome.
Ricci Z, Romagnoli S, Ronco C
Crit Care Clin 2021 Apr;37(2):335-347. Epub 2021 Feb 13 doi: 10.1016/j.ccc.2020.11.003. PMID: 33752859
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446
Cardiorenal Syndrome: An Overview.
Ronco C, Bellasi A, Di Lullo L
Adv Chronic Kidney Dis 2018 Sep;25(5):382-390. doi: 10.1053/j.ackd.2018.08.004. PMID: 30309455
Obesity and hypertension in Latin America: Current perspectives.
Ruilope LM, Nunes Filho ACB, Nadruz W Jr, Rodríguez Rosales FF, Verdejo-Paris J
Hipertens Riesgo Vasc 2018 Apr-Jun;35(2):70-76. Epub 2018 Feb 1 doi: 10.1016/j.hipert.2017.12.004. PMID: 29361428

Diagnosis

Cardiorenal Syndrome: New Pathways and Novel Biomarkers.
Gembillo G, Visconti L, Giusti MA, Siligato R, Gallo A, Santoro D, Mattina A
Biomolecules 2021 Oct 26;11(11) doi: 10.3390/biom11111581. PMID: 34827580Free PMC Article
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.
Njoroge JN, Teerlink JR
Circ Res 2021 May 14;128(10):1468-1486. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318186. PMID: 33983837Free PMC Article
Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association.
Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, Lerma EV, Mezue K, Molitch M, Mullens W, Ronco C, Tang WHW, McCullough PA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Circulation 2019 Apr 16;139(16):e840-e878. doi: 10.1161/CIR.0000000000000664. PMID: 30852913
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446
Cardiorenal Syndrome: An Overview.
Ronco C, Bellasi A, Di Lullo L
Adv Chronic Kidney Dis 2018 Sep;25(5):382-390. doi: 10.1053/j.ackd.2018.08.004. PMID: 30309455

Therapy

Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.
Njoroge JN, Teerlink JR
Circ Res 2021 May 14;128(10):1468-1486. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318186. PMID: 33983837Free PMC Article
Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection.
Hou YC, Zheng CM, Yen TH, Lu KC
Int J Mol Sci 2020 Oct 22;21(21) doi: 10.3390/ijms21217833. PMID: 33105763Free PMC Article
The Cardiorenal Syndrome in Heart Failure.
Costanzo MR
Heart Fail Clin 2020 Jan;16(1):81-97. doi: 10.1016/j.hfc.2019.08.010. PMID: 31735318
Clinical Pharmacology in Diuretic Use.
Ellison DH
Clin J Am Soc Nephrol 2019 Aug 7;14(8):1248-1257. Epub 2019 Apr 1 doi: 10.2215/CJN.09630818. PMID: 30936153Free PMC Article
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446

Prognosis

Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.
Njoroge JN, Teerlink JR
Circ Res 2021 May 14;128(10):1468-1486. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318186. PMID: 33983837Free PMC Article
Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association.
Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, Lerma EV, Mezue K, Molitch M, Mullens W, Ronco C, Tang WHW, McCullough PA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Circulation 2019 Apr 16;139(16):e840-e878. doi: 10.1161/CIR.0000000000000664. PMID: 30852913
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446
Cardiorenal Syndrome: An Overview.
Ronco C, Bellasi A, Di Lullo L
Adv Chronic Kidney Dis 2018 Sep;25(5):382-390. doi: 10.1053/j.ackd.2018.08.004. PMID: 30309455
Heart failure and kidney dysfunction: epidemiology, mechanisms and management.
Schefold JC, Filippatos G, Hasenfuss G, Anker SD, von Haehling S
Nat Rev Nephrol 2016 Oct;12(10):610-23. Epub 2016 Aug 30 doi: 10.1038/nrneph.2016.113. PMID: 27573728

Clinical prediction guides

Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys.
Patel KP, Katsurada K, Zheng H
Circ Res 2022 May 13;130(10):1601-1617. Epub 2022 May 12 doi: 10.1161/CIRCRESAHA.122.319989. PMID: 35549375Free PMC Article
Renal Compression in Heart Failure: The Renal Tamponade Hypothesis.
Boorsma EM, Ter Maaten JM, Voors AA, van Veldhuisen DJ
JACC Heart Fail 2022 Mar;10(3):175-183. Epub 2022 Feb 9 doi: 10.1016/j.jchf.2021.12.005. PMID: 35241245
Osteopontin in Cardiovascular Diseases.
Shirakawa K, Sano M
Biomolecules 2021 Jul 16;11(7) doi: 10.3390/biom11071047. PMID: 34356671Free PMC Article
IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4.
Huang Y, Wang S, Zhou J, Liu Y, Du C, Yang K, Bi X, Liu M, Han W, Wang K, Xiong J, Wang S, Wang Y, Nie L, Liu C, Zhang D, Gu J, Zeng C, Zhao J
Nat Commun 2020 Sep 16;11(1):4664. doi: 10.1038/s41467-020-18519-0. PMID: 32938919Free PMC Article
Heart failure and kidney dysfunction: epidemiology, mechanisms and management.
Schefold JC, Filippatos G, Hasenfuss G, Anker SD, von Haehling S
Nat Rev Nephrol 2016 Oct;12(10):610-23. Epub 2016 Aug 30 doi: 10.1038/nrneph.2016.113. PMID: 27573728

Recent systematic reviews

Right Heart Function in Cardiorenal Syndrome.
Kramer T, Brinkkoetter P, Rosenkranz S
Curr Heart Fail Rep 2022 Dec;19(6):386-399. Epub 2022 Sep 27 doi: 10.1007/s11897-022-00574-x. PMID: 36166185Free PMC Article
COVID-19 in patients with and without acute kidney injury.
Sabaghian T, Rommasi F, Omidi F, Hajikhani B, Nasiri MJ, Mirsaeidi M
Bratisl Lek Listy 2022;123(5):382-380. doi: 10.4149/BLL_2022_059. PMID: 35420885
GLP-1 receptor agonists and cardiorenal outcomes in type 2 diabetes: an updated meta-analysis of eight CVOTs.
Giugliano D, Scappaticcio L, Longo M, Caruso P, Maiorino MI, Bellastella G, Ceriello A, Chiodini P, Esposito K
Cardiovasc Diabetol 2021 Sep 15;20(1):189. doi: 10.1186/s12933-021-01366-8. PMID: 34526024Free PMC Article
Effect of ultrafiltration versus intravenous furosemide for decompensated heart failure in cardiorenal syndrome: a systematic review with meta-analysis of randomized controlled trials.
Chen HY, Chou KJ, Fang HC, Chen CL, Hsu CY, Huang WC, Huang CW, Huang CK, Lee PT
Nephron 2015;129(3):189-96. Epub 2015 Feb 27 doi: 10.1159/000371447. PMID: 25765606
Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative.
Ronco C, McCullough P, Anker SD, Anand I, Aspromonte N, Bagshaw SM, Bellomo R, Berl T, Bobek I, Cruz DN, Daliento L, Davenport A, Haapio M, Hillege H, House AA, Katz N, Maisel A, Mankad S, Zanco P, Mebazaa A, Palazzuoli A, Ronco F, Shaw A, Sheinfeld G, Soni S, Vescovo G, Zamperetti N, Ponikowski P; Acute Dialysis Quality Initiative (ADQI) consensus group
Eur Heart J 2010 Mar;31(6):703-11. Epub 2009 Dec 25 doi: 10.1093/eurheartj/ehp507. PMID: 20037146Free PMC Article

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