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Cardio-renal syndrome

MedGen UID:
453248
•Concept ID:
C2242703
•
Disease or Syndrome
Synonyms: Cardio Renal Syndrome; Cardio-Renal Syndrome; Cardio-Renal Syndromes; Cardiorenal Syndrome; Cardiorenal Syndromes; Reno Cardiac Syndrome; Reno-Cardiac Syndrome; Reno-Cardiac Syndromes; Renocardiac Syndrome; Renocardiac Syndromes; Syndrome, Cardio-Renal; Syndrome, Cardiorenal; Syndrome, Reno-Cardiac; Syndrome, Renocardiac; Syndromes, Cardio-Renal; Syndromes, Cardiorenal; Syndromes, Reno-Cardiac; Syndromes, Renocardiac
SNOMED CT: Cardiorenal syndrome (445236007)
 
Monarch Initiative: MONDO:0044079

Definition

A disorder of the heart and kidneys in which dysfunction of one of the organs induces dysfunction of the other organ. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardio-renal syndrome

Professional guidelines

PubMed

Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association.
Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, Lerma EV, Mezue K, Molitch M, Mullens W, Ronco C, Tang WHW, McCullough PA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Circulation 2019 Apr 16;139(16):e840-e878. doi: 10.1161/CIR.0000000000000664. PMID: 30852913
Cardio-renal syndrome type 4: epidemiology, pathophysiology and treatment.
House AA
Semin Nephrol 2012 Jan;32(1):40-8. doi: 10.1016/j.semnephrol.2011.11.006. PMID: 22365161
Cardio-renal syndrome type 1: epidemiology, pathophysiology, and treatment.
Ismail Y, Kasmikha Z, Green HL, McCullough PA
Semin Nephrol 2012 Jan;32(1):18-25. doi: 10.1016/j.semnephrol.2011.11.003. PMID: 22365158

Recent clinical studies

Etiology

Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.
Njoroge JN, Teerlink JR
Circ Res 2021 May 14;128(10):1468-1486. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318186. PMID: 33983837Free PMC Article
Cardiorenal Syndrome.
Ricci Z, Romagnoli S, Ronco C
Crit Care Clin 2021 Apr;37(2):335-347. Epub 2021 Feb 13 doi: 10.1016/j.ccc.2020.11.003. PMID: 33752859
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446
Cardiorenal Syndrome: An Overview.
Ronco C, Bellasi A, Di Lullo L
Adv Chronic Kidney Dis 2018 Sep;25(5):382-390. doi: 10.1053/j.ackd.2018.08.004. PMID: 30309455
The Transition From Hypertension to Heart Failure: Contemporary Update.
Messerli FH, Rimoldi SF, Bangalore S
JACC Heart Fail 2017 Aug;5(8):543-551. Epub 2017 Jul 12 doi: 10.1016/j.jchf.2017.04.012. PMID: 28711447

Diagnosis

The cardio-renal-metabolic connection: a review of the evidence.
Marassi M, Fadini GP
Cardiovasc Diabetol 2023 Jul 31;22(1):195. doi: 10.1186/s12933-023-01937-x. PMID: 37525273Free PMC Article
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.
Njoroge JN, Teerlink JR
Circ Res 2021 May 14;128(10):1468-1486. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318186. PMID: 33983837Free PMC Article
Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association.
Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, Lerma EV, Mezue K, Molitch M, Mullens W, Ronco C, Tang WHW, McCullough PA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Circulation 2019 Apr 16;139(16):e840-e878. doi: 10.1161/CIR.0000000000000664. PMID: 30852913
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446
Cardiorenal Syndrome: An Overview.
Ronco C, Bellasi A, Di Lullo L
Adv Chronic Kidney Dis 2018 Sep;25(5):382-390. doi: 10.1053/j.ackd.2018.08.004. PMID: 30309455

Therapy

Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.
Njoroge JN, Teerlink JR
Circ Res 2021 May 14;128(10):1468-1486. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318186. PMID: 33983837Free PMC Article
Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection.
Hou YC, Zheng CM, Yen TH, Lu KC
Int J Mol Sci 2020 Oct 22;21(21) doi: 10.3390/ijms21217833. PMID: 33105763Free PMC Article
Clinical Pharmacology in Diuretic Use.
Ellison DH
Clin J Am Soc Nephrol 2019 Aug 7;14(8):1248-1257. Epub 2019 Apr 1 doi: 10.2215/CJN.09630818. PMID: 30936153Free PMC Article
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446
The Transition From Hypertension to Heart Failure: Contemporary Update.
Messerli FH, Rimoldi SF, Bangalore S
JACC Heart Fail 2017 Aug;5(8):543-551. Epub 2017 Jul 12 doi: 10.1016/j.jchf.2017.04.012. PMID: 28711447

Prognosis

The cardio-renal-metabolic connection: a review of the evidence.
Marassi M, Fadini GP
Cardiovasc Diabetol 2023 Jul 31;22(1):195. doi: 10.1186/s12933-023-01937-x. PMID: 37525273Free PMC Article
Cardiorenal Syndrome: New Pathways and Novel Biomarkers.
Gembillo G, Visconti L, Giusti MA, Siligato R, Gallo A, Santoro D, Mattina A
Biomolecules 2021 Oct 26;11(11) doi: 10.3390/biom11111581. PMID: 34827580Free PMC Article
Cardiorenal Syndrome Revisited.
Zannad F, Rossignol P
Circulation 2018 Aug 28;138(9):929-944. doi: 10.1161/CIRCULATIONAHA.117.028814. PMID: 30354446
Cardiorenal Syndrome: An Overview.
Ronco C, Bellasi A, Di Lullo L
Adv Chronic Kidney Dis 2018 Sep;25(5):382-390. doi: 10.1053/j.ackd.2018.08.004. PMID: 30309455
Heart failure and kidney dysfunction: epidemiology, mechanisms and management.
Schefold JC, Filippatos G, Hasenfuss G, Anker SD, von Haehling S
Nat Rev Nephrol 2016 Oct;12(10):610-23. Epub 2016 Aug 30 doi: 10.1038/nrneph.2016.113. PMID: 27573728

Clinical prediction guides

Cardio-renal-metabolic syndrome: clinical features and dapagliflozin eligibility in a real-world heart failure cohort.
Beles M, Masuy I, Verstreken S, Bartunek J, Dierckx R, Heggermont W, Oeste C, De Boeck M, Fovel I, Maris M, Vermeulen Z, Vanderheyden M
ESC Heart Fail 2023 Aug;10(4):2269-2280. Epub 2023 Apr 24 doi: 10.1002/ehf2.14381. PMID: 37095712Free PMC Article
Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys.
Patel KP, Katsurada K, Zheng H
Circ Res 2022 May 13;130(10):1601-1617. Epub 2022 May 12 doi: 10.1161/CIRCRESAHA.122.319989. PMID: 35549375Free PMC Article
Renal Compression in Heart Failure: The Renal Tamponade Hypothesis.
Boorsma EM, Ter Maaten JM, Voors AA, van Veldhuisen DJ
JACC Heart Fail 2022 Mar;10(3):175-183. Epub 2022 Feb 9 doi: 10.1016/j.jchf.2021.12.005. PMID: 35241245
Heart failure and kidney dysfunction: epidemiology, mechanisms and management.
Schefold JC, Filippatos G, Hasenfuss G, Anker SD, von Haehling S
Nat Rev Nephrol 2016 Oct;12(10):610-23. Epub 2016 Aug 30 doi: 10.1038/nrneph.2016.113. PMID: 27573728
Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis.
Damman K, Valente MA, Voors AA, O'Connor CM, van Veldhuisen DJ, Hillege HL
Eur Heart J 2014 Feb;35(7):455-69. Epub 2013 Oct 27 doi: 10.1093/eurheartj/eht386. PMID: 24164864

Recent systematic reviews

Acute and Chronic Cardiovascular Consequences of Acute Kidney Injury: A Systematic Review and Meta-Analysis.
De Clercq L, Ailliet T, Schaubroeck H, Hoste EAJ
Cardiorenal Med 2023;13(1):26-33. Epub 2022 Nov 18 doi: 10.1159/000527198. PMID: 36404711
Right Heart Function in Cardiorenal Syndrome.
Kramer T, Brinkkoetter P, Rosenkranz S
Curr Heart Fail Rep 2022 Dec;19(6):386-399. Epub 2022 Sep 27 doi: 10.1007/s11897-022-00574-x. PMID: 36166185Free PMC Article
COVID-19 in patients with and without acute kidney injury.
Sabaghian T, Rommasi F, Omidi F, Hajikhani B, Nasiri MJ, Mirsaeidi M
Bratisl Lek Listy 2022;123(5):382-380. doi: 10.4149/BLL_2022_059. PMID: 35420885
GLP-1 receptor agonists and cardiorenal outcomes in type 2 diabetes: an updated meta-analysis of eight CVOTs.
Giugliano D, Scappaticcio L, Longo M, Caruso P, Maiorino MI, Bellastella G, Ceriello A, Chiodini P, Esposito K
Cardiovasc Diabetol 2021 Sep 15;20(1):189. doi: 10.1186/s12933-021-01366-8. PMID: 34526024Free PMC Article
Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative.
Ronco C, McCullough P, Anker SD, Anand I, Aspromonte N, Bagshaw SM, Bellomo R, Berl T, Bobek I, Cruz DN, Daliento L, Davenport A, Haapio M, Hillege H, House AA, Katz N, Maisel A, Mankad S, Zanco P, Mebazaa A, Palazzuoli A, Ronco F, Shaw A, Sheinfeld G, Soni S, Vescovo G, Zamperetti N, Ponikowski P; Acute Dialysis Quality Initiative (ADQI) consensus group
Eur Heart J 2010 Mar;31(6):703-11. Epub 2009 Dec 25 doi: 10.1093/eurheartj/ehp507. PMID: 20037146Free PMC Article

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