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Stage IV Gastric Gastrointestinal Stromal Tumor

MedGen UID:
453641
•Concept ID:
C2981414
•
Neoplastic Process
Synonym: Stage IV Gastric Gastrointestinal Stromal Tumor AJCC v7

Definition

Stage IV includes: (Any T, N1, M0, Mitotic rate: Any rate); (Any T, Any N, M1, Mitotic rate: Any rate). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IV Gastric Gastrointestinal Stromal Tumor

Recent clinical studies

Etiology

Gastric GIST and prognostic models. Which is the best to predict survival after surgery?
Di Vita M, Zanghì A, Cavallaro A, Cardì F, Uhlig M, Ursi P, Lo Menzo E, Panebianco V, Cappellani A
Ann Ital Chir 2019;90:31-40. PMID: 30942768
Gastrointestinal stromal tumors. A clinicopathological study.
Alghamdi HM, Amr SS, Shawarby MA, Sheikh SS, Alsayyah AA, Alamri AM, Ismail MH, Almarhabi A, Alrefaee MA, Ahmed MI
Saudi Med J 2019 Feb;40(2):126-130. doi: 10.15537/smj.2019.2.23913. PMID: 30723856Free PMC Article
Long-Term Surgical Outcome of 1057 Gastric GISTs According to 7th UICC/AJCC TNM System: Multicenter Observational Study From Korea and Japan.
Kim MC, Yook JH, Yang HK, Lee HJ, Sohn TS, Hyung WJ, Ryu SW, Kurokawa Y, Kim YW, Han SU, Kim HH, Park DJ, Kim W, Lee SI, Cho H, Cho GS, Kim JJ, Kim KH, Yoo MW
Medicine (Baltimore) 2015 Oct;94(41):e1526. doi: 10.1097/MD.0000000000001526. PMID: 26469894Free PMC Article
The role of i.v. and oral contrast enhanced ultrasonography in the characterization of gastric tumors. A preliminary study.
Badea R, Neciu C, Iancu C, Al Hajar N, Pojoga C, Botan E
Med Ultrason 2012 Sep;14(3):197-203. PMID: 22957324

Diagnosis

Gastrointestinal stromal tumors. A clinicopathological study.
Alghamdi HM, Amr SS, Shawarby MA, Sheikh SS, Alsayyah AA, Alamri AM, Ismail MH, Almarhabi A, Alrefaee MA, Ahmed MI
Saudi Med J 2019 Feb;40(2):126-130. doi: 10.15537/smj.2019.2.23913. PMID: 30723856Free PMC Article
The role of i.v. and oral contrast enhanced ultrasonography in the characterization of gastric tumors. A preliminary study.
Badea R, Neciu C, Iancu C, Al Hajar N, Pojoga C, Botan E
Med Ultrason 2012 Sep;14(3):197-203. PMID: 22957324

Therapy

Phase I PIANO trial-PIPAC-oxaliplatin and systemic nivolumab combination for gastric cancer peritoneal metastases: clinical and translational outcomes.
Sundar R, Chia DKA, Zhao JJ, Lee ARYB, Kim G, Tan HL, Pang A, Shabbir A, Willaert W, Ma H, Huang KK, Hagihara T, Tan ALK, Ong CJ, Wong JSM, Seo CJ, Walsh R, Chan G, Cheo SW, Soh CCC, Callebout E, Geboes K, Ng MCH, Lum JHY, Leow WQ, Selvarajan S, Hoorens A, Ang WH, Pang H, Tan P, Yong WP, Chia CSL, Ceelen W, So JBY
ESMO Open 2024 Sep;9(9):103681. Epub 2024 Sep 16 doi: 10.1016/j.esmoop.2024.103681. PMID: 39288528Free PMC Article
The role of i.v. and oral contrast enhanced ultrasonography in the characterization of gastric tumors. A preliminary study.
Badea R, Neciu C, Iancu C, Al Hajar N, Pojoga C, Botan E
Med Ultrason 2012 Sep;14(3):197-203. PMID: 22957324

Prognosis

Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma.
Huang L, Zhou Y, Sun Q, Cao L, Zhang X
Cancer Biomark 2022;33(1):123-129. doi: 10.3233/CBM-210178. PMID: 34459388
Gastric GIST and prognostic models. Which is the best to predict survival after surgery?
Di Vita M, Zanghì A, Cavallaro A, Cardì F, Uhlig M, Ursi P, Lo Menzo E, Panebianco V, Cappellani A
Ann Ital Chir 2019;90:31-40. PMID: 30942768
Long-Term Surgical Outcome of 1057 Gastric GISTs According to 7th UICC/AJCC TNM System: Multicenter Observational Study From Korea and Japan.
Kim MC, Yook JH, Yang HK, Lee HJ, Sohn TS, Hyung WJ, Ryu SW, Kurokawa Y, Kim YW, Han SU, Kim HH, Park DJ, Kim W, Lee SI, Cho H, Cho GS, Kim JJ, Kim KH, Yoo MW
Medicine (Baltimore) 2015 Oct;94(41):e1526. doi: 10.1097/MD.0000000000001526. PMID: 26469894Free PMC Article

Clinical prediction guides

Phase I PIANO trial-PIPAC-oxaliplatin and systemic nivolumab combination for gastric cancer peritoneal metastases: clinical and translational outcomes.
Sundar R, Chia DKA, Zhao JJ, Lee ARYB, Kim G, Tan HL, Pang A, Shabbir A, Willaert W, Ma H, Huang KK, Hagihara T, Tan ALK, Ong CJ, Wong JSM, Seo CJ, Walsh R, Chan G, Cheo SW, Soh CCC, Callebout E, Geboes K, Ng MCH, Lum JHY, Leow WQ, Selvarajan S, Hoorens A, Ang WH, Pang H, Tan P, Yong WP, Chia CSL, Ceelen W, So JBY
ESMO Open 2024 Sep;9(9):103681. Epub 2024 Sep 16 doi: 10.1016/j.esmoop.2024.103681. PMID: 39288528Free PMC Article
Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma.
Huang L, Zhou Y, Sun Q, Cao L, Zhang X
Cancer Biomark 2022;33(1):123-129. doi: 10.3233/CBM-210178. PMID: 34459388
Gastric GIST and prognostic models. Which is the best to predict survival after surgery?
Di Vita M, Zanghì A, Cavallaro A, Cardì F, Uhlig M, Ursi P, Lo Menzo E, Panebianco V, Cappellani A
Ann Ital Chir 2019;90:31-40. PMID: 30942768
Long-Term Surgical Outcome of 1057 Gastric GISTs According to 7th UICC/AJCC TNM System: Multicenter Observational Study From Korea and Japan.
Kim MC, Yook JH, Yang HK, Lee HJ, Sohn TS, Hyung WJ, Ryu SW, Kurokawa Y, Kim YW, Han SU, Kim HH, Park DJ, Kim W, Lee SI, Cho H, Cho GS, Kim JJ, Kim KH, Yoo MW
Medicine (Baltimore) 2015 Oct;94(41):e1526. doi: 10.1097/MD.0000000000001526. PMID: 26469894Free PMC Article

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