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Pancreatic Serous Adenoma

MedGen UID:
459395
•Concept ID:
C2987169
•
Neoplastic Process

Definition

A benign, non-metastasizing, usually cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of glycogen-rich epithelial cells which produce a watery fluid. Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss. [from NCI]

Professional guidelines

PubMed

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Pancreatic Cystic Lesions: Diagnostic, Management and Indications for Operation. Part I.
Bauer F
Chirurgia (Bucur) 2017 Mar-Apr;112(2):97-109. doi: 10.21614/chirurgia.112.2.97. PMID: 28463669
Diagnosis and Management of Pancreatic Cystic Neoplasms.
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903

Recent clinical studies

Etiology

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
Clin Cancer Res 2024 May 1;30(9):1750-1757. doi: 10.1158/1078-0432.CCR-23-2592. PMID: 38393723Free PMC Article
Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Rare pancreatic masses: a pictorial review of radiological concepts.
Bezerra ROF, Machado MC, Dos Santos Mota MM, Ezzedine TA, Siqueira LTB, Cerri GG
Clin Imaging 2018 Jul-Aug;50:314-323. Epub 2018 May 4 doi: 10.1016/j.clinimag.2018.05.004. PMID: 29751204
DNA testing of pancreatic cyst fluid: is it ready for prime time?
Singhi AD, Nikiforova MN, McGrath K
Lancet Gastroenterol Hepatol 2017 Jan;2(1):63-72. Epub 2016 Dec 10 doi: 10.1016/S2468-1253(16)30084-X. PMID: 28404017
Cystic Neoplasms of the Pancreas.
Chandwani R, Allen PJ
Annu Rev Med 2016;67:45-57. Epub 2015 Nov 6 doi: 10.1146/annurev-med-051914-022011. PMID: 26565675

Diagnosis

Imaging of pancreatic serous cystadenoma and common imitators.
Lopes Vendrami C, Hammond NA, Escobar DJ, Zilber Z, Dwyer M, Moreno CC, Mittal PK, Miller FH
Abdom Radiol (NY) 2024 Oct;49(10):3666-3685. Epub 2024 Jun 2 doi: 10.1007/s00261-024-04337-1. PMID: 38825609
Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Pancreatic Cystic Neoplasms: An Update.
Ketwaroo GA, Mortele KJ, Sawhney MS
Gastroenterol Clin North Am 2016 Mar;45(1):67-81. Epub 2016 Jan 13 doi: 10.1016/j.gtc.2015.10.006. PMID: 26895681
Diagnosis and Management of Pancreatic Cystic Neoplasms.
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Pancreatic cystic neoplasms.
Verbesey JE, Munson JL
Surg Clin North Am 2010 Apr;90(2):411-25. doi: 10.1016/j.suc.2009.12.006. PMID: 20362795

Therapy

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
Clin Cancer Res 2024 May 1;30(9):1750-1757. doi: 10.1158/1078-0432.CCR-23-2592. PMID: 38393723Free PMC Article
Radiomics Based on Contrast-Enhanced Ultrasound Images for Diagnosis of Pancreatic Serous Cystadenoma.
Zhang Y, Yao J, Liu F, Cheng Z, Qi E, Han Z, Yu J, Dou J, Liang P, Tan S, Dong X, Li X, Sun Y, Wang S, Wang Z, Yu X
Ultrasound Med Biol 2023 Dec;49(12):2469-2475. Epub 2023 Sep 24 doi: 10.1016/j.ultrasmedbio.2023.08.007. PMID: 37749013
Pancreatic serous cystadenoma with a positive octreotide scan.
Canakis A, Kesar V, Hardy N, Legesse TB, Darwin P
Gastrointest Endosc 2022 Jun;95(6):1269-1270. Epub 2022 Feb 2 doi: 10.1016/j.gie.2022.01.022. PMID: 35122809
Spleen-preserving distal pancreatectomy.
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554
Central pancreatectomy revisited.
Roggin KK, Rudloff U, Blumgart LH, Brennan MF
J Gastrointest Surg 2006 Jun;10(6):804-12. doi: 10.1016/j.gassur.2005.11.012. PMID: 16769536

Prognosis

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Molecular Diagnosis of Cystic Neoplasms of the Pancreas: a Review.
Chen JC, Beal EW, Pawlik TM, Cloyd J, Dillhoff ME
J Gastrointest Surg 2020 May;24(5):1201-1214. Epub 2020 Mar 3 doi: 10.1007/s11605-020-04537-2. PMID: 32128679
DNA testing of pancreatic cyst fluid: is it ready for prime time?
Singhi AD, Nikiforova MN, McGrath K
Lancet Gastroenterol Hepatol 2017 Jan;2(1):63-72. Epub 2016 Dec 10 doi: 10.1016/S2468-1253(16)30084-X. PMID: 28404017
Management of serous cystic neoplasms of the pancreas.
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Management of pancreatic serous cystadenomas.
Wargo JA, Fernandez-del-Castillo C, Warshaw AL
Adv Surg 2009;43:23-34. doi: 10.1016/j.yasu.2009.03.001. PMID: 19845167

Clinical prediction guides

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Molecular Diagnosis of Cystic Neoplasms of the Pancreas: a Review.
Chen JC, Beal EW, Pawlik TM, Cloyd J, Dillhoff ME
J Gastrointest Surg 2020 May;24(5):1201-1214. Epub 2020 Mar 3 doi: 10.1007/s11605-020-04537-2. PMID: 32128679
Pancreatic Cystic Lesions: Diagnostic, Management and Indications for Operation. Part I.
Bauer F
Chirurgia (Bucur) 2017 Mar-Apr;112(2):97-109. doi: 10.21614/chirurgia.112.2.97. PMID: 28463669
Management of serous cystic neoplasms of the pancreas.
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Spleen-preserving distal pancreatectomy.
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554

Recent systematic reviews

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Pancreatic lesions in von Hippel-Lindau disease? A systematic review and meta-synthesis of the literature.
Charlesworth M, Verbeke CS, Falk GA, Walsh M, Smith AM, Morris-Stiff G
J Gastrointest Surg 2012 Jul;16(7):1422-8. Epub 2012 Feb 28 doi: 10.1007/s11605-012-1847-0. PMID: 22370733

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