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Pancreatic Serous Adenoma

MedGen UID:
459395
Concept ID:
C2987169
Neoplastic Process

Definition

A benign, non-metastasizing, usually cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of glycogen-rich epithelial cells which produce a watery fluid. Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss. [from NCI]

Professional guidelines

PubMed

Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Al-Haddad M, Schmidt MC, Sandrasegaran K, Dewitt J
Clin Gastroenterol Hepatol 2011 Aug;9(8):635-48. Epub 2011 Mar 11 doi: 10.1016/j.cgh.2011.03.005. PMID: 21397725

Recent clinical studies

Etiology

Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Singhi AD, Nikiforova MN, McGrath K
Lancet Gastroenterol Hepatol 2017 Jan;2(1):63-72. Epub 2016 Dec 10 doi: 10.1016/S2468-1253(16)30084-X. PMID: 28404017
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554

Diagnosis

Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Ketwaroo GA, Mortele KJ, Sawhney MS
Gastroenterol Clin North Am 2016 Mar;45(1):67-81. Epub 2016 Jan 13 doi: 10.1016/j.gtc.2015.10.006. PMID: 26895681
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Scoazec JY, Vullierme MP, Barthet M, Gonzalez JM, Sauvanet A
J Visc Surg 2013 Apr;150(2):69-84. Epub 2013 Mar 19 doi: 10.1016/j.jviscsurg.2013.02.003. PMID: 23518192
Al-Haddad M, Schmidt MC, Sandrasegaran K, Dewitt J
Clin Gastroenterol Hepatol 2011 Aug;9(8):635-48. Epub 2011 Mar 11 doi: 10.1016/j.cgh.2011.03.005. PMID: 21397725

Therapy

Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
Clin Cancer Res 2024 May 1;30(9):1750-1757. doi: 10.1158/1078-0432.CCR-23-2592. PMID: 38393723Free PMC Article
Zhang Y, Yao J, Liu F, Cheng Z, Qi E, Han Z, Yu J, Dou J, Liang P, Tan S, Dong X, Li X, Sun Y, Wang S, Wang Z, Yu X
Ultrasound Med Biol 2023 Dec;49(12):2469-2475. Epub 2023 Sep 24 doi: 10.1016/j.ultrasmedbio.2023.08.007. PMID: 37749013
Canakis A, Kesar V, Hardy N, Legesse TB, Darwin P
Gastrointest Endosc 2022 Jun;95(6):1269-1270. Epub 2022 Feb 2 doi: 10.1016/j.gie.2022.01.022. PMID: 35122809
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554
Roggin KK, Rudloff U, Blumgart LH, Brennan MF
J Gastrointest Surg 2006 Jun;10(6):804-12. doi: 10.1016/j.gassur.2005.11.012. PMID: 16769536

Prognosis

Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Chen JC, Beal EW, Pawlik TM, Cloyd J, Dillhoff ME
J Gastrointest Surg 2020 May;24(5):1201-1214. Epub 2020 Mar 3 doi: 10.1007/s11605-020-04537-2. PMID: 32128679
Singhi AD, Nikiforova MN, McGrath K
Lancet Gastroenterol Hepatol 2017 Jan;2(1):63-72. Epub 2016 Dec 10 doi: 10.1016/S2468-1253(16)30084-X. PMID: 28404017
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Wargo JA, Fernandez-del-Castillo C, Warshaw AL
Adv Surg 2009;43:23-34. doi: 10.1016/j.yasu.2009.03.001. PMID: 19845167

Clinical prediction guides

Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Chen JC, Beal EW, Pawlik TM, Cloyd J, Dillhoff ME
J Gastrointest Surg 2020 May;24(5):1201-1214. Epub 2020 Mar 3 doi: 10.1007/s11605-020-04537-2. PMID: 32128679
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554

Recent systematic reviews

Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Charlesworth M, Verbeke CS, Falk GA, Walsh M, Smith AM, Morris-Stiff G
J Gastrointest Surg 2012 Jul;16(7):1422-8. Epub 2012 Feb 28 doi: 10.1007/s11605-012-1847-0. PMID: 22370733

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