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Pancreatic Serous Adenoma

MedGen UID:
459395
•Concept ID:
C2987169
•
Neoplastic Process

Definition

A benign, non-metastasizing, usually cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of glycogen-rich epithelial cells which produce a watery fluid. Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss. [from NCI]

Professional guidelines

PubMed

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Diagnosis and Management of Pancreatic Cystic Neoplasms.
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Diagnosis and treatment of cystic pancreatic tumors.
Al-Haddad M, Schmidt MC, Sandrasegaran K, Dewitt J
Clin Gastroenterol Hepatol 2011 Aug;9(8):635-48. Epub 2011 Mar 11 doi: 10.1016/j.cgh.2011.03.005. PMID: 21397725

Recent clinical studies

Etiology

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
Clin Cancer Res 2024 May 1;30(9):1750-1757. doi: 10.1158/1078-0432.CCR-23-2592. PMID: 38393723Free PMC Article
Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Cystic Neoplasms of the Pancreas.
Chandwani R, Allen PJ
Annu Rev Med 2016;67:45-57. Epub 2015 Nov 6 doi: 10.1146/annurev-med-051914-022011. PMID: 26565675
Diagnosis and Management of Pancreatic Cystic Neoplasms.
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Management of serous cystic neoplasms of the pancreas.
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593

Diagnosis

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
The many faces of pancreatic serous cystadenoma: Radiologic and pathologic correlation.
Chu LC, Singhi AD, Haroun RR, Hruban RH, Fishman EK
Diagn Interv Imaging 2017 Mar;98(3):191-202. Epub 2016 Sep 7 doi: 10.1016/j.diii.2016.08.005. PMID: 27614585
Pancreatic Cystic Neoplasms: An Update.
Ketwaroo GA, Mortele KJ, Sawhney MS
Gastroenterol Clin North Am 2016 Mar;45(1):67-81. Epub 2016 Jan 13 doi: 10.1016/j.gtc.2015.10.006. PMID: 26895681
Diagnosis and Management of Pancreatic Cystic Neoplasms.
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Pancreatic neoplasms.
Levy MJ, Wiersema MJ
Gastrointest Endosc Clin N Am 2005 Jan;15(1):117-42, x. doi: 10.1016/j.giec.2004.07.014. PMID: 15555956

Therapy

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
Clin Cancer Res 2024 May 1;30(9):1750-1757. doi: 10.1158/1078-0432.CCR-23-2592. PMID: 38393723Free PMC Article
Pancreatic serous cystadenoma with a positive octreotide scan.
Canakis A, Kesar V, Hardy N, Legesse TB, Darwin P
Gastrointest Endosc 2022 Jun;95(6):1269-1270. Epub 2022 Feb 2 doi: 10.1016/j.gie.2022.01.022. PMID: 35122809
Pancreatic tuberculosis masquerading as pancreatic serous cystadenoma.
Hong SG, Kim JS, Joo MK, Lee KG, Kim KH, Oh CR, Park JJ, Bak YT
World J Gastroenterol 2009 Feb 28;15(8):1010-3. doi: 10.3748/wjg.15.1010. PMID: 19248204Free PMC Article
Spleen-preserving distal pancreatectomy.
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554
Central pancreatectomy revisited.
Roggin KK, Rudloff U, Blumgart LH, Brennan MF
J Gastrointest Surg 2006 Jun;10(6):804-12. doi: 10.1016/j.gassur.2005.11.012. PMID: 16769536

Prognosis

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
DNA testing of pancreatic cyst fluid: is it ready for prime time?
Singhi AD, Nikiforova MN, McGrath K
Lancet Gastroenterol Hepatol 2017 Jan;2(1):63-72. Epub 2016 Dec 10 doi: 10.1016/S2468-1253(16)30084-X. PMID: 28404017
Management of serous cystic neoplasms of the pancreas.
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Primary pancreatic cystic neoplasms revisited. Part I: serous cystic neoplasms.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG
Surg Oncol 2011 Jun;20(2):e84-92. Epub 2011 Jan 14 doi: 10.1016/j.suronc.2010.12.002. PMID: 21237638
Management of pancreatic serous cystadenomas.
Wargo JA, Fernandez-del-Castillo C, Warshaw AL
Adv Surg 2009;43:23-34. doi: 10.1016/j.yasu.2009.03.001. PMID: 19845167

Clinical prediction guides

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts.
Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, Brand RE, Khalid A, Kubiliun N, O'Broin-Lennon AM, Park WG, Klapman J, Tharian B, Inamdar S, Fasanella K, Nasr J, Chennat J, Das R, DeWitt J, Easler JJ, Bick B, Singh H, Fairley KJ, Sarkaria S, Sawas T, Skef W, Slivka A, Tavakkoli A, Thakkar S, Kim V, Vanderveldt HD, Richardson A, Wallace MB, Brahmbhatt B, Engels M, Gabbert C, Dugum M, El-Dika S, Bhat Y, Ramrakhiani S, Bakis G, Rolshud D, Millspaugh G, Tielleman T, Schmidt C, Mansour J, Marsh W, Ongchin M, Centeno B, Monaco SE, Ohori NP, Lajara S, Thompson ED, Hruban RH, Bell PD, Smith K, Permuth JB, Vandenbussche C, Ernst W, Grupillo M, Kaya C, Hogg M, He J, Wolfgang CL, Lee KK, Zeh H, Zureikat A, Nikiforova MN, Singhi AD
Gastroenterology 2023 Jan;164(1):117-133.e7. Epub 2022 Oct 6 doi: 10.1053/j.gastro.2022.09.028. PMID: 36209796Free PMC Article
Molecular Diagnosis of Cystic Neoplasms of the Pancreas: a Review.
Chen JC, Beal EW, Pawlik TM, Cloyd J, Dillhoff ME
J Gastrointest Surg 2020 May;24(5):1201-1214. Epub 2020 Mar 3 doi: 10.1007/s11605-020-04537-2. PMID: 32128679
Diagnosis and Management of Pancreatic Cystic Neoplasms.
Kim TS, Fernandez-del Castillo C
Hematol Oncol Clin North Am 2015 Aug;29(4):655-74. Epub 2015 Jun 6 doi: 10.1016/j.hoc.2015.04.002. PMID: 26226903
Management of serous cystic neoplasms of the pancreas.
Antonini F, Fuccio L, Fabbri C, Macarri G, Palazzo L
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):115-25. Epub 2014 Jul 1 doi: 10.1586/17474124.2014.934675. PMID: 24981593
Spleen-preserving distal pancreatectomy.
Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL
Singapore Med J 2008 Nov;49(11):883-5. PMID: 19037554

Recent systematic reviews

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Pancreatic lesions in von Hippel-Lindau disease? A systematic review and meta-synthesis of the literature.
Charlesworth M, Verbeke CS, Falk GA, Walsh M, Smith AM, Morris-Stiff G
J Gastrointest Surg 2012 Jul;16(7):1422-8. Epub 2012 Feb 28 doi: 10.1007/s11605-012-1847-0. PMID: 22370733

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