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Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

MedGen UID:
459417
•Concept ID:
C2987191
•
Neoplastic Process

Definition

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that are similar to gastric foveolar epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

Professional guidelines

PubMed

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Clinical implication of morphological subtypes in management of intraductal papillary mucinous neoplasm.
Yamada S, Fujii T, Shimoyama Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y
Ann Surg Oncol 2014 Jul;21(7):2444-52. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3565-1. PMID: 24562937
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article

Recent clinical studies

Etiology

Comparative clinicopathological study of biliary intraductal papillary neoplasms and papillary cholangiocarcinomas.
Fujikura K, Fukumoto T, Ajiki T, Otani K, Kanzawa M, Akita M, Kido M, Ku Y, Itoh T, Zen Y
Histopathology 2016 Dec;69(6):950-961. Epub 2016 Sep 23 doi: 10.1111/his.13037. PMID: 27410028
Intraductal tubular neoplasms of the pancreas: an overview.
Chelliah A, Kalimuthu S, Chetty R
Ann Diagn Pathol 2016 Oct;24:68-72. Epub 2016 Apr 26 doi: 10.1016/j.anndiagpath.2016.04.009. PMID: 27185640
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article

Diagnosis

Tumoral Intraductal Neoplasms of the Bile Ducts Comprise Morphologically and Genetically Distinct Entities.
Wang T, Askan G, Ozcan K, Rana S, Zehir A, Bhanot UK, Yantiss RK, Rao DS, Wahl SJ, Bagci P, Balci S, Balachandran V, Jarnagin WR, Adsay NV, Klimstra DS, Basturk O
Arch Pathol Lab Med 2023 Dec 1;147(12):1390-1401. doi: 10.5858/arpa.2022-0343-OA. PMID: 36821179
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.
Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article

Therapy

Malignant transformation and overall survival of morphological subtypes of intraductal papillary mucinous neoplasms of the pancreas: A network meta-analysis.
Qi X, Zhao X, Su J, Xu M, Zhang W, Sheng H, Li Z, Wang J
Eur J Intern Med 2015 Oct;26(8):652-7. Epub 2015 Aug 12 doi: 10.1016/j.ejim.2015.07.016. PMID: 26275457
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Sessa F, Solcia E, Capella C, Bonato M, Scarpa A, Zamboni G, Pellegata NS, Ranzani GN, Rickaert F, Klöppel G
Virchows Arch 1994;425(4):357-67. doi: 10.1007/BF00189573. PMID: 7820300

Prognosis

Expression of PD-L1 and VISTA in Intraductal Papillary Mucinous Neoplasm With Associated Invasive Carcinoma of the Pancreas.
Mo S, Zou L, Hu Y, Chang X, Chen J
Mod Pathol 2023 Sep;36(9):100223. Epub 2023 May 25 doi: 10.1016/j.modpat.2023.100223. PMID: 37244388
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.
Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article

Clinical prediction guides

Expression of PD-L1 and VISTA in Intraductal Papillary Mucinous Neoplasm With Associated Invasive Carcinoma of the Pancreas.
Mo S, Zou L, Hu Y, Chang X, Chen J
Mod Pathol 2023 Sep;36(9):100223. Epub 2023 May 25 doi: 10.1016/j.modpat.2023.100223. PMID: 37244388
Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas.
Kobayashi T, Omori Y, Ono Y, Karasaki H, Mizukami Y, Makino N, Motoi F, Unno M, Ueno Y, Furukawa T
J Gastroenterol 2021 Jun;56(6):581-592. Epub 2021 Apr 1 doi: 10.1007/s00535-021-01783-2. PMID: 33796937
Biliary intraductal tubule-forming neoplasm: a whole exome sequencing study of MUC5AC-positive and -negative cases.
Akita M, Hong SM, Sung YN, Kim MJ, Ajiki T, Fukumoto T, Itoh T, Zen Y
Histopathology 2020 Jun;76(7):1005-1012. Epub 2020 May 15 doi: 10.1111/his.14103. PMID: 32181510
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.
Hirabayashi K, Zamboni G, Ito H, Ogawa M, Kawaguchi Y, Yamashita T, Nakagohri T, Nakamura N
World J Gastroenterol 2013 Jun 7;19(21):3358-63. doi: 10.3748/wjg.v19.i21.3358. PMID: 23745041Free PMC Article

Recent systematic reviews

Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.
Milanetto AC, Tonello AS, Valotto G, Munari G, Luchini C, Fassan M, Pasquali C
Virchows Arch 2021 Jul;479(1):179-189. Epub 2021 Jan 28 doi: 10.1007/s00428-021-03029-1. PMID: 33511431Free PMC Article

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