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Esophageal Basal Cell Hyperplasia

MedGen UID:
459479
•Concept ID:
C2987253
•
Pathologic Function

Definition

A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation. Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium. Its association with an increase risk of developing squamous cell carcinoma remains controversial. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Basal Cell Hyperplasia

Professional guidelines

PubMed

Autoantibody detection to tumor-associated antigens of P53, IMP1, P16, cyclin B1, P62, C-myc, Survivn, and Koc for the screening of high-risk subjects and early detection of esophageal squamous cell carcinoma.
Zhou SL, Yue WB, Fan ZM, Du F, Liu BC, Li B, Han XN, Ku JW, Zhao XK, Zhang P, Cui J, Zhou FY, Zhang LQ, Fan XP, Zhou YF, Zhu LL, Liu HY, Wang LD
Dis Esophagus 2014 Nov-Dec;27(8):790-7. Epub 2013 Oct 21 doi: 10.1111/dote.12145. PMID: 24147952

Recent clinical studies

Etiology

CD73(+) Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis.
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature.
Nie L, Wu HY, Shen YH, Fan XS, Sun Q, Huang Q, Chen J
Dis Esophagus 2016 Nov;29(8):1048-1053. Epub 2015 Nov 6 doi: 10.1111/dote.12442. PMID: 26542981
What is the role of endoscopy and oesophageal biopsies in the management of GERD?
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
Precancerous lesions and biologic markers in esophageal cancer.
Mufti SI, Zirvi KA, Garewal HS
Cancer Detect Prev 1991;15(4):291-301. PMID: 1794136

Diagnosis

Machine learning-based identification and characterization of mast cells in eosinophilic esophagitis.
Zhang S, Caldwell JM, Rochman M, Collins MH, Rothenberg ME
J Allergy Clin Immunol 2024 May;153(5):1381-1391.e6. Epub 2024 Feb 22 doi: 10.1016/j.jaci.2024.01.026. PMID: 38395083Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Remodeling and fibrosis in chronic eosinophil inflammation.
Aceves SS
Dig Dis 2014;32(1-2):15-21. Epub 2014 Feb 28 doi: 10.1159/000357004. PMID: 24603375Free PMC Article
Eosinophilic oesophagitis versus reflux oesophagitis.
Ensari A
Acta Gastroenterol Belg 2011 Jun;74(2):323-9. PMID: 21861318
Precancerous lesions and biologic markers in esophageal cancer.
Mufti SI, Zirvi KA, Garewal HS
Cancer Detect Prev 1991;15(4):291-301. PMID: 1794136

Therapy

Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis.
Yadavalli CS, Upparahalli Venkateshaiah S, Kumar S, Kandikattu HK, Oruganti L, Kathera CS, Mishra A
Commun Biol 2023 Jul 31;6(1):763. doi: 10.1038/s42003-023-05130-4. PMID: 37524769Free PMC Article
CD73(+) Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis.
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy.
Beppu L, Yang T, Luk M, Newbury RO, Palmquist J, Dohil R, Kurten RC, Broide DH, Aceves SS
J Pediatr Gastroenterol Nutr 2015 Aug;61(2):194-9. doi: 10.1097/MPG.0000000000000668. PMID: 25539192Free PMC Article
The value of esophageal histology in the diagnosis of gastroesophageal reflux disease in patients with heartburn and normal endoscopy.
Tytgat GN
Curr Gastroenterol Rep 2008 Jun;10(3):231-4. doi: 10.1007/s11894-008-0048-1. PMID: 18625131

Prognosis

Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Novel Insights Into Tissue-Specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy.
Hiremath G, Locke A, Thomas G, Gautam R, Acra S, Correa H, Dellon ES, Mahadevan-Jansen A
Clin Transl Gastroenterol 2020 Jul;11(7):e00195. doi: 10.14309/ctg.0000000000000195. PMID: 32764208Free PMC Article
Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis.
Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H
Clin Gastroenterol Hepatol 2020 Jun;18(7):1475-1482.e1. Epub 2019 Sep 6 doi: 10.1016/j.cgh.2019.08.055. PMID: 31499251Free PMC Article
Toll-like receptor 9 is a novel biomarker for esophageal squamous cell dysplasia and squamous cell carcinoma progression.
Takala H, Kauppila JH, Soini Y, Selander KS, Vuopala KS, Lehenkari PP, Saarnio J, Karttunen TJ
J Innate Immun 2011;3(6):631-8. Epub 2011 Aug 29 doi: 10.1159/000329115. PMID: 21876325
Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus.
Li H, Diao TY, Zhou ZY, Yang FY, Ma Q, Li QH
J Exp Clin Cancer Res 2009 Nov 25;28(1):145. doi: 10.1186/1756-9966-28-145. PMID: 19939248Free PMC Article

Clinical prediction guides

Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.
Masuda MY, Pyon GC, Luo H, LeSuer WE, Putikova A, Dao A, Ortiz DR, Schulze AR, Fritz N, Kobayashi T, Iijima K, Klein-Szanto AJ, Shimonosono M, Flashner S, Morimoto M, Pai RK, Rank MA, Nakagawa H, Kita H, Wright BL, Doyle AD
J Allergy Clin Immunol 2024 May;153(5):1355-1368. Epub 2024 Feb 3 doi: 10.1016/j.jaci.2024.01.017. PMID: 38310974Free PMC Article
Suprabasal cells retain progenitor cell identity programs in eosinophilic esophagitis-driven basal cell hyperplasia.
Clevenger MH, Karami AL, Carlson DA, Kahrilas PJ, Gonsalves N, Pandolfino JE, Winter DR, Whelan KA, Tétreault MP
JCI Insight 2023 Oct 9;8(19) doi: 10.1172/jci.insight.171765. PMID: 37672481Free PMC Article
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus.
Li H, Diao TY, Zhou ZY, Yang FY, Ma Q, Li QH
J Exp Clin Cancer Res 2009 Nov 25;28(1):145. doi: 10.1186/1756-9966-28-145. PMID: 19939248Free PMC Article

Recent systematic reviews

The role of histology in the diagnosis of non-erosive reflux disease: A systematic review and meta-analysis.
Kataria J, Rivera D, Grin A, Reed DE, Rodrigues DM
Neurogastroenterol Motil 2023 Dec;35(12):e14631. Epub 2023 Jul 13 doi: 10.1111/nmo.14631. PMID: 37448170

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