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Esophageal Basal Cell Hyperplasia

MedGen UID:
459479
•Concept ID:
C2987253
•
Pathologic Function

Definition

A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation. Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium. Its association with an increase risk of developing squamous cell carcinoma remains controversial. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Basal Cell Hyperplasia

Professional guidelines

PubMed

Autoantibody detection to tumor-associated antigens of P53, IMP1, P16, cyclin B1, P62, C-myc, Survivn, and Koc for the screening of high-risk subjects and early detection of esophageal squamous cell carcinoma.
Zhou SL, Yue WB, Fan ZM, Du F, Liu BC, Li B, Han XN, Ku JW, Zhao XK, Zhang P, Cui J, Zhou FY, Zhang LQ, Fan XP, Zhou YF, Zhu LL, Liu HY, Wang LD
Dis Esophagus 2014 Nov-Dec;27(8):790-7. Epub 2013 Oct 21 doi: 10.1111/dote.12145. PMID: 24147952

Recent clinical studies

Etiology

Mucosal color changes on narrow-band imaging in esophageal eosinophilic infiltration.
Suda T, Shirota Y, Hodo Y, Sato K, Wakabayashi T
Medicine (Baltimore) 2022 Sep 23;101(38):e29891. doi: 10.1097/MD.0000000000029891. PMID: 36197201Free PMC Article
CD73(+) Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis.
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature.
Nie L, Wu HY, Shen YH, Fan XS, Sun Q, Huang Q, Chen J
Dis Esophagus 2016 Nov;29(8):1048-1053. Epub 2015 Nov 6 doi: 10.1111/dote.12442. PMID: 26542981
What is the role of endoscopy and oesophageal biopsies in the management of GERD?
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976

Diagnosis

Machine learning-based identification and characterization of mast cells in eosinophilic esophagitis.
Zhang S, Caldwell JM, Rochman M, Collins MH, Rothenberg ME
J Allergy Clin Immunol 2024 May;153(5):1381-1391.e6. Epub 2024 Feb 22 doi: 10.1016/j.jaci.2024.01.026. PMID: 38395083Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Remodeling and fibrosis in chronic eosinophil inflammation.
Aceves SS
Dig Dis 2014;32(1-2):15-21. Epub 2014 Feb 28 doi: 10.1159/000357004. PMID: 24603375Free PMC Article
What is the role of endoscopy and oesophageal biopsies in the management of GERD?
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
Eosinophilic oesophagitis versus reflux oesophagitis.
Ensari A
Acta Gastroenterol Belg 2011 Jun;74(2):323-9. PMID: 21861318

Therapy

Effect of Proton Pump Inhibitor Treatment in "PPI Non-responsive" Patients with Eosinophilic Esophagitis.
Thakkar KP, Philpott H, Lafata S, Fowler M, Keene S, Iuga A, Dellon E
J Gastrointestin Liver Dis 2023 Mar 31;32(1):15-22. doi: 10.15403/jgld-4746. PMID: 37004219Free PMC Article
CD73(+) Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis.
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy.
Beppu L, Yang T, Luk M, Newbury RO, Palmquist J, Dohil R, Kurten RC, Broide DH, Aceves SS
J Pediatr Gastroenterol Nutr 2015 Aug;61(2):194-9. doi: 10.1097/MPG.0000000000000668. PMID: 25539192Free PMC Article

Prognosis

Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis.
Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES
Am J Gastroenterol 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022Free PMC Article
Association of Incidental Positron Emission Tomography Uptake in the Esophagus to Gastroesophageal Reflux Disease.
Kamboj AK, Agarwal S, Carroll EF, Young JR, Katzka DA
Clin Gastroenterol Hepatol 2022 Nov;20(11):2644-2646.e1. Epub 2021 Sep 3 doi: 10.1016/j.cgh.2021.08.044. PMID: 34481958
Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Correlation of endoscopic signs and mucosal alterations in children with eosinophilic esophagitis.
Hiremath G, Correa H, Acra S, Dellon ES
Gastrointest Endosc 2020 Apr;91(4):785-794.e1. Epub 2019 Nov 28 doi: 10.1016/j.gie.2019.11.031. PMID: 31785273
Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis.
Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H
Clin Gastroenterol Hepatol 2020 Jun;18(7):1475-1482.e1. Epub 2019 Sep 6 doi: 10.1016/j.cgh.2019.08.055. PMID: 31499251Free PMC Article

Clinical prediction guides

Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.
Masuda MY, Pyon GC, Luo H, LeSuer WE, Putikova A, Dao A, Ortiz DR, Schulze AR, Fritz N, Kobayashi T, Iijima K, Klein-Szanto AJ, Shimonosono M, Flashner S, Morimoto M, Pai RK, Rank MA, Nakagawa H, Kita H, Wright BL, Doyle AD
J Allergy Clin Immunol 2024 May;153(5):1355-1368. Epub 2024 Feb 3 doi: 10.1016/j.jaci.2024.01.017. PMID: 38310974Free PMC Article
Suprabasal cells retain progenitor cell identity programs in eosinophilic esophagitis-driven basal cell hyperplasia.
Clevenger MH, Karami AL, Carlson DA, Kahrilas PJ, Gonsalves N, Pandolfino JE, Winter DR, Whelan KA, Tétreault MP
JCI Insight 2023 Oct 9;8(19) doi: 10.1172/jci.insight.171765. PMID: 37672481Free PMC Article
Mucosal color changes on narrow-band imaging in esophageal eosinophilic infiltration.
Suda T, Shirota Y, Hodo Y, Sato K, Wakabayashi T
Medicine (Baltimore) 2022 Sep 23;101(38):e29891. doi: 10.1097/MD.0000000000029891. PMID: 36197201Free PMC Article
Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis.
Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES
Am J Gastroenterol 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article

Recent systematic reviews

The role of histology in the diagnosis of non-erosive reflux disease: A systematic review and meta-analysis.
Kataria J, Rivera D, Grin A, Reed DE, Rodrigues DM
Neurogastroenterol Motil 2023 Dec;35(12):e14631. Epub 2023 Jul 13 doi: 10.1111/nmo.14631. PMID: 37448170

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