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Esophageal Basal Cell Hyperplasia

MedGen UID:
459479
•Concept ID:
C2987253
•
Pathologic Function

Definition

A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation. Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium. Its association with an increase risk of developing squamous cell carcinoma remains controversial. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Basal Cell Hyperplasia

Professional guidelines

PubMed

Autoantibody detection to tumor-associated antigens of P53, IMP1, P16, cyclin B1, P62, C-myc, Survivn, and Koc for the screening of high-risk subjects and early detection of esophageal squamous cell carcinoma.
Zhou SL, Yue WB, Fan ZM, Du F, Liu BC, Li B, Han XN, Ku JW, Zhao XK, Zhang P, Cui J, Zhou FY, Zhang LQ, Fan XP, Zhou YF, Zhu LL, Liu HY, Wang LD
Dis Esophagus 2014 Nov-Dec;27(8):790-7. Epub 2013 Oct 21 doi: 10.1111/dote.12145. PMID: 24147952

Recent clinical studies

Etiology

Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature.
Nie L, Wu HY, Shen YH, Fan XS, Sun Q, Huang Q, Chen J
Dis Esophagus 2016 Nov;29(8):1048-1053. Epub 2015 Nov 6 doi: 10.1111/dote.12442. PMID: 26542981
What is the role of endoscopy and oesophageal biopsies in the management of GERD?
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
Development of consensus guidelines for the histologic recognition of microscopic esophagitis in patients with gastroesophageal reflux disease: the Esohisto project.
Fiocca R, Mastracci L, Riddell R, Takubo K, Vieth M, Yerian L, Sharma P, Fernström P, Ruth M
Hum Pathol 2010 Feb;41(2):223-31. Epub 2009 Oct 1 doi: 10.1016/j.humpath.2009.07.016. PMID: 19800099
Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus.
Li H, Diao TY, Zhou ZY, Yang FY, Ma Q, Li QH
J Exp Clin Cancer Res 2009 Nov 25;28(1):145. doi: 10.1186/1756-9966-28-145. PMID: 19939248Free PMC Article
Severity of basal cell hyperplasia differs in reflux versus eosinophilic esophagitis.
Steiner SJ, Kernek KM, Fitzgerald JF
J Pediatr Gastroenterol Nutr 2006 May;42(5):506-9. doi: 10.1097/01.mpg.0000221906.06899.1b. PMID: 16707971

Diagnosis

Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature.
Nie L, Wu HY, Shen YH, Fan XS, Sun Q, Huang Q, Chen J
Dis Esophagus 2016 Nov;29(8):1048-1053. Epub 2015 Nov 6 doi: 10.1111/dote.12442. PMID: 26542981
Remodeling and fibrosis in chronic eosinophil inflammation.
Aceves SS
Dig Dis 2014;32(1-2):15-21. Epub 2014 Feb 28 doi: 10.1159/000357004. PMID: 24603375Free PMC Article
What is the role of endoscopy and oesophageal biopsies in the management of GERD?
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
Eosinophilic oesophagitis versus reflux oesophagitis.
Ensari A
Acta Gastroenterol Belg 2011 Jun;74(2):323-9. PMID: 21861318
The value of esophageal histology in the diagnosis of gastroesophageal reflux disease in patients with heartburn and normal endoscopy.
Tytgat GN
Curr Gastroenterol Rep 2008 Jun;10(3):231-4. doi: 10.1007/s11894-008-0048-1. PMID: 18625131

Therapy

Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy.
Beppu L, Yang T, Luk M, Newbury RO, Palmquist J, Dohil R, Kurten RC, Broide DH, Aceves SS
J Pediatr Gastroenterol Nutr 2015 Aug;61(2):194-9. doi: 10.1097/MPG.0000000000000668. PMID: 25539192Free PMC Article
Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis.
Zayachkivska O, Havryluk O, Hrycevych N, Bula N, Grushka O, Wallace JL
PLoS One 2014;9(10):e110688. Epub 2014 Oct 21 doi: 10.1371/journal.pone.0110688. PMID: 25333941Free PMC Article
The value of esophageal histology in the diagnosis of gastroesophageal reflux disease in patients with heartburn and normal endoscopy.
Tytgat GN
Curr Gastroenterol Rep 2008 Jun;10(3):231-4. doi: 10.1007/s11894-008-0048-1. PMID: 18625131

Prognosis

Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis.
Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H
Clin Gastroenterol Hepatol 2020 Jun;18(7):1475-1482.e1. Epub 2019 Sep 6 doi: 10.1016/j.cgh.2019.08.055. PMID: 31499251Free PMC Article
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
Toll-like receptor 9 is a novel biomarker for esophageal squamous cell dysplasia and squamous cell carcinoma progression.
Takala H, Kauppila JH, Soini Y, Selander KS, Vuopala KS, Lehenkari PP, Saarnio J, Karttunen TJ
J Innate Immun 2011;3(6):631-8. Epub 2011 Aug 29 doi: 10.1159/000329115. PMID: 21876325
Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus.
Li H, Diao TY, Zhou ZY, Yang FY, Ma Q, Li QH
J Exp Clin Cancer Res 2009 Nov 25;28(1):145. doi: 10.1186/1756-9966-28-145. PMID: 19939248Free PMC Article

Clinical prediction guides

Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
Endoscopic findings using narrow-band imaging to distinguish between basal cell hyperplasia and carcinoma of the pharynx.
Yagishita A, Fujii S, Yano T, Kaneko K
Cancer Sci 2014 Jul;105(7):857-61. Epub 2014 Jun 3 doi: 10.1111/cas.12440. PMID: 24815674Free PMC Article
Combining proteomics, serum biomarkers and bioinformatics to discriminate between esophageal squamous cell carcinoma and pre-cancerous lesion.
Zhai XH, Yu JK, Lin C, Wang LD, Zheng S
J Zhejiang Univ Sci B 2012 Dec;13(12):964-71. doi: 10.1631/jzus.B1200066. PMID: 23225851Free PMC Article
Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus.
Li H, Diao TY, Zhou ZY, Yang FY, Ma Q, Li QH
J Exp Clin Cancer Res 2009 Nov 25;28(1):145. doi: 10.1186/1756-9966-28-145. PMID: 19939248Free PMC Article

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