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Esophageal Basal Cell Hyperplasia

MedGen UID:
459479
Concept ID:
C2987253
Pathologic Function

Definition

A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation. Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium. Its association with an increase risk of developing squamous cell carcinoma remains controversial. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Basal Cell Hyperplasia

Professional guidelines

PubMed

Zhou SL, Yue WB, Fan ZM, Du F, Liu BC, Li B, Han XN, Ku JW, Zhao XK, Zhang P, Cui J, Zhou FY, Zhang LQ, Fan XP, Zhou YF, Zhu LL, Liu HY, Wang LD
Dis Esophagus 2014 Nov-Dec;27(8):790-7. Epub 2013 Oct 21 doi: 10.1111/dote.12145. PMID: 24147952

Recent clinical studies

Etiology

Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Nie L, Wu HY, Shen YH, Fan XS, Sun Q, Huang Q, Chen J
Dis Esophagus 2016 Nov;29(8):1048-1053. Epub 2015 Nov 6 doi: 10.1111/dote.12442. PMID: 26542981
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
Fiocca R, Mastracci L, Riddell R, Takubo K, Vieth M, Yerian L, Sharma P, Fernström P, Ruth M
Hum Pathol 2010 Feb;41(2):223-31. Epub 2009 Oct 1 doi: 10.1016/j.humpath.2009.07.016. PMID: 19800099

Diagnosis

Zhang S, Caldwell JM, Rochman M, Collins MH, Rothenberg ME
J Allergy Clin Immunol 2024 May;153(5):1381-1391.e6. Epub 2024 Feb 22 doi: 10.1016/j.jaci.2024.01.026. PMID: 38395083Free PMC Article
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Aceves SS
Dig Dis 2014;32(1-2):15-21. Epub 2014 Feb 28 doi: 10.1159/000357004. PMID: 24603375Free PMC Article
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
Ensari A
Acta Gastroenterol Belg 2011 Jun;74(2):323-9. PMID: 21861318

Therapy

Yadavalli CS, Upparahalli Venkateshaiah S, Kumar S, Kandikattu HK, Oruganti L, Kathera CS, Mishra A
Commun Biol 2023 Jul 31;6(1):763. doi: 10.1038/s42003-023-05130-4. PMID: 37524769Free PMC Article
Thakkar KP, Philpott H, Lafata S, Fowler M, Keene S, Iuga A, Dellon E
J Gastrointestin Liver Dis 2023 Mar 31;32(1):15-22. doi: 10.15403/jgld-4746. PMID: 37004219Free PMC Article
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910

Prognosis

Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES
Am J Gastroenterol 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022Free PMC Article
Kamboj AK, Agarwal S, Carroll EF, Young JR, Katzka DA
Clin Gastroenterol Hepatol 2022 Nov;20(11):2644-2646.e1. Epub 2021 Sep 3 doi: 10.1016/j.cgh.2021.08.044. PMID: 34481958
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H
Clin Gastroenterol Hepatol 2020 Jun;18(7):1475-1482.e1. Epub 2019 Sep 6 doi: 10.1016/j.cgh.2019.08.055. PMID: 31499251Free PMC Article
Li H, Diao TY, Zhou ZY, Yang FY, Ma Q, Li QH
J Exp Clin Cancer Res 2009 Nov 25;28(1):145. doi: 10.1186/1756-9966-28-145. PMID: 19939248Free PMC Article

Clinical prediction guides

Masuda MY, Pyon GC, Luo H, LeSuer WE, Putikova A, Dao A, Ortiz DR, Schulze AR, Fritz N, Kobayashi T, Iijima K, Klein-Szanto AJ, Shimonosono M, Flashner S, Morimoto M, Pai RK, Rank MA, Nakagawa H, Kita H, Wright BL, Doyle AD
J Allergy Clin Immunol 2024 May;153(5):1355-1368. Epub 2024 Feb 3 doi: 10.1016/j.jaci.2024.01.017. PMID: 38310974Free PMC Article
Clevenger MH, Karami AL, Carlson DA, Kahrilas PJ, Gonsalves N, Pandolfino JE, Winter DR, Whelan KA, Tétreault MP
JCI Insight 2023 Oct 9;8(19) doi: 10.1172/jci.insight.171765. PMID: 37672481Free PMC Article
Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES
Am J Gastroenterol 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022Free PMC Article
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article

Recent systematic reviews

Kataria J, Rivera D, Grin A, Reed DE, Rodrigues DM
Neurogastroenterol Motil 2023 Dec;35(12):e14631. Epub 2023 Jul 13 doi: 10.1111/nmo.14631. PMID: 37448170

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