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Esophageal Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
459490
•Concept ID:
C2987264
•
Neoplastic Process
Synonym: Esophageal MANEC

Definition

A carcinoma that arises from the esophagus and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Management of resectable esophageal and gastric (mixed adeno)neuroendocrine carcinoma: A nationwide cohort study.
van der Veen A, Seesing MFJ, Wijnhoven BPL, de Steur WO, van Berge Henegouwen MI, Rosman C, van Sandick JW, Mook S, Haj Mohammad N, Ruurda JP, Brosens LAA, van Hillegersberg R; (MA)NEC group
Eur J Surg Oncol 2018 Dec;44(12):1955-1962. Epub 2018 Aug 2 doi: 10.1016/j.ejso.2018.07.058. PMID: 30201419

Recent clinical studies

Etiology

THE PROGNOSIS OF THE DIFFERENT ESOPHAGEAL NEUROENDOCRINE CARCINOMA SUBTYPES: A POPULATION-BASED STUDY.
Tustumi F, Marques SSB, Barros EF, Henriques AC, Waisberg J, Dias AR
Arq Gastroenterol 2022 Jan-Mar;59(1):53-57. doi: 10.1590/S0004-2803.202200001-10. PMID: 35442337
Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.
Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z, Sun Y, Li Y, Zhou J, Wang X, Peng Z, Shen L, Lu M
Cancer Med 2021 Jul;10(14):4855-4863. Epub 2021 Jun 10 doi: 10.1002/cam4.4031. PMID: 34109756Free PMC Article
Management of resectable esophageal and gastric (mixed adeno)neuroendocrine carcinoma: A nationwide cohort study.
van der Veen A, Seesing MFJ, Wijnhoven BPL, de Steur WO, van Berge Henegouwen MI, Rosman C, van Sandick JW, Mook S, Haj Mohammad N, Ruurda JP, Brosens LAA, van Hillegersberg R; (MA)NEC group
Eur J Surg Oncol 2018 Dec;44(12):1955-1962. Epub 2018 Aug 2 doi: 10.1016/j.ejso.2018.07.058. PMID: 30201419
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity.
Sahnane N, Furlan D, Monti M, Romualdi C, Vanoli A, Vicari E, Solcia E, Capella C, Sessa F, La Rosa S
Endocr Relat Cancer 2015 Feb;22(1):35-45. Epub 2014 Dec 2 doi: 10.1530/ERC-14-0410. PMID: 25465415

Diagnosis

Mixed neuroendocrine-non-neuroendocrine neoplasm arising from long-segment Barrett's esophagus showing exceptionally aggressive clinical behavior.
Miyaguchi K, Kawasaki T, Tashima T, Ryozawa S
Cancer Rep (Hoboken) 2022 Sep;5(9):e1644. Epub 2022 Jul 8 doi: 10.1002/cnr2.1644. PMID: 35801304Free PMC Article
A Rare Case of Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gastroesophageal Junction with HER2/neu Overexpression and Distinct Orbital and Optic Nerve Toxicity after Intravenous Administration of Cisplatin.
Golombek T, Henker R, Rehak M, Quäschling U, Lordick F, Knödler M
Oncol Res Treat 2019;42(3):123-127. Epub 2019 Feb 23 doi: 10.1159/000495218. PMID: 30799422
Management of resectable esophageal and gastric (mixed adeno)neuroendocrine carcinoma: A nationwide cohort study.
van der Veen A, Seesing MFJ, Wijnhoven BPL, de Steur WO, van Berge Henegouwen MI, Rosman C, van Sandick JW, Mook S, Haj Mohammad N, Ruurda JP, Brosens LAA, van Hillegersberg R; (MA)NEC group
Eur J Surg Oncol 2018 Dec;44(12):1955-1962. Epub 2018 Aug 2 doi: 10.1016/j.ejso.2018.07.058. PMID: 30201419
The role of next-generation sequencing in the differential diagnosis of composite neoplasms.
Acosta AM, Al Rasheed MRH, Pins MR, Borgen KR, Panchal D, Rogozinska M, Wiley EL, Behm FG, Mohapatra G
Hum Pathol 2018 Nov;81:78-88. Epub 2018 Jun 26 doi: 10.1016/j.humpath.2018.06.022. PMID: 29958927
Paired Box 5 (PAX5) Expression in Poorly Differentiated Neuroendocrine Carcinoma of the Gastrointestinal and Pancreatobiliary Tract: Diagnostic and Potentially Therapeutic Implications.
Ainechi S, Mann SA, Lin J, Patil D, Sheehan CE, Yang Z, Zuo C, Lee H
Appl Immunohistochem Mol Morphol 2018 Sep;26(8):545-551. doi: 10.1097/PAI.0000000000000473. PMID: 27941564

Therapy

Neuroendocrine carcinoma of the esophagus with an adenocarcinoma component.
Kaneko Y, Saito S, Takahashi K, Kanamaru R, Hosoya Y, Yamaguchi H, Kitayama J, Niki T, Lefor AK, Sata N
Clin J Gastroenterol 2019 Dec;12(6):534-538. Epub 2019 May 27 doi: 10.1007/s12328-019-00995-7. PMID: 31134449
A Rare Case of Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gastroesophageal Junction with HER2/neu Overexpression and Distinct Orbital and Optic Nerve Toxicity after Intravenous Administration of Cisplatin.
Golombek T, Henker R, Rehak M, Quäschling U, Lordick F, Knödler M
Oncol Res Treat 2019;42(3):123-127. Epub 2019 Feb 23 doi: 10.1159/000495218. PMID: 30799422
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Prognosis

THE PROGNOSIS OF THE DIFFERENT ESOPHAGEAL NEUROENDOCRINE CARCINOMA SUBTYPES: A POPULATION-BASED STUDY.
Tustumi F, Marques SSB, Barros EF, Henriques AC, Waisberg J, Dias AR
Arq Gastroenterol 2022 Jan-Mar;59(1):53-57. doi: 10.1590/S0004-2803.202200001-10. PMID: 35442337
Neuroendocrine carcinoma of the esophagus with an adenocarcinoma component.
Kaneko Y, Saito S, Takahashi K, Kanamaru R, Hosoya Y, Yamaguchi H, Kitayama J, Niki T, Lefor AK, Sata N
Clin J Gastroenterol 2019 Dec;12(6):534-538. Epub 2019 May 27 doi: 10.1007/s12328-019-00995-7. PMID: 31134449
Management of resectable esophageal and gastric (mixed adeno)neuroendocrine carcinoma: A nationwide cohort study.
van der Veen A, Seesing MFJ, Wijnhoven BPL, de Steur WO, van Berge Henegouwen MI, Rosman C, van Sandick JW, Mook S, Haj Mohammad N, Ruurda JP, Brosens LAA, van Hillegersberg R; (MA)NEC group
Eur J Surg Oncol 2018 Dec;44(12):1955-1962. Epub 2018 Aug 2 doi: 10.1016/j.ejso.2018.07.058. PMID: 30201419
The role of next-generation sequencing in the differential diagnosis of composite neoplasms.
Acosta AM, Al Rasheed MRH, Pins MR, Borgen KR, Panchal D, Rogozinska M, Wiley EL, Behm FG, Mohapatra G
Hum Pathol 2018 Nov;81:78-88. Epub 2018 Jun 26 doi: 10.1016/j.humpath.2018.06.022. PMID: 29958927
Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity.
Sahnane N, Furlan D, Monti M, Romualdi C, Vanoli A, Vicari E, Solcia E, Capella C, Sessa F, La Rosa S
Endocr Relat Cancer 2015 Feb;22(1):35-45. Epub 2014 Dec 2 doi: 10.1530/ERC-14-0410. PMID: 25465415

Clinical prediction guides

Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.
Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z, Sun Y, Li Y, Zhou J, Wang X, Peng Z, Shen L, Lu M
Cancer Med 2021 Jul;10(14):4855-4863. Epub 2021 Jun 10 doi: 10.1002/cam4.4031. PMID: 34109756Free PMC Article
The role of next-generation sequencing in the differential diagnosis of composite neoplasms.
Acosta AM, Al Rasheed MRH, Pins MR, Borgen KR, Panchal D, Rogozinska M, Wiley EL, Behm FG, Mohapatra G
Hum Pathol 2018 Nov;81:78-88. Epub 2018 Jun 26 doi: 10.1016/j.humpath.2018.06.022. PMID: 29958927
Paired Box 5 (PAX5) Expression in Poorly Differentiated Neuroendocrine Carcinoma of the Gastrointestinal and Pancreatobiliary Tract: Diagnostic and Potentially Therapeutic Implications.
Ainechi S, Mann SA, Lin J, Patil D, Sheehan CE, Yang Z, Zuo C, Lee H
Appl Immunohistochem Mol Morphol 2018 Sep;26(8):545-551. doi: 10.1097/PAI.0000000000000473. PMID: 27941564
Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity.
Sahnane N, Furlan D, Monti M, Romualdi C, Vanoli A, Vicari E, Solcia E, Capella C, Sessa F, La Rosa S
Endocr Relat Cancer 2015 Feb;22(1):35-45. Epub 2014 Dec 2 doi: 10.1530/ERC-14-0410. PMID: 25465415

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