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Zinc deficiency

MedGen UID:
472966
•Concept ID:
C0235950
•
Disease or Syndrome
Synonym: Zinc Deficiency Disorder
SNOMED CT: Zinc deficiency (238124008)

Definition

A genetic or acquired metabolic disorder that is associated with zinc deficiency in the tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZinc deficiency

Professional guidelines

PubMed

Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo.
Fong LY, Huebner K, Jing R, Smalley KJ, Brydges CR, Fiehn O, Farber JL, Croce CM
Proc Natl Acad Sci U S A 2023 May 16;120(20):e2220334120. Epub 2023 May 8 doi: 10.1073/pnas.2220334120. PMID: 37155893Free PMC Article
Onset Mechanism and Pharmaceutical Management of Dry Skin.
Ooi K
Biol Pharm Bull 2021;44(8):1037-1043. doi: 10.1248/bpb.b21-00150. PMID: 34334489
Zinc deficiency and its association with treatment-related toxicity in children with cancer.
Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB
Pediatr Blood Cancer 2021 Sep;68(9):e29104. Epub 2021 Jun 1 doi: 10.1002/pbc.29104. PMID: 34061438

Recent clinical studies

Etiology

Dietary and Physiological Effects of Zinc on the Immune System.
Wessels I, Fischer HJ, Rink L
Annu Rev Nutr 2021 Oct 11;41:133-175. Epub 2021 Jul 13 doi: 10.1146/annurev-nutr-122019-120635. PMID: 34255547
Role of zinc in female reproduction.
Garner TB, Hester JM, Carothers A, Diaz FJ
Biol Reprod 2021 May 7;104(5):976-994. doi: 10.1093/biolre/ioab023. PMID: 33598687Free PMC Article
The Role of Zinc in Antiviral Immunity.
Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G
Adv Nutr 2019 Jul 1;10(4):696-710. doi: 10.1093/advances/nmz013. PMID: 31305906Free PMC Article
Zinc: an essential micronutrient.
Saper RB, Rash R
Am Fam Physician 2009 May 1;79(9):768-72. PMID: 20141096Free PMC Article
Zinc requirements and the risks and benefits of zinc supplementation.
Maret W, Sandstead HH
J Trace Elem Med Biol 2006;20(1):3-18. Epub 2006 Feb 21 doi: 10.1016/j.jtemb.2006.01.006. PMID: 16632171

Diagnosis

Zinc deficiency and supplementation in autism spectrum disorder and Phelan-McDermid syndrome.
Alsufiani HM, Alkhanbashi AS, Laswad NAB, Bakhadher KK, Alghamdi SA, Tayeb HO, Tarazi FI
J Neurosci Res 2022 Apr;100(4):970-978. Epub 2022 Feb 3 doi: 10.1002/jnr.25019. PMID: 35114017
Zinc and skin: an update.
Glutsch V, Hamm H, Goebeler M
J Dtsch Dermatol Ges 2019 Jun;17(6):589-596. Epub 2019 Mar 15 doi: 10.1111/ddg.13811. PMID: 30873720
Nutrition and hair: deficiencies and supplements.
Finner AM
Dermatol Clin 2013 Jan;31(1):167-72. Epub 2012 Oct 18 doi: 10.1016/j.det.2012.08.015. PMID: 23159185
Zinc in wound healing: theoretical, experimental, and clinical aspects.
Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS
Wound Repair Regen 2007 Jan-Feb;15(1):2-16. doi: 10.1111/j.1524-475X.2006.00179.x. PMID: 17244314
Zinc requirements and the risks and benefits of zinc supplementation.
Maret W, Sandstead HH
J Trace Elem Med Biol 2006;20(1):3-18. Epub 2006 Feb 21 doi: 10.1016/j.jtemb.2006.01.006. PMID: 16632171

Therapy

Zinc and Kidney Disease: A Review.
Abdollahi A, Ghahramani A, Ghahramani N
Iran J Kidney Dis 2022 Mar;16(2):79-87. PMID: 35489076
Zinc in Cancer Therapy Revisited.
Gelbard A
Isr Med Assoc J 2022 Apr;24(4):258-262. PMID: 35415986
Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications.
Wang J, Um P, Dickerman BA, Liu J
Nutrients 2018 May 9;10(5) doi: 10.3390/nu10050584. PMID: 29747386Free PMC Article
Zinc: an essential micronutrient.
Saper RB, Rash R
Am Fam Physician 2009 May 1;79(9):768-72. PMID: 20141096Free PMC Article
Zinc requirements and the risks and benefits of zinc supplementation.
Maret W, Sandstead HH
J Trace Elem Med Biol 2006;20(1):3-18. Epub 2006 Feb 21 doi: 10.1016/j.jtemb.2006.01.006. PMID: 16632171

Prognosis

Zinc and Cadmium in the Aetiology and Pathogenesis of Osteoarthritis and Rheumatoid Arthritis.
Frangos T, Maret W
Nutrients 2020 Dec 26;13(1) doi: 10.3390/nu13010053. PMID: 33375344Free PMC Article
Zinc in Infection and Inflammation.
Gammoh NZ, Rink L
Nutrients 2017 Jun 17;9(6) doi: 10.3390/nu9060624. PMID: 28629136Free PMC Article
Global burden of childhood pneumonia and diarrhoea.
Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O'Brien KL, Campbell H, Black RE
Lancet 2013 Apr 20;381(9875):1405-1416. Epub 2013 Apr 12 doi: 10.1016/S0140-6736(13)60222-6. PMID: 23582727Free PMC Article
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2010 Sep;26(5):490-8. doi: 10.1097/MOG.0b013e32833d11b2. PMID: 20693896
Zinc and diarrhea.
Hambidge KM
Acta Paediatr Suppl 1992 Sep;381:82-6. doi: 10.1111/j.1651-2227.1992.tb12377.x. PMID: 1421947

Clinical prediction guides

Association of Zinc with Anemia.
Jeng SS, Chen YH
Nutrients 2022 Nov 20;14(22) doi: 10.3390/nu14224918. PMID: 36432604Free PMC Article
Zinc at the crossroads of exercise and proteostasis.
Hernández-Camacho JD, Vicente-García C, Parsons DS, Navas-Enamorado I
Redox Biol 2020 Aug;35:101529. Epub 2020 Apr 1 doi: 10.1016/j.redox.2020.101529. PMID: 32273258Free PMC Article
Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis.
Sanna A, Firinu D, Zavattari P, Valera P
Nutrients 2018 Jan 11;10(1) doi: 10.3390/nu10010068. PMID: 29324654Free PMC Article
Discovery of human zinc deficiency: its impact on human health and disease.
Prasad AS
Adv Nutr 2013 Mar 1;4(2):176-90. doi: 10.3945/an.112.003210. PMID: 23493534Free PMC Article
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2010 Sep;26(5):490-8. doi: 10.1097/MOG.0b013e32833d11b2. PMID: 20693896

Recent systematic reviews

Zinc Deficiency and Therapeutic Value of Zinc Supplementation in Pediatric Gastrointestinal Diseases.
Chao HC
Nutrients 2023 Sep 22;15(19) doi: 10.3390/nu15194093. PMID: 37836377Free PMC Article
Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Zupo R, Sila A, Castellana F, Bringiotti R, Curlo M, De Pergola G, De Nucci S, Giannelli G, Mastronardi M, Sardone R
Nutrients 2022 Sep 29;14(19) doi: 10.3390/nu14194052. PMID: 36235709Free PMC Article
Relation Between Zinc and Thyroid Hormones in Humans: a Systematic Review.
Beserra JB, Morais JBS, Severo JS, Cruz KJC, de Oliveira ARS, Henriques GS, do Nascimento Marreiro D
Biol Trace Elem Res 2021 Nov;199(11):4092-4100. Epub 2021 Jan 7 doi: 10.1007/s12011-020-02562-5. PMID: 33409921
Zinc deficiency and febrile seizure: a systematic review and meta-analysis.
Heydarian F, Nakhaei AA, Majd HM, Bakhtiari E
Turk J Pediatr 2020;62(3):347-358. doi: 10.24953/turkjped.2020.03.001. PMID: 32558408
Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis.
Sanna A, Firinu D, Zavattari P, Valera P
Nutrients 2018 Jan 11;10(1) doi: 10.3390/nu10010068. PMID: 29324654Free PMC Article

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