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Lymphoplasmacytic lymphoma

MedGen UID:
473052
•Concept ID:
C0334633
•
Neoplastic Process
Synonyms: Immunocytoma; Immunocytoma, lymphoplasmacytic type; lymphoma, lymphoplasmacytic, malignant; lymphoma, plasmacytic; Lymphoplasmacytic Lymphoma; lymphoplasmacytic lymphoma; lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia); Lymphoplasmacytoid Lymphoma; lymphoplasmacytoid lymphoma; Malignant lymphoma - lymphoplasmacytic; Malignant lymphoma, lymphoplasmacytic; Malignant lymphoma, lymphoplasmacytoid; Malignant lymphoma, lymphoplasmacytoid type; Malignant lymphoma, plasmacytoid; Plasmacytic lymphoma
SNOMED CT: Malignant lymphoma, lymphoplasmacytic (19340000); Malignant lymphoma, lymphoplasmacytoid (19340000); Immunocytoma (19340000); Malignant lymphoma, plasmacytoid (19340000); Plasmacytic lymphoma (19340000); Malignant lymphoma - lymphoplasmacytic (307623001); Malignant lymphoma, lymphoplasmacytoid type (307623001); Immunocytoma (307623001); Plasmacytic lymphoma (307623001)
 
Monarch Initiative: MONDO:0000432

Definition

A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein. [from NCI]

Professional guidelines

PubMed

Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Diagnosis and management of Waldenström macroglobulinaemia-A British Society for Haematology guideline.
Pratt G, El-Sharkawi D, Kothari J, D'Sa S, Auer R, McCarthy H, Krishna R, Miles O, Kyriakou C, Owen R
Br J Haematol 2022 Apr;197(2):171-187. Epub 2022 Jan 12 doi: 10.1111/bjh.18036. PMID: 35020191
Waldenström macroglobulinemia: 2021 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476

Recent clinical studies

Etiology

Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Plasma cell neoplasms and related entities-evolution in diagnosis and classification.
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Updates in Plasma Cell Dyscrasias and Related Monoclonal Immunoglobulin-Mediated Renal Disease.
Midha S, Nadeem O, Selamet U
Semin Nephrol 2022 Nov;42(6):151352. Epub 2023 May 29 doi: 10.1016/j.semnephrol.2023.151352. PMID: 37257390
Diagnosis and management of Waldenström macroglobulinaemia-A British Society for Haematology guideline.
Pratt G, El-Sharkawi D, Kothari J, D'Sa S, Auer R, McCarthy H, Krishna R, Miles O, Kyriakou C, Owen R
Br J Haematol 2022 Apr;197(2):171-187. Epub 2022 Jan 12 doi: 10.1111/bjh.18036. PMID: 35020191
Waldenström macroglobulinemia: 2021 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476

Diagnosis

Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Plasma cell neoplasms and related entities-evolution in diagnosis and classification.
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Current approach to Waldenström Macroglobulinemia.
Ravi G, Kapoor P
Cancer Treat Res Commun 2022;31:100527. Epub 2022 Feb 2 doi: 10.1016/j.ctarc.2022.100527. PMID: 35149375
Waldenström macroglobulinemia: 2021 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476
Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma.
Yoshino T, Tanaka T, Sato Y
J Clin Exp Hematop 2020 Dec 15;60(4):124-129. Epub 2020 Apr 3 doi: 10.3960/jslrt.19041. PMID: 32249238Free PMC Article

Therapy

Current approach to Waldenström macroglobulinemia.
Kapoor P, Rajkumar SV
Blood Rev 2023 Nov;62:101129. Epub 2023 Aug 26 doi: 10.1016/j.blre.2023.101129. PMID: 37659912Free PMC Article
Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Current approach to Waldenström Macroglobulinemia.
Ravi G, Kapoor P
Cancer Treat Res Commun 2022;31:100527. Epub 2022 Feb 2 doi: 10.1016/j.ctarc.2022.100527. PMID: 35149375
Diagnosis and management of Waldenström macroglobulinaemia-A British Society for Haematology guideline.
Pratt G, El-Sharkawi D, Kothari J, D'Sa S, Auer R, McCarthy H, Krishna R, Miles O, Kyriakou C, Owen R
Br J Haematol 2022 Apr;197(2):171-187. Epub 2022 Jan 12 doi: 10.1111/bjh.18036. PMID: 35020191
A Deep Insight Into CAR-T Cell Therapy in Non-Hodgkin Lymphoma: Application, Opportunities, and Future Directions.
Marofi F, Rahman HS, Achmad MH, Sergeevna KN, Suksatan W, Abdelbasset WK, Mikhailova MV, Shomali N, Yazdanifar M, Hassanzadeh A, Ahmadi M, Motavalli R, Pathak Y, Izadi S, Jarahian M
Front Immunol 2021;12:681984. Epub 2021 Jun 23 doi: 10.3389/fimmu.2021.681984. PMID: 34248965Free PMC Article

Prognosis

Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Plasma cell neoplasms and related entities-evolution in diagnosis and classification.
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Current approach to Waldenström Macroglobulinemia.
Ravi G, Kapoor P
Cancer Treat Res Commun 2022;31:100527. Epub 2022 Feb 2 doi: 10.1016/j.ctarc.2022.100527. PMID: 35149375
Waldenström macroglobulinemia: 2021 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476
Lymphoplasmacytic Lymphoma and Marginal Zone Lymphoma.
Juárez-Salcedo LM, Castillo JJ
Hematol Oncol Clin North Am 2019 Aug;33(4):639-656. Epub 2019 Apr 30 doi: 10.1016/j.hoc.2019.03.004. PMID: 31229160

Clinical prediction guides

Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
New treatment strategies for Waldenström macroglobulinemia.
Moreno DF, de Larrea CF, Castillo JJ
Clin Adv Hematol Oncol 2022 Aug;20(8):506-515. PMID: 36125957
Waldenström macroglobulinemia: 2021 update on diagnosis, risk stratification, and management.
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476
Lymphoplasmacytic Lymphoma and Marginal Zone Lymphoma.
Juárez-Salcedo LM, Castillo JJ
Hematol Oncol Clin North Am 2019 Aug;33(4):639-656. Epub 2019 Apr 30 doi: 10.1016/j.hoc.2019.03.004. PMID: 31229160
Lymphoplasmacytic lymphoma-Waldenstrom's macroglobulinemia.
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469

Recent systematic reviews

Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review.
van den Brand M, van Krieken JH
Haematologica 2013 Jul;98(7):1003-13. doi: 10.3324/haematol.2012.083386. PMID: 23813646Free PMC Article
Bendamustine for patients with indolent B cell lymphoid malignancies including chronic lymphocytic leukaemia.
Vidal L, Gafter-Gvili A, Gurion R, Raanani P, Dreyling M, Shpilberg O
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD009045. doi: 10.1002/14651858.CD009045.pub2. PMID: 22972131Free PMC Article

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