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Lymphoplasmacytic lymphoma

MedGen UID:
473052
Concept ID:
C0334633
Neoplastic Process
Synonyms: Immunocytoma; Immunocytoma, lymphoplasmacytic type; lymphoma, lymphoplasmacytic, malignant; lymphoma, plasmacytic; Lymphoplasmacytic Lymphoma; lymphoplasmacytic lymphoma; lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia); Lymphoplasmacytoid Lymphoma; lymphoplasmacytoid lymphoma; Malignant lymphoma - lymphoplasmacytic; Malignant lymphoma, lymphoplasmacytic; Malignant lymphoma, lymphoplasmacytoid; Malignant lymphoma, lymphoplasmacytoid type; Malignant lymphoma, plasmacytoid; Plasmacytic lymphoma
SNOMED CT: Malignant lymphoma, lymphoplasmacytic (19340000); Malignant lymphoma, lymphoplasmacytoid (19340000); Immunocytoma (19340000); Malignant lymphoma, plasmacytoid (19340000); Plasmacytic lymphoma (19340000); Malignant lymphoma - lymphoplasmacytic (307623001); Malignant lymphoma, lymphoplasmacytoid type (307623001); Immunocytoma (307623001); Plasmacytic lymphoma (307623001)
 
Monarch Initiative: MONDO:0000432

Definition

A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein. [from NCI]

Professional guidelines

PubMed

Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Pratt G, El-Sharkawi D, Kothari J, D'Sa S, Auer R, McCarthy H, Krishna R, Miles O, Kyriakou C, Owen R
Br J Haematol 2022 Apr;197(2):171-187. Epub 2022 Jan 12 doi: 10.1111/bjh.18036. PMID: 35020191
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476

Recent clinical studies

Etiology

McMaster ML
Semin Hematol 2023 Mar;60(2):65-72. Epub 2023 Mar 31 doi: 10.1053/j.seminhematol.2023.03.008. PMID: 37099032Free PMC Article
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Midha S, Nadeem O, Selamet U
Semin Nephrol 2022 Nov;42(6):151352. Epub 2023 May 29 doi: 10.1016/j.semnephrol.2023.151352. PMID: 37257390
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476

Diagnosis

Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Ravi G, Kapoor P
Cancer Treat Res Commun 2022;31:100527. Epub 2022 Feb 2 doi: 10.1016/j.ctarc.2022.100527. PMID: 35149375
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476
Juárez-Salcedo LM, Castillo JJ
Hematol Oncol Clin North Am 2019 Aug;33(4):639-656. Epub 2019 Apr 30 doi: 10.1016/j.hoc.2019.03.004. PMID: 31229160

Therapy

Kapoor P, Rajkumar SV
Blood Rev 2023 Nov;62:101129. Epub 2023 Aug 26 doi: 10.1016/j.blre.2023.101129. PMID: 37659912Free PMC Article
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Ravi G, Kapoor P
Cancer Treat Res Commun 2022;31:100527. Epub 2022 Feb 2 doi: 10.1016/j.ctarc.2022.100527. PMID: 35149375
Marofi F, Rahman HS, Achmad MH, Sergeevna KN, Suksatan W, Abdelbasset WK, Mikhailova MV, Shomali N, Yazdanifar M, Hassanzadeh A, Ahmadi M, Motavalli R, Pathak Y, Izadi S, Jarahian M
Front Immunol 2021;12:681984. Epub 2021 Jun 23 doi: 10.3389/fimmu.2021.681984. PMID: 34248965Free PMC Article
Juárez-Salcedo LM, Castillo JJ
Hematol Oncol Clin North Am 2019 Aug;33(4):639-656. Epub 2019 Apr 30 doi: 10.1016/j.hoc.2019.03.004. PMID: 31229160

Prognosis

Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Ravi G, Kapoor P
Cancer Treat Res Commun 2022;31:100527. Epub 2022 Feb 2 doi: 10.1016/j.ctarc.2022.100527. PMID: 35149375
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476
Juárez-Salcedo LM, Castillo JJ
Hematol Oncol Clin North Am 2019 Aug;33(4):639-656. Epub 2019 Apr 30 doi: 10.1016/j.hoc.2019.03.004. PMID: 31229160

Clinical prediction guides

Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Moreno DF, de Larrea CF, Castillo JJ
Clin Adv Hematol Oncol 2022 Aug;20(8):506-515. PMID: 36125957
Gertz MA
Am J Hematol 2021 Feb 1;96(2):258-269. doi: 10.1002/ajh.26082. PMID: 33368476
Juárez-Salcedo LM, Castillo JJ
Hematol Oncol Clin North Am 2019 Aug;33(4):639-656. Epub 2019 Apr 30 doi: 10.1016/j.hoc.2019.03.004. PMID: 31229160
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469

Recent systematic reviews

van den Brand M, van Krieken JH
Haematologica 2013 Jul;98(7):1003-13. doi: 10.3324/haematol.2012.083386. PMID: 23813646Free PMC Article
Vidal L, Gafter-Gvili A, Gurion R, Raanani P, Dreyling M, Shpilberg O
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD009045. doi: 10.1002/14651858.CD009045.pub2. PMID: 22972131Free PMC Article

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