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Gastric Large Cell Neuroendocrine Carcinoma

MedGen UID:
474043
•Concept ID:
C3272410
•
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. It is characterized by the presence of malignant large cells. [from NCI]

Professional guidelines

PubMed

Current Treatment Options in Gastroenteropancreatic Neuroendocrine Carcinoma.
Thomas KEH, Voros BA, Boudreaux JP, Thiagarajan R, Woltering EA, Ramirez RA
Oncologist 2019 Aug;24(8):1076-1088. Epub 2019 Jan 11 doi: 10.1634/theoncologist.2018-0604. PMID: 30635447Free PMC Article
Clinicopathological, treatment, and prognosis study of 43 gastric neuroendocrine carcinomas.
Liu DJ, Fu XL, Liu W, Zheng LY, Zhang JF, Huo YM, Li J, Hua R, Liu Q, Sun YW
World J Gastroenterol 2017 Jan 21;23(3):516-524. doi: 10.3748/wjg.v23.i3.516. PMID: 28210088Free PMC Article
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Diagnosis

Clinical and pathological characteristics of gastric large cell neuroendocrine carcinoma: A report of 2 cases series and literature review.
Wang B, Si Y, Dou Y, Li Y, Liu Z, Huang C, Xu X
Medicine (Baltimore) 2024 Oct 4;103(40):e39851. doi: 10.1097/MD.0000000000039851. PMID: 39465709Free PMC Article
Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review.
Qin W, Shang J, Cui H, Chang Z, Yang S
J Int Med Res 2023 Apr;51(4):3000605231163709. doi: 10.1177/03000605231163709. PMID: 37017400Free PMC Article
Yet Another Extracolonic Manifestation of Familial Adenomatous Polyposis: Gastric Large-Cell Neuroendocrine Carcinoma.
Venu N, Gault C, Kozarek R, Hwang D, Mankaney G
Am J Gastroenterol 2022 Jun 1;117(6):837. Epub 2022 Feb 17 doi: 10.14309/ajg.0000000000001697. PMID: 35175954
Gastric large cell neuroendocrine carcinoma with venous tumor thrombus: the value of PET/CT and contrast-enhanced computed tomography.
Song L, Jin Z, Zhang W, Zhang Y
Clin Imaging 2015 Mar-Apr;39(2):325-8. Epub 2014 Oct 16 doi: 10.1016/j.clinimag.2014.09.002. PMID: 25496669
Metastatic gastric large cell neuroendocrine carcinoma: a case report and review of literature.
Oberstein PE, Kenney B, Krishnamoorthy SK, Woo Y, Saif MW
Clin Colorectal Cancer 2012 Sep;11(3):218-23. Epub 2012 Mar 14 doi: 10.1016/j.clcc.2012.01.005. PMID: 22421002

Therapy

Clinical and pathological characteristics of gastric large cell neuroendocrine carcinoma: A report of 2 cases series and literature review.
Wang B, Si Y, Dou Y, Li Y, Liu Z, Huang C, Xu X
Medicine (Baltimore) 2024 Oct 4;103(40):e39851. doi: 10.1097/MD.0000000000039851. PMID: 39465709Free PMC Article

Prognosis

Clinical and pathological characteristics of gastric large cell neuroendocrine carcinoma: A report of 2 cases series and literature review.
Wang B, Si Y, Dou Y, Li Y, Liu Z, Huang C, Xu X
Medicine (Baltimore) 2024 Oct 4;103(40):e39851. doi: 10.1097/MD.0000000000039851. PMID: 39465709Free PMC Article
Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review.
Qin W, Shang J, Cui H, Chang Z, Yang S
J Int Med Res 2023 Apr;51(4):3000605231163709. doi: 10.1177/03000605231163709. PMID: 37017400Free PMC Article
Metastatic gastric large cell neuroendocrine carcinoma: a case report and review of literature.
Oberstein PE, Kenney B, Krishnamoorthy SK, Woo Y, Saif MW
Clin Colorectal Cancer 2012 Sep;11(3):218-23. Epub 2012 Mar 14 doi: 10.1016/j.clcc.2012.01.005. PMID: 22421002
Incarceration of a large cell neuroendocrine carcinoma arising from the proximal stomach with an organoaxial gastric volvulus through an esophageal hiatal hernia: report of a case.
Iso Y, Tagaya N, Nemoto T, Kita J, Sawada T, Kubota K
Surg Today 2009;39(2):148-52. Epub 2009 Feb 7 doi: 10.1007/s00595-008-3804-9. PMID: 19198995

Clinical prediction guides

Clinical and pathological characteristics of gastric large cell neuroendocrine carcinoma: A report of 2 cases series and literature review.
Wang B, Si Y, Dou Y, Li Y, Liu Z, Huang C, Xu X
Medicine (Baltimore) 2024 Oct 4;103(40):e39851. doi: 10.1097/MD.0000000000039851. PMID: 39465709Free PMC Article

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