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Small Intestinal Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
474166
•Concept ID:
C3272533
•
Neoplastic Process
Synonym: Small Intestinal MANEC

Definition

A carcinoma that arises from the small intestine and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Recent clinical studies

Etiology

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report.
Li X, Li D, Sun X, Lv G
J Int Med Res 2020 Aug;48(8):300060520947918. doi: 10.1177/0300060520947918. PMID: 32833541Free PMC Article
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Gastroenteropancreatic neuroendocrine neoplasms: a 10-year experience of a single center.
Lewkowicz E, Trofimiuk-Müldner M, Wysocka K, Pach D, Kiełtyka A, Stefańska A, Sowa-Staszczak A, Tomaszewska R, Hubalewska-Dydejczyk A
Pol Arch Med Wewn 2015;125(5):337-46. Epub 2015 Apr 29 doi: 10.20452/pamw.2832. PMID: 25924181
Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours.
Kim J, Lee WJ, Lee SH, Lee KB, Ryu JK, Kim YT, Kim SW, Yoon YB, Hwang JH, Han HS, Woo SM, Park SJ
Dig Liver Dis 2011 Dec;43(12):965-70. doi: 10.1016/j.dld.2011.07.010. PMID: 21856258

Diagnosis

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla: two case reports with review of literature.
Zhang L, DeMay RM
Diagn Cytopathol 2014 Dec;42(12):1075-84. Epub 2014 Feb 19 doi: 10.1002/dc.23107. PMID: 24554593

Prognosis

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report.
Li X, Li D, Sun X, Lv G
J Int Med Res 2020 Aug;48(8):300060520947918. doi: 10.1177/0300060520947918. PMID: 32833541Free PMC Article
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986

Clinical prediction guides

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Neuroendocrine Neoplasms of the Major Duodenal Papilla With Focus on Histopathological Features and Prognosis.
Zhang Q, Lu CJ, Zhang X, Ma Z, Xin Q, Zhang CS
Int J Surg Pathol 2015 Sep;23(6):433-8. Epub 2015 May 18 doi: 10.1177/1066896915586808. PMID: 25987105

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615

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