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Appendix hyperplastic polyp

MedGen UID:
474394
•Concept ID:
C3272761
•
Disease or Syndrome
Synonyms: Appendix Hyperplastic Polyp; appendix hyperplastic polyp; Appendix Metaplastic Polyp; appendix metaplastic polyp; Hyperplastic polyp of appendix; vermiform appendix hyperplastic polyp
SNOMED CT: Hyperplastic polyp of appendix (860862007)
 
Monarch Initiative: MONDO:0006090

Definition

A non-neoplastic polyp that arises from the appendix. It is characterized by the presence of elongated serrated crypts and the absence of atypia or dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix hyperplastic polyp

Professional guidelines

PubMed

Appendiceal tumors in patients undergoing primary surgery for mucinous ovarian tumors in a tertiary hospital, in Southern Thailand.
Nanthamongkolkul K, Wattanapaisal P, Boonyapipat S, Suphasynth Y, Pichatechaiyoot A, Geater AF, Kayasut K, Peeyananjarassri K
Taiwan J Obstet Gynecol 2022 Jul;61(4):657-662. doi: 10.1016/j.tjog.2022.03.042. PMID: 35779917

Recent clinical studies

Etiology

Appendiceal tumors in patients undergoing primary surgery for mucinous ovarian tumors in a tertiary hospital, in Southern Thailand.
Nanthamongkolkul K, Wattanapaisal P, Boonyapipat S, Suphasynth Y, Pichatechaiyoot A, Geater AF, Kayasut K, Peeyananjarassri K
Taiwan J Obstet Gynecol 2022 Jul;61(4):657-662. doi: 10.1016/j.tjog.2022.03.042. PMID: 35779917
Histopathological features of incidental appendectomy specimens obtained from living liver donors.
Akbulut S, Koç C, Sarıcı B, Özcan M, Şamdancı E, Yılmaz S
Turk J Gastroenterol 2020 Mar;31(3):257-263. doi: 10.5152/tjg.2020.19010. PMID: 32343238Free PMC Article
Preemptive Appendicectomy at the Time of Pancreas Transplantation: Is It Necessary?
Thakkar RG, Kanwar A, Singh A, Hawche G, Talbot D, Wilson C, Manas DM, White SA
Exp Clin Transplant 2019 Dec;17(6):792-795. Epub 2019 Oct 1 doi: 10.6002/ect.2019.0186. PMID: 31580234
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127
Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix.
Pai RK, Hartman DJ, Gonzalo DH, Lai KK, Downs-Kelly E, Goldblum JR, Liu X, Patil DT, Bennett AE, Plesec TP, Kuan SF, Nikiforova MN, Shadrach B, Pai RK
Hum Pathol 2014 Feb;45(2):227-35. Epub 2013 Oct 30 doi: 10.1016/j.humpath.2013.10.021. PMID: 24439221

Diagnosis

Appendiceal tumors in patients undergoing primary surgery for mucinous ovarian tumors in a tertiary hospital, in Southern Thailand.
Nanthamongkolkul K, Wattanapaisal P, Boonyapipat S, Suphasynth Y, Pichatechaiyoot A, Geater AF, Kayasut K, Peeyananjarassri K
Taiwan J Obstet Gynecol 2022 Jul;61(4):657-662. doi: 10.1016/j.tjog.2022.03.042. PMID: 35779917
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127
Primary epithelial neoplasms and other epithelial lesions of the appendix (excluding carcinoid tumors).
Misdraji J, Young RH
Semin Diagn Pathol 2004 May;21(2):120-33. doi: 10.1053/j.semdp.2004.11.005. PMID: 15807472
Unusual tumors of the appendix and pseudomyxoma peritonei.
Carr NJ, Sobin LH
Semin Diagn Pathol 1996 Nov;13(4):314-25. PMID: 8946609
Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia.
Longacre TA, Fenoglio-Preiser CM
Am J Surg Pathol 1990 Jun;14(6):524-37. doi: 10.1097/00000478-199006000-00003. PMID: 2186644

Therapy

Preemptive Appendicectomy at the Time of Pancreas Transplantation: Is It Necessary?
Thakkar RG, Kanwar A, Singh A, Hawche G, Talbot D, Wilson C, Manas DM, White SA
Exp Clin Transplant 2019 Dec;17(6):792-795. Epub 2019 Oct 1 doi: 10.6002/ect.2019.0186. PMID: 31580234
Unexpected findings in the routine histopathological examinations of appendectomy specimens A retrospective analysis of 1,970 patients.
Dincel O, Goksu M, Turk BA, Pehlivanoglu B, Isler S
Ann Ital Chir 2017;88:519-525. PMID: 29339597
Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal.
Bellizzi AM, Rock J, Marsh WL, Frankel WL
Am J Clin Pathol 2010 Apr;133(4):623-32. doi: 10.1309/AJCP1UJPX6UURLCH. PMID: 20231616

Prognosis

Uncommon causes of acute appendicitis: Retrospective analysis of 6785 histopathological findings in a tertiary center.
Harman Kamali G, Ulusoy C, Nikolovski A, Eğin S, Kamalı S
Ulus Travma Acil Cerrahi Derg 2022 Dec;28(12):1708-1715. doi: 10.14744/tjtes.2022.84937. PMID: 36453793Free PMC Article
Molecular profiling of appendiceal serrated lesions, polyps and mucinous neoplasms: a single-centre experience.
Munari G, Businello G, Mattiolo P, Pennelli G, Sbaraglia M, Borga C, Pucciarelli S, Spolverato G, Mescoli C, Galuppini F, Sommariva A, Bellan E, Lonardi S, Loupakis F, Luchini C, Dei Tos AP, Fassan M
J Cancer Res Clin Oncol 2021 Jul;147(7):1897-1904. Epub 2021 Mar 12 doi: 10.1007/s00432-021-03589-4. PMID: 33712927Free PMC Article
Gastrointestinal Malakoplakia: Clinicopathologic Analysis of 26 Cases.
Zhang Y, Byrnes K, Lam-Himlin D, Pittman M, Pezhouh M, Gonzalez RS, Alruwaii Z, Larman T, Miller JA, Matoso A, Oshima K, Epstein JI, Montgomery EA, Voltaggio L
Am J Surg Pathol 2020 Sep;44(9):1251-1258. doi: 10.1097/PAS.0000000000001491. PMID: 32301754
Primary epithelial neoplasms and other epithelial lesions of the appendix (excluding carcinoid tumors).
Misdraji J, Young RH
Semin Diagn Pathol 2004 May;21(2):120-33. doi: 10.1053/j.semdp.2004.11.005. PMID: 15807472
Unusual tumors of the appendix and pseudomyxoma peritonei.
Carr NJ, Sobin LH
Semin Diagn Pathol 1996 Nov;13(4):314-25. PMID: 8946609

Clinical prediction guides

Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma.
Tahara T, Takahama K, Tahara S, Horiguchi N, Funasaka K, Nakagawa Y, Shibata T, Tsukamoto T, Ieda HO, Fukui T, Naganuma M, Ohmiya N
PLoS One 2023;18(5):e0286300. Epub 2023 May 30 doi: 10.1371/journal.pone.0286300. PMID: 37253036Free PMC Article
Histopathological features of incidental appendectomy specimens obtained from living liver donors.
Akbulut S, Koç C, Sarıcı B, Özcan M, Şamdancı E, Yılmaz S
Turk J Gastroenterol 2020 Mar;31(3):257-263. doi: 10.5152/tjg.2020.19010. PMID: 32343238Free PMC Article
Serrated lesions of the appendix: do they differ from their colorectal counterparts?
Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127
Reactive lymphoid hyperplasia with a lipomatous component associated with fecal compaction in an appendiceal orifice.
Iwamuro M, Kawai Y, Takata K, Miyabe Y, Okada H, Yamamoto K
Intern Med 2014;53(10):1049-53. doi: 10.2169/internalmedicine.53.1635. PMID: 24827483
Pedunculated hamartomatous polyp of the appendix: report of a case.
Nozoe T, Mori E, Iguchi T, Kohno M, Maeda T, Matsukuma A, Sueishi K, Ezaki T
Surg Today 2013 Feb;43(2):191-3. Epub 2012 May 20 doi: 10.1007/s00595-012-0190-0. PMID: 22610489

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