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Hyperplastic polyp

MedGen UID:
87189
•Concept ID:
C0333983
•
Neoplastic Process
Synonyms: HP; Hyperplasic polyp; Hyperplastic Polyp; hyperplastic polyp; Metaplastic polyp; Metaplastic Polyp; metaplastic polyp; MP
SNOMED CT: Hyperplastic polyp (62047007); Hyperplasic polyp (277163006); Metaplastic polyp (277163006)
 
Monarch Initiative: MONDO:0006249

Definition

A polyp found mainly in the stomach and colon. Microscopically, it is characterized by elongated, serrated crypts lined by proliferative epithelium. Hyperplastic polyps are traditionally considered non-neoplastic, but ras mutation is common, clonality has been demonstrated and biochemical abnormalities and epidemiological associations that occur in colorectal adenomas and carcinomas have been found (WHO Tumors of the Digestive System, 2000). [from NCI]

Professional guidelines

PubMed

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537
Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp.
Boylan KE, Kanth P, Delker D, Hazel MW, Boucher KM, Affolter K, Clayton F, Evason KJ, Jedrzkiewicz J, Pletneva M, Samowitz W, Swanson E, Bronner MP
Hum Pathol 2023 Jul;137:25-35. Epub 2023 Apr 11 doi: 10.1016/j.humpath.2023.04.002. PMID: 37044202Free PMC Article
The Differential Diagnosis of Colorectal Polyps Using Colon Capsule Endoscopy.
Nakazawa K, Nouda S, Kakimoto K, Kinoshita N, Tanaka Y, Tawa H, Koshiba R, Naka Y, Hirata Y, Ota K, Kawakami K, Takeuchi T, Inoue T, Miyazaki T, Sanomura M, Nakamura S, Saito Y, Higuchi K
Intern Med 2021 Jun 15;60(12):1805-1812. Epub 2021 Jan 15 doi: 10.2169/internalmedicine.6446-20. PMID: 33456043Free PMC Article

Recent clinical studies

Etiology

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128
Serrated Polyps of Colon and Rectum: a Clinicopathologic Review.
Geramizadeh B, Robertson S
J Gastrointest Cancer 2017 Dec;48(4):291-298. doi: 10.1007/s12029-017-9977-y. PMID: 28639142

Diagnosis

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537
Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128
Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team.
Sano Y, Tanaka S, Kudo SE, Saito S, Matsuda T, Wada Y, Fujii T, Ikematsu H, Uraoka T, Kobayashi N, Nakamura H, Hotta K, Horimatsu T, Sakamoto N, Fu KI, Tsuruta O, Kawano H, Kashida H, Takeuchi Y, Machida H, Kusaka T, Yoshida N, Hirata I, Terai T, Yamano HO, Kaneko K, Nakajima T, Sakamoto T, Yamaguchi Y, Tamai N, Nakano N, Hayashi N, Oka S, Iwatate M, Ishikawa H, Murakami Y, Yoshida S, Saito Y
Dig Endosc 2016 Jul;28(5):526-33. Epub 2016 Apr 20 doi: 10.1111/den.12644. PMID: 26927367

Therapy

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article
Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial.
Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS
Dig Dis Sci 2020 Dec;65(12):3652-3659. Epub 2020 Jan 23 doi: 10.1007/s10620-020-06065-0. PMID: 31974914
Polyp guideline: diagnosis, treatment, and surveillance for patients with nonfamilial colorectal polyps. The Practice Parameters Committee of the American College of Gastroenterology.
Bond JH
Ann Intern Med 1993 Oct 15;119(8):836-43. doi: 10.7326/0003-4819-119-8-199310150-00010. PMID: 8379605

Prognosis

Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128
Polyp characterization at colonoscopy: Clinical implications.
Allen JE, Sharma P
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):435-440. Epub 2017 Jul 6 doi: 10.1016/j.bpg.2017.07.001. PMID: 28842053
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698
Endoscopic gastroduodenal polypectomy.
Ghazi A, Ferstenberg H, Shinya H
Ann Surg 1984 Aug;200(2):175-80. doi: 10.1097/00000658-198408000-00010. PMID: 6465972Free PMC Article

Clinical prediction guides

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal Cancer.
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128
Polyp characterization at colonoscopy: Clinical implications.
Allen JE, Sharma P
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):435-440. Epub 2017 Jul 6 doi: 10.1016/j.bpg.2017.07.001. PMID: 28842053
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Recent systematic reviews

Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128

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