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Hyperplastic polyp

MedGen UID:
87189
•Concept ID:
C0333983
•
Neoplastic Process
Synonyms: HP; Hyperplasic polyp; Hyperplastic Polyp; hyperplastic polyp; Metaplastic polyp; Metaplastic Polyp; metaplastic polyp; MP
SNOMED CT: Hyperplastic polyp (62047007); Hyperplasic polyp (277163006); Metaplastic polyp (277163006)
 
Monarch Initiative: MONDO:0006249

Definition

A polyp found mainly in the stomach and colon. Microscopically, it is characterized by elongated, serrated crypts lined by proliferative epithelium. Hyperplastic polyps are traditionally considered non-neoplastic, but ras mutation is common, clonality has been demonstrated and biochemical abnormalities and epidemiological associations that occur in colorectal adenomas and carcinomas have been found (WHO Tumors of the Digestive System, 2000). [from NCI]

Professional guidelines

PubMed

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537
Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp.
Boylan KE, Kanth P, Delker D, Hazel MW, Boucher KM, Affolter K, Clayton F, Evason KJ, Jedrzkiewicz J, Pletneva M, Samowitz W, Swanson E, Bronner MP
Hum Pathol 2023 Jul;137:25-35. Epub 2023 Apr 11 doi: 10.1016/j.humpath.2023.04.002. PMID: 37044202Free PMC Article
The Differential Diagnosis of Colorectal Polyps Using Colon Capsule Endoscopy.
Nakazawa K, Nouda S, Kakimoto K, Kinoshita N, Tanaka Y, Tawa H, Koshiba R, Naka Y, Hirata Y, Ota K, Kawakami K, Takeuchi T, Inoue T, Miyazaki T, Sanomura M, Nakamura S, Saito Y, Higuchi K
Intern Med 2021 Jun 15;60(12):1805-1812. Epub 2021 Jan 15 doi: 10.2169/internalmedicine.6446-20. PMID: 33456043Free PMC Article

Recent clinical studies

Therapy

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Significance of serrated epithelial change in inflammatory bowel disease.
Batts KP, Atwaibi M, Weinberg DI, McCabe RP
Postgrad Med 2021 Jan;133(1):66-70. Epub 2020 Sep 29 doi: 10.1080/00325481.2020.1802138. PMID: 32746680
Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial.
Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS
Dig Dis Sci 2020 Dec;65(12):3652-3659. Epub 2020 Jan 23 doi: 10.1007/s10620-020-06065-0. PMID: 31974914
Nonsteroidal anti-inflammatory drug use and risk of adenomatous and hyperplastic polyps.
Murff HJ, Shrubsole MJ, Chen Z, Smalley WE, Chen H, Shyr Y, Ness RM, Zheng W
Cancer Prev Res (Phila) 2011 Nov;4(11):1799-807. Epub 2011 Jul 15 doi: 10.1158/1940-6207.CAPR-11-0107. PMID: 21764857Free PMC Article

Prognosis

Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128
Polyp characterization at colonoscopy: Clinical implications.
Allen JE, Sharma P
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):435-440. Epub 2017 Jul 6 doi: 10.1016/j.bpg.2017.07.001. PMID: 28842053
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Clinical prediction guides

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal Cancer.
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128
Polyp characterization at colonoscopy: Clinical implications.
Allen JE, Sharma P
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):435-440. Epub 2017 Jul 6 doi: 10.1016/j.bpg.2017.07.001. PMID: 28842053
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Recent systematic reviews

Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128

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