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Appendix Intraepithelial Neoplasia

MedGen UID:
474396
•Concept ID:
C3272763
•
Neoplastic Process
Synonyms: Appendiceal Dysplasia; Appendix Dysplasia

Definition

A precancerous intraepithelial neoplastic lesion that affects the appendix. It is characterized by low or high grade dysplasia of the mucosal epithelium. There is no evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Intraepithelial Neoplasia

Professional guidelines

PubMed

Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.
Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896Free PMC Article
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article
Chemoprevention of breast cancer. A joint guideline from the Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer.
Levine M, Moutquin JM, Walton R, Feightner J; Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
CMAJ 2001 Jun 12;164(12):1681-90. PMID: 11450210Free PMC Article

Recent clinical studies

Etiology

Assessment of the usefulness of prognostic Van Nuys Prognostic Index in the treatment in ductal carcinoma in situ in 15-year observation.
Kunkiel M, Niwińska A
Sci Rep 2021 Nov 22;11(1):22645. doi: 10.1038/s41598-021-02126-0. PMID: 34811426Free PMC Article
Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis.
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.
Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896Free PMC Article
Chemoprevention of breast cancer. A joint guideline from the Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer.
Levine M, Moutquin JM, Walton R, Feightner J; Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
CMAJ 2001 Jun 12;164(12):1681-90. PMID: 11450210Free PMC Article
Ovarian tumors of borderline malignancy (tumors of low malignant potential): a critical appraisal.
Prat J
Adv Anat Pathol 1999 Sep;6(5):247-74. doi: 10.1097/00125480-199909000-00002. PMID: 10472378

Diagnosis

Endometriosis with colonic mucosal colonisation: a diagnostic confounder.
Adler J, Algashaamy K, Garcia de Buitrago MT, Pinto A, Montgomery EA
J Clin Pathol 2024 Feb 19;77(3):145-150. doi: 10.1136/jcp-2023-209176. PMID: 38123989
Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, DeCaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2020 May 22;5(5):CD007334. doi: 10.1002/14651858.CD007334.pub5. PMID: 32442322Free PMC Article
Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis.
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, Decaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2012 Nov 14;11:CD007334. doi: 10.1002/14651858.CD007334.pub4. PMID: 23152243
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article

Therapy

Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, DeCaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2020 May 22;5(5):CD007334. doi: 10.1002/14651858.CD007334.pub5. PMID: 32442322Free PMC Article
Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis.
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.
Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896Free PMC Article
Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, Decaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2012 Nov 14;11:CD007334. doi: 10.1002/14651858.CD007334.pub4. PMID: 23152243
Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, Barr H, Bhandari P, Decaestecker J, Ragunath K, Singh R, Tawil A, Jankowski J
Cochrane Database Syst Rev 2010 May 12;(5):CD007334. doi: 10.1002/14651858.CD007334.pub3. PMID: 20464752

Prognosis

Assessment of the usefulness of prognostic Van Nuys Prognostic Index in the treatment in ductal carcinoma in situ in 15-year observation.
Kunkiel M, Niwińska A
Sci Rep 2021 Nov 22;11(1):22645. doi: 10.1038/s41598-021-02126-0. PMID: 34811426Free PMC Article
Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis.
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.
Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896Free PMC Article
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article
Ovarian tumors of borderline malignancy (tumors of low malignant potential): a critical appraisal.
Prat J
Adv Anat Pathol 1999 Sep;6(5):247-74. doi: 10.1097/00125480-199909000-00002. PMID: 10472378

Clinical prediction guides

Endometriosis with colonic mucosal colonisation: a diagnostic confounder.
Adler J, Algashaamy K, Garcia de Buitrago MT, Pinto A, Montgomery EA
J Clin Pathol 2024 Feb 19;77(3):145-150. doi: 10.1136/jcp-2023-209176. PMID: 38123989
Assessment of the usefulness of prognostic Van Nuys Prognostic Index in the treatment in ductal carcinoma in situ in 15-year observation.
Kunkiel M, Niwińska A
Sci Rep 2021 Nov 22;11(1):22645. doi: 10.1038/s41598-021-02126-0. PMID: 34811426Free PMC Article
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article
Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells.
O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH
Am J Pathol 2002 Aug;161(2):551-64. doi: 10.1016/S0002-9440(10)64211-3. PMID: 12163380Free PMC Article
Appendectomy and carcinoma ovarii. Cytoreduction, palliation, or simple tradition?
Corfitsen MT, Pedersen IR, Lebech AM, Kaae HH
Acta Obstet Gynecol Scand 1991;70(7-8):601-4. doi: 10.3109/00016349109007924. PMID: 1785278

Recent systematic reviews

Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, DeCaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2020 May 22;5(5):CD007334. doi: 10.1002/14651858.CD007334.pub5. PMID: 32442322Free PMC Article
Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis.
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, Decaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2012 Nov 14;11:CD007334. doi: 10.1002/14651858.CD007334.pub4. PMID: 23152243
Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus.
Bennett C, Green S, Barr H, Bhandari P, Decaestecker J, Ragunath K, Singh R, Tawil A, Jankowski J
Cochrane Database Syst Rev 2010 May 12;(5):CD007334. doi: 10.1002/14651858.CD007334.pub3. PMID: 20464752
Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett's oesophagus.
Green S, Tawil A, Barr H, Bennett C, Bhandari P, Decaestecker J, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2009 Apr 15;(2):CD007334. doi: 10.1002/14651858.CD007334.pub2. PMID: 19370683

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