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Appendix Neuroma

MedGen UID:
474412
•Concept ID:
C3272779
•
Neoplastic Process
Synonyms: Appendix Fibrous Obliteration; Appendix Neurogenous Hyperplasia; Neurogenic Appendicopathy

Definition

A neuroma that arises from the appendix. It is characterized by a neural spindle cell proliferation that replaces the appendiceal mucosa and lymphoid tissue. It usually results in the obliteration of the appendiceal lumen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Neuroma

Recent clinical studies

Etiology

Neoplasms of the appendix: Single institution and ten-year experiences results.
Yıldırım E, Kegin M, Özdemir M, Bektaş S, Pelen Z, Er M
Ulus Travma Acil Cerrahi Derg 2022 Mar;28(3):352-360. doi: 10.14744/tjtes.2021.86032. PMID: 35485573Free PMC Article
Complicated appendiceal diverticulosis versus low-grade appendiceal mucinous neoplasms: a major diagnostic dilemma.
Lowes H, Rowaiye B, Carr NJ, Shepherd NA
Histopathology 2019 Oct;75(4):478-485. Epub 2019 Sep 3 doi: 10.1111/his.13931. PMID: 31166613
Neurogenic appendicopathy: clinical, macroscopic, and histopathological presentation in pediatric patients.
Sesia SB, Mayr J, Bruder E, Haecker FM
Eur J Pediatr Surg 2013 Jun;23(3):238-42. Epub 2013 Feb 26 doi: 10.1055/s-0032-1333119. PMID: 23444074
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Neurogenic appendicopathy in children.
Franke C, Gerharz CD, Böhner H, Ohmann C, Heydrich G, Krämling HJ, Stock W, Rosen D, Kurpreugsch K, Willnow U, Röher HD
Eur J Pediatr Surg 2002 Feb;12(1):28-31. doi: 10.1055/s-2002-25092. PMID: 11967756

Diagnosis

Neoplasms of the appendix: Single institution and ten-year experiences results.
Yıldırım E, Kegin M, Özdemir M, Bektaş S, Pelen Z, Er M
Ulus Travma Acil Cerrahi Derg 2022 Mar;28(3):352-360. doi: 10.14744/tjtes.2021.86032. PMID: 35485573Free PMC Article
Appendicular schwannoma Review of the literature on a rare benign tumor often mistaken for hyperplasia.
Intagliata E
Ann Ital Chir 2022;93:168-173. PMID: 35122426
Complicated appendiceal diverticulosis versus low-grade appendiceal mucinous neoplasms: a major diagnostic dilemma.
Lowes H, Rowaiye B, Carr NJ, Shepherd NA
Histopathology 2019 Oct;75(4):478-485. Epub 2019 Sep 3 doi: 10.1111/his.13931. PMID: 31166613
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Unusual tumors of the appendix and pseudomyxoma peritonei.
Carr NJ, Sobin LH
Semin Diagn Pathol 1996 Nov;13(4):314-25. PMID: 8946609

Therapy

Unexpected findings in the routine histopathological examinations of appendectomy specimens A retrospective analysis of 1,970 patients.
Dincel O, Goksu M, Turk BA, Pehlivanoglu B, Isler S
Ann Ital Chir 2017;88:519-525. PMID: 29339597
Incidental appendectomy in donors undergoing hepatectomy for living-donor liver transplantation.
Yilmaz M, Olmez A, Piskin T, Unal B, Ersan V, Sarici KB, Dirican A, Yilmaz S
Transplant Proc 2012 Jul-Aug;44(6):1630-4. doi: 10.1016/j.transproceed.2012.04.012. PMID: 22841232
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Neurogenic appendicopathy in children.
Franke C, Gerharz CD, Böhner H, Ohmann C, Heydrich G, Krämling HJ, Stock W, Rosen D, Kurpreugsch K, Willnow U, Röher HD
Eur J Pediatr Surg 2002 Feb;12(1):28-31. doi: 10.1055/s-2002-25092. PMID: 11967756
Neuromas of the appendix. A light-microscopic, immunohistochemical and electron-microscopic study of 20 cases.
Stanley MW, Cherwitz D, Hagen K, Snover DC
Am J Surg Pathol 1986 Nov;10(11):801-15. PMID: 2430480

Prognosis

Appendicular schwannoma Review of the literature on a rare benign tumor often mistaken for hyperplasia.
Intagliata E
Ann Ital Chir 2022;93:168-173. PMID: 35122426
Neurogenic appendicopathy: clinical, macroscopic, and histopathological presentation in pediatric patients.
Sesia SB, Mayr J, Bruder E, Haecker FM
Eur J Pediatr Surg 2013 Jun;23(3):238-42. Epub 2013 Feb 26 doi: 10.1055/s-0032-1333119. PMID: 23444074
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Neurogenic appendicopathy in children.
Franke C, Gerharz CD, Böhner H, Ohmann C, Heydrich G, Krämling HJ, Stock W, Rosen D, Kurpreugsch K, Willnow U, Röher HD
Eur J Pediatr Surg 2002 Feb;12(1):28-31. doi: 10.1055/s-2002-25092. PMID: 11967756
Unusual tumors of the appendix and pseudomyxoma peritonei.
Carr NJ, Sobin LH
Semin Diagn Pathol 1996 Nov;13(4):314-25. PMID: 8946609

Clinical prediction guides

Perilesional Lymph Node Swelling Might be a Radiologic Clue for Appendiceal Schwannoma: A Case Report.
Suzuki K, Saito K, Yamada T, Arizono E, Kumita H, Kasahara K, Katsumata K, Tasaki K, Matsubayashi J, Nagao T
Curr Med Imaging 2021;17(10):1266-1270. doi: 10.2174/1573405617666210608152957. PMID: 34102981Free PMC Article
Tumors of the appendix.
Schmutzer KJ, Bayar M, Zaki AE, Regan JF, Poletti JB
Dis Colon Rectum 1975 May-Jun;18(4):324-31. doi: 10.1007/BF02587395. PMID: 1126268

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