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Colorectal Goblet Cell Rich Hyperplastic Polyp

MedGen UID:
474431
•Concept ID:
C3272798
•
Disease or Syndrome
Synonym: Colorectal GCHP

Definition

A serrated hyperplastic polyp that arises from the colon and rectum. It is characterized by the presence of goblet cells and the absence of microvacuolated columnar cells. There is no evidence of epithelial atypia or dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Goblet Cell Rich Hyperplastic Polyp

Recent clinical studies

Etiology

Exploring the spectrum of serrated epithelium encountered in inflammatory bowel disease.
Waters KM, Singhi AD, Montgomery EA
Hum Pathol 2023 Feb;132:126-134. Epub 2022 Jun 23 doi: 10.1016/j.humpath.2022.06.018. PMID: 35753410Free PMC Article
Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article

Diagnosis

The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential.
Renaud F, Mariette C, Vincent A, Wacrenier A, Maunoury V, Leclerc J, Coppin L, Crépin M, Van Seuningen I, Leteurtre E, Buisine MP
Int J Cancer 2016 Mar 15;138(6):1472-81. Epub 2015 Oct 30 doi: 10.1002/ijc.29891. PMID: 26476272

Therapy

Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article

Prognosis

Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article
The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential.
Renaud F, Mariette C, Vincent A, Wacrenier A, Maunoury V, Leclerc J, Coppin L, Crépin M, Van Seuningen I, Leteurtre E, Buisine MP
Int J Cancer 2016 Mar 15;138(6):1472-81. Epub 2015 Oct 30 doi: 10.1002/ijc.29891. PMID: 26476272

Clinical prediction guides

Increased GS-II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps.
Matoba H, Iwaya M, Sato Y, Kobayashi N, Takemura H, Kouno Y, Karasawa A, Nakayama J
Pathol Int 2023 Jun;73(6):246-254. Epub 2023 Apr 10 doi: 10.1111/pin.13321. PMID: 37036163
Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article

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