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Colorectal Mucin Poor Hyperplastic Polyp

MedGen UID:
474432
•Concept ID:
C3272799
•
Disease or Syndrome
Synonym: Colorectal MP/HP

Definition

A serrated hyperplastic polyp that arises from the colon and rectum. It is characterized by the presence of small cells in the crypts that do not contain mucin. Reactive epithelial atypia may be present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Mucin Poor Hyperplastic Polyp

Recent clinical studies

Etiology

Morphologic reappraisal of serrated colorectal polyps.
Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM
Am J Surg Pathol 2003 Jan;27(1):65-81. doi: 10.1097/00000478-200301000-00008. PMID: 12502929

Diagnosis

Molecular characteristics of colorectal hyperplastic polyp subgroups.
Ünlü M, Uzun E, Bengi G, Sağol Ö, Sarıoğlu S
Turk J Gastroenterol 2020 Aug;31(8):573-580. doi: 10.5152/tjg.2020.19322. PMID: 32915145Free PMC Article

Prognosis

p107 Expression in colorectal tumours rises during carcinogenesis and falls during invasion.
Wu F, Li JQ, Miki H, Nishioka M, Fujita J, Ohmori M, Imaida K, Kuriyama S
Eur J Cancer 2002 Sep;38(14):1838-48. doi: 10.1016/s0959-8049(02)00146-6. PMID: 12204665
Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma.
Li JQ, Miki H, Ohmori M, Wu F, Funamoto Y
Hum Pathol 2001 Sep;32(9):945-53. doi: 10.1053/hupa.2001.27116. PMID: 11567224

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