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Colorectal Microvesicular Hyperplastic Polyp

MedGen UID:
474433
•Concept ID:
C3272800
•
Disease or Syndrome
Synonym: Colorectal MVHP

Definition

A serrated hyperplastic polyp that arises from the colon and rectum. It is characterized by the presence of microvacuolated columnar cells that are admixed with small numbers of goblet cells. There is no evidence of epithelial atypia or dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Microvesicular Hyperplastic Polyp

Recent clinical studies

Etiology

Exploring the spectrum of serrated epithelium encountered in inflammatory bowel disease.
Waters KM, Singhi AD, Montgomery EA
Hum Pathol 2023 Feb;132:126-134. Epub 2022 Jun 23 doi: 10.1016/j.humpath.2022.06.018. PMID: 35753410Free PMC Article
Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Epidemiology of goblet cell and microvesicular hyperplastic polyps.
Qazi TM, O'Brien MJ, Farraye FA, Gould RW, Chen CA, Schroy PC 3rd
Am J Gastroenterol 2014 Dec;109(12):1922-32. Epub 2014 Oct 28 doi: 10.1038/ajg.2014.325. PMID: 25350766
Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea.
Kim KM, Lee EJ, Ha S, Kang SY, Jang KT, Park CK, Kim JY, Kim YH, Chang DK, Odze RD
Am J Surg Pathol 2011 Sep;35(9):1274-86. doi: 10.1097/PAS.0b013e318224cd2e. PMID: 21836485

Diagnosis

Molecular characteristics of colorectal hyperplastic polyp subgroups.
Ünlü M, Uzun E, Bengi G, Sağol Ö, Sarıoğlu S
Turk J Gastroenterol 2020 Aug;31(8):573-580. doi: 10.5152/tjg.2020.19322. PMID: 32915145Free PMC Article
Colonic perineurioma (benign fibroblastic polyp): case report and review of the literature.
van Wyk AC, van Zyl H, Rigby J
Diagn Pathol 2018 Feb 20;13(1):16. doi: 10.1186/s13000-018-0694-z. PMID: 29463272Free PMC Article
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Gastric-type expression signature in serrated pathway-associated colorectal tumors.
Kim JH, Kim KJ, Rhee YY, Bae JM, Cho NY, Lee HS, Kang GH
Hum Pathol 2015 May;46(5):643-56. Epub 2015 Jan 15 doi: 10.1016/j.humpath.2015.01.003. PMID: 25704805
Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics.
Rosty C, Buchanan DD, Walsh MD, Pearson SA, Pavluk E, Walters RJ, Clendenning M, Spring KJ, Jenkins MA, Win AK, Hopper JL, Sweet K, Frankel WL, Aronson M, Gallinger S, Goldblatt J, Woodall S, Arnold J, Walker NI, Jass JR, Parry S, Young JP
Am J Surg Pathol 2012 Jun;36(6):876-82. doi: 10.1097/PAS.0b013e31824e133f. PMID: 22510757Free PMC Article

Therapy

Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article
Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma.
Carr NJ, Mahajan H, Tan KL, Hawkins NJ, Ward RL
J Clin Pathol 2009 Jun;62(6):516-8. Epub 2009 Jan 6 doi: 10.1136/jcp.2008.061960. PMID: 19126563

Prognosis

Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article
The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential.
Renaud F, Mariette C, Vincent A, Wacrenier A, Maunoury V, Leclerc J, Coppin L, Crépin M, Van Seuningen I, Leteurtre E, Buisine MP
Int J Cancer 2016 Mar 15;138(6):1472-81. Epub 2015 Oct 30 doi: 10.1002/ijc.29891. PMID: 26476272
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Critical appraisal of the diagnosis of the sessile serrated adenoma.
Bettington M, Walker N, Rosty C, Brown I, Clouston A, Wockner L, Whitehall V, Leggett B
Am J Surg Pathol 2014 Feb;38(2):158-66. doi: 10.1097/PAS.0000000000000103. PMID: 24418851
Improved molecular classification of serrated lesions of the colon by immunohistochemical detection of BRAF V600E.
Mesteri I, Bayer G, Meyer J, Capper D, Schoppmann SF, von Deimling A, Birner P
Mod Pathol 2014 Jan;27(1):135-44. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.126. PMID: 23887306

Clinical prediction guides

Increased GS-II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps.
Matoba H, Iwaya M, Sato Y, Kobayashi N, Takemura H, Kouno Y, Karasawa A, Nakayama J
Pathol Int 2023 Jun;73(6):246-254. Epub 2023 Apr 10 doi: 10.1111/pin.13321. PMID: 37036163
Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.
Crockett SD, Barry EL, Mott LA, Snover DC, Wallace K, Baron JA
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1058-1067. doi: 10.1158/1055-9965.EPI-21-1226. PMID: 35506244Free PMC Article
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Critical appraisal of the diagnosis of the sessile serrated adenoma.
Bettington M, Walker N, Rosty C, Brown I, Clouston A, Wockner L, Whitehall V, Leggett B
Am J Surg Pathol 2014 Feb;38(2):158-66. doi: 10.1097/PAS.0000000000000103. PMID: 24418851
Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea.
Kim KM, Lee EJ, Ha S, Kang SY, Jang KT, Park CK, Kim JY, Kim YH, Chang DK, Odze RD
Am J Surg Pathol 2011 Sep;35(9):1274-86. doi: 10.1097/PAS.0b013e318224cd2e. PMID: 21836485

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