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Age-Related Atrophy

MedGen UID:
474844
•Concept ID:
C3273211
•
Pathologic Function

Definition

Atrophy of the nervous system tissues and/or muscle tissues that is related to aging. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAge-Related Atrophy

Professional guidelines

PubMed

Clinical utility of brain computed tomography in prediction of post-stroke delirium.
Czyzycki M, Glen A, Slowik A, Chrzan R, Dziedzic T
J Neural Transm (Vienna) 2021 Feb;128(2):207-213. Epub 2021 Jan 8 doi: 10.1007/s00702-020-02294-9. PMID: 33417010
Recent advances in the treatment of graft-versus-host disease.
Iwasaki T
Clin Med Res 2004 Nov;2(4):243-52. doi: 10.3121/cmr.2.4.243. PMID: 15931364Free PMC Article

Recent clinical studies

Etiology

Long-term depressive symptoms and midlife brain age.
Dintica CS, Habes M, Erus G, Simone T, Schreiner P, Yaffe K
J Affect Disord 2023 Jan 1;320:436-441. Epub 2022 Oct 3 doi: 10.1016/j.jad.2022.09.164. PMID: 36202300Free PMC Article
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).
Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, B Emesh T, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I
Am J Clin Nutr 2022 May 1;115(5):1270-1281. doi: 10.1093/ajcn/nqac001. PMID: 35021194Free PMC Article
Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.
Cheng Y, Xu J, Dong C, Shen Z, Zhou C, Li N, Lu Y, Ran L, Xu L, Shan B, Xu X
Neuroimage Clin 2020;28:102384. Epub 2020 Aug 26 doi: 10.1016/j.nicl.2020.102384. PMID: 32911427Free PMC Article
Autologous fibroblasts for vocal scars and age-related atrophy: A randomized clinical trial.
Ma Y, Long J, Amin MR, Branski RC, Damrose EJ, Sung CK, Achlatis S, Kearney A, Chhetri DK
Laryngoscope 2020 Nov;130(11):2650-2658. Epub 2019 Dec 5 doi: 10.1002/lary.28453. PMID: 31804729Free PMC Article
Effects of the antidiabetic drugs on the age-related atrophy and sarcopenia associated with diabetes type II.
Cetrone M, Mele A, Tricarico D
Curr Diabetes Rev 2014;10(4):231-7. doi: 10.2174/1573399810666140918121022. PMID: 25245021

Diagnosis

Long-term depressive symptoms and midlife brain age.
Dintica CS, Habes M, Erus G, Simone T, Schreiner P, Yaffe K
J Affect Disord 2023 Jan 1;320:436-441. Epub 2022 Oct 3 doi: 10.1016/j.jad.2022.09.164. PMID: 36202300Free PMC Article
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).
Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, B Emesh T, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I
Am J Clin Nutr 2022 May 1;115(5):1270-1281. doi: 10.1093/ajcn/nqac001. PMID: 35021194Free PMC Article
Regional age-related atrophy after screening for preclinical alzheimer disease.
Koenig LN, LaMontagne P, Glasser MF, Bateman R, Holtzman D, Yakushev I, Chhatwal J, Day GS, Jack C, Mummery C, Perrin RJ, Gordon BA, Morris JC, Shimony JS, Benzinger TLS; Dominantly Inherited Alzheimer Network (DIAN)
Neurobiol Aging 2022 Jan;109:43-51. Epub 2021 Sep 15 doi: 10.1016/j.neurobiolaging.2021.09.010. PMID: 34655980Free PMC Article
Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.
Cheng Y, Xu J, Dong C, Shen Z, Zhou C, Li N, Lu Y, Ran L, Xu L, Shan B, Xu X
Neuroimage Clin 2020;28:102384. Epub 2020 Aug 26 doi: 10.1016/j.nicl.2020.102384. PMID: 32911427Free PMC Article
Age-related changes in the structure and function of brain regions involved in pain processing.
Farrell MJ
Pain Med 2012 Apr;13 Suppl 2:S37-43. doi: 10.1111/j.1526-4637.2011.01287.x. PMID: 22497746

Therapy

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).
Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, B Emesh T, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I
Am J Clin Nutr 2022 May 1;115(5):1270-1281. doi: 10.1093/ajcn/nqac001. PMID: 35021194Free PMC Article
Autologous fibroblasts for vocal scars and age-related atrophy: A randomized clinical trial.
Ma Y, Long J, Amin MR, Branski RC, Damrose EJ, Sung CK, Achlatis S, Kearney A, Chhetri DK
Laryngoscope 2020 Nov;130(11):2650-2658. Epub 2019 Dec 5 doi: 10.1002/lary.28453. PMID: 31804729Free PMC Article
Effects of the antidiabetic drugs on the age-related atrophy and sarcopenia associated with diabetes type II.
Cetrone M, Mele A, Tricarico D
Curr Diabetes Rev 2014;10(4):231-7. doi: 10.2174/1573399810666140918121022. PMID: 25245021
cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration.
Berdeaux R, Stewart R
Am J Physiol Endocrinol Metab 2012 Jul 1;303(1):E1-17. Epub 2012 Feb 21 doi: 10.1152/ajpendo.00555.2011. PMID: 22354781Free PMC Article
Neurotrophic factors and diseases of the nervous system.
Tuszynski MH, Gage FH
Ann Neurol 1994;35 Suppl:S9-12. doi: 10.1002/ana.410350705. PMID: 8185304

Prognosis

Neural Presbyacusis in Humans Inferred from Age-Related Differences in Auditory Nerve Function and Structure.
Harris KC, Ahlstrom JB, Dias JW, Kerouac LB, McClaskey CM, Dubno JR, Eckert MA
J Neurosci 2021 Dec 15;41(50):10293-10304. Epub 2021 Nov 9 doi: 10.1523/JNEUROSCI.1747-21.2021. PMID: 34753738Free PMC Article
Select Atrophied Regions in Alzheimer disease (SARA): An improved volumetric model for identifying Alzheimer disease dementia.
Koenig LN, Day GS, Salter A, Keefe S, Marple LM, Long J, LaMontagne P, Massoumzadeh P, Snider BJ, Kanthamneni M, Raji CA, Ghoshal N, Gordon BA, Miller-Thomas M, Morris JC, Shimony JS, Benzinger TLS; Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN)
Neuroimage Clin 2020;26:102248. Epub 2020 Mar 16 doi: 10.1016/j.nicl.2020.102248. PMID: 32334404Free PMC Article
Effects of the antidiabetic drugs on the age-related atrophy and sarcopenia associated with diabetes type II.
Cetrone M, Mele A, Tricarico D
Curr Diabetes Rev 2014;10(4):231-7. doi: 10.2174/1573399810666140918121022. PMID: 25245021
Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease.
Grothe M, Heinsen H, Teipel SJ
Biol Psychiatry 2012 May 1;71(9):805-13. Epub 2011 Aug 4 doi: 10.1016/j.biopsych.2011.06.019. PMID: 21816388Free PMC Article
Neurotrophic factors and diseases of the nervous system.
Tuszynski MH, Gage FH
Ann Neurol 1994;35 Suppl:S9-12. doi: 10.1002/ana.410350705. PMID: 8185304

Clinical prediction guides

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).
Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, B Emesh T, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I
Am J Clin Nutr 2022 May 1;115(5):1270-1281. doi: 10.1093/ajcn/nqac001. PMID: 35021194Free PMC Article
Neural Presbyacusis in Humans Inferred from Age-Related Differences in Auditory Nerve Function and Structure.
Harris KC, Ahlstrom JB, Dias JW, Kerouac LB, McClaskey CM, Dubno JR, Eckert MA
J Neurosci 2021 Dec 15;41(50):10293-10304. Epub 2021 Nov 9 doi: 10.1523/JNEUROSCI.1747-21.2021. PMID: 34753738Free PMC Article
Autologous fibroblasts for vocal scars and age-related atrophy: A randomized clinical trial.
Ma Y, Long J, Amin MR, Branski RC, Damrose EJ, Sung CK, Achlatis S, Kearney A, Chhetri DK
Laryngoscope 2020 Nov;130(11):2650-2658. Epub 2019 Dec 5 doi: 10.1002/lary.28453. PMID: 31804729Free PMC Article
Targeting age-related differences in brain and cognition with multimodal imaging and connectome topography profiling.
Lowe AJ, Paquola C, Vos de Wael R, Girn M, Lariviere S, Tavakol S, Caldairou B, Royer J, Schrader DV, Bernasconi A, Bernasconi N, Spreng RN, Bernhardt BC
Hum Brain Mapp 2019 Dec 15;40(18):5213-5230. Epub 2019 Aug 24 doi: 10.1002/hbm.24767. PMID: 31444896Free PMC Article
Cortical complexity as a measure of age-related brain atrophy.
Madan CR, Kensinger EA
Neuroimage 2016 Jul 1;134:617-629. Epub 2016 Apr 19 doi: 10.1016/j.neuroimage.2016.04.029. PMID: 27103141Free PMC Article

Recent systematic reviews

Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression.
Dallaway A, Kite C, Griffen C, Duncan M, Tallis J, Renshaw D, Hattersley J
Exp Gerontol 2020 May;133:110856. Epub 2020 Jan 30 doi: 10.1016/j.exger.2020.110856. PMID: 32006635

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