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Small Intestinal Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

MedGen UID:
475775
•Concept ID:
C3274142
•
Neoplastic Process
Synonyms: Small Intestinal EC-Cell Serotonin-Producing NET; Small Intestinal EC-Cell Serotonin-Producing Neuroendocrine Tumor; Small Intestinal Enterochromaffin Cell (EC-Cell), Serotonin-Producing Neuroendocrine Tumor; Small Intestinal Enterochromaffin Cell, Serotonin-Producing Neuroendocrine Tumor

Definition

A well differentiated neuroendocrine tumor that arises from the small intestine and produces serotonin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

Recent clinical studies

Etiology

From the archives of the AFIP: Gastrointestinal carcinoids: imaging features with clinicopathologic comparison.
Levy AD, Sobin LH
Radiographics 2007 Jan-Feb;27(1):237-57. doi: 10.1148/rg.271065169. PMID: 17235010

Diagnosis

The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK
Endocr Relat Cancer 2010 Mar;17(1):283-91. Epub 2010 Feb 18 doi: 10.1677/ERC-09-0243. PMID: 20048018
Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas.
Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V
Mod Pathol 2009 Feb;22(2):261-72. Epub 2008 Oct 24 doi: 10.1038/modpathol.2008.174. PMID: 18953328
From the archives of the AFIP: Gastrointestinal carcinoids: imaging features with clinicopathologic comparison.
Levy AD, Sobin LH
Radiographics 2007 Jan-Feb;27(1):237-57. doi: 10.1148/rg.271065169. PMID: 17235010

Prognosis

Pathology of gastrointestinal disorders.
Rindi G, Inzani F, Solcia E
Endocrinol Metab Clin North Am 2010 Dec;39(4):713-27. doi: 10.1016/j.ecl.2010.08.009. PMID: 21095540
From the archives of the AFIP: Gastrointestinal carcinoids: imaging features with clinicopathologic comparison.
Levy AD, Sobin LH
Radiographics 2007 Jan-Feb;27(1):237-57. doi: 10.1148/rg.271065169. PMID: 17235010

Clinical prediction guides

Pathology of gastrointestinal disorders.
Rindi G, Inzani F, Solcia E
Endocrinol Metab Clin North Am 2010 Dec;39(4):713-27. doi: 10.1016/j.ecl.2010.08.009. PMID: 21095540
The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK
Endocr Relat Cancer 2010 Mar;17(1):283-91. Epub 2010 Feb 18 doi: 10.1677/ERC-09-0243. PMID: 20048018

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