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Small intestinal L-cell glucagon-like peptide producing tumor

MedGen UID:
475776
•Concept ID:
C3274143
•
Neoplastic Process
Synonyms: L-cell glucagon-like peptide-producing neuroendocrine tumor of small intestine; L-cell glucagon-like peptide-producing neuroendocrine tumour of small intestine; small intestinal L-cell glucagon-like peptide producing tumor; Small Intestinal L-Cell Glucagon-Like Peptide-Producing NET; small intestinal L-cell glucagon-like peptide-producing NET; Small Intestinal L-Cell Glucagon-Like Peptide-Producing Neuroendocrine Tumor; small intestinal L-cell glucagon-like peptide-producing neuroendocrine tumor; small intestinal L-cell glucagon-like peptide-producing neuroendocrine tumour; Small Intestinal L-Cell, Glucagon-Like Peptide-Producing Neuroendocrine Tumor; small intestinal L-cell, glucagon-like peptide-producing neuroendocrine tumor; small intestinal L-cell, glucagon-like peptide-producing neuroendocrine tumour; small intestine L-cell glucagon-like peptide-producing neuroendocrine tumor; small intestine L-cell glucagon-like peptide-producing neuroendocrine tumour
 
Monarch Initiative: MONDO:0004252

Definition

A neuroendocrine tumor that arises from the small intestine and produces glucagon-like peptides. Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall intestinal L-cell glucagon-like peptide producing tumor

Recent clinical studies

Etiology

Abundance and turnover of GLP-1 producing L-cells in ileal mucosa are not different in patients with and without type 2 diabetes.
Kampmann K, Ueberberg S, Menge BA, Breuer TG, Uhl W, Tannapfel A, Meier JJ
Metabolism 2016 Mar;65(3):84-91. Epub 2015 Oct 23 doi: 10.1016/j.metabol.2015.10.025. PMID: 26892519

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