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EWSR1-FLI1 Fusion Protein Expression

MedGen UID:
476795
Concept ID:
C3275162
Cell or Molecular Dysfunction
Synonyms: EWS-FLI1 Fusion Protein Expression; EWS/FLI1 Fusion Protein Expression; EWSR1/FLI1 Fusion Protein Expression

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEWSR1-FLI1 Fusion Protein Expression

Recent clinical studies

Etiology

Mo J, Tan K, Dong Y, Lu W, Liu F, Mei Y, Huang H, Zhao K, Lv Z, Ye Y, Tang Y
Oncogene 2023 Jan;42(1):11-25. Epub 2022 Nov 10 doi: 10.1038/s41388-022-02533-1. PMID: 36357572
Vasileva E, Warren M, Triche TJ, Amatruda JF
Elife 2022 Mar 14;11 doi: 10.7554/eLife.69734. PMID: 35285802Free PMC Article
Lindén M, Thomsen C, Grundevik P, Jonasson E, Andersson D, Runnberg R, Dolatabadi S, Vannas C, Luna Santamarίa M, Fagman H, Ståhlberg A, Åman P
EMBO Rep 2019 May;20(5) Epub 2019 Apr 8 doi: 10.15252/embr.201845766. PMID: 30962207Free PMC Article
Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U
Nat Rev Dis Primers 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. PMID: 29977059
Graham RP, Nair AA, Davila JI, Jin L, Jen J, Sukov WR, Wu TT, Appelman HD, Torres-Mora J, Perry KD, Zhang L, Kloft-Nelson SM, Knudson RA, Greipp PT, Folpe AL
Mod Pathol 2017 Oct;30(10):1443-1452. Epub 2017 Jul 21 doi: 10.1038/modpathol.2017.68. PMID: 28731043

Diagnosis

Yin T, Shao M, Sun M, Zhao L, Lao IW, Yu L, Wang J
Am J Surg Pathol 2024 Mar 1;48(3):275-283. Epub 2023 Dec 8 doi: 10.1097/PAS.0000000000002163. PMID: 38062799
Knott MML, Cidre-Aranaz F
Methods Mol Biol 2021;2226:119-138. doi: 10.1007/978-1-0716-1020-6_9. PMID: 33326097
Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U
Nat Rev Dis Primers 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. PMID: 29977059
Charville GW, Wang WL, Ingram DR, Roy A, Thomas D, Patel RM, Hornick JL, van de Rijn M, Lazar AJ
Mod Pathol 2017 Sep;30(9):1312-1320. Epub 2017 Jun 23 doi: 10.1038/modpathol.2017.49. PMID: 28643791
Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, Greninger P, Thompson IR, Luo X, Soares J, Liu Q, Iorio F, Surdez D, Chen L, Milano RJ, Bignell GR, Tam AT, Davies H, Stevenson JA, Barthorpe S, Lutz SR, Kogera F, Lawrence K, McLaren-Douglas A, Mitropoulos X, Mironenko T, Thi H, Richardson L, Zhou W, Jewitt F, Zhang T, O'Brien P, Boisvert JL, Price S, Hur W, Yang W, Deng X, Butler A, Choi HG, Chang JW, Baselga J, Stamenkovic I, Engelman JA, Sharma SV, Delattre O, Saez-Rodriguez J, Gray NS, Settleman J, Futreal PA, Haber DA, Stratton MR, Ramaswamy S, McDermott U, Benes CH
Nature 2012 Mar 28;483(7391):570-5. doi: 10.1038/nature11005. PMID: 22460902Free PMC Article

Therapy

Hölting TLB, Cidre-Aranaz F, Matzek D, Popper B, Jacobi SJ, Funk CM, Geyer FH, Li J, Piseddu I, Cadilha BL, Ledderose S, Zwilling J, Ohmura S, Anz D, Künkele A, Klauschen F, Grünewald TGP, Knott MML
Mol Cancer 2022 Oct 13;21(1):199. doi: 10.1186/s12943-022-01641-6. PMID: 36229873Free PMC Article
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG
Cell Chem Biol 2022 Aug 18;29(8):1325-1332.e4. Epub 2022 Jul 7 doi: 10.1016/j.chembiol.2022.06.002. PMID: 35803262Free PMC Article
Khoogar R, Li F, Chen Y, Ignatius M, Lawlor ER, Kitagawa K, Huang TH, Phelps DA, Houghton PJ
Cell Oncol (Dordr) 2022 Feb;45(1):19-40. Epub 2022 Jan 7 doi: 10.1007/s13402-021-00640-x. PMID: 34997546Free PMC Article
Pascual-Pasto G, Castillo-Ecija H, Unceta N, Aschero R, Resa-Pares C, Gómez-Caballero A, Vila-Ubach M, Muñoz-Aznar O, Suñol M, Burgueño V, Gomez-Gonzalez S, Sosnik A, Ibarra M, Schaiquevich P, de Álava E, Tirado OM, Mora J, Carcaboso AM
J Control Release 2022 Feb;342:81-92. Epub 2021 Dec 30 doi: 10.1016/j.jconrel.2021.12.035. PMID: 34974029
Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Hölting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, Wehweck FS, Romero-Pérez L, Gerke JS, Orth MF, Marchetto A, Kirchner T, Bach H, Sannino G, Grünewald TGP
Cell Death Dis 2019 Feb 11;10(2):116. doi: 10.1038/s41419-019-1372-0. PMID: 30741933Free PMC Article

Prognosis

Yin T, Shao M, Sun M, Zhao L, Lao IW, Yu L, Wang J
Am J Surg Pathol 2024 Mar 1;48(3):275-283. Epub 2023 Dec 8 doi: 10.1097/PAS.0000000000002163. PMID: 38062799
Ceranski AK, Carreño-Gonzalez MJ, Ehlers AC, Colombo MV, Cidre-Aranaz F, Grünewald TGP
Mol Cancer 2023 Mar 13;22(1):49. doi: 10.1186/s12943-023-01750-w. PMID: 36915100Free PMC Article
Kim MS, Lee WS, Lee H, Jin W
Cell Death Dis 2022 Sep 28;13(9):836. doi: 10.1038/s41419-022-05275-w. PMID: 36171207Free PMC Article
Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Hölting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, Wehweck FS, Romero-Pérez L, Gerke JS, Orth MF, Marchetto A, Kirchner T, Bach H, Sannino G, Grünewald TGP
Cell Death Dis 2019 Feb 11;10(2):116. doi: 10.1038/s41419-019-1372-0. PMID: 30741933Free PMC Article
Graham RP, Nair AA, Davila JI, Jin L, Jen J, Sukov WR, Wu TT, Appelman HD, Torres-Mora J, Perry KD, Zhang L, Kloft-Nelson SM, Knudson RA, Greipp PT, Folpe AL
Mod Pathol 2017 Oct;30(10):1443-1452. Epub 2017 Jul 21 doi: 10.1038/modpathol.2017.68. PMID: 28731043

Clinical prediction guides

Doll S, Schweizer L, Bollwein C, Steiger K, Pfarr N, Walker M, Wörtler K, Knebel C, von Eisenhart-Rothe R, Hartmann W, Weichert W, Mann M, Kuhn PH, Specht K
Mod Pathol 2024 Jul;37(7):100511. Epub 2024 May 3 doi: 10.1016/j.modpat.2024.100511. PMID: 38705279
Lee OW, Rodrigues C, Lin SH, Luo W, Jones K, Brown DW, Zhou W, Karlins E, Khan SM, Baulande S, Raynal V, Surdez D, Reynaud S, Rubio RA, Zaidi S, Grossetête S, Ballet S, Lapouble E, Laurence V, Pierron G, Gaspar N, Corradini N, Marec-Bérard P, Rothman N, Dagnall CL, Burdett L, Manning M, Wyatt K, Yeager M, Chari R, Leisenring WM, Kulozik AE, Kriebel J, Meitinger T, Strauch K, Kirchner T, Dirksen U, Mirabello L, Tucker MA, Tirode F, Armstrong GT, Bhatia S, Robison LL, Yasui Y, Romero-Pérez L, Hartmann W, Metzler M, Diver WR, Lori A, Freedman ND, Hoover RN, Morton LM, Chanock SJ, Grünewald TGP, Delattre O, Machiela MJ
Am J Hum Genet 2023 Mar 2;110(3):427-441. Epub 2023 Feb 13 doi: 10.1016/j.ajhg.2023.01.017. PMID: 36787739Free PMC Article
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG
Cell Chem Biol 2022 Aug 18;29(8):1325-1332.e4. Epub 2022 Jul 7 doi: 10.1016/j.chembiol.2022.06.002. PMID: 35803262Free PMC Article
Surdez D, Zaidi S, Grossetête S, Laud-Duval K, Ferre AS, Mous L, Vourc'h T, Tirode F, Pierron G, Raynal V, Baulande S, Brunet E, Hill V, Delattre O
Cancer Cell 2021 Jun 14;39(6):810-826.e9. Epub 2021 Apr 29 doi: 10.1016/j.ccell.2021.04.001. PMID: 33930311
Charville GW, Wang WL, Ingram DR, Roy A, Thomas D, Patel RM, Hornick JL, van de Rijn M, Lazar AJ
Mod Pathol 2017 Sep;30(9):1312-1320. Epub 2017 Jun 23 doi: 10.1038/modpathol.2017.49. PMID: 28643791

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