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Crypt hyperplasia

MedGen UID:
482134
Concept ID:
C3280504
Finding
HPO: HP:0034588

Definition

Crypt hyperplasia denotes elongation of the length of the crypts of Lieberkuhn, a process that initially precedes villous atrophy. Elongation may be caused by expansion of the lamina propria as a result of the proliferation of stromal cells, an influx of inflammatory cells and tissue remodelling. [from HPO]

Conditions with this feature

Congenital diarrhea 5 with tufting enteropathy
MedGen UID:
413031
Concept ID:
C2750737
Disease or Syndrome
Congenital tufting enteropathy (CTE) is a rare inherited intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum. CTE presents in the first few months of life with chronic watery diarrhea and failure to thrive, and most affected individuals require parenteral nutrition for normal growth and development (summary by Sivagnanam et al., 2008). Semiquantitative assessment of the epithelial surface in CTE patients revealed that 80 to 90% contained tufts, compared to only 16% in patients with celiac disease and less than 10% in normal jejunum (Reifen et al., 1994). For a discussion of genetic heterogeneity of diarrhea, see DIAR1 (214700).

Professional guidelines

PubMed

Elli L, Ferretti F, Orlando S, Vecchi M, Monguzzi E, Roncoroni L, Schuppan D
Eur J Intern Med 2019 Mar;61:15-24. Epub 2018 Dec 5 doi: 10.1016/j.ejim.2018.11.012. PMID: 30528262
Hvas CL, Jensen MD, Reimer MC, Riis LB, Rumessen JJ, Skovbjerg H, Teisner A, Wildt S
Dan Med J 2015 Apr;62(4):C5051. PMID: 25872537
Setty M, Hormaza L, Guandalini S
Mol Diagn Ther 2008;12(5):289-98. doi: 10.1007/BF03256294. PMID: 18803427

Recent clinical studies

Etiology

Bhat VS, Cohen SM, Gordon EB, Wood CE, Cullen JM, Harris MA, Proctor DM, Thompson CM
Crit Rev Toxicol 2020 Sep;50(8):685-706. Epub 2020 Nov 4 doi: 10.1080/10408444.2020.1823934. PMID: 33146058
Volta U, Caio G, Ghirardi C, Lungaro L, Mansueto P, Carroccio A, De Giorgio R
Dig Dis Sci 2020 Oct;65(10):2761-2768. doi: 10.1007/s10620-020-06571-1. PMID: 32875530
Elli L, Ferretti F, Orlando S, Vecchi M, Monguzzi E, Roncoroni L, Schuppan D
Eur J Intern Med 2019 Mar;61:15-24. Epub 2018 Dec 5 doi: 10.1016/j.ejim.2018.11.012. PMID: 30528262
Hvas CL, Jensen MD, Reimer MC, Riis LB, Rumessen JJ, Skovbjerg H, Teisner A, Wildt S
Dan Med J 2015 Apr;62(4):C5051. PMID: 25872537
Antonioli DA
Mod Pathol 2003 Apr;16(4):342-6. doi: 10.1097/01.MP.0000062997.16339.47. PMID: 12692199

Diagnosis

ShibenduGhosh CV, Yusuf SA
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443489
Francalanci P, Cafferata B, Alaggio R, de Angelis P, Diamanti A, Parente P, Granai M, Lazzi S
Pathologica 2022 Feb;114(1):32-39. Epub 2021 Dec 2 doi: 10.32074/1591-951X-339. PMID: 34856606Free PMC Article
Domsa EM, Berindan-Neagoe I, Para I, Munteanu L, Matei D, Andreica V
J Physiol Pharmacol 2020 Feb;71(1) Epub 2020 Apr 27 doi: 10.26402/jpp.2020.1.01. PMID: 32350146
Hvas CL, Jensen MD, Reimer MC, Riis LB, Rumessen JJ, Skovbjerg H, Teisner A, Wildt S
Dan Med J 2015 Apr;62(4):C5051. PMID: 25872537
Rodrigo L
World J Gastroenterol 2006 Nov 7;12(41):6585-93. doi: 10.3748/wjg.v12.i41.6585. PMID: 17075969

Therapy

Kulkarni A, Patel S, Khanna D, Parmar MS
Eur J Pharmacol 2021 Oct 15;909:174434. Epub 2021 Aug 18 doi: 10.1016/j.ejphar.2021.174434. PMID: 34418405
Escudero-Hernández C
Int Rev Cell Mol Biol 2021;358:133-164. Epub 2020 Oct 28 doi: 10.1016/bs.ircmb.2020.09.007. PMID: 33707053
Domsa EM, Berindan-Neagoe I, Para I, Munteanu L, Matei D, Andreica V
J Physiol Pharmacol 2020 Feb;71(1) Epub 2020 Apr 27 doi: 10.26402/jpp.2020.1.01. PMID: 32350146
Lindfors K, Lähdeaho ML, Kalliokoski S, Kurppa K, Collin P, Mäki M, Kaukinen K
Expert Opin Ther Targets 2012 Jul;16(7):665-75. Epub 2012 May 24 doi: 10.1517/14728222.2012.688808. PMID: 22620264
Rodrigo L
World J Gastroenterol 2006 Nov 7;12(41):6585-93. doi: 10.3748/wjg.v12.i41.6585. PMID: 17075969

Prognosis

Singh A, Kleinhenz J, Brill H, Fahey L, Silvester JA, Sparks B, Verma R, Lee D, Mallon D, Leonard MM
J Pediatr Gastroenterol Nutr 2023 Dec 1;77(6):698-702. Epub 2023 Aug 23 doi: 10.1097/MPG.0000000000003923. PMID: 37608439Free PMC Article
Kulkarni A, Patel S, Khanna D, Parmar MS
Eur J Pharmacol 2021 Oct 15;909:174434. Epub 2021 Aug 18 doi: 10.1016/j.ejphar.2021.174434. PMID: 34418405
Volta U, Caio G, Ghirardi C, Lungaro L, Mansueto P, Carroccio A, De Giorgio R
Dig Dis Sci 2020 Oct;65(10):2761-2768. doi: 10.1007/s10620-020-06571-1. PMID: 32875530
Liu W, Rodgers GP
Cancer Metastasis Rev 2016 Jun;35(2):201-12. doi: 10.1007/s10555-016-9624-2. PMID: 27178440
Hvas CL, Jensen MD, Reimer MC, Riis LB, Rumessen JJ, Skovbjerg H, Teisner A, Wildt S
Dan Med J 2015 Apr;62(4):C5051. PMID: 25872537

Clinical prediction guides

ShibenduGhosh CV, Yusuf SA
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443489
Volta U, Caio G, Ghirardi C, Lungaro L, Mansueto P, Carroccio A, De Giorgio R
Dig Dis Sci 2020 Oct;65(10):2761-2768. doi: 10.1007/s10620-020-06571-1. PMID: 32875530
Domsa EM, Berindan-Neagoe I, Para I, Munteanu L, Matei D, Andreica V
J Physiol Pharmacol 2020 Feb;71(1) Epub 2020 Apr 27 doi: 10.26402/jpp.2020.1.01. PMID: 32350146
Rossi T
Adolesc Med Clin 2004 Feb;15(1):91-103, ix. doi: 10.1016/j.admecli.2003.11.006. PMID: 15272258
Guandalini S
Drugs 1988;36 Suppl 4:26-38. doi: 10.2165/00003495-198800364-00006. PMID: 3069442

Recent systematic reviews

Harper KM, Mutasa M, Prendergast AJ, Humphrey J, Manges AR
PLoS Negl Trop Dis 2018 Jan;12(1):e0006205. Epub 2018 Jan 19 doi: 10.1371/journal.pntd.0006205. PMID: 29351288Free PMC Article

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