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Rabies

MedGen UID:
48308
•Concept ID:
C0034494
•
Disease or Syndrome
Synonym: Lyssa
SNOMED CT: Rabies (14168008); Hydrophobia (14168008); Lyssa (14168008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019173
Orphanet: ORPHA770

Definition

Rabies is a viral zoonosis leading to a fatal encephalopathy if not treated. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRabies
Follow this link to review classifications for Rabies in Orphanet.

Professional guidelines

PubMed

Human Rabies Treatment-From Palliation to Promise.
Lacy M, Phasuk N, Scholand SJ
Viruses 2024 Jan 22;16(1) doi: 10.3390/v16010160. PMID: 38275970Free PMC Article
Management and treatment of animal bites.
Hurt JB, Maday KR
JAAPA 2018 Apr;31(4):27-31. doi: 10.1097/01.JAA.0000531049.59137.cd. PMID: 30973531
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163

Recent clinical studies

Therapy

Development of mRNA rabies vaccines.
Fang Z, Yu P, Zhu W
Hum Vaccin Immunother 2024 Dec 31;20(1):2382499. Epub 2024 Jul 28 doi: 10.1080/21645515.2024.2382499. PMID: 39069645Free PMC Article
Rabies postexposure prophylaxis: What the U.S. emergency medicine provider needs to know.
Gibbons K, Dvoracek K
Acad Emerg Med 2023 Nov;30(11):1144-1149. Epub 2023 Jun 14 doi: 10.1111/acem.14755. PMID: 37245074
Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial.
Datoo MS, Natama HM, Somé A, Bellamy D, Traoré O, Rouamba T, Tahita MC, Ido NFA, Yameogo P, Valia D, Millogo A, Ouedraogo F, Soma R, Sawadogo S, Sorgho F, Derra K, Rouamba E, Ramos-Lopez F, Cairns M, Provstgaard-Morys S, Aboagye J, Lawrie A, Roberts R, Valéa I, Sorgho H, Williams N, Glenn G, Fries L, Reimer J, Ewer KJ, Shaligram U, Hill AVS, Tinto H
Lancet Infect Dis 2022 Dec;22(12):1728-1736. Epub 2022 Sep 7 doi: 10.1016/S1473-3099(22)00442-X. PMID: 36087586
Rabies.
Gelbart D
JAAPA 2019 Oct;32(10):46-47. doi: 10.1097/01.JAA.0000580572.87216.17. PMID: 31567742
Preface.
Fooks AR
Vaccine 2019 Aug 2;37(33):4659. Epub 2019 Jul 6 doi: 10.1016/j.vaccine.2019.07.006. PMID: 31288995

Prognosis

Travel vaccines-priorities determined by incidence and impact.
Steffen R, Chen LH, Leggat PA
J Travel Med 2023 Nov 18;30(7) doi: 10.1093/jtm/taad085. PMID: 37341307
Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial.
Datoo MS, Natama HM, Somé A, Bellamy D, Traoré O, Rouamba T, Tahita MC, Ido NFA, Yameogo P, Valia D, Millogo A, Ouedraogo F, Soma R, Sawadogo S, Sorgho F, Derra K, Rouamba E, Ramos-Lopez F, Cairns M, Provstgaard-Morys S, Aboagye J, Lawrie A, Roberts R, Valéa I, Sorgho H, Williams N, Glenn G, Fries L, Reimer J, Ewer KJ, Shaligram U, Hill AVS, Tinto H
Lancet Infect Dis 2022 Dec;22(12):1728-1736. Epub 2022 Sep 7 doi: 10.1016/S1473-3099(22)00442-X. PMID: 36087586
Global burden and trends of neglected tropical diseases from 1990 to 2019.
Lin Y, Fang K, Zheng Y, Wang HL, Wu J
J Travel Med 2022 May 31;29(3) doi: 10.1093/jtm/taac031. PMID: 35238925
Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017.
Dong Y, Wang L, Burgner DP, Miller JE, Song Y, Ren X, Li Z, Xing Y, Ma J, Sawyer SM, Patton GC
BMJ 2020 Apr 2;369:m1043. doi: 10.1136/bmj.m1043. PMID: 32241761Free PMC Article
Dog and cat bites.
Ellis R, Ellis C
Am Fam Physician 2014 Aug 15;90(4):239-43. PMID: 25250997

Clinical prediction guides

Neuroimmunology of rabies: New insights into an ancient disease.
Bastos V, Pacheco V, Rodrigues ÉDL, Moraes CNS, Nóbile AL, Fonseca DLM, Souza KBS, do Vale FYN, Filgueiras IS, Schimke LF, Giil LM, Moll G, Cabral-Miranda G, Ochs HD, Vasconcelos PFDC, de Melo GD, Bourhy H, Casseb LMN, Cabral-Marques O
J Med Virol 2023 Oct;95(10):e29042. doi: 10.1002/jmv.29042. PMID: 37885152
Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models.
Yang L, Han B, Zhang Z, Wang S, Bai Y, Zhang Y, Tang Y, Du L, Xu L, Wu F, Zuo L, Chen X, Lin Y, Liu K, Ye Q, Chen B, Li B, Tang T, Wang Y, Shen L, Wang G, Ju M, Yuan M, Jiang W, Zhang JH, Hu G, Wang J, Yao H
Circulation 2020 Aug 11;142(6):556-574. Epub 2020 May 22 doi: 10.1161/CIRCULATIONAHA.120.045765. PMID: 32441115
Rabies, rabies vaccine, and renal failure: Clinical issues.
Sriwijitalai W, Wiwanitkit V
Saudi J Kidney Dis Transpl 2019 May-Jun;30(3):560-563. doi: 10.4103/1319-2442.261327. PMID: 31249218
Rabies in Alaska, from the past to an uncertain future.
Hueffer K, Murphy M
Int J Circumpolar Health 2018 Dec;77(1):1475185. doi: 10.1080/22423982.2018.1475185. PMID: 29764319Free PMC Article
Rabies diagnosis.
Barrat J, Picard-Meyer E, Cliquet F
Dev Biol (Basel) 2006;125:71-7. PMID: 16878462

Recent systematic reviews

Human rabies despite post-exposure prophylaxis: a systematic review of fatal breakthrough infections after zoonotic exposures.
Whitehouse ER, Mandra A, Bonwitt J, Beasley EA, Taliano J, Rao AK
Lancet Infect Dis 2023 May;23(5):e167-e174. Epub 2022 Dec 16 doi: 10.1016/S1473-3099(22)00641-7. PMID: 36535276Free PMC Article
Immunogenicity after pre- and post-exposure rabies vaccination: A systematic review and dose-response meta-analysis.
Xu C, Lau CL, Clark J, Rafferty AC, Mills DJ, Ramsey L, Gilbert B, Doi SAR, Furuya-Kanamori L
Vaccine 2021 Feb 12;39(7):1044-1050. Epub 2021 Jan 18 doi: 10.1016/j.vaccine.2021.01.023. PMID: 33478786
Infections associated with adventure travel: A systematic review.
Gundacker ND, Rolfe RJ, Rodriguez JM
Travel Med Infect Dis 2017 Mar-Apr;16:3-10. Epub 2017 Mar 27 doi: 10.1016/j.tmaid.2017.03.010. PMID: 28351605Free PMC Article
Pre-exposure rabies prophylaxis: a systematic review.
Kessels JA, Recuenco S, Navarro-Vela AM, Deray R, Vigilato M, Ertl H, Durrheim D, Rees H, Nel LH, Abela-Ridder B, Briggs D
Bull World Health Organ 2017 Mar 1;95(3):210-219C. Epub 2016 Nov 25 doi: 10.2471/BLT.16.173039. PMID: 28250534Free PMC Article
Epidemiology, Impact and Control of Rabies in Nepal: A Systematic Review.
Devleesschauwer B, Aryal A, Sharma BK, Ale A, Declercq A, Depraz S, Gaire TN, Gongal G, Karki S, Pandey BD, Pun SB, Duchateau L, Dorny P, Speybroeck N
PLoS Negl Trop Dis 2016 Feb;10(2):e0004461. Epub 2016 Feb 12 doi: 10.1371/journal.pntd.0004461. PMID: 26871689Free PMC Article

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