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Schistosomiasis

MedGen UID:
48573
•Concept ID:
C0036323
•
Disease or Syndrome
Synonyms: Bilharziases; Bilharziasis; Fever, Katayama; Infection, Schistoma; Infections, Schistoma; Katayama Fever; Schistoma Infection; Schistoma Infections; Schistosomiases
SNOMED CT: Disease due to Schistosomatidae (105661001); Infection by Schistosoma (10087007); Schistosomiasis (10087007); Bilharziasis (10087007); Hemic distomiasis (10087007); Schistosomosis (10087007); Bilharzia (10087007); Schistosomiasis - bilharziasis (10087007); Blood fluke infection (10087007); Disease caused by Schistosomatidae (105661001); Infection caused by Schistosoma (10087007)
 
Monarch Initiative: MONDO:0015254

Definition

A parasitic infection caused by flukes of the genus Schistosoma. Signs and symptoms include fever, abdominal pain, eosinophilia and hepatosplenomegaly. If left untreated it may eventually cause liver damage leading to cirrhosis, bladder cancer and kidney failure. [from NCI]

Professional guidelines

PubMed

Splenomegaly: Diagnosis and Management in Adults.
Aldulaimi S, Mendez AM
Am Fam Physician 2021 Sep 1;104(3):271-276. PMID: 34523897
Schistosomiasis and its treatment.
Caffrey CR
Future Med Chem 2015;7(6):675-6. doi: 10.4155/fmc.15.27. PMID: 25996057
Non-cirrhotic portal hypertension - diagnosis and management.
Khanna R, Sarin SK
J Hepatol 2014 Feb;60(2):421-41. Epub 2013 Aug 23 doi: 10.1016/j.jhep.2013.08.013. PMID: 23978714

Recent clinical studies

Etiology

Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines.
Anisuzzaman, Tsuji N
Parasitol Int 2020 Apr;75:102051. Epub 2020 Jan 3 doi: 10.1016/j.parint.2020.102051. PMID: 31911156
Paediatric schistosomiasis: What we know and what we need to know.
Osakunor DNM, Woolhouse MEJ, Mutapi F
PLoS Negl Trop Dis 2018 Feb;12(2):e0006144. Epub 2018 Feb 8 doi: 10.1371/journal.pntd.0006144. PMID: 29420537Free PMC Article
Schistosomiasis.
Jenkins-Holick DS, Kaul TL
Urol Nurs 2013 Jul-Aug;33(4):163-70. PMID: 24079113
Schistosomiasis.
Gryseels B
Infect Dis Clin North Am 2012 Jun;26(2):383-97. doi: 10.1016/j.idc.2012.03.004. PMID: 22632645
Schistosomiasis.
MacConnachie A
J R Coll Physicians Edinb 2012 Mar;42(1):47-9; quiz 50. doi: 10.4997/JRCPE.2012.111. PMID: 22441065

Diagnosis

Schistosomiasis.
LoVerde PT
Adv Exp Med Biol 2019;1154:45-70. doi: 10.1007/978-3-030-18616-6_3. PMID: 31297759
Schistosomiasis in Malaysia: A review.
Chuah C, Gobert GN, Latif B, Heo CC, Leow CY
Acta Trop 2019 Feb;190:137-143. Epub 2018 Nov 16 doi: 10.1016/j.actatropica.2018.11.012. PMID: 30448471
Diagnosis, Monitoring, and Control of Schistosomiasis-An Update.
Wu Y, Liu J, Lin Y, Weng R, Chen R, Li J, Lv Z
J Biomed Nanotechnol 2018 Mar 1;14(3):430-455. doi: 10.1166/jbn.2018.2517. PMID: 29663919
Schistosomiasis.
Gryseels B
Infect Dis Clin North Am 2012 Jun;26(2):383-97. doi: 10.1016/j.idc.2012.03.004. PMID: 22632645
Schistosomiasis.
MacConnachie A
J R Coll Physicians Edinb 2012 Mar;42(1):47-9; quiz 50. doi: 10.4997/JRCPE.2012.111. PMID: 22441065

Therapy

Schistosomiasis vaccine development: update on human clinical trials.
Molehin AJ
J Biomed Sci 2020 Jan 22;27(1):28. doi: 10.1186/s12929-020-0621-y. PMID: 31969170Free PMC Article
Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines.
Anisuzzaman, Tsuji N
Parasitol Int 2020 Apr;75:102051. Epub 2020 Jan 3 doi: 10.1016/j.parint.2020.102051. PMID: 31911156
Correlates of GLA family adjuvants' activities.
Reed SG, Carter D, Casper C, Duthie MS, Fox CB
Semin Immunol 2018 Oct;39:22-29. Epub 2018 Oct 23 doi: 10.1016/j.smim.2018.10.004. PMID: 30366662Free PMC Article
Use of artesunate in non-malarial indications.
Raffetin A, Bruneel F, Roussel C, Thellier M, Buffet P, Caumes E, Jauréguiberry S
Med Mal Infect 2018 Jun;48(4):238-249. Epub 2018 Feb 13 doi: 10.1016/j.medmal.2018.01.004. PMID: 29422423
Bladder cancer.
Patton SE, Hall MC, Ozen H
Curr Opin Oncol 2002 May;14(3):265-72. doi: 10.1097/00001622-200205000-00003. PMID: 11981270

Prognosis

One Health approach to improve the malaria elimination programme in Henan Province.
Liu Y, He ZQ, Wang D, Hu YB, Qian D, Yang CY, Zhou RM, Li SH, Lu DL, Zhang HW
Adv Parasitol 2022;116:153-186. Epub 2022 Mar 26 doi: 10.1016/bs.apar.2022.02.001. PMID: 35752447
Snail-Related Contributions from the Schistosomiasis Consortium for Operational Research and Evaluation Program Including Xenomonitoring, Focal Mollusciciding, Biological Control, and Modeling.
Allan F, Ame SM, Tian-Bi YT, Hofkin BV, Webster BL, Diakité NR, N'Goran EK, Kabole F, Khamis IS, Gouvras AN, Emery AM, Pennance T, Rabone M, Kinung'hi S, Hamidou AA, Mkoji GM, McLaughlin JP, Kuris AM, Loker ES, Knopp S, Rollinson D
Am J Trop Med Hyg 2020 Jul;103(1_Suppl):66-79. doi: 10.4269/ajtmh.19-0831. PMID: 32400353Free PMC Article
The Effect of Climate Change and the Snail-Schistosome Cycle in Transmission and Bio-Control of Schistosomiasis in Sub-Saharan Africa.
Adekiya TA, Aruleba RT, Oyinloye BE, Okosun KO, Kappo AP
Int J Environ Res Public Health 2019 Dec 26;17(1) doi: 10.3390/ijerph17010181. PMID: 31887979Free PMC Article
Integration of schistosomiasis control activities within the primary health care system: a critical review.
Bizimana P, Ortu G, Van Geertruyden JP, Nsabiyumva F, Nkeshimana A, Muhimpundu E, Polman K
Parasit Vectors 2019 Aug 7;12(1):393. doi: 10.1186/s13071-019-3652-z. PMID: 31391100Free PMC Article
Schistosomiasis and the kidney.
Barsoum RS
Semin Nephrol 2003 Jan;23(1):34-41. doi: 10.1053/snep.2003.50003a. PMID: 12563599

Clinical prediction guides

Noninvasive Assessment of Schistosoma-Related Periportal Fibrosis.
Hashim A, Berzigotti A
J Ultrasound Med 2021 Nov;40(11):2273-2287. Epub 2021 Jan 15 doi: 10.1002/jum.15623. PMID: 33448437
The Schistosomiasis Consortium for Operational Research and Evaluation 2008-2020: Approaches, Experiences, Lessons, and Recommendations.
Binder S, Campbell CH, Andros TS, Castleman JD, Kittur N, King CH, Colley DG
Am J Trop Med Hyg 2020 Jul;103(1_Suppl):114-124. doi: 10.4269/ajtmh.19-0786. PMID: 32400350Free PMC Article
Contributions of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) to Schistosomiasis Control and Elimination: Key Findings and Messages for Future Goals, Thresholds, and Operational Research.
Colley DG, Fleming FM, Matendechero SH, Knopp S, Rollinson D, Utzinger J, Castleman JD, Kittur N, King CH, Campbell CH, Kabole FM, Kinung'hi S, Ramzy RMR, Binder S
Am J Trop Med Hyg 2020 Jul;103(1_Suppl):125-134. doi: 10.4269/ajtmh.19-0787. PMID: 32400345Free PMC Article
Schistosomiasis Consortium for Operational Research and Evaluation (SCORE): Its Foundations, Development, and Evolution.
Colley DG, Jacobson JA, Binder S
Am J Trop Med Hyg 2020 Jul;103(1_Suppl):5-13. doi: 10.4269/ajtmh.19-0785. PMID: 32400343Free PMC Article
Research and control of advanced schistosomiasis japonica in China.
Wu W, Feng A, Huang Y
Parasitol Res 2015 Jan;114(1):17-27. Epub 2014 Nov 19 doi: 10.1007/s00436-014-4225-x. PMID: 25403379

Recent systematic reviews

Praziquantel efficacy, urinary and intestinal schistosomiasis reinfection - a systematic review.
Aboagye IF, Addison YAA
Pathog Glob Health 2023 Oct;117(7):623-630. Epub 2022 Nov 17 doi: 10.1080/20477724.2022.2145070. PMID: 36394218Free PMC Article
Possible association and co-existence of schistosome infection and prostate cancer: A systematic review.
Choto ET, Mduluza T, Sibanda EN, Mutapi F, Chimbari MJ
Afr J Reprod Health 2020 Dec;24(4):185-197. doi: 10.29063/ajrh2020/v24i4.19. PMID: 34077083
Effects of agrochemical pollution on schistosomiasis transmission: a systematic review and modelling analysis.
Hoover CM, Rumschlag SL, Strgar L, Arakala A, Gambhir M, de Leo GA, Sokolow SH, Rohr JR, Remais JV
Lancet Planet Health 2020 Jul;4(7):e280-e291. doi: 10.1016/S2542-5196(20)30105-4. PMID: 32681899Free PMC Article
Schistosomiasis in Zambia: a systematic review of past and present experiences.
Kalinda C, Chimbari MJ, Mukaratirwa S
Infect Dis Poverty 2018 Apr 30;7(1):41. doi: 10.1186/s40249-018-0424-5. PMID: 29706131Free PMC Article
The relationship between water, sanitation and schistosomiasis: a systematic review and meta-analysis.
Grimes JE, Croll D, Harrison WE, Utzinger J, Freeman MC, Templeton MR
PLoS Negl Trop Dis 2014 Dec;8(12):e3296. Epub 2014 Dec 4 doi: 10.1371/journal.pntd.0003296. PMID: 25474705Free PMC Article

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