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Sclerosis

MedGen UID:
48587
Concept ID:
C0036429
Pathologic Function
Synonym: Scleroses
SNOMED CT: Sclerosis (43846000); Fibrosclerosis (43846000)

Definition

A pathological hardening or thickening of tissue, especially that of the interstitial substance. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSclerosis

Professional guidelines

PubMed

Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, Jóźwiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA; International Tuberous Sclerosis Complex Consensus Group
Pediatr Neurol 2021 Oct;123:50-66. Epub 2021 Jul 24 doi: 10.1016/j.pediatrneurol.2021.07.011. PMID: 34399110
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977

Recent clinical studies

Etiology

Dobson R, Giovannoni G
Eur J Neurol 2019 Jan;26(1):27-40. Epub 2018 Nov 18 doi: 10.1111/ene.13819. PMID: 30300457
Louapre C, Papeix C, Lubetzki C, Maillart E
Geriatr Psychol Neuropsychiatr Vieil 2017 Dec 1;15(4):402-408. doi: 10.1684/pnv.2017.0685. PMID: 29081400
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774
Nicholas R, Rashid W
Am Fam Physician 2013 May 15;87(10):712-4. PMID: 23939450
Compston A, Coles A
Lancet 2008 Oct 25;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7. PMID: 18970977

Diagnosis

The Lancet Neurology
Lancet Neurol 2021 Jul;20(7):497. doi: 10.1016/S1474-4422(21)00170-8. PMID: 34146496
Oh J, Vidal-Jordana A, Montalban X
Curr Opin Neurol 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622. PMID: 30300239
Schiess N, Calabresi PA
Semin Neurol 2016 Aug;36(4):350-6. Epub 2016 Sep 19 doi: 10.1055/s-0036-1585456. PMID: 27643903
Wei FC
Biomed J 2014 Mar-Apr;37(2):33. doi: 10.4103/2319-4170.130317. PMID: 24732656
Nicholas R, Rashid W
Am Fam Physician 2013 May 15;87(10):712-4. PMID: 23939450

Therapy

Kappos L, Traboulsee A, Li DKB, Bar-Or A, Barkhof F, Montalban X, Leppert D, Baldinotti A, Schneble HM, Koendgen H, Sauter A, Wang Q, Hauser SL
J Neurol 2024 Feb;271(2):642-657. Epub 2023 Oct 31 doi: 10.1007/s00415-023-11943-4. PMID: 37906326Free PMC Article
Paganoni S, Berry JD, Quintana M, Macklin E, Saville BR, Detry MA, Chase M, Sherman AV, Yu H, Drake K, Andrews J, Shefner J, Chibnik LB, Vestrucci M, Cudkowicz ME; Healey ALS Platform Trial Study Group
Ann Neurol 2022 Feb;91(2):165-175. Epub 2022 Jan 10 doi: 10.1002/ana.26285. PMID: 34935174
Alessandrini M, Preynat-Seauve O, De Bruin K, Pepper MS
S Afr Med J 2019 Sep 10;109(8b):70-77. doi: 10.7196/SAMJ.2019.v109i8b.14009. PMID: 31662153
McDermott CJ
Curr Opin Neurol 2019 Oct;32(5):758-763. doi: 10.1097/WCO.0000000000000731. PMID: 31335338
Lasky J
IDrugs 2004 Feb;7(2):166-72. PMID: 15057662

Prognosis

Longinetti E, Fang F
Curr Opin Neurol 2019 Oct;32(5):771-776. doi: 10.1097/WCO.0000000000000730. PMID: 31361627Free PMC Article
GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article
Flachenecker P
J Neurol 2006 Sep;253 Suppl 5:V2-8. doi: 10.1007/s00415-006-5001-3. PMID: 16998750
Schwarz S, Leweling H
Mult Scler 2005 Feb;11(1):24-32. doi: 10.1191/1352458505ms1119oa. PMID: 15732263
Kurtzke JF
Neuroepidemiology 1991;10(1):1-8. doi: 10.1159/000110240. PMID: 2062411

Clinical prediction guides

Mitsumoto H, Chiuzan C, Gilmore M, Zhang Y, Simmons Z, Paganoni S, Kisanuki YY, Zinman L, Jawdat O, Sorenson E, Floeter MK, Pioro EP, Fernandes Filho JAM, Heitzman D, Fournier CN, Oskarsson B, Heiman-Patterson T, Maragakis N, Joyce N, Hayat G, Nations S, Scelsa S, Walk D, Elman L, Hupf J, McHale B; PLSFRS study group
Muscle Nerve 2020 Feb;61(2):163-172. Epub 2019 Dec 13 doi: 10.1002/mus.26765. PMID: 31758557
Mateos-Pérez JM, Dadar M, Lacalle-Aurioles M, Iturria-Medina Y, Zeighami Y, Evans AC
Neuroimage Clin 2018;20:506-522. Epub 2018 Aug 10 doi: 10.1016/j.nicl.2018.08.019. PMID: 30167371Free PMC Article
Fragoso YD, Willie PR, Goncalves MVM, Brooks JBB
Arq Neuropsiquiatr 2017 Jul;75(7):464-469. doi: 10.1590/0004-282X20170072. PMID: 28746434
Zamecki KJ, Jabs DA
Am J Ophthalmol 2010 Feb;149(2):189-193.e2. doi: 10.1016/j.ajo.2009.09.018. PMID: 20103052
Markowitz GS, D'Agati VD
Kidney Int 2007 Mar;71(6):491-5. Epub 2007 Jan 31 doi: 10.1038/sj.ki.5002118. PMID: 17264872

Recent systematic reviews

Corvillo I, Varela E, Armijo F, Alvarez-Badillo A, Armijo O, Maraver F
Eur J Phys Rehabil Med 2017 Dec;53(6):944-952. Epub 2017 Feb 17 doi: 10.23736/S1973-9087.17.04570-1. PMID: 28215060
Olsen TG, Frederiksen J
Surv Ophthalmol 2017 Jan-Feb;62(1):89-95. Epub 2016 Aug 1 doi: 10.1016/j.survophthal.2016.07.002. PMID: 27491475
Renauld S, Mohamed-Saïd L, Macoir J
Mult Scler Relat Disord 2016 Nov;10:103-111. Epub 2016 Sep 28 doi: 10.1016/j.msard.2016.09.005. PMID: 27919475
Gábor M, Ferianec V, Mečiarová I, Papcun P, Holomáň K
Ceska Gynekol 2014 Jun;79(3):186-9. PMID: 25054953
Zhornitsky S, Yong VW, Weiss S, Metz LM
Mult Scler 2013 Jan;19(1):15-23. Epub 2012 Aug 29 doi: 10.1177/1352458512458555. PMID: 22933621

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