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Sclerosis

MedGen UID:
48587
Concept ID:
C0036429
Pathologic Function
Synonym: Scleroses
SNOMED CT: Sclerosis (43846000); Fibrosclerosis (43846000)

Definition

A pathological hardening or thickening of tissue, especially that of the interstitial substance. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSclerosis

Professional guidelines

PubMed

Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977
Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G
Cephalalgia 2017 Jun;37(7):648-657. Epub 2017 Jan 11 doi: 10.1177/0333102416687280. PMID: 28076964

Recent clinical studies

Etiology

Lin J, Zhou J, Xu Y
Brain 2023 Aug 1;146(8):3364-3372. doi: 10.1093/brain/awad070. PMID: 36864689Free PMC Article
Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Dobson R, Giovannoni G
Eur J Neurol 2019 Jan;26(1):27-40. Epub 2018 Nov 18 doi: 10.1111/ene.13819. PMID: 30300457
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Diagnosis

Hughes M, Herrick AL
Br J Hosp Med (Lond) 2019 Sep 2;80(9):530-536. doi: 10.12968/hmed.2019.80.9.530. PMID: 31498665
Oh J, Vidal-Jordana A, Montalban X
Curr Opin Neurol 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622. PMID: 30300239
Doshi A, Chataway J
Clin Med (Lond) 2016 Dec;16(Suppl 6):s53-s59. doi: 10.7861/clinmedicine.16-6-s53. PMID: 27956442Free PMC Article
Howard J, Trevick S, Younger DS
Neurol Clin 2016 Nov;34(4):919-939. Epub 2016 Aug 18 doi: 10.1016/j.ncl.2016.06.016. PMID: 27720001
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Therapy

Kiernan MC, Vucic S, Talbot K, McDermott CJ, Hardiman O, Shefner JM, Al-Chalabi A, Huynh W, Cudkowicz M, Talman P, Van den Berg LH, Dharmadasa T, Wicks P, Reilly C, Turner MR
Nat Rev Neurol 2021 Feb;17(2):104-118. Epub 2020 Dec 18 doi: 10.1038/s41582-020-00434-z. PMID: 33340024Free PMC Article
Piehl F
J Intern Med 2021 Jun;289(6):771-791. Epub 2020 Dec 20 doi: 10.1111/joim.13215. PMID: 33258193Free PMC Article
Blair HA
Drugs 2019 Dec;79(18):1965-1976. doi: 10.1007/s40265-019-01229-3. PMID: 31784875
Alessandrini M, Preynat-Seauve O, De Bruin K, Pepper MS
S Afr Med J 2019 Sep 10;109(8b):70-77. doi: 10.7196/SAMJ.2019.v109i8b.14009. PMID: 31662153
Amatya B, Khan F, Galea M
Cochrane Database Syst Rev 2019 Jan 14;1(1):CD012732. doi: 10.1002/14651858.CD012732.pub2. PMID: 30637728Free PMC Article

Prognosis

Lane J, Ng HS, Poyser C, Lucas RM, Tremlett H
Mult Scler Relat Disord 2022 Jul;63:103932. Epub 2022 May 29 doi: 10.1016/j.msard.2022.103932. PMID: 35667315
Marrie RA, Maxwell C, Mahar A, Ekuma O, McClintock C, Seitz D, Webber C, Groome PA
Neurology 2021 Jan 26;96(4):e501-e512. Epub 2020 Nov 25 doi: 10.1212/WNL.0000000000011219. PMID: 33239364
Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P
Mult Scler 2020 Dec;26(14):1816-1821. Epub 2020 Nov 11 doi: 10.1177/1352458520970841. PMID: 33174475Free PMC Article
Longinetti E, Fang F
Curr Opin Neurol 2019 Oct;32(5):771-776. doi: 10.1097/WCO.0000000000000730. PMID: 31361627Free PMC Article
GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article

Clinical prediction guides

Chung KK, Altmann D, Barkhof F, Miszkiel K, Brex PA, O'Riordan J, Ebner M, Prados F, Cardoso MJ, Vercauteren T, Ourselin S, Thompson A, Ciccarelli O, Chard DT
Ann Neurol 2020 Jan;87(1):63-74. Epub 2019 Nov 22 doi: 10.1002/ana.25637. PMID: 31693200Free PMC Article
Louapre C, Bodini B, Lubetzki C, Freeman L, Stankoff B
Curr Opin Neurol 2017 Jun;30(3):231-236. doi: 10.1097/WCO.0000000000000456. PMID: 28362719
Giffroy X, Maes N, Albert A, Maquet P, Crielaard JM, Dive D
Acta Neurol Belg 2017 Mar;117(1):53-59. Epub 2016 May 19 doi: 10.1007/s13760-016-0650-1. PMID: 27194163
Uher T, Vaneckova M, Sobisek L, Tyblova M, Seidl Z, Krasensky J, Ramasamy D, Zivadinov R, Havrdova E, Kalincik T, Horakova D
Mult Scler 2017 Jan;23(1):51-61. Epub 2016 Jul 11 doi: 10.1177/1352458516642314. PMID: 27053635
Lee JY, Taghian K, Petratos S
Acta Neuropathol Commun 2014 Aug 27;2:97. doi: 10.1186/s40478-014-0097-7. PMID: 25159125Free PMC Article

Recent systematic reviews

Salari N, Hayati A, Kazeminia M, Rahmani A, Mohammadi M, Fatahian R, Shohaimi S
Neurol Sci 2022 Jan;43(1):167-185. Epub 2021 Oct 28 doi: 10.1007/s10072-021-05689-y. PMID: 34709478
Morales-Suarez-Varela M, Collado Sánchez E, Peraita-Costa I, Llopis-Morales A, Soriano JM
Nutrients 2021 Sep 13;13(9) doi: 10.3390/nu13093179. PMID: 34579056Free PMC Article
Liu Z, Liao Q, Wen H, Zhang Y
Autoimmun Rev 2021 Jun;20(6):102826. Epub 2021 Apr 18 doi: 10.1016/j.autrev.2021.102826. PMID: 33878488
Ortega-Hombrados L, Molina-Torres G, Galán-Mercant A, Sánchez-Guerrero E, González-Sánchez M, Ruiz-Muñoz M
Int J Environ Res Public Health 2021 Jan 26;18(3) doi: 10.3390/ijerph18031074. PMID: 33530383Free PMC Article
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994

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