U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated urinary catecholamine level

MedGen UID:
488807
Concept ID:
C0241577
Finding
Synonym: Elevated urinary catecholamines
 
HPO: HP:0011976

Definition

The concentration of a catecholamine in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Conditions with this feature

Paragangliomas 4
MedGen UID:
349380
Concept ID:
C1861848
Neoplastic Process
Hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndromes are characterized by paragangliomas (tumors that arise from neuroendocrine tissues distributed along the paravertebral axis from the base of the skull to the pelvis) and pheochromocytomas (paragangliomas that are confined to the adrenal medulla). Sympathetic paragangliomas cause catecholamine excess; parasympathetic paragangliomas are most often nonsecretory. Extra-adrenal parasympathetic paragangliomas are located predominantly in the skull base and neck (referred to as head and neck PGL [HNPGL]) and sometimes in the upper mediastinum; approximately 95% of such tumors are nonsecretory. In contrast, sympathetic extra-adrenal paragangliomas are generally confined to the lower mediastinum, abdomen, and pelvis, and are typically secretory. Pheochromocytomas, which arise from the adrenal medulla, typically lead to catecholamine excess. Symptoms of PGL/PCC result from either mass effects or catecholamine hypersecretion (e.g., sustained or paroxysmal elevations in blood pressure, headache, episodic profuse sweating, forceful palpitations, pallor, and apprehension or anxiety). The risk for developing metastatic disease is greater for extra-adrenal sympathetic paragangliomas than for pheochromocytomas.
Neuroblastoma, susceptibility to, 1
MedGen UID:
412713
Concept ID:
C2749485
Finding

Professional guidelines

PubMed

Gubbi S, Mathias P, Palaiodimos L, Hulkower R, Schubart U
Hormones (Athens) 2023 Mar;22(1):121-130. Epub 2023 Jan 4 doi: 10.1007/s42000-022-00422-6. PMID: 36596928
Berchtold P, Sims EA, Horton ES, Berger M
Biomed Pharmacother 1983;37(6):251-8. PMID: 6367845
Hardaway RM 3rd
Compr Ther 1979 Mar;5(3):14-25. PMID: 445980

Recent clinical studies

Etiology

Verly IRN, Matser YAH, Leen R, Meinsma R, Fiocco M, Koster J, Volckmann R, Savci-Heijink D, Cangemi G, Barco S, Valentijn LJ, Tytgat GAM, van Kuilenburg ABP
JCO Precis Oncol 2022 Jan;6:e2000447. doi: 10.1200/PO.20.00447. PMID: 35085004Free PMC Article
Scarinci F, Ghiciuc CM, Patacchioli FR, Palmery M, Parravano M
Curr Eye Res 2019 Jun;44(6):583-589. Epub 2019 Jan 28 doi: 10.1080/02713683.2019.1565891. PMID: 30624085
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
Vanitallie TB
Metabolism 2002 Jun;51(6 Suppl 1):40-5. doi: 10.1053/meta.2002.33191. PMID: 12040540
Berchtold P, Sims EA, Horton ES, Berger M
Biomed Pharmacother 1983;37(6):251-8. PMID: 6367845

Diagnosis

Verly IRN, Matser YAH, Leen R, Meinsma R, Fiocco M, Koster J, Volckmann R, Savci-Heijink D, Cangemi G, Barco S, Valentijn LJ, Tytgat GAM, van Kuilenburg ABP
JCO Precis Oncol 2022 Jan;6:e2000447. doi: 10.1200/PO.20.00447. PMID: 35085004Free PMC Article
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
Sasaki S, Yasuda T, Kaneto H, Otsuki M, Tabuchi Y, Fujita Y, Kubo F, Tsuji M, Fujisawa K, Kasami R, Kitamura T, Miyatsuka T, Katakami N, Kawamori D, Matsuoka TA, Imagawa A, Shimomura I
Intern Med 2012;51(17):2365-70. Epub 2012 Sep 1 doi: 10.2169/internalmedicine.51.7726. PMID: 22975550
Robertson D, Beck C, Gary T, Picklo M
Int Angiol 1993 Jun;12(2):93-102. PMID: 8371002

Therapy

Savransky A, Chiappelli J, Du X, Carino K, Kvarta M, Bruce H, Kochunov P, Goldwaser E, Tan Y, Hare S, Hong LE
J Psychiatr Res 2021 May;137:89-95. Epub 2021 Feb 13 doi: 10.1016/j.jpsychires.2021.02.005. PMID: 33662656
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A, Lauda PH, Bibus DM, Jurnak F, Lietha R, Hoffer A
Altern Ther Health Med 2008 May-Jun;14(3):56-62. PMID: 18517107
McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A, Lauda PH, Bibus DM, Jurnak F, Lietha R, Hoffer A
Altern Ther Health Med 2008 Mar-Apr;14(2):40-50. PMID: 18383989
Naschitz JE, Yeshurun D, Shahar J
Angiology 1990 Nov;41(11):893-900. doi: 10.1177/000331979004101101. PMID: 2244692

Prognosis

Verly IRN, Matser YAH, Leen R, Meinsma R, Fiocco M, Koster J, Volckmann R, Savci-Heijink D, Cangemi G, Barco S, Valentijn LJ, Tytgat GAM, van Kuilenburg ABP
JCO Precis Oncol 2022 Jan;6:e2000447. doi: 10.1200/PO.20.00447. PMID: 35085004Free PMC Article
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Scarinci F, Ghiciuc CM, Patacchioli FR, Palmery M, Parravano M
Curr Eye Res 2019 Jun;44(6):583-589. Epub 2019 Jan 28 doi: 10.1080/02713683.2019.1565891. PMID: 30624085
Naschitz JE, Yeshurun D, Shahar J
Angiology 1990 Nov;41(11):893-900. doi: 10.1177/000331979004101101. PMID: 2244692
LaBrosse EH, Comoy E, Bohuon C, Zucker JM, Schweisguth O
J Natl Cancer Inst 1976 Sep;57(3):633-8. doi: 10.1093/jnci/57.3.633. PMID: 10450

Clinical prediction guides

Verly IRN, Matser YAH, Leen R, Meinsma R, Fiocco M, Koster J, Volckmann R, Savci-Heijink D, Cangemi G, Barco S, Valentijn LJ, Tytgat GAM, van Kuilenburg ABP
JCO Precis Oncol 2022 Jan;6:e2000447. doi: 10.1200/PO.20.00447. PMID: 35085004Free PMC Article
Wang W, Dong D, Wen J, Li H
Medicine (Baltimore) 2021 Mar 12;100(10):e25088. doi: 10.1097/MD.0000000000025088. PMID: 33725899Free PMC Article
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Desir GV
Curr Opin Nephrol Hypertens 2011 Jan;20(1):31-6. doi: 10.1097/MNH.0b013e3283412721. PMID: 21099685
Naschitz JE, Yeshurun D, Shahar J
Angiology 1990 Nov;41(11):893-900. doi: 10.1177/000331979004101101. PMID: 2244692

Recent systematic reviews

Gervais MK, Gagnon A, Henri M, Bendavid Y
J Cardiovasc Med (Hagerstown) 2015 Jan;16 Suppl 2:S113-7. doi: 10.2459/JCM.0b013e3283356651. PMID: 20154633
Häuser W, Urrútia G, Tort S, Uçeyler N, Walitt B
Cochrane Database Syst Rev 2013 Jan 31;(1):CD010292. doi: 10.1002/14651858.CD010292. PMID: 23440848

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...