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Tertiary hyperparathyroidism

MedGen UID:
488837
•Concept ID:
C0271858
•
Disease or Syndrome
Synonyms: Tertiary Hyperparathyroidism; tertiary hyperparathyroidism
SNOMED CT: Tertiary hyperparathyroidism (78200003)
 
HPO: HP:0011770
Monarch Initiative: MONDO:0021132

Definition

A type of hyperparathyroidism that occurs following kidney transplantation, which is a treatment for secondary hyperparathyroidism. Although kidney transplantation leads to a normalization of serum calcium and parathyroid hormone in most patients. The state of persistent hypercalcemia and hyperparathyroidism is referred to as tertiary hyperparathyroidism. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTertiary hyperparathyroidism

Professional guidelines

PubMed

Treatment of Secondary Hyperparathyroidism and Posttransplant Tertiary Hyperparathyroidism.
Egan CE, Qazi M, Lee J, Lee-Saxton YJ, Greenberg JA, Beninato T, Zarnegar R, Fahey TJ 3rd, Finnerty BM
J Surg Res 2023 Nov;291:330-335. Epub 2023 Jul 26 doi: 10.1016/j.jss.2023.06.031. PMID: 37506432
Advances in the treatment of secondary and tertiary hyperparathyroidism.
Zhang LX, Zhang B, Liu XY, Wang ZM, Qi P, Zhang TY, Zhang Q
Front Endocrinol (Lausanne) 2022;13:1059828. Epub 2022 Dec 6 doi: 10.3389/fendo.2022.1059828. PMID: 36561571Free PMC Article
X-Linked Hypophosphatemic Rickets: Multisystemic Disorder in Children Requiring Multidisciplinary Management.
Baroncelli GI, Mora S
Front Endocrinol (Lausanne) 2021;12:688309. Epub 2021 Aug 6 doi: 10.3389/fendo.2021.688309. PMID: 34421819Free PMC Article

Recent clinical studies

Etiology

Treatment of Secondary Hyperparathyroidism and Posttransplant Tertiary Hyperparathyroidism.
Egan CE, Qazi M, Lee J, Lee-Saxton YJ, Greenberg JA, Beninato T, Zarnegar R, Fahey TJ 3rd, Finnerty BM
J Surg Res 2023 Nov;291:330-335. Epub 2023 Jul 26 doi: 10.1016/j.jss.2023.06.031. PMID: 37506432
Missed Opportunities to Diagnose and Treat Tertiary Hyperparathyroidism After Transplant.
Green RL, Karhadkar SS, Kuo LE
J Surg Res 2023 Jul;287:8-15. Epub 2023 Feb 27 doi: 10.1016/j.jss.2023.01.008. PMID: 36857809
Management of X-linked hypophosphatemia in adults.
Lecoq AL, Brandi ML, Linglart A, Kamenický P
Metabolism 2020 Feb;103S:154049. Epub 2019 Dec 18 doi: 10.1016/j.metabol.2019.154049. PMID: 31863781
Secondary and Tertiary Hyperparathyroidism: A Narrative Review.
van der Plas WY, Noltes ME, van Ginhoven TM, Kruijff S
Scand J Surg 2020 Dec;109(4):271-278. Epub 2019 Jul 31 doi: 10.1177/1457496919866015. PMID: 31364494
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537

Diagnosis

Parathyroid Imaging.
Lalonde MN, Correia RD, Syktiotis GP, Schaefer N, Matter M, Prior JO
Semin Nucl Med 2023 Jul;53(4):490-502. Epub 2023 Mar 14 doi: 10.1053/j.semnuclmed.2023.02.004. PMID: 36922339
Secondary and Tertiary Hyperparathyroidism.
Messa P, Alfieri CM
Front Horm Res 2019;51:91-108. Epub 2018 Nov 19 doi: 10.1159/000491041. PMID: 30641516
Hypercalcemic Disorders in Children.
Stokes VJ, Nielsen MF, Hannan FM, Thakker RV
J Bone Miner Res 2017 Nov;32(11):2157-2170. Epub 2017 Nov 2 doi: 10.1002/jbmr.3296. PMID: 28914984Free PMC Article
Secondary and tertiary hyperparathyroidism.
Jamal SA, Miller PD
J Clin Densitom 2013 Jan-Mar;16(1):64-8. Epub 2012 Dec 23 doi: 10.1016/j.jocd.2012.11.012. PMID: 23267748
Hyperparathyroidism.
Fraser WD
Lancet 2009 Jul 11;374(9684):145-58. doi: 10.1016/S0140-6736(09)60507-9. PMID: 19595349

Therapy

Treatment of Secondary Hyperparathyroidism and Posttransplant Tertiary Hyperparathyroidism.
Egan CE, Qazi M, Lee J, Lee-Saxton YJ, Greenberg JA, Beninato T, Zarnegar R, Fahey TJ 3rd, Finnerty BM
J Surg Res 2023 Nov;291:330-335. Epub 2023 Jul 26 doi: 10.1016/j.jss.2023.06.031. PMID: 37506432
X-Linked Hypophosphatemic Rickets: Multisystemic Disorder in Children Requiring Multidisciplinary Management.
Baroncelli GI, Mora S
Front Endocrinol (Lausanne) 2021;12:688309. Epub 2021 Aug 6 doi: 10.3389/fendo.2021.688309. PMID: 34421819Free PMC Article
Vitamin D in Chronic Kidney Disease and Dialysis Patients.
Jean G, Souberbielle JC, Chazot C
Nutrients 2017 Mar 25;9(4) doi: 10.3390/nu9040328. PMID: 28346348Free PMC Article
Secondary and tertiary hyperparathyroidism.
Jamal SA, Miller PD
J Clin Densitom 2013 Jan-Mar;16(1):64-8. Epub 2012 Dec 23 doi: 10.1016/j.jocd.2012.11.012. PMID: 23267748
Post-transplantation tertiary hyperparathyroidism.
Gioviale MC, Bellavia M, Damiano G, Lo Monte AI
Ann Transplant 2012 Jul-Sep;17(3):111-9. PMID: 23018263

Prognosis

Parathyroidectomy and Cinacalcet Use in Medicare-Insured Kidney Transplant Recipients.
Wang AX, Liu S, Montez-Rath ME, Chertow GM, Lenihan CR
Am J Kidney Dis 2023 Mar;81(3):270-280.e1. Epub 2022 Sep 24 doi: 10.1053/j.ajkd.2022.07.015. PMID: 36162617Free PMC Article
Secondary and Tertiary Hyperparathyroidism.
Messa P, Alfieri CM
Front Horm Res 2019;51:91-108. Epub 2018 Nov 19 doi: 10.1159/000491041. PMID: 30641516
Parathyroidectomy for tertiary hyperparathyroidism: A systematic review.
Tang JA, Friedman J, Hwang MS, Salapatas AM, Bonzelaar LB, Friedman M
Am J Otolaryngol 2017 Sep-Oct;38(5):630-635. Epub 2017 Jun 21 doi: 10.1016/j.amjoto.2017.06.009. PMID: 28735762
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Hyperparathyroidism.
Fraser WD
Lancet 2009 Jul 11;374(9684):145-58. doi: 10.1016/S0140-6736(09)60507-9. PMID: 19595349

Clinical prediction guides

Calcium homeostasis and hyperparathyroidism: Nephrologic and endocrinologic points of view.
Lemoine S, Figueres L, Bacchetta J, Frey S, Dubourg L
Ann Endocrinol (Paris) 2022 Aug;83(4):237-243. Epub 2022 May 19 doi: 10.1016/j.ando.2022.05.003. PMID: 35598638
Is preoperative parathyroid localization necessary for tertiary hyperparathyroidism?
Wang R, Abraham P, Lindeman B, Chen H, Fazendin J
Am J Surg 2022 Sep;224(3):918-922. Epub 2022 May 6 doi: 10.1016/j.amjsurg.2022.05.002. PMID: 35581031
Parathyroidectomy for tertiary hyperparathyroidism: A systematic review.
Tang JA, Friedman J, Hwang MS, Salapatas AM, Bonzelaar LB, Friedman M
Am J Otolaryngol 2017 Sep-Oct;38(5):630-635. Epub 2017 Jun 21 doi: 10.1016/j.amjoto.2017.06.009. PMID: 28735762
Vitamin D in Chronic Kidney Disease and Dialysis Patients.
Jean G, Souberbielle JC, Chazot C
Nutrients 2017 Mar 25;9(4) doi: 10.3390/nu9040328. PMID: 28346348Free PMC Article
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537

Recent systematic reviews

Challenges and controversies in the surgical management of uremic hyperparathyroidism: A systematic review.
Cabo J, Gallagher KC, Baregamian N
Am J Surg 2018 Oct;216(4):713-722. Epub 2018 Jul 24 doi: 10.1016/j.amjsurg.2018.07.030. PMID: 30057108
Systematic review of oral manifestations related to hyperparathyroidism.
Palla B, Burian E, Fliefel R, Otto S
Clin Oral Investig 2018 Jan;22(1):1-27. Epub 2017 Jun 14 doi: 10.1007/s00784-017-2124-0. PMID: 28616750
Parathyroidectomy for tertiary hyperparathyroidism: A systematic review.
Tang JA, Friedman J, Hwang MS, Salapatas AM, Bonzelaar LB, Friedman M
Am J Otolaryngol 2017 Sep-Oct;38(5):630-635. Epub 2017 Jun 21 doi: 10.1016/j.amjoto.2017.06.009. PMID: 28735762
Systematic review of surgical and medical treatment for tertiary hyperparathyroidism.
Dulfer RR, Franssen GJH, Hesselink DA, Hoorn EJ, van Eijck CHJ, van Ginhoven TM
Br J Surg 2017 Jun;104(7):804-813. doi: 10.1002/bjs.10554. PMID: 28518414
Outcomes of bisphosphonate therapy in kidney transplant recipients: a systematic review and meta-analysis.
Toth-Manikowski SM, Francis JM, Gautam A, Gordon CE
Clin Transplant 2016 Sep;30(9):1090-6. Epub 2016 Jul 19 doi: 10.1111/ctr.12792. PMID: 27327448

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