U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of the parathyroid gland

MedGen UID:
893009
•Concept ID:
C4025822
•
Anatomical Abnormality
Synonyms: disease of parathyroid gland; disease of parathyroid glands; disease or disorder of parathyroid gland; disorder of parathyroid gland; Parathyroid disease; parathyroid disease; parathyroid gland disease; parathyroid gland disease or disorder; parathyroid gland diseases; parathyroid gland disorder; parathyroid gland disorders
 
HPO: HP:0000828
Monarch Initiative: MONDO:0001223

Definition

An abnormality of the parathyroid gland. [from HPO]

Professional guidelines

PubMed

Primary hyperparathyroidism: from guidelines to outpatient clinic.
Palermo A, Tabacco G, Makras P, Zavatta G, Trimboli P, Castellano E, Yavropoulou MP, Naciu AM, Anastasilakis AD
Rev Endocr Metab Disord 2024 Oct;25(5):875-896. Epub 2024 Aug 20 doi: 10.1007/s11154-024-09899-5. PMID: 39162944
Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
The medical and surgical treatment in secondary and tertiary hyperparathyroidism. Review.
Cocchiara G, Fazzotta S, Palumbo VD, Damiano G, Cajozzo M, Maione C, Buscemi S, Spinelli G, Ficarella S, Maffongelli A, Caternicchia F, Ignazio Lo Monte A, Buscemi G
Clin Ter 2017 Mar-Apr;168(2):e158-e167. doi: 10.7417/CT.2017.1999. PMID: 28383630

Recent clinical studies

Etiology

LECT-2 amyloidosis: what do we know?
Mann BK, Bhandohal JS, Cobos E, Chitturi C, Eppanapally S
J Investig Med 2022 Feb;70(2):348-353. Epub 2021 Nov 30 doi: 10.1136/jim-2021-002149. PMID: 34848562
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Sudden death in babies: epidemiology.
Froggatt P, Lynas MA, Marshall TK
Am J Cardiol 1968 Oct;22(4):457-68. doi: 10.1016/0002-9149(68)90152-5. PMID: 4880100

Diagnosis

Overview of the 2022 WHO Classification of Parathyroid Tumors.
Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ
Endocr Pathol 2022 Mar;33(1):64-89. Epub 2022 Feb 17 doi: 10.1007/s12022-022-09709-1. PMID: 35175514
DiGeorge syndrome: consider the diagnosis.
Altshuler E, Saidi A, Budd J
BMJ Case Rep 2022 Feb 2;15(2) doi: 10.1136/bcr-2021-245164. PMID: 35110278Free PMC Article
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article
Endocrine disorders in children.
Chernausek SD, Leslie ND, Bloch CA, Sperling MA
Surg Clin North Am 1985 Dec;65(6):1527-49. doi: 10.1016/s0039-6109(16)43785-0. PMID: 2866586

Therapy

Parathyroid Disorders.
Sell J, Ramirez S, Partin M
Am Fam Physician 2022 Mar 1;105(3):289-298. PMID: 35289573
Lithium-associated hyperparathyroidism.
Mifsud S, Cilia K, Mifsud EL, Gruppetta M
Br J Hosp Med (Lond) 2020 Nov 2;81(11):1-9. Epub 2020 Nov 17 doi: 10.12968/hmed.2020.0457. PMID: 33263481
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Immune deficiency diseases.
Hitzig WH
J Clin Pathol Suppl (Assoc Clin Pathol) 1975;6:83-91. doi: 10.1136/jcp.s1-6.1.83. PMID: 802876Free PMC Article
Endocrine surgery in children.
Schwartz DL, Gann DS, Haller JA Jr
Surg Clin North Am 1974 Apr;54(2):363-85. doi: 10.1016/s0039-6109(16)40285-9. PMID: 4361606

Prognosis

Diagnosis and Evaluation of Primary Hyperparathyroidism.
Machado NN, Wilhelm SM
Surg Clin North Am 2019 Aug;99(4):649-666. Epub 2019 May 10 doi: 10.1016/j.suc.2019.04.006. PMID: 31255197
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV
Nat Rev Endocrinol 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. PMID: 30443043Free PMC Article
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article
Sudden death in babies: epidemiology.
Froggatt P, Lynas MA, Marshall TK
Am J Cardiol 1968 Oct;22(4):457-68. doi: 10.1016/0002-9149(68)90152-5. PMID: 4880100

Clinical prediction guides

Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
Calcium homeostasis and hyperparathyroidism: Nephrologic and endocrinologic points of view.
Lemoine S, Figueres L, Bacchetta J, Frey S, Dubourg L
Ann Endocrinol (Paris) 2022 Aug;83(4):237-243. Epub 2022 May 19 doi: 10.1016/j.ando.2022.05.003. PMID: 35598638
Primary hyperparathyroidism.
Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F
Nat Rev Dis Primers 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33. PMID: 27194212Free PMC Article
Sonography of Normal and Abnormal Thyroid and Parathyroid Glands.
Andrioli M, Valcavi R
Front Horm Res 2016;45:1-15. Epub 2016 Mar 15 doi: 10.1159/000442273. PMID: 27002829
Sestamibi parathyroid imaging.
McBiles M, Lambert AT, Cote MG, Kim SY
Semin Nucl Med 1995 Jul;25(3):221-34. doi: 10.1016/s0001-2998(95)80012-3. PMID: 7570042

Recent systematic reviews

Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
The otolaryngologic manifestations of Sotos syndrome 1: A systematic review.
Danis DO 3rd, Bodamer O, Levi JR
Int J Pediatr Otorhinolaryngol 2021 Apr;143:110649. Epub 2021 Feb 12 doi: 10.1016/j.ijporl.2021.110649. PMID: 33640723
Assessment and Comparison of (18)F-Fluorocholine PET and (99m)Tc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis.
Whitman J, Allen IE, Bergsland EK, Suh I, Hope TA
J Nucl Med 2021 Sep 1;62(9):1285-1291. Epub 2021 Jan 15 doi: 10.2967/jnumed.120.257303. PMID: 33452040Free PMC Article
Systematic review of intravenous methylene blue in parathyroid surgery.
Patel HP, Chadwick DR, Harrison BJ, Balasubramanian SP
Br J Surg 2012 Oct;99(10):1345-51. doi: 10.1002/bjs.8814. PMID: 22961511
Parathyroid imaging: how good is it and how should it be done?
Kettle AG, O'Doherty MJ
Semin Nucl Med 2006 Jul;36(3):206-11. doi: 10.1053/j.semnuclmed.2006.03.003. PMID: 16762611

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...