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Acute hemorrhagic leukoencephalitis

MedGen UID:
4937
Concept ID:
C0014077
Disease or Syndrome
Synonyms: Acute Hemorrhagic Encephalomyelitides; Acute Hemorrhagic Encephalomyelitis; Acute Hemorrhagic Leukoencephalitides; Acute Hemorrhagic Leukoencephalitis; Disease, Hurst; Disease, Hurst's; Encephalomyelitides, Acute Hemorrhagic; Encephalomyelitis, Acute Hemorrhagic; Encephalomyelitis, Acute Necrotizing Hemorrhagic; Hemorrhagic Encephalomyelitides, Acute; Hemorrhagic Encephalomyelitis, Acute; Hemorrhagic Leukoencephalitides, Acute; Hemorrhagic Leukoencephalitis, Acute; Hurst Disease; Hurst Syndrome; Hurst's Disease; Hursts Disease; Leukoencephalitides, Acute Hemorrhagic; Leukoencephalitis Acuta Hemorrhagica; Leukoencephalitis, Acute Hemorrhagic; Syndrome, Hurst
SNOMED CT: Acute hemorrhagic leukoencephalitis (72986009); Hurst's disease (72986009); Acute hemorrhagic leukoencephalitis of Weston Hurst (72986009)
 
Monarch Initiative: MONDO:0011716
OMIM®: 606752

Definition

A degenerative brain disorder presenting with acute neurological manifestations. It usually associated with an acute infection or vaccination. It is characterized by brain hemorrhage, vascular necrosis and demyelination. Signs and symptoms include fever, headache, vomiting, convulsions and loss of consciousness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute hemorrhagic leukoencephalitis

Professional guidelines

PubMed

Alromaihi M
Biomed Res Int 2022;2022:6008375. Epub 2022 Nov 15 doi: 10.1155/2022/6008375. PMID: 36425337Free PMC Article
Sonneville R, Klein IF, Wolff M
Curr Opin Neurol 2010 Jun;23(3):300-4. doi: 10.1097/WCO.0b013e32833925ec. PMID: 20442573
Sonneville R, Klein I, de Broucker T, Wolff M
J Infect 2009 May;58(5):321-8. Epub 2009 Apr 14 doi: 10.1016/j.jinf.2009.02.011. PMID: 19368974Free PMC Article

Recent clinical studies

Etiology

Pujari SS, Kulkarni RV, Ojha P, Gursahani R, Nadgir D, Patil S, Soni G, Bangar S, Harshe A, Mandolkar M, Joshi A, Kadam S, Goyal A
J Neuroimmunol 2021 Dec 15;361:577751. Epub 2021 Oct 13 doi: 10.1016/j.jneuroim.2021.577751. PMID: 34739912
Herman C, Mayer K, Sarwal A
Neurology 2020 Jul 14;95(2):77-84. Epub 2020 Apr 28 doi: 10.1212/WNL.0000000000009673. PMID: 32345728
Jan F, Jafri SK, Ibrahim SH
J Coll Physicians Surg Pak 2019 Jul;29(7):649-653. doi: 10.29271/jcpsp.2019.07.649. PMID: 31253217
Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923
Tenembaum S, Chitnis T, Ness J, Hahn JS; International Pediatric MS Study Group
Neurology 2007 Apr 17;68(16 Suppl 2):S23-36. doi: 10.1212/01.wnl.0000259404.51352.7f. PMID: 17438235

Diagnosis

Alromaihi M
Biomed Res Int 2022;2022:6008375. Epub 2022 Nov 15 doi: 10.1155/2022/6008375. PMID: 36425337Free PMC Article
Bamnawat H, Khera D, Didel S, Tiwari S
BMJ Case Rep 2022 Jun 9;15(6) doi: 10.1136/bcr-2021-246654. PMID: 35680284Free PMC Article
Levine JM, Ahsan N, Ho E, Santoro JD
Mult Scler Relat Disord 2020 Aug;43:102194. Epub 2020 May 15 doi: 10.1016/j.msard.2020.102194. PMID: 32426208Free PMC Article
Jan F, Jafri SK, Ibrahim SH
J Coll Physicians Surg Pak 2019 Jul;29(7):649-653. doi: 10.29271/jcpsp.2019.07.649. PMID: 31253217
Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923

Therapy

Pujari SS, Kulkarni RV, Ojha P, Gursahani R, Nadgir D, Patil S, Soni G, Bangar S, Harshe A, Mandolkar M, Joshi A, Kadam S, Goyal A
J Neuroimmunol 2021 Dec 15;361:577751. Epub 2021 Oct 13 doi: 10.1016/j.jneuroim.2021.577751. PMID: 34739912
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Aug 27 doi: 10.1212/NXI.0000000000001080. PMID: 34452974Free PMC Article
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Bevan CJ, Cree BA
Semin Neurol 2015 Dec;35(6):656-66. Epub 2015 Nov 23 doi: 10.1055/s-0035-1564682. PMID: 26595866
Sonneville R, Klein I, de Broucker T, Wolff M
J Infect 2009 May;58(5):321-8. Epub 2009 Apr 14 doi: 10.1016/j.jinf.2009.02.011. PMID: 19368974Free PMC Article

Prognosis

Bamnawat H, Khera D, Didel S, Tiwari S
BMJ Case Rep 2022 Jun 9;15(6) doi: 10.1136/bcr-2021-246654. PMID: 35680284Free PMC Article
Levine JM, Ahsan N, Ho E, Santoro JD
Mult Scler Relat Disord 2020 Aug;43:102194. Epub 2020 May 15 doi: 10.1016/j.msard.2020.102194. PMID: 32426208Free PMC Article
Jan F, Jafri SK, Ibrahim SH
J Coll Physicians Surg Pak 2019 Jul;29(7):649-653. doi: 10.29271/jcpsp.2019.07.649. PMID: 31253217
Ayrignac X, Carra-Dallière C, Labauge P
Rev Neurol (Paris) 2018 Jun;174(6):408-418. Epub 2018 Apr 16 doi: 10.1016/j.neurol.2018.03.007. PMID: 29673573
Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923

Clinical prediction guides

Wu L, Peng H, Jiang Y, He L, Jiang L, Hu Y
Int J Dev Neurosci 2022 Aug;82(5):447-457. Epub 2022 Jun 22 doi: 10.1002/jdn.10201. PMID: 35688614
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Aug 27 doi: 10.1212/NXI.0000000000001080. PMID: 34452974Free PMC Article
Garg RK, Paliwal VK, Malhotra HS, Sharma PK
Neurol India 2021 Mar-Apr;69(2):260-271. doi: 10.4103/0028-3886.314531. PMID: 33904434
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923

Recent systematic reviews

Lee IT, Lin PJ, Yen HH
Int J Infect Dis 2024 Jan;138:29-37. Epub 2023 Nov 7 doi: 10.1016/j.ijid.2023.11.006. PMID: 37944584
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Aug 27 doi: 10.1212/NXI.0000000000001080. PMID: 34452974Free PMC Article

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