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Post-traumatic epilepsy

MedGen UID:
4991
Concept ID:
C0014557
Disease or Syndrome
Synonyms: Disorder, Post-Traumatic Seizure; Disorders, Post-Traumatic Seizure; Epilepsies, Post-Traumatic; Epilepsies, Traumatic; Epilepsy, Post Traumatic; Epilepsy, Post-Traumatic; Epilepsy, Traumatic; Post Traumatic Seizure Disorder; Post-Traumatic Epilepsies; Post-Traumatic Epilepsy; Post-Traumatic Seizure Disorder; Post-Traumatic Seizure Disorders; Seizure Disorder, Post Traumatic; Seizure Disorder, Post-Traumatic; Seizure Disorders, Post-Traumatic; Traumatic Epilepsies; Traumatic Epilepsy
SNOMED CT: PTE - Post-traumatic epilepsy (75023009); Post-traumatic epilepsy (75023009); Traumatic epilepsy (75023009); Epilepsy due to and following traumatic brain injury (75023009)
 
Monarch Initiative: MONDO:0043264

Definition

Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-traumatic epilepsy

Professional guidelines

PubMed

Irimia A, Van Horn JD
J Clin Neurosci 2015 Apr;22(4):627-31. Epub 2014 Oct 31 doi: 10.1016/j.jocn.2014.09.019. PMID: 25542591Free PMC Article
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Curr Opin Neurol Neurosurg 1992 Feb;5(1):3-10. PMID: 1623234

Recent clinical studies

Etiology

Golub VM, Reddy DS
Pharmacol Rev 2022 Apr;74(2):387-438. doi: 10.1124/pharmrev.121.000375. PMID: 35302046Free PMC Article
Fordington S, Manford M
J Neurol 2020 Oct;267(10):3105-3111. Epub 2020 May 22 doi: 10.1007/s00415-020-09926-w. PMID: 32444981Free PMC Article
Pitkänen A, Kemppainen S, Ndode-Ekane XE, Huusko N, Huttunen JK, Gröhn O, Immonen R, Sierra A, Bolkvadze T
Epilepsy Behav 2014 Sep;38:19-24. Epub 2014 Feb 12 doi: 10.1016/j.yebeh.2014.01.013. PMID: 24529830
Dalmady-Israel C, Zasler ND
Brain Inj 1993 May-Jun;7(3):263-73. doi: 10.3109/02699059309029679. PMID: 8508183
Pascual-Leone A, Dhuna A, Altafullah I, Anderson DC
Neurology 1990 Mar;40(3 Pt 1):404-7. doi: 10.1212/wnl.40.3_part_1.404. PMID: 2107459

Diagnosis

Fordington S, Manford M
J Neurol 2020 Oct;267(10):3105-3111. Epub 2020 May 22 doi: 10.1007/s00415-020-09926-w. PMID: 32444981Free PMC Article
Galanopoulou AS, Engel J Jr, Moshé SL
Neurobiol Dis 2019 Mar;123:1-2. Epub 2018 Oct 9 doi: 10.1016/j.nbd.2018.10.003. PMID: 30312758Free PMC Article
Hart YM
J R Coll Physicians Edinb 2012 Jun;42(2):151-4. doi: 10.4997/JRCPE.2012.213. PMID: 22693702
Pascual-Leone A, Dhuna A, Altafullah I, Anderson DC
Neurology 1990 Mar;40(3 Pt 1):404-7. doi: 10.1212/wnl.40.3_part_1.404. PMID: 2107459
Jacome DE, FitzGerald R
Neurology 1982 Feb;32(2):209-12. doi: 10.1212/wnl.32.2.209. PMID: 6798492

Therapy

Galanopoulou AS, Engel J Jr, Moshé SL
Neurobiol Dis 2019 Mar;123:1-2. Epub 2018 Oct 9 doi: 10.1016/j.nbd.2018.10.003. PMID: 30312758Free PMC Article
Dugan EM, Howell JM
Emerg Med Clin North Am 1994 Nov;12(4):1081-7. PMID: 7956888
Dalmady-Israel C, Zasler ND
Brain Inj 1993 May-Jun;7(3):263-73. doi: 10.3109/02699059309029679. PMID: 8508183
Jacome DE, FitzGerald R
Neurology 1982 Feb;32(2):209-12. doi: 10.1212/wnl.32.2.209. PMID: 6798492
Friedlander WJ
Prog Neurol Psychiatry 1968;23:203-41. PMID: 4388825

Prognosis

Chen Y, Cappucci SP, Kim JA
Semin Neurol 2024 Jun;44(3):333-341. Epub 2024 Apr 15 doi: 10.1055/s-0044-1785502. PMID: 38621706
Laing J, Gabbe B, Chen Z, Perucca P, Kwan P, O'Brien TJ
JAMA Neurol 2022 Apr 1;79(4):334-341. doi: 10.1001/jamaneurol.2021.5420. PMID: 35188950Free PMC Article
Dugan EM, Howell JM
Emerg Med Clin North Am 1994 Nov;12(4):1081-7. PMID: 7956888
Willmore LJ
Neurol Clin 1992 Nov;10(4):869-78. PMID: 1435661
Pascual-Leone A, Dhuna A, Altafullah I, Anderson DC
Neurology 1990 Mar;40(3 Pt 1):404-7. doi: 10.1212/wnl.40.3_part_1.404. PMID: 2107459

Clinical prediction guides

Laing J, Gabbe B, Chen Z, Perucca P, Kwan P, O'Brien TJ
JAMA Neurol 2022 Apr 1;79(4):334-341. doi: 10.1001/jamaneurol.2021.5420. PMID: 35188950Free PMC Article
Mikkonen ED, Skrifvars MB, Reinikainen M, Bendel S, Laitio R, Hoppu S, Ala-Kokko T, Karppinen A, Raj R
Epilepsia 2020 Apr;61(4):693-701. Epub 2020 Mar 28 doi: 10.1111/epi.16483. PMID: 32221978
Pop-Jordanova N
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2019 May 1;40(1):5-40. doi: 10.2478/prilozi-2019-0001. PMID: 31152643
Tényi D, Gyimesi C, Horváth R, Kovács N, Ábrahám H, Darnai G, Fogarasi A, Büki A, Janszky J
Epilepsia 2016 Aug;57(8):1310-6. Epub 2016 Jun 23 doi: 10.1111/epi.13432. PMID: 27334642
Dugan EM, Howell JM
Emerg Med Clin North Am 1994 Nov;12(4):1081-7. PMID: 7956888

Recent systematic reviews

Ferreira LD, Tabaeizadeh M, Haneef Z
J Neurotrauma 2024 Feb;41(3-4):319-330. Epub 2023 Oct 20 doi: 10.1089/neu.2023.0084. PMID: 37658840
Kumar P
Metab Brain Dis 2023 Mar;38(3):749-765. Epub 2023 Jan 30 doi: 10.1007/s11011-023-01172-z. PMID: 36715879
Kuhl NO, Yengo-Kahn AM, Burnette H, Solomon GS, Zuckerman SL
Phys Sportsmed 2018 Feb;46(1):1-7. Epub 2017 Dec 27 doi: 10.1080/00913847.2018.1419775. PMID: 29280684
Cotter D, Kelso A, Neligan A
Seizure 2017 Mar;46:53-58. Epub 2017 Feb 9 doi: 10.1016/j.seizure.2017.02.002. PMID: 28242442
Xu T, Yu X, Ou S, Liu X, Yuan J, Huang H, Yang J, He L, Chen Y
Epilepsy Behav 2017 Feb;67:1-6. Epub 2017 Jan 8 doi: 10.1016/j.yebeh.2016.10.026. PMID: 28076834

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