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Peptic esophagitis

MedGen UID:
5028
•Concept ID:
C0014869
•
Disease or Syndrome
Synonyms: Esophagitides, Peptic; Esophagitides, Reflux; Esophagitis, Peptic; Esophagitis, Reflux; Peptic Esophagitides; Peptic Esophagitis; Reflux Esophagitides; Reflux Esophagitis
 
Monarch Initiative: MONDO:0006896

Definition

Inflammation of the esophagus that is caused by the reflux of gastric juice with contents of the stomach and duodenum. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeptic esophagitis

Professional guidelines

PubMed

ACR Appropriateness Criteria® Epigastric Pain.
Expert Panel on Gastrointestinal Imaging, Vij A, Zaheer A, Kamel IR, Porter KK, Arif-Tiwari H, Bashir MR, Fung A, Goldstein A, Herr KD, Kamaya A, Kobi M, Landler MP, Russo GK, Thakrar KH, Turturro MA, Wahab SA, Wardrop RM 3rd, Wright CL, Yang X, Carucci LR
J Am Coll Radiol 2021 Nov;18(11S):S330-S339. doi: 10.1016/j.jacr.2021.08.006. PMID: 34794592
Current status of gastroesophageal reflux disease : diagnosis and treatment.
Chuang TW, Chen SC, Chen KT
Acta Gastroenterol Belg 2017 Jul-Sep;80(3):396-404. PMID: 29560670
Diagnosis and treatment of gastroesophageal reflux in infants and children.
Reyes HM, Ostrovsky E
Surg Annu 1983;15:61-71. PMID: 6353639

Recent clinical studies

Etiology

Obesity, sleeve gastrectomy and gastro-esophageal reflux disease.
Veziant J, Benhalima S, Piessen G, Slim K
J Visc Surg 2023 Apr;160(2S):S47-S54. Epub 2023 Jan 30 doi: 10.1016/j.jviscsurg.2023.01.004. PMID: 36725450
Reflux monitoring in children.
Singendonk MM, Benninga MA, van Wijk MP
Neurogastroenterol Motil 2016 Oct;28(10):1452-9. doi: 10.1111/nmo.12922. PMID: 27682990
Key Issues Associated with Helicobacter pylori Eradication.
Kawai T, Moriyasu F, Tsuchida A
Digestion 2016;93(1):19-23. Epub 2016 Jan 14 doi: 10.1159/000441667. PMID: 26788997
Healing of oesophagitis.
Rodrigo L
Drugs 2005;65 Suppl 1:51-7. doi: 10.2165/00003495-200565001-00008. PMID: 16335858
Laparoscopic Hill repair.
Kraemer SJ, Aye R, Kozarek RA, Hill LD
Gastrointest Endosc 1994 Mar-Apr;40(2 Pt 1):155-9. doi: 10.1016/s0016-5107(94)70158-x. PMID: 8013813

Diagnosis

Unique causes of esophageal inflammation: a histopathologic perspective.
Gopal P, Gibson JA, Lisovsky M, Nalbantoglu I
Ann N Y Acad Sci 2018 Dec;1434(1):219-226. Epub 2018 May 16 doi: 10.1111/nyas.13732. PMID: 29766506
Reflux monitoring in children.
Singendonk MM, Benninga MA, van Wijk MP
Neurogastroenterol Motil 2016 Oct;28(10):1452-9. doi: 10.1111/nmo.12922. PMID: 27682990
Esophagitis in Adolescents.
Putnam PE
Adolesc Med State Art Rev 2016 Spring;27(1):1-18. PMID: 27363230
Inflammation and Barrett's carcinogenesis.
Poehlmann A, Kuester D, Malfertheiner P, Guenther T, Roessner A
Pathol Res Pract 2012 May 15;208(5):269-80. Epub 2012 Apr 27 doi: 10.1016/j.prp.2012.03.007. PMID: 22541897
Reflux esophagitis: overview.
Orlando RC
Scand J Gastroenterol Suppl 1995;210:36-7. doi: 10.3109/00365529509090267. PMID: 8578203

Therapy

Comparative Efficacy of P-CAB vs Proton Pump Inhibitors for Grade C/D Esophagitis: A Systematic Review and Network Meta-analysis.
Zhuang Q, Chen S, Zhou X, Jia X, Zhang M, Tan N, Chen F, Zhang Z, Hu J, Xiao Y
Am J Gastroenterol 2024 May 1;119(5):803-813. Epub 2024 Feb 12 doi: 10.14309/ajg.0000000000002714. PMID: 38345252
Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia.
Werner YB, Hakanson B, Martinek J, Repici A, von Rahden BHA, Bredenoord AJ, Bisschops R, Messmann H, Vollberg MC, Noder T, Kersten JF, Mann O, Izbicki J, Pazdro A, Fumagalli U, Rosati R, Germer CT, Schijven MP, Emmermann A, von Renteln D, Fockens P, Boeckxstaens G, Rösch T
N Engl J Med 2019 Dec 5;381(23):2219-2229. doi: 10.1056/NEJMoa1905380. PMID: 31800987
Vonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: A systematic review.
Miyazaki H, Igarashi A, Takeuchi T, Teng L, Uda A, Deguchi H, Higuchi K, Tango T
J Gastroenterol Hepatol 2019 Aug;34(8):1316-1328. Epub 2019 Apr 11 doi: 10.1111/jgh.14664. PMID: 30883868
Omeprazole: a comprehensive review.
Massoomi F, Savage J, Destache CJ
Pharmacotherapy 1993 Jan-Feb;13(1):46-59. PMID: 8437967
Omeprazole.
Walan A
Baillieres Clin Gastroenterol 1988 Jul;2(3):629-40. doi: 10.1016/s0950-3528(88)80010-1. PMID: 3048454

Prognosis

Clinical and endoscopic characteristics of acute esophageal necrosis and severe reflux esophagitis.
Okamoto T, Suzuki H, Fukuda K
Medicine (Baltimore) 2021 Nov 5;100(44):e27672. doi: 10.1097/MD.0000000000027672. PMID: 34871245Free PMC Article
Reflux monitoring in children.
Singendonk MM, Benninga MA, van Wijk MP
Neurogastroenterol Motil 2016 Oct;28(10):1452-9. doi: 10.1111/nmo.12922. PMID: 27682990
Inflammation and Barrett's carcinogenesis.
Poehlmann A, Kuester D, Malfertheiner P, Guenther T, Roessner A
Pathol Res Pract 2012 May 15;208(5):269-80. Epub 2012 Apr 27 doi: 10.1016/j.prp.2012.03.007. PMID: 22541897
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849
Laparoscopic Hill repair.
Kraemer SJ, Aye R, Kozarek RA, Hill LD
Gastrointest Endosc 1994 Mar-Apr;40(2 Pt 1):155-9. doi: 10.1016/s0016-5107(94)70158-x. PMID: 8013813

Clinical prediction guides

Clinical and endoscopic characteristics of acute esophageal necrosis and severe reflux esophagitis.
Okamoto T, Suzuki H, Fukuda K
Medicine (Baltimore) 2021 Nov 5;100(44):e27672. doi: 10.1097/MD.0000000000027672. PMID: 34871245Free PMC Article
Gastroesophageal reflux with children requiring adenotonsillectomy.
Tumgor G, Midilli R, Doganavsargil B, Ozgenc F, Arikan C, Kirazli T, Yagci RV
Minerva Pediatr (Torino) 2021 Jun;73(3):256-262. doi: 10.23736/S2724-5276.17.04354-7. PMID: 34047149
Post-POEM reflux: who's at risk?
Arevalo G, Sippey M, Martin-Del-Campo LA, He J, Ali A, Marks J
Surg Endosc 2020 Jul;34(7):3163-3168. Epub 2019 Oct 18 doi: 10.1007/s00464-019-07086-1. PMID: 31628620
Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia.
Werner YB, Hakanson B, Martinek J, Repici A, von Rahden BHA, Bredenoord AJ, Bisschops R, Messmann H, Vollberg MC, Noder T, Kersten JF, Mann O, Izbicki J, Pazdro A, Fumagalli U, Rosati R, Germer CT, Schijven MP, Emmermann A, von Renteln D, Fockens P, Boeckxstaens G, Rösch T
N Engl J Med 2019 Dec 5;381(23):2219-2229. doi: 10.1056/NEJMoa1905380. PMID: 31800987
Reflux monitoring in children.
Singendonk MM, Benninga MA, van Wijk MP
Neurogastroenterol Motil 2016 Oct;28(10):1452-9. doi: 10.1111/nmo.12922. PMID: 27682990

Recent systematic reviews

Comparative Efficacy of P-CAB vs Proton Pump Inhibitors for Grade C/D Esophagitis: A Systematic Review and Network Meta-analysis.
Zhuang Q, Chen S, Zhou X, Jia X, Zhang M, Tan N, Chen F, Zhang Z, Hu J, Xiao Y
Am J Gastroenterol 2024 May 1;119(5):803-813. Epub 2024 Feb 12 doi: 10.14309/ajg.0000000000002714. PMID: 38345252
Association Between Anxiety/Depression and Gastroesophageal Reflux: A Systematic Review and Meta-Analysis.
Zamani M, Alizadeh-Tabari S, Chan WW, Talley NJ
Am J Gastroenterol 2023 Dec 1;118(12):2133-2143. Epub 2023 Jul 19 doi: 10.14309/ajg.0000000000002411. PMID: 37463429
Efficacy and safety of proton pump inhibitors versus vonoprazan in treatment of erosive esophagitis: A PRISMA-compliant systematic review and network meta-analysis.
Yang S, Deng W, Xie Z, Chen J
Medicine (Baltimore) 2022 Nov 25;101(47):e31807. doi: 10.1097/MD.0000000000031807. PMID: 36451489Free PMC Article
Association between Schatzki ring and eosinophilic esophagitis: a systematic review and meta-analysis.
Sarbinowska J, Wiatrak B, Waśko-Czopnik D
Eur J Gastroenterol Hepatol 2021 Sep 1;33(9):1167-1173. doi: 10.1097/MEG.0000000000002067. PMID: 33470703
Vonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: A systematic review.
Miyazaki H, Igarashi A, Takeuchi T, Teng L, Uda A, Deguchi H, Higuchi K, Tango T
J Gastroenterol Hepatol 2019 Aug;34(8):1316-1328. Epub 2019 Apr 11 doi: 10.1111/jgh.14664. PMID: 30883868

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